Additional File 1: Logistic regressionin women with hormonesonly

Additional File 2: Hirsutism and androgens

Additional File 5: Unrecognized PCOS as referent

Additional File 3: Models without adjustment forrace

Additional file 1: Methodological supplement and additional results.

Abstract Background A recent WHO recommendation for perennial malaria chemoprevention (PMC) encourages countries to adapt dose timing and number to local conditions. However, knowledge gaps on the epidemiological impact of PMC and possible combination with the malaria vaccine RTS,S hinder informed policy decisions in countries where malaria burden in young children remains high. Methods The EMOD malaria model was used to predict the impact of PMC with and without RTS,S on clinical and severe malaria...

Abstract Background Decision-makers impose COVID-19 mitigations based on public health indicators such as reported cases, which are sensitive to fluctuations in supply and demand for diagnostic testing, and hospital admissions, which lag infections by up to two weeks. Imposing mitigations too early has unnecessary economic costs while imposing too late leads to uncontrolled epidemics with unnecessary cases and deaths. Sentinel surveillance of recently-symptomatic individuals in outpatient testing sites may overcome biases and lags in conventional...

Abstract Subacute sclerosing panencephalitis (SSPE) occurs in some individuals after measles infection, following a symptom-free period of several years. It resembles chronic traumatic encephalopathy (CTE), which happens after repetitive head impacts or exposure to blast waves, following a symptom-free period. As in CTE, the neurofibrillary changes of SSPE are concentrated in superficial cortical layers. Here we used electron cryo-microscopy (cryo-EM) of tau filaments from two cases of SSPE to show that the tau folds of...

Abstract Background High dose vasopressors portend poor outcome in vasodilatory shock. We aimed to evaluate the impact of baseline vasopressor dose on outcomes in patients treated with angiotensin II (AT II). Methods Exploratory post-hoc analysis of the Angiotensin II for the Treatment of High-Output Shock (ATHOS-3) trial data. The ATHOS-3 trial randomized 321 patients with vasodilatory shock, who remained hypotensive (mean arterial pressure of 55–70 mmHg) despite receiving standard of care vasopressor support at a...

Additional file 1: Supplementary Table 1. Kendall’s tau B of the questionnaire survey based on the five-point Likert scale. Supplementary Table 2. A five-point Likert scale questionnaire was used to collect the feedback from dental students (n=72)

Abstract Background The integration of patient–reported outcome measures (PROMS) into health care delivery systems is being increasingly recognized as an important component of quality, person-centered care, especially for chronic illnesses like congestive heart failure (CHF). However, while PROMS are increasingly being used to follow up CHF patients in high income countries, their use in sub-Saharan Africa is still limited. We adapted the Kansas City Cardiomyopathy Questionnaire (KCCQ-23), an internationally validated, CHF-specific PROM and tested its...

Additional file 1: Figure S1. Assignment of 774 LGAs in Nigeria into 22 epidemiological archetypes. Figure S2. Simulated seasonality of clinical malaria by archetype compared with the Rapid Impact Assessment health facility data for years 2014 – 2018. Thin red lines show 50 stochastic realizations and solid red dots and line show the mean over the realizations. Figure S3. a: Case management among children under the age, insecticide treated nets use and PfPR among children...

Supplementary material

Supplementary Material 1

Supplementary Material 4

Additional file 2. Overview of stained sections from all tissue microarray before and after fluorescence imaging.

Supplementary Material 6

Supplementary Fig. S3: A table showing dog breeds represented in this study.

Supplementary Fig. S4: A bar graph showing the seasonal distribution of cases.

Supplementary Fig. S5: A bar graph showing the incidence of antimicrobial resistance.

Abstract Background The Cancer Center Cessation Initiative (C3I) is a National Cancer Institute (NCI) Cancer Moonshot Program that supports NCI-designated cancer centers developing tobacco treatment programs for oncology patients who smoke. C3I-funded centers implement evidence-based programs that offer various smoking cessation treatment components (e.g., counseling, Quitline referrals, access to medications). While evaluation of implementation outcomes in C3I is guided by evaluation of reach and effectiveness (via RE-AIM), little is known about technical efficiency—i.e., how inputs...

Supplemental Materials for What Public Comments During Rulemaking Do (and Why) by Brian Libgober, and Steven Rashin in American Politics Research.

Public comments on proposed federal regulations are thought to influence bureaucratic policy choices, but why? While reelection incentives give politicians straightforward reasons for catering to public preferences, regulators lack similarly direct incentives to accede to demands from stake-holders. We argue commenters may adopt several different tactics to try and persuade regulators. Broadly, they may either describe policy consequences or threaten the regulator with sanctions, especially by the Courts or Congress. But which tactics do members...

Objective: The identification of effective therapeutics for ALS necessitates valid and responsive outcome measures to track disease progression and therapeutic gain in clinical trial settings. The Amyotrophic Lateral Sclerosis-Health Index (ALS-HI) is a multifaceted, disease-specific patient-reported outcome measure (PRO) designed to measure ALS symptomatic disease burden in adults with ALS. Methods: Through a national cross-sectional study of individuals with ALS, we identified the most important symptoms in ALS. These symptoms were incorporated into the ALS-HI,...

Background:The ulcerative colitis (UC) Mayo endoscopy score is a useful tool for evaluating the severity of UC in patients in clinical practice.Objectives:We aimed to develop and validate a deep learning-based approach to automatically predict the Mayo endoscopic score using UC endoscopic images.Design:A multicenter, diagnostic retrospective study.Methods:We collected 15120 colonoscopy images of 768 UC patients from two hospitals in China and developed a deep model based on a vision transformer named the UC-former. The performance of...