409 Works

MicroRNA-665-3p exacerbates nonalcoholic fatty liver disease in mice

Yuanjie Yu, Tian Tian, Shiyun Tan, Pengbo Wu, Yitian Guo, Ming Li & Mengjun Huang
Oxidative stress and chronic inflammation are major culprits of nonalcoholic fatty liver disease (NAFLD). MicroRNA-665-3p (miR-665-3p) is implicated in regulating inflammation and oxidative stress; however, its role and molecular basis in NAFLD remain elusive. Herein, we measured a significant upregulation of miR-665-3p level in the liver and primary hepatocytes upon high fat diet (HFD) or 0.5 mmol/L palmitic acid plus 1.0 mmol/L oleic acid stimulation, and the elevated miR-665-3p expression aggravated oxidative stress, inflammation and...

Identification and potential mechanism of different components from the aerial part of Bupleurum chinense DC. for epileptic treatment

Xiaomao Li, Yan Liu, Siyi Wang, Wei Guan, Juan Pan, Haixue Kuang & Bingyou Yang
The present study aimed to assess the effects of epileptic treatment of the aerial part of Bupleurum chinense DC. in kainic acid (KA)-induced epilepsy rats and LPS-induced BV2 cells, as well as to identify the active chemical constituents. The in vivo and vitro results showed that 20% ethanol elution fractions of the aerial part of B. chinense DC. (BCE-20) and 70% ethanol elution fractions of the aerial part of B. chinense DC. (BCE-70) could improve...

Gapless genome assembly of East Asian finless porpoise, Neophocaena asiaeorientalis sunameri

Denghua Yin, Chunhai Chen, Danqing Lin, Jialun Zhang, Congping Ying, Yan Liu, Wang Liu, Zhichen Cao, Chenxi Zhao, Chenhe Wang, Liping Liang, Pao Xu, Jianbo Jian & Kai Liu
There are the genome sequence, gene set, coding sequence and protein sequence of Neophocaena asiaeorientalis sunameri.

Development and validation of an ECM-related prognostic signature to predict the immune landscape of human hepatocellular carcinoma

Guozhi Wu, Yuan Yang, Rong Ye, Hanxun Yue, Huiyun Zhang, Taobi Huang, Min Liu, Ya Zheng, Yuping Wang, Yongning Zhou & Qinghong Guo
Abstract Background The global burden of hepatocellular carcinoma (HCC) is increasing, negatively impacting social health and economies. The discovery of novel and valuable biomarkers for the early diagnosis and therapeutic guidance of HCC is urgently needed. Methods Extracellular matrix (ECM)-related gene sets, transcriptome data and mutation profiles were downloaded from the Matrisome Project and The Cancer Genome Atlas (TCGA)-LIHC datasets. Coexpression analysis was initially performed with the aim of identifying ECM-related lncRNAs (r > 0.4,...

Development and validation of an ECM-related prognostic signature to predict the immune landscape of human hepatocellular carcinoma

Guozhi Wu, Yuan Yang, Rong Ye, Hanxun Yue, Huiyun Zhang, Taobi Huang, Min Liu, Ya Zheng, Yuping Wang, Yongning Zhou & Qinghong Guo
Abstract Background The global burden of hepatocellular carcinoma (HCC) is increasing, negatively impacting social health and economies. The discovery of novel and valuable biomarkers for the early diagnosis and therapeutic guidance of HCC is urgently needed. Methods Extracellular matrix (ECM)-related gene sets, transcriptome data and mutation profiles were downloaded from the Matrisome Project and The Cancer Genome Atlas (TCGA)-LIHC datasets. Coexpression analysis was initially performed with the aim of identifying ECM-related lncRNAs (r > 0.4,...

Additional file 1 of Development and validation of an ECM-related prognostic signature to predict the immune landscape of human hepatocellular carcinoma

Guozhi Wu, Yuan Yang, Rong Ye, Hanxun Yue, Huiyun Zhang, Taobi Huang, Min Liu, Ya Zheng, Yuping Wang, Yongning Zhou & Qinghong Guo
Additional file 1.

