381 Works

Additional file 1 of Age- and sex-related differences in the retinal capillary plexus in healthy Chinese adults

Binbin Su, Xiaoxuan Zhu, Kai Yang, Yunfan Xiao, Chunmei Li, Keai Shi, Jia Qu, Fan Lu, Ming Li & Lele Cui
Additional file 1: Figure S1. Vessel densities of the whole measured area, parafovea, and four quadrants (temporal, superior, nasal, and inferior) in the (a, c) SCP and (b, d) DCP measured with optical coherence tomography angiography stratified by age in males and females. Table S1. Baseline characteristics of male participants in the study. Table S2. Baseline characteristics of female participants in the study. Table S3. Vessel densities of the whole measured area, parafovea, and four...

Additional file 1 of Clinical value of fetal facial profile markers during the first trimester

Xiaofeng Zhou, Chunya Ji, Lingling Sun, Linliang Yin, Xuedong Deng, Qi Pan, Jun Zhang, Zhong Yang, Chenhan Zheng, Chen Ling, Liping Shi & Yanqing Wu
Additional file 1.

Gapless genome assembly of East Asian finless porpoise, Neophocaena asiaeorientalis sunameri

Denghua Yin, Chunhai Chen, Danqing Lin, Jialun Zhang, Congping Ying, Yan Liu, Wang Liu, Zhichen Cao, Chenxi Zhao, Chenhe Wang, Liping Liang, Pao Xu, Jianbo Jian & Kai Liu
There are the genome sequence, gene set, coding sequence and protein sequence of Neophocaena asiaeorientalis sunameri.

Additional file 6 of Transcriptomic analysis of paternal behaviors in prairie voles

Florian Duclot, Yan Liu, Samantha K. Saland, Zuoxin Wang & Mohamed Kabbaj
Additional file 6. Relationships between parental behavior test behaviors. For each pair of behavior, a linear model was fit. Each individual point represents a distinct animal, and the shaded area depicts the 95% confidence interval.

Transcriptomic analysis of paternal behaviors in prairie voles

Florian Duclot, Yan Liu, Samantha K. Saland, Zuoxin Wang & Mohamed Kabbaj
Abstract Background The importance of fathers’ engagement in care and its critical role in the offspring’s cognitive and emotional development is now well established. Yet, little is known on the underlying neurobiology due to the lack of appropriate animal models. In the socially monogamous and bi-parental prairie vole (Microtus ochrogaster), while 60–80% of virgin males show spontaneous paternal behaviors (Paternal), others display pup-directed aggression (Attackers). Here we took advantage of this phenotypic dichotomy and used...

Transcriptomic analysis of paternal behaviors in prairie voles

Florian Duclot, Yan Liu, Samantha K. Saland, Zuoxin Wang & Mohamed Kabbaj
Abstract Background The importance of fathers’ engagement in care and its critical role in the offspring’s cognitive and emotional development is now well established. Yet, little is known on the underlying neurobiology due to the lack of appropriate animal models. In the socially monogamous and bi-parental prairie vole (Microtus ochrogaster), while 60–80% of virgin males show spontaneous paternal behaviors (Paternal), others display pup-directed aggression (Attackers). Here we took advantage of this phenotypic dichotomy and used...

Additional file 3 of Circulating tumor DNA integrating tissue clonality detects minimal residual disease in resectable non-small-cell lung cancer

Siwei Wang, Ming Li, Jingyuan Zhang, Peng Xing, Min Wu, Fancheng Meng, Feng Jiang, Jie Wang, Hua Bao, Jianfeng Huang, Binhui Ren, Mingfeng Yu, Ninglei Qiu, Houhuai Li, Fangliang Yuan, Zhi Zhang, Hui Jia, Xinxin Lu, Shuai Zhang, Xiaojun Wang, Youtao Xu, Wenjia Xia, Tongyan Liu, Weizhang Xu, Xinyu Xu … & Rong Yin
Additional file 3. Table S3: Performance of three strategies.

Additional file 5 of Circulating tumor DNA integrating tissue clonality detects minimal residual disease in resectable non-small-cell lung cancer

Siwei Wang, Ming Li, Jingyuan Zhang, Peng Xing, Min Wu, Fancheng Meng, Feng Jiang, Jie Wang, Hua Bao, Jianfeng Huang, Binhui Ren, Mingfeng Yu, Ninglei Qiu, Houhuai Li, Fangliang Yuan, Zhi Zhang, Hui Jia, Xinxin Lu, Shuai Zhang, Xiaojun Wang, Youtao Xu, Wenjia Xia, Tongyan Liu, Weizhang Xu, Xinyu Xu … & Rong Yin
Additional file 5. Figure S2: Mutational profile of plasma samples. Gene mutations detected in tissue and plasma samples in each patient. Colors denote different variant types. Horizontal and vertical bars denote the detection of tissue mutations in presurgical and postsurgical plasma samples, respectively. Twenty most prevalent gene mutations in tissue samples were shown.

