The above Video Abstract, Key Points and Plain Language Summary represent the opinions of the authors. For a full list of declarations, including funding and author disclosure statements, and copyright information, please see the full text online (see “read the peer-reviewed publication” opposite). © The authors, CC-BY-NC 2022

Observational studies showed renal function had associations with Alzheimer’s disease (AD), Parkinson’s disease (PD), Lewy body dementia (LBD) and multiple sclerosis (MS). However, it is unknown whether these associations are causal. We use a two-sample Mendelian randomization (MR) analysis to investigate causal relationships between renal function and 6 neurodegenerative diseases (NDDs): AD (including familial AD), PD, LBD, frontotemporal dementia (FTD), amyotrophic lateral sclerosis (ALS) and MS. Blood urea nitrogen (BUN), chronic kidney disease (CKD) and...

The above videos represent the opinions of the authors. For a full list of declarations, including funding and author disclosure statements, and copyright information, please see the full text online. (see “read the peer-reviewed publication” opposite).

BackgroundHypertension (high blood pressure) is a modifiable risk factor for cardiovascular disease. However, patients may lack confidence in their understanding of what constitutes normal/healthy blood pressure, potentially affecting intentions to seek necessary care. The American Heart Association defines normal/healthy blood pressure as <120/80 mm Hg, with a 130/80 mm Hg threshold for hypertension diagnosis.MethodsOur US sample (N = 6,592) included 1,342 adults with hypertension alone and 795 with hypertension and relevant comorbidities (heart disease, kidney...

The emerging COVID-19 caused by SARS-CoV-2 infection poses severe challenges to global public health. Serum antibody testing is becoming one of the critical methods for the diagnosis of COVID-19 patients. We investigated IgM and IgG responses against SARS-CoV-2 nucleocapsid (N) and spike (S) protein after symptom onset in the intensive care unit (ICU) and non-ICU patients. 130 blood samples from 38 COVID-19 patients were collected. The levels of IgM and IgG specific to N and...

BackgroundMicroRNA-3612 (miR-3612) is considered a tumor suppressor in different cancers. Nonetheless, its function in nasopharyngeal carcinoma (NPC) has yet to be uncovered.MethodsNPC cells and tissues were tested by means of reverse transcription quantitative polymerase chain reaction (RT-qPCR) analysis and western blotting to quantify the expressions of miR-3612 and Thrombospondin 1 (THBS1). Cell Counting Kit-8 (CCK-8) and scratch experiments were carried out to evaluate the migration and proliferation of NPC cells. NPC cell adhesion was also...

BackgroundMicroRNA-3612 (miR-3612) is considered a tumor suppressor in different cancers. Nonetheless, its function in nasopharyngeal carcinoma (NPC) has yet to be uncovered.MethodsNPC cells and tissues were tested by means of reverse transcription quantitative polymerase chain reaction (RT-qPCR) analysis and western blotting to quantify the expressions of miR-3612 and Thrombospondin 1 (THBS1). Cell Counting Kit-8 (CCK-8) and scratch experiments were carried out to evaluate the migration and proliferation of NPC cells. NPC cell adhesion was also...

This project, a competing renewal of grant R01AI139254, will enable point of care (POC) testing of noninvasive oral swab samples for diagnosis of active tuberculosis (TB). Pulmonary TB is usually detected by analysis of sputum, which many patients cannot routinely produce for testing, especially at POC. Moreover, sputum collection is not routinely possible in community screening settings among non-symptomatic people. TB case-finding would be facilitated by use of a sample that is safe and easy...

The proposed research will develop computer-based methods to perform and update systematic literature reviews in the field of implementation research. It addresses the need of sophisticated information extraction tools for tracking measures and methods, implementation strategies, and implementation outcomes. These new tools will be useful for implementation researchers who want to identify patterns in funded studies over time, and reveal opportunities to synthesize and generalize across studies.

Supplemental material, sj-docx-1-wmr-10.1177_0734242X231160077 for Application of zeolite synthesized from coal fly ash via wet milling as a sustainable resource on lead(II) removal by Wenxia Wang, Zihan Zheng, Chao Feng, Xiangpeng Gao, Yu Qiao and Minghou Xu in Waste Management & Research

In this work, zeolite based on coal fly ash was firstly synthesized via wet milling for the adsorption of lead (Pb(II)). The effects of contact time, solid-to-liquid ratio and initial pH of solution on Pb(II) removal were investigated in detail. The experimental data showed that synthesized zeolite has high adsorption capacity of 99.082 mg of Pb(II) per gram of adsorbent. Coal fly ash zeolite synthesized by wet milling has good Pb(II) adsorption performance when the...