Additional file 1 of Development and validation of an ECM-related prognostic signature to predict the immune landscape of human hepatocellular carcinoma

Guozhi Wu, Yuan Yang, Rong Ye, Hanxun Yue, Huiyun Zhang, Taobi Huang, Min Liu, Ya Zheng, Yuping Wang, Yongning Zhou & Qinghong Guo
Additional file 1.

Additional file 5 of Genome-wide identification, new classification, expression analysis and screening of drought & heat resistance related candidates in the RING zinc finger gene family of bread wheat (Triticum aestivum L.)

Yongliang Li, Pai Qin, Aolong Sun, Wenjun Xiao, Fenglin Chen, Yang He, Keyao Yu, You Li, Meng Zhang & Xinhong Guo
Additional file 5: Table S2. One-to-one orthologous relationships among T.aestivum and T.aestivum, A.thaliana, A. tauschii, B. distachyon, H. vulgare, rice, S.italica and Zea mays, respectively.

Additional file 6 of Genome-wide identification, new classification, expression analysis and screening of drought & heat resistance related candidates in the RING zinc finger gene family of bread wheat (Triticum aestivum L.)

Yongliang Li, Pai Qin, Aolong Sun, Wenjun Xiao, Fenglin Chen, Yang He, Keyao Yu, You Li, Meng Zhang & Xinhong Guo
Additional file 6: Table S3. The information of cis-acting elements on the promoters of T. aestivum RING-zf genes.

Additional file 6 of Genome-wide identification, new classification, expression analysis and screening of drought & heat resistance related candidates in the RING zinc finger gene family of bread wheat (Triticum aestivum L.)

Yongliang Li, Pai Qin, Aolong Sun, Wenjun Xiao, Fenglin Chen, Yang He, Keyao Yu, You Li, Meng Zhang & Xinhong Guo
Additional file 6: Table S3. The information of cis-acting elements on the promoters of T. aestivum RING-zf genes.

Theoretical analysis of 60-W solar-pumped single crystal fiber laser

Pengfei Xiang, Lanling Lan, Yan Liu, Hongfei Qi, Yulong Tang & xiuhua ma
In order to improve the output power of solar-pumped single-crystal fiber (SCF) lasers, a novel solar concentrating system is proposed, which consists of a parabolic mirror, a 3D-CPC, and a hollow-core reflector. By ray tracing with TracePro, influence of the fiber’s diameter and the hollow reflector’s shape on the solar absorption efficiency is theoretically investigated. A typical Nd:YAG SCF with a core-diameter of 1 mm, length of 150 mm and doping concentration of 1 at.%...

Additional file 1 of Decreased influenza vaccination coverage among Chinese healthcare workers during the COVID-19 pandemic

Libing Ma, Xuan Han, Yuan Ma, Yuan Yang, Yunshao Xu, Di Liu, Weizhong Yang & Luzhao Feng
Additional file 1: Questionnaire

Additional file 1 of Decreased influenza vaccination coverage among Chinese healthcare workers during the COVID-19 pandemic

Libing Ma, Xuan Han, Yuan Ma, Yuan Yang, Yunshao Xu, Di Liu, Weizhong Yang & Luzhao Feng
Additional file 1: Questionnaire

Additional file 1 of Gray matter reduction in bilateral insula mediating adverse psychiatric effects of body mass index in schizophrenia

Hui Wu, Guochao Dai, Muyeseer Aizezi, Juan Tang, Ke Zou, Yuhua Wu & Xiaoli Wu
Additional file 1: Fig. S1. Partial correlation analysis between BMI and bilateral insula in SZ group, controlling for sex, age and education. Fig. S2. Partial correction analysis between negative symptom and bilateral insula in SZ group, controlling for sex, age and education. Fig. S3. Results of bilateral insula in the whole-brain VBM analyses. Red indicates the bilateral insula in the main effects of diagnosis (SZ