Additional file 5 of Circulating tumor DNA integrating tissue clonality detects minimal residual disease in resectable non-small-cell lung cancer

Siwei Wang, Ming Li, Jingyuan Zhang, Peng Xing, Min Wu, Fancheng Meng, Feng Jiang, Jie Wang, Hua Bao, Jianfeng Huang, Binhui Ren, Mingfeng Yu, Ninglei Qiu, Houhuai Li, Fangliang Yuan, Zhi Zhang, Hui Jia, Xinxin Lu, Shuai Zhang, Xiaojun Wang, Youtao Xu, Wenjia Xia, Tongyan Liu, Weizhang Xu, Xinyu Xu … & Rong Yin
Additional file 5. Figure S2: Mutational profile of plasma samples. Gene mutations detected in tissue and plasma samples in each patient. Colors denote different variant types. Horizontal and vertical bars denote the detection of tissue mutations in presurgical and postsurgical plasma samples, respectively. Twenty most prevalent gene mutations in tissue samples were shown.

Additional file 22 of Transcriptomic analysis of paternal behaviors in prairie voles

Florian Duclot, Yan Liu, Samantha K. Saland, Zuoxin Wang & Mohamed Kabbaj
Additional file 22. Structure-specific associations of gene coexpression modules with parental behaviors. The correlation of each co-expression module from the weighted gene coexpression network analysis with behavioral traits (behaviors scored during parental behavior test and phenotype status) is depicted for each structure. The correlation value is detailed alongside its corresponding p-value in parentheses. Note that within each structure, only modules with at least one significant association are depicted. MPOA: medial preoptic area, NAc: nucleus accumbens,...

Additional file 24 of Transcriptomic analysis of paternal behaviors in prairie voles

Florian Duclot, Yan Liu, Samantha K. Saland, Zuoxin Wang & Mohamed Kabbaj
Additional file 24. Functional enrichment of gene ontologies of the biological processes category in gene co-expression modules derived from the weighted gene coexpression network analysis (WGCNA).

Additional file 16 of Transcriptomic analysis of paternal behaviors in prairie voles

Florian Duclot, Yan Liu, Samantha K. Saland, Zuoxin Wang & Mohamed Kabbaj
Additional file 16. Representation of the number of genes differentially expressed in the medial preoptic area (MPOA, top), nucleus accumbens (NAc, middle), and lateral septum (LS, bottom) across all chromosomes and linkage groups in the prairie vole assembly. Only cases with at least one differentially expressed gene are depicted.

Additional file 17 of Transcriptomic analysis of paternal behaviors in prairie voles

Florian Duclot, Yan Liu, Samantha K. Saland, Zuoxin Wang & Mohamed Kabbaj
Additional file 17. Functional enrichment of genes differentially expressed in the nucleus accumbens (NAc). For each pairwise comparison, the functional enrichments in gene ontologies of the biological processes (A), cellular components (B), and molecular functions (C) categories as well as in pathways from the Kyoto Encyclopedia of Genes and Genomes (KEGG, D) were tested for the differentially expressed genes up- or down-regulated (UP, and DOWN, respectively). The labels of pairwise comparisons were coded in two...

Development and validation of an ECM-related prognostic signature to predict the immune landscape of human hepatocellular carcinoma

Guozhi Wu, Yuan Yang, Rong Ye, Hanxun Yue, Huiyun Zhang, Taobi Huang, Min Liu, Ya Zheng, Yuping Wang, Yongning Zhou & Qinghong Guo
Abstract Background The global burden of hepatocellular carcinoma (HCC) is increasing, negatively impacting social health and economies. The discovery of novel and valuable biomarkers for the early diagnosis and therapeutic guidance of HCC is urgently needed. Methods Extracellular matrix (ECM)-related gene sets, transcriptome data and mutation profiles were downloaded from the Matrisome Project and The Cancer Genome Atlas (TCGA)-LIHC datasets. Coexpression analysis was initially performed with the aim of identifying ECM-related lncRNAs (r > 0.4,...

Development and validation of an ECM-related prognostic signature to predict the immune landscape of human hepatocellular carcinoma

Guozhi Wu, Yuan Yang, Rong Ye, Hanxun Yue, Huiyun Zhang, Taobi Huang, Min Liu, Ya Zheng, Yuping Wang, Yongning Zhou & Qinghong Guo
Abstract Background The global burden of hepatocellular carcinoma (HCC) is increasing, negatively impacting social health and economies. The discovery of novel and valuable biomarkers for the early diagnosis and therapeutic guidance of HCC is urgently needed. Methods Extracellular matrix (ECM)-related gene sets, transcriptome data and mutation profiles were downloaded from the Matrisome Project and The Cancer Genome Atlas (TCGA)-LIHC datasets. Coexpression analysis was initially performed with the aim of identifying ECM-related lncRNAs (r > 0.4,...

Additional file 1 of Development and validation of an ECM-related prognostic signature to predict the immune landscape of human hepatocellular carcinoma

Guozhi Wu, Yuan Yang, Rong Ye, Hanxun Yue, Huiyun Zhang, Taobi Huang, Min Liu, Ya Zheng, Yuping Wang, Yongning Zhou & Qinghong Guo
Additional file 1.

