787 Works

Tasks performed by parents to enable telepractice for children with communication disorders: an interview study with clinicians and parents

Kinga Pozniak, Peter Rosenbaum & Elaine Yuen Ling Kwok
Current service models in childhood rehabilitation promote the active participation of parents/caregivers in their children’s therapies. The existing literature provides a limited understanding of the tasks and responsibilities parents undertake in their children’s therapies, especially over telepractice. This study describes the tasks undertaken by parents in their children’s speech therapy delivered virtually during the COVID-19 pandemic. A qualitative descriptive study was conducted with parents and speech-language pathologists, using open-ended interviews. Interviews were analyzed using a...

Additional file 1 of Implicating genes, pleiotropy, and sexual dimorphism at blood lipid loci through multi-ancestry meta-analysis

Stavroula Kanoni, Sarah E. Graham, Yuxuan Wang, Ida Surakka, Shweta Ramdas, Xiang Zhu, Shoa L. Clarke, Konain Fatima Bhatti, Sailaja Vedantam, Thomas W. Winkler, Adam E. Locke, Eirini Marouli, Greg J. M. Zajac, Kuan-Han H. Wu, Ioanna Ntalla, Qin Hui, Derek Klarin, Austin T. Hilliard, Zeyuan Wang, Chao Xue, Gudmar Thorleifsson, Anna Helgadottir, Daniel F. Gudbjartsson, Hilma Holm, Isleifur Olafsson … & Gina M. Peloso
Additional file 1: Table S1. Characteristics of contributing cohorts (as provided by each participating cohort).

Additional file 5 of Implicating genes, pleiotropy, and sexual dimorphism at blood lipid loci through multi-ancestry meta-analysis

Stavroula Kanoni, Sarah E. Graham, Yuxuan Wang, Ida Surakka, Shweta Ramdas, Xiang Zhu, Shoa L. Clarke, Konain Fatima Bhatti, Sailaja Vedantam, Thomas W. Winkler, Adam E. Locke, Eirini Marouli, Greg J. M. Zajac, Kuan-Han H. Wu, Ioanna Ntalla, Qin Hui, Derek Klarin, Austin T. Hilliard, Zeyuan Wang, Chao Xue, Gudmar Thorleifsson, Anna Helgadottir, Daniel F. Gudbjartsson, Hilma Holm, Isleifur Olafsson … & Gina M. Peloso
Additional file 5: Table S4. Frequency of lipid-related publications for the PoPS+ prioritized genes.

Implicating genes, pleiotropy, and sexual dimorphism at blood lipid loci through multi-ancestry meta-analysis

Stavroula Kanoni, Sarah E. Graham, Yuxuan Wang, Ida Surakka, Shweta Ramdas, Xiang Zhu, Shoa L. Clarke, Konain Fatima Bhatti, Sailaja Vedantam, Thomas W. Winkler, Adam E. Locke, Eirini Marouli, Greg J. M. Zajac, Kuan-Han H. Wu, Ioanna Ntalla, Qin Hui, Derek Klarin, Austin T. Hilliard, Zeyuan Wang, Chao Xue, Gudmar Thorleifsson, Anna Helgadottir, Daniel F. Gudbjartsson, Hilma Holm, Isleifur Olafsson … & Gina M. Peloso
Abstract Background Genetic variants within nearly 1000 loci are known to contribute to modulation of blood lipid levels. However, the biological pathways underlying these associations are frequently unknown, limiting understanding of these findings and hindering downstream translational efforts such as drug target discovery. Results To expand our understanding of the underlying biological pathways and mechanisms controlling blood lipid levels, we leverage a large multi-ancestry meta-analysis (N = 1,654,960) of blood lipids to prioritize putative causal...

Implicating genes, pleiotropy, and sexual dimorphism at blood lipid loci through multi-ancestry meta-analysis

Stavroula Kanoni, Sarah E. Graham, Yuxuan Wang, Ida Surakka, Shweta Ramdas, Xiang Zhu, Shoa L. Clarke, Konain Fatima Bhatti, Sailaja Vedantam, Thomas W. Winkler, Adam E. Locke, Eirini Marouli, Greg J. M. Zajac, Kuan-Han H. Wu, Ioanna Ntalla, Qin Hui, Derek Klarin, Austin T. Hilliard, Zeyuan Wang, Chao Xue, Gudmar Thorleifsson, Anna Helgadottir, Daniel F. Gudbjartsson, Hilma Holm, Isleifur Olafsson … & Gina M. Peloso
Abstract Background Genetic variants within nearly 1000 loci are known to contribute to modulation of blood lipid levels. However, the biological pathways underlying these associations are frequently unknown, limiting understanding of these findings and hindering downstream translational efforts such as drug target discovery. Results To expand our understanding of the underlying biological pathways and mechanisms controlling blood lipid levels, we leverage a large multi-ancestry meta-analysis (N = 1,654,960) of blood lipids to prioritize putative causal...