Additional file 1 of Interaction of miR-200a-3p with YAP regulates cell proliferation and metastasis differentially in HPV-positive and HPV-negative cervical cancer cells

Hong Chen, Lingling Gu, Min Zhang, Huifen Chen, Hong Liao, Xueping Cao, Lu Yu & Jun Zhang
Additional file 1: Supplementary Fig. S1. qRT-PCRassessmentsoftransfectionefficiencies The transfection efficiencies of miR-200a-3p mimics (A), sh-miR-200a-3p (B), and YAP(C)wereperformedinC33A,SihaandHelacells.*p<0.05, **p<0.01,***p<0.001,ns:notsignificant. The authors declare that they have no competing interests. Supplementary Fig. S2. themRNAandproteinlevelsofYAPinHelacells Significant decreases in levels of YAP mRNA (A) and YAP protein (B) following up-regulations of miR-200a-3p, or significant increases in levels of YAP mRNA (C) and protein (D) following down-regulations of miR-200a-3p were not observed in Helacells.*p<0.05,**p<0.01,***p<0.001,ns:notsignificant.

Additional file 3 of Interaction of miR-200a-3p with YAP regulates cell proliferation and metastasis differentially in HPV-positive and HPV-negative cervical cancer cells

Hong Chen, Lingling Gu, Min Zhang, Huifen Chen, Hong Liao, Xueping Cao, Lu Yu & Jun Zhang
Additional file 3.

Interaction of miR-200a-3p with YAP regulates cell proliferation and metastasis differentially in HPV-positive and HPV-negative cervical cancer cells

Hong Chen, Lingling Gu, Min Zhang, Huifen Chen, Hong Liao, Xueping Cao, Lu Yu & Jun Zhang
Abstract Background Although evidence has revealed that miR-200a-3p is involved in the malignant progression of various tumors, the regulatory mechanism of miR-200a-3p in the development of cervical cancer (CC) cells with different HPV statuses remains unknown. The present study was to investigate the differential effects of either miR-200a-3p or YAP on tumorous cells’ fate in vitro in HPV-negative and HPV-positive cervical cancer cell models, and to explore if the changes in proliferation, migration, and invasion...

Anti-liver fibrosis effects of the total flavonoids of litchi semen on CCl4-induced liver fibrosis in rats associated with the upregulation of retinol metabolism

Jiongyi Yan, Yinyi Feng, Xuewan Fang, Xiaojuan Cui, Xing Xia, Fang Li, Weisheng Luo, Jianqin Liang, Jianfang Feng & Kai Yu
The litchi semen are traditional medications for treating liver fibrosis (LF) in China. The mechanism remains unclear. This study investigates the anti-liver fibrotic mechanism of the total flavonoids of litchi semen (TFL). Sprague-Dawley rats with carbon tetrachloride-induced LF were treated with TFL (50 and 100 mg/kg) for 4 weeks. The anti-liver fibrotic effects of TFL were evaluated and the underlying mechanisms were investigated via histopathological analysis, proteomic analysis and molecular biology technology. Significant anti-LF effects...

Racism by Design?

Hao Ding & Anastasia Loukaitou-Sideris
We examined land use and design controls in three municipalities in Los Angeles County (CA)—Alhambra, Arcadia, and San Gabriel—that have experienced a recent influx of Asian residents. We drew from archival research of newspaper articles, planning documents, city council and planning commission meeting minutes, and interviews with 14 local planners, architects, planning and design review commissioners, and resident groups. We found that the three cities developed stringent development controls, encouraged Anglo or Spanish heritage architectural...