Additional file 1 of Development and validation of an ECM-related prognostic signature to predict the immune landscape of human hepatocellular carcinoma

Guozhi Wu, Yuan Yang, Rong Ye, Hanxun Yue, Huiyun Zhang, Taobi Huang, Min Liu, Ya Zheng, Yuping Wang, Yongning Zhou & Qinghong Guo
Additional file 1.

Additional file 1 of Interaction of miR-200a-3p with YAP regulates cell proliferation and metastasis differentially in HPV-positive and HPV-negative cervical cancer cells

Hong Chen, Lingling Gu, Min Zhang, Huifen Chen, Hong Liao, Xueping Cao, Lu Yu & Jun Zhang
Additional file 1: Supplementary Fig. S1. qRT-PCRassessmentsoftransfectionefficiencies The transfection efficiencies of miR-200a-3p mimics (A), sh-miR-200a-3p (B), and YAP(C)wereperformedinC33A,SihaandHelacells.*p<0.05, **p<0.01,***p<0.001,ns:notsignificant. The authors declare that they have no competing interests. Supplementary Fig. S2. themRNAandproteinlevelsofYAPinHelacells Significant decreases in levels of YAP mRNA (A) and YAP protein (B) following up-regulations of miR-200a-3p, or significant increases in levels of YAP mRNA (C) and protein (D) following down-regulations of miR-200a-3p were not observed in Helacells.*p<0.05,**p<0.01,***p<0.001,ns:notsignificant.

Interaction of miR-200a-3p with YAP regulates cell proliferation and metastasis differentially in HPV-positive and HPV-negative cervical cancer cells

Hong Chen, Lingling Gu, Min Zhang, Huifen Chen, Hong Liao, Xueping Cao, Lu Yu & Jun Zhang
Abstract Background Although evidence has revealed that miR-200a-3p is involved in the malignant progression of various tumors, the regulatory mechanism of miR-200a-3p in the development of cervical cancer (CC) cells with different HPV statuses remains unknown. The present study was to investigate the differential effects of either miR-200a-3p or YAP on tumorous cells’ fate in vitro in HPV-negative and HPV-positive cervical cancer cell models, and to explore if the changes in proliferation, migration, and invasion...

Additional file 3 of Interaction of miR-200a-3p with YAP regulates cell proliferation and metastasis differentially in HPV-positive and HPV-negative cervical cancer cells

Hong Chen, Lingling Gu, Min Zhang, Huifen Chen, Hong Liao, Xueping Cao, Lu Yu & Jun Zhang
Additional file 3.

Additional file 5 of Genome-wide identification, new classification, expression analysis and screening of drought & heat resistance related candidates in the RING zinc finger gene family of bread wheat (Triticum aestivum L.)

Yongliang Li, Pai Qin, Aolong Sun, Wenjun Xiao, Fenglin Chen, Yang He, Keyao Yu, You Li, Meng Zhang & Xinhong Guo
Additional file 5: Table S2. One-to-one orthologous relationships among T.aestivum and T.aestivum, A.thaliana, A. tauschii, B. distachyon, H. vulgare, rice, S.italica and Zea mays, respectively.

Additional file 6 of Genome-wide identification, new classification, expression analysis and screening of drought & heat resistance related candidates in the RING zinc finger gene family of bread wheat (Triticum aestivum L.)

Yongliang Li, Pai Qin, Aolong Sun, Wenjun Xiao, Fenglin Chen, Yang He, Keyao Yu, You Li, Meng Zhang & Xinhong Guo
Additional file 6: Table S3. The information of cis-acting elements on the promoters of T. aestivum RING-zf genes.

Additional file 6 of Genome-wide identification, new classification, expression analysis and screening of drought & heat resistance related candidates in the RING zinc finger gene family of bread wheat (Triticum aestivum L.)

Yongliang Li, Pai Qin, Aolong Sun, Wenjun Xiao, Fenglin Chen, Yang He, Keyao Yu, You Li, Meng Zhang & Xinhong Guo
Additional file 6: Table S3. The information of cis-acting elements on the promoters of T. aestivum RING-zf genes.

Additional file 2 of Genome-wide identification, new classification, expression analysis and screening of drought & heat resistance related candidates in the RING zinc finger gene family of bread wheat (Triticum aestivum L.)

Yongliang Li, Pai Qin, Aolong Sun, Wenjun Xiao, Fenglin Chen, Yang He, Keyao Yu, You Li, Meng Zhang & Xinhong Guo
Additional file 2: Figure S2. Phylogenetic relationships, gene structure and architecture of conserved protein motifs in 138 TaRING-zfs from T. aestivum. a The name of 138 TaRING-zf genes. b Exon, intron, and UTR structure of 138 TaRING-zf genes. Yellow boxes indicate untranslated 5’ and 3’ regions, green boxes indicate exon, and black lines indicate introns. The gene full length and protein length can be estimated by using the scale at the bottom. c The motif...

Additional file 1 of Decreased influenza vaccination coverage among Chinese healthcare workers during the COVID-19 pandemic

Libing Ma, Xuan Han, Yuan Ma, Yuan Yang, Yunshao Xu, Di Liu, Weizhong Yang & Luzhao Feng
Additional file 1: Questionnaire

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