Additional file 1 of Crosstalk between 5-methylcytosine and N6-methyladenosine machinery defines disease progression, therapeutic response and pharmacogenomic landscape in hepatocellular carcinoma

Yu Tian, Haijuan Xiao, Yanhui Yang, Pingping Zhang, Jiahui Yuan, Wei Zhang, Lijie Chen, Yibao Fan, Jinze Zhang, Huan Cheng, Tingwei Deng, Lin Yang, Weiwei Wang, Guoyong Chen, Peiqin Wang, Peng Gong, Xing Niu & Xianbin Zhang
Additional file 1: Supplementary figure 1. Landscape of the expression levels and genetic alterations of 5mC/m6A regulators across 33 cancer types. (A) Gene expression profiling of 5mC/m6A regulators across pan-cancer. For a given 5mC/m6A regulator in each cancer type, the median expression value is shown. (B, C) Spearman correlations of CNVs with transcript levels of 5mC/m6A regulators in pan-cancer, reflecting the gene expression significantly affected by CNVs. (D, E) Pie chart for heterozygous and homozygous...

Additional file 3 of Crosstalk between 5-methylcytosine and N6-methyladenosine machinery defines disease progression, therapeutic response and pharmacogenomic landscape in hepatocellular carcinoma

Yu Tian, Haijuan Xiao, Yanhui Yang, Pingping Zhang, Jiahui Yuan, Wei Zhang, Lijie Chen, Yibao Fan, Jinze Zhang, Huan Cheng, Tingwei Deng, Lin Yang, Weiwei Wang, Guoyong Chen, Peiqin Wang, Peng Gong, Xing Niu & Xianbin Zhang
Additional file 3: Supplementary figure 3. Drug sensitivity of 5mC/m6A regulators in pan-cancer. (A, B) Spearman correlation analysis between the expression levels of 5mC/m6A regulators and the small molecule compound sensitivity (IC50).

Additional file 1 of First-in-human phase I dose-escalation and dose-expansion trial of the selective MEK inhibitor HL-085 in patients with advanced melanoma harboring NRAS mutations

Xuan Wang, Zhiguo Luo, Jing Chen, Yu Chen, Dongmei Ji, Li Fan, Ling Chen, Qian Zhao, Pei Hu, Peng Sun, Zhongwei Jia, Jun Guo & Lu Si
Additional file 1.

Additional file 1 of Co-occurring conditions in children with Down syndrome and autism: a retrospective study

Noemi A. Spinazzi, Jonathan D. Santoro, Katherine Pawlowski, Gabriel Anzueto, Yamini J. Howe, Lina R. Patel & Nicole T. Baumer
Additional file 1. Explanation of Grouped Variables.

Male and female mice display consistent lifelong ability to address potential life-threatening cues using different post-threat coping strategies

Xue Liu, Xiaolong Feng, Hongren Huang, Kang Huang, Yang Xu, Shuwei Ye, Yu-Ting Tseng, Pengfei Wei, Liping Wang & Feng Wang
Abstract Background Sex differences ranging from physiological functions to pathological disorders are developmentally hard-wired in a broad range of animals, from invertebrates to humans. These differences ensure that animals can display appropriate behaviors under a variety of circumstances, such as aggression, hunting, sleep, mating, and parental care, which are often thought to be important in the acquisition of resources, including territory, food, and mates. Although there are reports of an absence of sexual dimorphism in...

Additional file 1 of Patient-provider communication while using a clinical decision support tool: explaining satisfaction with shared decision making for mammography screening

Yan Liu, Rachel Kornfield, Ellie Fan Yang, Elizabeth Burnside, Jon Keevil & Dhavan V. Shah
Additional file 1. Figure S1a. ‘Data’ page from the Breast Cancer Risk Estimator Decision Aid. Figure S1b. ‘Assessment’ page from the Breast Cancer Risk Estimator Decision Aid.Figure S1c. ‘Decision’ page from the Breast Cancer Risk Estimator Decision Ai. Table S3. Linear Mixed-effect Model of Linguistic Features and System Use on Patient’s Feeling Informed. Table S4. Linear Mixed-effect Model of Linguistic Features and System Use on Patient’s Benefit/Risk Clarity. Table S5. Linear Mixed-effect Model of Linguistic...