Virtual Interview Training for Transition-Age Youth and Virtual Reality Job Interview Training are job interview simulators with demonstrated effectiveness in randomized controlled trials. We evaluated their dose responses via secondary data analysis of 558 transition-age youth with disabilities in 47 schools where the simulators were implemented in quasi-experimental studies. Cut-point analyses determined dosing efficiency and efficacy to optimize competitive employment. The most efficient dose when accounting for the balance between dose and employment was completing...

Ab initio calculations are implemented to investigate the structural and helium diffusion behaviour in Fe 6.25 at.% Cr binary alloys based on FCC–Fe. Our simulation results confirmed that the increase of Cr contents in the AFM phase is beneficial to strengthen the shear deformation resistance and hardness of the alloys, and also leads to greater lattice distortion. The presence of Cr atoms accelerates the migration of mono-helium atoms between tetrahedral and octahedral gaps in varying...

Chromosomal microarray analysis (CMA) has been widely applied to genetic diagnosis in miscarriages in clinical practice. However, the prognostic value of CMA testing of products of conception (POCs) after the first clinical miscarriage remains unknown. The aim of this study was to evaluate the reproductive outcomes after embryonic genetic testing by CMA in SM couples. In this retrospective study, a total of 1142 SM couples referred for embryonic genetic testing by CMA, and 1022 couples...

Poly-ADP-ribose polymerase inhibitors (PARPis) have emerged as a new class of therapeutic agents for breast cancer patients with breast cancer susceptibility gene (BRCA) mutations. However, the efficacy and toxicity of PARPis have not been clearly established. This study comprehensively evaluated the efficacy and safety of PARPis in patients with BRCA-mutated breast cancer. Online databases were systematically searched, and six clinical trials were included. The primary endpoint of efficacy was progression-free survival (PFS), whereas the secondary...

While some evidence of an effect of radiation exposure on respiratory disease at low dose levels has now emerged, there is heterogeneity in the risks between different studies and countries. In this paper, we aim to show the effect of radiation on three different sub-types of respiratory disease mortality through the analysis of the NRRW cohort in UK. The NRRW cohort consisted of 174,541 radiation workers. Doses to the surface of the body were monitored...

The above video abstract and infographic represents the opinions of the authors. For a full list of declarations, including funding and author disclosure statements, and copyright information, please see the full text online. (see “read the peer-reviewed publication” opposite).

Supplemental material, sj-docx-1-cat-10.1177_10760296231165056 for Perioperative Outcomes of Patients with Bleeding Disorders Undergoing Major Surgery at an Academic Hemophilia Treatment Center by Ruben Rhoades, Zachary French, Amy Yang, Karen Walsh, Douglass A. Drelich and Steven E. McKenzie in Clinical and Applied Thrombosis/Hemostasis

Background: Control over automatic tendencies is often compromised in challenging situations when people fall back on automatic defensive reactions, such as freeze–fight–flight responses. Stress-induced lack of control over automatic defensive responses constitutes a problem endemic to high-risk professions, such as the police. Difficulties controlling automatic defensive responses may not only impair split-second decisions under threat, but also increase the risk for and persistence of posttraumatic stress disorder (PTSD) symptoms. However, the significance of these automatic...

Supplementary file containing materials and additional sensitivity analysis

Epidemiological and interventional studies have been rarely conducted among those with positive interferon-γ release assay (IGRA) results and radiologically inactive tuberculosis (TB) lesions on chest radiograph. This study aimed to estimate the effectiveness and safety of a six-week twice-weekly regimen (rifapentine plus isoniazid) among this key population in rural China. First, chest digital radiography was conducted to screen individuals with inactive TB lesions. Then, the identified participants were further evaluated and eligible participants with IGRA-positive...

BackgroundHypertension (high blood pressure) is a modifiable risk factor for cardiovascular disease. However, patients may lack confidence in their understanding of what constitutes normal/healthy blood pressure, potentially affecting intentions to seek necessary care. The American Heart Association defines normal/healthy blood pressure as <120/80 mm Hg, with a 130/80 mm Hg threshold for hypertension diagnosis.MethodsOur US sample (N = 6,592) included 1,342 adults with hypertension alone and 795 with hypertension and relevant comorbidities (heart disease, kidney...

Supplemental material, sj-xlsx-1-tct-10.1177_15330338221150069 for The Application of Morphogo in the Detection of Megakaryocytes from Bone Marrow Digital Images with Convolutional Neural Networks by Xiaofen Wang, Ying Wang, Chao Qi, Sai Qiao, Suwen Yang, Rongrong Wang, Hong Jin and Jun Zhang in Technology in Cancer Research & Treatment

Supplemental material, sj-xlsx-1-tct-10.1177_15330338221150069 for The Application of Morphogo in the Detection of Megakaryocytes from Bone Marrow Digital Images with Convolutional Neural Networks by Xiaofen Wang, Ying Wang, Chao Qi, Sai Qiao, Suwen Yang, Rongrong Wang, Hong Jin and Jun Zhang in Technology in Cancer Research & Treatment