50 Works

Removal Characteristics of Heavy Metal ions in Rainwater Runoff by Bioretention Cell Modified with Biochar

Jiaqing Xiong, Guohao Li, Junguo Zhu, Jianqiang Li, Yuan Yang, Shengxia An & Chengkui Liu
As a form of pollution source control and a low-impact development measure, bioretention is a convenient, economical and effective method for the removal of heavy metals from stormwater runoff, which can adapt to the randomness and uncontrollability of non-point source pollution. However, few studies have assessed the performance of bioretention in the simultaneous removal multiple heavy metals and the impact of heavy metal migration on the bioretention life cycle. In this study, the removal rates...

Compound Danshen Dripping Pill inhibits high altitude-induced hypoxic damage by suppressing oxidative stress and inflammatory responses

Yunhui Hu, Jia Sun, Tongxing Wang, Hairong Wang, Chunlai Zhao, Wenjia Wang, Kaijing Yan, Xijun Yan & He Sun
Previous studies indicate that compound Danshen Dripping Pill (CDDP) improves the adaptation to high-altitude exposure. However, its mechanism of action is not clear. To explore the protective effect of CDDP on hypobaric hypoxia (HH) and its possible mechanism. A meta-analysis of 1051 human volunteers was performed to evaluate the effectiveness of CDDP at high altitudes. Male Sprague-Dawley rats were randomized into 5 groups (n = 6): control at normal pressure, model, CDDP-170 mg/kg, CDDP-340 mg/kg...

A new cycloheptane derivative from the fungus Penicillium crustosum JT-8

Jun-Tao Hu, Jia-Peng Wang, Yan Shu, Xue-Yun Cai, Cheng-Tong Sun, Hao Ding, Le Cai & Zhong-Tao Ding
A new highly oxygenated cycloheptane derivative crustane (1), along with fourteen known compounds (2–15) were isolated from Penicillium crustosum JT-8. The structure of compound 1 was determined by extensive spectroscopic data, DP4+ probability analyses and dimolybdenum CD method. Compound 1 exhibited moderate antibacterial activity against Staphylococcus aureus with MIC of 4.0 μg/mL.

Temporal and Spatial Characteristics of Flocculated Suspended Solids in a Deep Reservoir: an in situ Observation in the Biliuhe Reservoir

Yuyu Liu, Yuqing Feng, Xin Jiang, Shiguo Xu, Lin Zhu & Guoqing Sang
The amount of total suspended solids (TSS) is the most visible indicator for evaluating water quality in reservoirs. Previous investigations paid more attention to TSS of the surface layer in reservoirs, while suspended particles are prone to settle, resuspend, and aggregate at the bottom of reservoir. There may be different patterns of the TSS in different depths. Hence, it is significant to explore the temporal and spatial characteristics of suspended solids in different depths of...

Temporal and spatial characteristics of flocculated suspended solids in a deep reservoir: an in situ observation in the Biliuhe Reservoir

Yuyu Liu, Yuqing Feng, Xin Jiang, Shiguo Xu, Lin Zhu & Guoqing Sang
The amount of total suspended solids (TSS) is the most visible indicator for evaluating water quality in reservoirs. Previous investigations paid more attention to TSS of the surface layer in reservoirs, while suspended particles are prone to settle, resuspend, and aggregate at the bottom of reservoir. There may be different patterns of the TSS in different depths. This study is to assess the TSS concentration by weight analysis, find the evidence of the existence of...

Additional file 3 of Using a WeChat mini-program-based lactation consultant intervention to increase the consumption of mother’s own milk by preterm infants in the neonatal intensive care unit: a study protocol for a cluster randomized controlled trial

Jie Huo, Xinping Wu, Chuanli Gu, Zhangbin Yu, Jun Zhang, Xiaohui Chen, Jingai Zhu, Feng Liu, Beibei Liu, Qianqian Li & Shuping Han
Additional file 3.

The effect of amiloride in decreasing albuminuria in patients with diabetic kidney diseases: a prospective, crossover, open-label study

Ruizhao Li, Zhiyong Xie, Li Zhang, Ying Huang, Jianchao Ma, Wei Dong, Zhilian Li, Yuanhan Chen, Huaban Liang, Yanhua Wu, Xingchen Zhao, Wenjian Wang, Zhiming Ye, Shuangxin Liu, Wei Shi & Xinling Liang
Diabetic kidney diseases (DKD) were the leading cause of End-stage renal diseases worldwide. Albuminuria was a target for treatment in DKD and decreasing albuminuria was particularly important for improving its prognosis. However, there is still a lack of specific treatment for DKD. We conducted a prospective, crossover, open-label study to investigate the effect of amiloride in patients with DKD. Safety and efficacy were assessed by monitoring urine protein creatinine ratio(uPCR), urinary albumin creatinine ratio (uACR),...