Patient-provider communication while using a clinical decision support tool: explaining satisfaction with shared decision making for mammography screening

Yan Liu, Rachel Kornfield, Ellie Fan Yang, Elizabeth Burnside, Jon Keevil & Dhavan V. Shah
Abstract Background Clinical decision aids may support shared decision-making for screening mammography. To inform shared decision-making between patients and their providers, this study examines how patterns of using an EHR-integrated decision aid and accompanying verbal patient-provider communication predict decision-making satisfaction. Methods For 51 patient visits during which a mammography decision aid was used, linguistic characteristics of patient-provider verbal communication were extracted from transcribed audio recordings and system logs automatically captured uses of the decision aid....

A food bank program to help food pantries improve healthy food choices: mixed methods evaluation of The Greater Boston Food Bank’s Healthy Pantry Program

Jenny Jia, Rachel Burgun, Alexa Reilly, Ross Sonnenblick, Lauren Fiechtner, Rachel M. Zack, Bianca Porneala & Anne N. Thorndike
Abstract Background The Greater Boston Food Bank’s (GBFB) Healthy Pantry Program (HPP) is an online training that teaches food pantry staff to implement behavioral nudges (e.g., traffic-light nutrition labels, choice architecture) to promote healthier client choices. This study assessed if HPP was associated with healthier food bank orders by food pantries and identified implementation facilitators and barriers. Methods This mixed methods study collected quantitative data from a matched cohort of 10 HPP food pantries and...

A food bank program to help food pantries improve healthy food choices: mixed methods evaluation of The Greater Boston Food Bank’s Healthy Pantry Program

Jenny Jia, Rachel Burgun, Alexa Reilly, Ross Sonnenblick, Lauren Fiechtner, Rachel M. Zack, Bianca Porneala & Anne N. Thorndike
Abstract Background The Greater Boston Food Bank’s (GBFB) Healthy Pantry Program (HPP) is an online training that teaches food pantry staff to implement behavioral nudges (e.g., traffic-light nutrition labels, choice architecture) to promote healthier client choices. This study assessed if HPP was associated with healthier food bank orders by food pantries and identified implementation facilitators and barriers. Methods This mixed methods study collected quantitative data from a matched cohort of 10 HPP food pantries and...

Additional file 1 of Low-dose pleiotropic radiosensitive nanoformulations for three-pronged radiochemotherapy of hypoxic brain glioblastoma under BOLD/DWI monitoring

Fangshi Zhao, Xiaoyi Wang, Wei Zhu, Dongju Zhao, Caihua Ye, Yanyan Guo & Yan Dou
Additional file 1: Figure S1. Schematic diagram of the synthesis of SLC-AN/SN@AQ NPs. Figure S2. BCA standard curve. Figure S3. Size stability of SLC-AN/SN@AQ NPs incubated in different biological media for 14 days. Figure S4. Cytotoxicity of SLC-AN NPs, SLC-AN/SN NPs, and SLC-AN/SN@AQ NPs to U87MG cells under normoxic or hypoxic conditions. Figure S5. NO production in U87MG cells after various treatments under normoxic conditions. Figure S6. TEER values of the bEnd.3 cell monolayer before...

Low-dose pleiotropic radiosensitive nanoformulations for three-pronged radiochemotherapy of hypoxic brain glioblastoma under BOLD/DWI monitoring

Fangshi Zhao, Xiaoyi Wang, Wei Zhu, Dongju Zhao, Caihua Ye, Yanyan Guo & Yan Dou
Abstract Background Hypoxia-mediated radioresistance is the main obstacle to the successful treatment of glioblastoma (GBM). Enhancing hypoxic radiosensitivity and alleviating tumor hypoxia are both effective means to improve therapeutic efficacy, and the combination of the two is highly desirable and meaningful. Results Herein, we construct a low-dose pleiotropic radiosensitive nanoformulation consisting of a high-Z atomic nanocrystal core and mesoporous silica shell, surface-modified with angiopep-2 (ANG) peptide and loaded with nitric oxide (NO) donor and hypoxia-activated...

Additional file 1 of Identification of critical prognosis signature associated with lymph node metastasis of stomach adenocarcinomas

Xiaohui Wang, Wei Zhang, Yulin Guo, Yifei Zhang, Xiaofeng Bai & Yibin Xie
Additional file 1: Fig. S1. The LNM-DEGs associated with OS for STAD patients in TCGA Datasets based on uniCox (A) and multiCox (B) proportional hazard.