Learning Coefficient Heterogeneity over Networks: A Distributed Spanning-Tree-Based Fused-Lasso Regression

Xin Zhang, Jia Liu & Zhengyuan Zhu
Identifying the latent cluster structure based on model heterogeneity is a fundamental but challenging task arises in many machine learning applications. In this article, we study the clustered coefficient regression problem in the distributed network systems, where the data are locally collected and held by nodes. Our work aims to improve the regression estimation efficiency by aggregating the neighbors’ information while also identifying the cluster membership for nodes. To achieve efficient estimation and clustering, we...

Additional file 2 of Genome-wide identification, new classification, expression analysis and screening of drought & heat resistance related candidates in the RING zinc finger gene family of bread wheat (Triticum aestivum L.)

Yongliang Li, Pai Qin, Aolong Sun, Wenjun Xiao, Fenglin Chen, Yang He, Keyao Yu, You Li, Meng Zhang & Xinhong Guo
Additional file 2: Figure S2. Phylogenetic relationships, gene structure and architecture of conserved protein motifs in 138 TaRING-zfs from T. aestivum. a The name of 138 TaRING-zf genes. b Exon, intron, and UTR structure of 138 TaRING-zf genes. Yellow boxes indicate untranslated 5’ and 3’ regions, green boxes indicate exon, and black lines indicate introns. The gene full length and protein length can be estimated by using the scale at the bottom. c The motif...

A pharmacovigilance analysis of FDA adverse event reporting system events for romosozumab

Zepeng Chen, Ming Li, Shuzhen Li, Yuxi Li, Junyan Wu, Kaifeng Qiu, Xiaoxia Yu, Lin Huang & Guanghui Chen
Romosozumab is a novel drug for the treatment of osteoporosis. The adverse reactions of romosozumab still need to be explored. The FDA Adverse Event Reporting System (FAERS) provides an enormous dataset for adverse events (AEs) analysis. AEs registered in FAERS between January 2019 and December 2020 were collected for this study. The reporting odds ratio (ROR) method was applied to analyze the AEs of romosozumab. The number of AEs ≥4 cases and ROR value 95%...

Additional file 1 of Clinical value of fetal facial profile markers during the first trimester

Xiaofeng Zhou, Chunya Ji, Lingling Sun, Linliang Yin, Xuedong Deng, Qi Pan, Jun Zhang, Zhong Yang, Chenhan Zheng, Chen Ling, Liping Shi & Yanqing Wu
Additional file 1.

Additional file 6 of Transcriptomic analysis of paternal behaviors in prairie voles

Florian Duclot, Yan Liu, Samantha K. Saland, Zuoxin Wang & Mohamed Kabbaj
Additional file 6. Relationships between parental behavior test behaviors. For each pair of behavior, a linear model was fit. Each individual point represents a distinct animal, and the shaded area depicts the 95% confidence interval.

Transcriptomic analysis of paternal behaviors in prairie voles

Florian Duclot, Yan Liu, Samantha K. Saland, Zuoxin Wang & Mohamed Kabbaj
Abstract Background The importance of fathers’ engagement in care and its critical role in the offspring’s cognitive and emotional development is now well established. Yet, little is known on the underlying neurobiology due to the lack of appropriate animal models. In the socially monogamous and bi-parental prairie vole (Microtus ochrogaster), while 60–80% of virgin males show spontaneous paternal behaviors (Paternal), others display pup-directed aggression (Attackers). Here we took advantage of this phenotypic dichotomy and used...

Registration Year

  • 2022
    409

Resource Types

  • Text
    193
  • Dataset
    104
  • Collection
    94
  • Image
    12
  • Other
    4
  • Audiovisual
    2

Affiliations

  • Guilin Medical University
    409
  • Shanghai Jiao Tong University
    258
  • Sun Yat-sen University
    217
  • Second Military Medical University
    201
  • Southern Medical University
    196
  • Shandong Academy of Medical Science
    192
  • Capital Medical University
    186
  • Peking University
    184
  • Chinese Academy of Sciences
    181
  • Fudan University
    176