T-box transcription factor TBX1, targeted by microRNA-6727-5p, inhibits cell growth and enhances cisplatin chemosensitivity of cervical cancer cells through AKT and MAPK pathways

Haixia Liu, Mei Song, Xiaoyan Sun, Xin Zhang, Huayan Miao & Yankui Wang
Cervical cancer (CC) is the fourth most common cancers among women worldwide. T-box transcription factor 1 (TBX1), a member of the T-box family, has anti-tumor effects in some types of cancer, but its role in CC is yet unknown. The aim of this study is to investigate the functions and underlying mechanisms of TBX1 in CC. Online database UALCAN showed that TBX1 was down-regulated in CC tissues compared with normal tissues and patients with lower...

Ferritinophagy is involved in the zinc oxide nanoparticles-induced ferroptosis of vascular endothelial cells

Xia Qin, Jun Zhang, Bin Wang, Ge Xu, Xi Yang, Zhen Zou & Chao Yu
Zinc oxide nanoparticles (ZnONPs) hold great promise for biomedical applications. Previous studies have revealed that ZnONPs exposure can induce toxicity in endothelial cells, but the underlying mechanisms have not been fully elucidated. In this study, we report that ZnONPs can induce ferroptosis of both HUVECs and EA.hy926 cells, as evidenced by the elevation of intracellular iron levels, lipid peroxidation and cell death in a dose- and time-dependent manner. In addition, both the lipid reactive oxygen...

A new cycloheptane derivative from the fungus Penicillium crustosum JT-8

Jun-Tao Hu, Jia-Peng Wang, Yan Shu, Xue-Yun Cai, Cheng-Tong Sun, Hao Ding, Le Cai & Zhong-Tao Ding
A new highly oxygenated cycloheptane derivative crustane (1), along with fourteen known compounds (2–15) were isolated from Penicillium crustosum JT-8. The structure of compound 1 was determined by extensive spectroscopic data, DP4+ probability analyses and dimolybdenum CD method. Compound 1 exhibited moderate antibacterial activity against Staphylococcus aureus with MIC of 4.0 μg/mL.

Removal characteristics of heavy metal ions in rainwater runoff by bioretention cell modified with biochar

Jiaqing Xiong, Guohao Li, Junguo Zhu, Jianqiang Li, Yuan Yang, Shengxia An & Chengkui Liu
As a form of pollution source control and a low-impact development measure, bioretention is a convenient, economical, and effective method for the removal of heavy metals from stormwater runoff, which can adapt to the randomness and uncontrollability of non-point source pollution. However, few studies have assessed the performance of bioretention in the simultaneous removal of multiple heavy metals and the impact of heavy metal migration on the bioretention life cycle. In this study, the removal...

Additional file 2 of Using a WeChat mini-program-based lactation consultant intervention to increase the consumption of mother’s own milk by preterm infants in the neonatal intensive care unit: a study protocol for a cluster randomized controlled trial

Jie Huo, Xinping Wu, Chuanli Gu, Zhangbin Yu, Jun Zhang, Xiaohui Chen, Jingai Zhu, Feng Liu, Beibei Liu, Qianqian Li & Shuping Han
Additional file 2.

Aromatic glycosides from the aerial part of Bupleurum chinense

Yan Liu, Dong-Xv Lu, Jin Huang, Juan Pan, Wei Guan, Bing-You Yang & Hai-Xue Kuang
A new aromatic glycoside (1) and twelve (2–13) known aromatic glycosides were isolated from the n-butyl alcohol of the 70% EtOH extract of the aerial part of Bupleurum chinense. Among them, compounds 4–7, 9, 11–13 were isolated from Umbelliferae plants for the first time. Their structures were elucidated by NMR and MS spectroscopy, and the absolute configuration of compound 1 was elucidated by single-crystal X-ray diffraction. Compounds 6 and 10 showed moderate cytotoxic activities on...