Additional file 3 of Identification of critical prognosis signature associated with lymph node metastasis of stomach adenocarcinomas

Xiaohui Wang, Wei Zhang, Yulin Guo, Yifei Zhang, Xiaofeng Bai & Yibin Xie
Additional file 3: Fig. S3. The original images of WB in this study to detect the protein expression level of 10-mRNA signature and GAPDH which as the internal control.

Additional file 5 of Identification of critical prognosis signature associated with lymph node metastasis of stomach adenocarcinomas

Xiaohui Wang, Wei Zhang, Yulin Guo, Yifei Zhang, Xiaofeng Bai & Yibin Xie
Additional file 5: Table S2. The sequence of primers in this study.

Additional file 8 of Identification of critical prognosis signature associated with lymph node metastasis of stomach adenocarcinomas

Xiaohui Wang, Wei Zhang, Yulin Guo, Yifei Zhang, Xiaofeng Bai & Yibin Xie
Additional file 8: Table S5. GO analysis of the nonLNM-specific DEGs.

Additional file 11 of Identification of critical prognosis signature associated with lymph node metastasis of stomach adenocarcinomas

Xiaohui Wang, Wei Zhang, Yulin Guo, Yifei Zhang, Xiaofeng Bai & Yibin Xie
Additional file 11: Table S8. Pathway enrichment analysis of the nonLNM-specific DEGs.

Additional file 2 of Belowground microbiota analysis indicates that Fusarium spp. exacerbate grapevine trunk disease

Yonghua Li, Xinghong Li, Wei Zhang, Jiao Zhang, Hui Wang, Junbo Peng, Xuncheng Wang & Jiye Yan
Additional file 2: Fig. S1. Typical grapevine trunk disease (GTD) symptoms in grapevines collected in this study. A The overall condition of symptomatic grapevines with yellow spots or tiger stripes on the leaves of multiple branches. B Foliar symptoms that initially appeared as chlorotic spots and subsequently coalesced and finally became necrotic. C Internal symptoms of the same vine with foliar symptoms showing dark brown necrosis. Fig. S2. Species accumulation curves for fungal communities based...

Enhanced survival of hypoimmunogenic otic progenitors following intracochlear xenotransplantation: repercussions for stem cell therapy in hearing loss models

Luisa H. Andrade da Silva, Rachel A. Heuer, Christian B. Roque, Tammy L. McGuire, Tomonori Hosoya, Hironobu Kimura, Kouichi Tamura & Akihiro J. Matsuoka
Abstract Stem cell replacement holds the potential for sensorineural hearing loss (SNHL) treatment. However, its translation into clinical practice requires strategies for improving stem cell survival following intracochlear transplantation. Considering recent findings showing that the inner ear contains a resident population of immune cells, we hypothesized that immune evasion would improve the survival and residence time of transplanted stem cells in the cochlea, potentially leading to better outcomes. To test this, we leveraged genetic engineering...

Additional file 2 of Receptor-Like Cytoplasmic Kinase STK Confers Salt Tolerance in Rice

Yanbiao Zhou, Zhihui Zhang, Xinhui Zhao, Lan Liu, Qianying Tang, Jun Fu, Xiaodan Tang, Runqiu Yang, Jianzhong Lin, Xuanming Liu & Yuanzhu Yang
Additional file 2. Table S1: List of primers used in this study. Table S2: Differential expression data of stress-related in the STK-OE plants.

Additional file 1 of Novel fusion protein PK5-RL-Gal-3C inhibits hepatocellular carcinoma via anti-angiogenesis and cytotoxicity

Xiaoge Gao, Pin Jiang, Xiaohuan Wei, Wei Zhang, Jiwei Zheng, Shishuo Sun, Hong Yao, Xiangye Liu & Qing Zhang
Additional file 1.

Registration Year

  • 2023
    787

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    179
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    74
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    33
  • Output Management Plan
    6
  • Other
    5
  • Interactive Resource
    2

Affiliations

  • Northwestern University
    787
  • Zhejiang University
    501
  • Sun Yat-sen University
    455
  • Shanghai Jiao Tong University
    444
  • Sichuan University
    440
  • Huazhong University of Science and Technology
    430
  • Fudan University
    428
  • Chinese Academy of Medical Sciences & Peking Union Medical College
    425
  • Chinese Academy of Sciences
    403
  • Shandong University
    401