Using a WeChat mini-program-based lactation consultant intervention to increase the consumption of mother’s own milk by preterm infants in the neonatal intensive care unit: a study protocol for a cluster randomized controlled trial

Jie Huo, Xinping Wu, Chuanli Gu, Zhangbin Yu, Jun Zhang, Xiaohui Chen, Jingai Zhu, Feng Liu, Beibei Liu, Qianqian Li & Shuping Han
Abstract Background The benefits of mother’s own milk (MOM) for preterm infants have been widely recognized. Many studies have shown that the rate of breastfeeding of premature infants remains very low. Although many studies use measures to promote breastfeeding, few high-quality cluster randomized controlled studies have evaluated the effectiveness of these measures. WeChat is an instant messaging software for smart terminals, and WeChat mini-programs have been widely used to promote health and self-management in China....

Study on the working mechanism of fluid loss additive for chlorination titanium blast furnace slag

Ping Zhou, Yuanpeng Wu, Huiting Liu, Ming Li, Weiyuan Xiao, Meng Liu, Jianzhang Hao, Yanming Li & Chengxin Li
The chlorination titanium blast furnace slag belongs to industrial waste, but after grinding, they can be used to prepare cementing fluids to realize the secondary utilization of solid waste resources. As a common additive, fluid loss additives are mostly used in oil well cement systems, and there is still a lot of room for development when applied to chlorination titanium blast furnace slag systems. In this paper, the AMPS/DN-1/DMC/AA tetramer fluid loss additive was synthesized...

Using a WeChat mini-program-based lactation consultant intervention to increase the consumption of mother’s own milk by preterm infants in the neonatal intensive care unit: a study protocol for a cluster randomized controlled trial

Jie Huo, Xinping Wu, Chuanli Gu, Zhangbin Yu, Jun Zhang, Xiaohui Chen, Jingai Zhu, Feng Liu, Beibei Liu, Qianqian Li & Shuping Han
Abstract Background The benefits of mother’s own milk (MOM) for preterm infants have been widely recognized. Many studies have shown that the rate of breastfeeding of premature infants remains very low. Although many studies use measures to promote breastfeeding, few high-quality cluster randomized controlled studies have evaluated the effectiveness of these measures. WeChat is an instant messaging software for smart terminals, and WeChat mini-programs have been widely used to promote health and self-management in China....

Additional file 1 of Using a WeChat mini-program-based lactation consultant intervention to increase the consumption of mother’s own milk by preterm infants in the neonatal intensive care unit: a study protocol for a cluster randomized controlled trial

Jie Huo, Xinping Wu, Chuanli Gu, Zhangbin Yu, Jun Zhang, Xiaohui Chen, Jingai Zhu, Feng Liu, Beibei Liu, Qianqian Li & Shuping Han
Additional file 1.

Additional file 1 of Using a WeChat mini-program-based lactation consultant intervention to increase the consumption of mother’s own milk by preterm infants in the neonatal intensive care unit: a study protocol for a cluster randomized controlled trial

Jie Huo, Xinping Wu, Chuanli Gu, Zhangbin Yu, Jun Zhang, Xiaohui Chen, Jingai Zhu, Feng Liu, Beibei Liu, Qianqian Li & Shuping Han
Additional file 1.

Temporal and spatial characteristics of flocculated suspended solids in a deep reservoir: an in situ observation in the Biliuhe Reservoir

Yuyu Liu, Yuqing Feng, Xin Jiang, Shiguo Xu, Lin Zhu & Guoqing Sang
The amount of total suspended solids (TSS) is the most visible indicator for evaluating water quality in reservoirs. Previous investigations paid more attention to TSS of the surface layer in reservoirs, while suspended particles are prone to settle, resuspend, and aggregate at the bottom of reservoir. There may be different patterns of the TSS in different depths. This study is to assess the TSS concentration by weight analysis, find the evidence of the existence of...

Compound Danshen Dripping Pill inhibits high altitude-induced hypoxic damage by suppressing oxidative stress and inflammatory responses

Yunhui Hu, Jia Sun, Tongxing Wang, Hairong Wang, Chunlai Zhao, Wenjia Wang, Kaijing Yan, Xijun Yan & He Sun
Previous studies indicate that compound Danshen Dripping Pill (CDDP) improves the adaptation to high-altitude exposure. However, its mechanism of action is not clear. To explore the protective effect of CDDP on hypobaric hypoxia (HH) and its possible mechanism. A meta-analysis of 1051 human volunteers was performed to evaluate the effectiveness of CDDP at high altitudes. Male Sprague-Dawley rats were randomized into 5 groups (n = 6): control at normal pressure, model, CDDP-170 mg/kg, CDDP-340 mg/kg...

Long non-coding RNA DUXAP8 promotes the cell proliferation, migration, and invasion of papillary thyroid carcinoma via miR-223-3p mediated regulation of CXCR4

Yan Liu, Hejia Zhang, Hui Wang, Jiarui Du, Peng Dong, Meihan Liu & Yuanqiang Lin
Papillary thyroid carcinoma (PTC) is a differentiated type of thyroid malignancy with a high incidence. Long non-coding RNA (lncRNA) DUXAP8 has been reported to participate in the proliferation, migration, and invasion of several cancer types. However, its association with PTC has not yet been reported. The current study aimed to investigate the role of DUXAP8 in PTC and revealed the underlying mechanisms. The expression of DUXAP8 was knocked down in two PTC cell lines and...

Ferritinophagy is involved in the zinc oxide nanoparticles-induced ferroptosis of vascular endothelial cells

Xia Qin, Jun Zhang, Bin Wang, Ge Xu, Xi Yang, Zhen Zou & Chao Yu
Zinc oxide nanoparticles (ZnONPs) hold great promise for biomedical applications. Previous studies have revealed that ZnONPs exposure can induce toxicity in endothelial cells, but the underlying mechanisms have not been fully elucidated. In this study, we report that ZnONPs can induce ferroptosis of both HUVECs and EA.hy926 cells, as evidenced by the elevation of intracellular iron levels, lipid peroxidation and cell death in a dose- and time-dependent manner. In addition, both the lipid reactive oxygen...

Three new sesquiterpenoid alkaloids from the roots of Tripterygium wilfordii and its cytotoxicity

Hong Liang Ye, Yan Liu, Juan Pan, Wei Guan, Yuan Liu, Xiao Mao Li, Si Yi Wang, Adnan Mohammed Algradi, Bing You Yang & Hai Xue Kuang
Three new sesquiterpenoid alkaloids, cangorin K (1), dimacroregelines C (2) and D (3), as well as two known sesquiterpenoids (4–5), were isolated from the roots of Tripterygium wilfordii Hook. f. The structures of new compounds were characterised by extensive 1D and 2D NMR spectroscopic analyses, as well as HRESIMS data, and the known compounds were established by 1 D NMR spectra referring to the literatures. Cytotoxicity evaluation of these compounds against two human tumour lines...

Alkaloids constituents from the roots of Phragmites australis (Cav.) Trin. ex Steud. with their cytotoxic activities

Ying Chen, Li Li, Li-Rui Jiang, Jia-Yin Tan, Li-Na Guo, Xiao-Li Wang, Wei Dong, Wen-Bao Wang, Ji-Kai Sun & Bo Song
Two new alkaloids, phranisines A–B (1–2), along with two known compounds, N-p-Coumaroyl serotonin (3) and N-p-coumaroyl-tryptamine (4), were isolated from the roots of Phragmites australis. The structures of 1–4 were established on the basis of extensive spectroscopic. The absolute configuration of compounds 1–2 were identified through quantum-chemical electronic circular dichroism (ECD) calculation compared with their experimental CD. All the isolated compounds were tested for their cytotoxic activities against HeLa and MCF-7 human cancer cell lines,...

Four new secoiridoids from the stem barks of Syringa reticulata (Bl.) Hara

Shuang Guo, Yan Liu, Yan-Ping Sun, Juan Pan, Wei Guan, Xiao-Mao Li, Si-Yi Wang, Adnan Mohammed Algradi, Bing-You Yang & Hai-Xue Kuang
Four new secoiridoids, syrretoside A (1), syrretoside B (2), 5β, 8β-syrretaglucone C(3), 5β, 8α-syrretaglucone C (4), together with eight known secoiridoids (5–12), were isolated from the stem barks of Syringa reticulata (Bl.) Hara. The structures of isolated compounds were established based on the physical and chemical means, NMR spectroscopy, high-resolution mass spectrometry (HR-ESI-MS), and circular dichroism spectrum (CD), as well as in comparison with the literature. The cytotoxicity of isolated compounds was investigated using CCK8...

Registration Year

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  • Guilin Medical University
    50
  • Chinese Academy of Medical Sciences & Peking Union Medical College
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  • Huazhong University of Science and Technology
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