Identifying the latent cluster structure based on model heterogeneity is a fundamental but challenging task arises in many machine learning applications. In this article, we study the clustered coefficient regression problem in the distributed network systems, where the data are locally collected and held by nodes. Our work aims to improve the regression estimation efficiency by aggregating the neighbors’ information while also identifying the cluster membership for nodes. To achieve efficient estimation and clustering, we...

Additional file 2: Figure S2. Phylogenetic relationships, gene structure and architecture of conserved protein motifs in 138 TaRING-zfs from T. aestivum. a The name of 138 TaRING-zf genes. b Exon, intron, and UTR structure of 138 TaRING-zf genes. Yellow boxes indicate untranslated 5’ and 3’ regions, green boxes indicate exon, and black lines indicate introns. The gene full length and protein length can be estimated by using the scale at the bottom. c The motif...

Additional file 1: Supplementary Fig. S1. qRT-PCRassessmentsoftransfectionefficiencies The transfection efficiencies of miR-200a-3p mimics (A), sh-miR-200a-3p (B), and YAP(C)wereperformedinC33A,SihaandHelacells.*p<0.05, **p<0.01,***p<0.001,ns:notsignificant. The authors declare that they have no competing interests. Supplementary Fig. S2. themRNAandproteinlevelsofYAPinHelacells Significant decreases in levels of YAP mRNA (A) and YAP protein (B) following up-regulations of miR-200a-3p, or significant increases in levels of YAP mRNA (C) and protein (D) following down-regulations of miR-200a-3p were not observed in Helacells.*p<0.05,**p<0.01,***p<0.001,ns:notsignificant.

Additional file 3.

Abstract Background Although evidence has revealed that miR-200a-3p is involved in the malignant progression of various tumors, the regulatory mechanism of miR-200a-3p in the development of cervical cancer (CC) cells with different HPV statuses remains unknown. The present study was to investigate the differential effects of either miR-200a-3p or YAP on tumorous cells’ fate in vitro in HPV-negative and HPV-positive cervical cancer cell models, and to explore if the changes in proliferation, migration, and invasion...

Supplemental material, sj-docx-1-cix-10.1177_11769351221136056 for Optimizing Drug Response Study Design in Patient-Derived Tumor Xenografts by Jessica Weiss, Nhu-An Pham, Melania Pintilie, Ming Li, Geoffrey Liu, Frances A Shepherd, Ming-Sound Tsao and Wei Xu in Cancer Informatics

Supplemental material, sj-xlsx-2-cix-10.1177_11769351221136056 for Optimizing Drug Response Study Design in Patient-Derived Tumor Xenografts by Jessica Weiss, Nhu-An Pham, Melania Pintilie, Ming Li, Geoffrey Liu, Frances A Shepherd, Ming-Sound Tsao and Wei Xu in Cancer Informatics

Patient-derived tumor xenograft (PDX) models were used to evaluate the effectiveness of preclinical anticancer agents. A design using 1 mouse per patient per drug (1 × 1 × 1) was considered practical for large-scale drug efficacy studies. We evaluated modifiable parameters that could increase the statistical power of this design based on our consolidated PDX experiments. Real studies were used as a reference to investigate the relationship between statistical power with treatment effect size, inter-mouse...

Abstract Background Previous studies have reported that maternal smoking during pregnancy and breastfeeding may affect the occurrence of hypertension, but whether early life factors modify the impact of the offspring’s genetic risk on hypertension is still unknown. The aim of this study was to investigate the relationships among maternal smoking and breastfeeding with adult-onset hypertension and the modified impact of offspring genetic susceptibility. Methods This study included 437,185 participants from the UK Biobank who were...

Hepatitis E virus (HEV) is a pathogen of global significance, but the value of HEV-related markers in the diagnosis of hepatitis E remains controversial. Previous studies on hepatitis E profiles have been mainly cross-sectional and conducted among inpatients in large hospitals, and hepatitis E cases have been primarily defined by limited partial markers. In this community-based study, 4,110 active hepatitis cases from a population of nearly 600,000 were followed over 48 months and serial serum...

Coordinates for nucleotide-based alignments between scaffolds from the FC5 isolate genome and scaffolds from the F1RT metagenome assembled by metaSPAdes.

Three new steroids (1–3) and 13 reported analogs (4–16) were extracted from Datura metel L. pericarps. Structure analysis of these extracted compounds was performed by 1 D-NMR and 2 D-NMR spectroscopy, and their spectra were compared with those of similar compounds previously described in the literature. The extracted steroids (1–3) and known compounds (4–16) were evaluated for anti-inflammatory activity against LPS-activated RAW 264.7 cells. Compounds 5, 7, 9, 12 and 15 showed potential anti-inflammatory activity...

Experiment setup of open aperture Z-scan measurements and femtosecond time-resolved transient absorption measurement

The process and condition of saturable absorption (SA) and reverse saturable absorption (RSA) of ultrafast nonlinear optics in metal nanoparticles are essential for applications including light generation, amplification, modulation, and switching. Here, we first discover and explore the multiple transformations (SA-RSA-SA) of ultrafast nonlinear absorption behavior of metal nanoparticles in femtosecond pulses. Correspondingly, the energy level model and fitting formula of multiple transformations are established to illustrate the process of optical response. The femtosecond transient...

The process and condition of saturable absorption (SA) and reverse saturable absorption (RSA) of ultrafast nonlinear optics in metal nanoparticles are essential for applications including light generation, amplification, modulation, and switching. Here, we first discover and explore the multiple transformations (SA-RSA-SA) of ultrafast nonlinear absorption behavior of metal nanoparticles in femtosecond pulses. Correspondingly, the energy level model and fitting formula of multiple transformations are established to illustrate the process of optical response. The femtosecond transient...

Supplement 1

Experiment setup of open aperture Z-scan measurements and femtosecond time-resolved transient absorption measurement

Esterase is an essential hydrolase in organisms. Many severe diseases are caused by its abnormal expression. Sensitive probes for the esterase activity need to be developed. However, the currently reported fluorescence probes for esterase have drawbacks, such as long response times, low sensitivity, and high dosages. In this work, three fluorophores with the cyano group were designed and synthesized. The optical properties of these fluorophores were measured. A turn-on fluorescence detector for the determination of...

Esterase is an essential hydrolase in organisms. Many severe diseases are caused by its abnormal expression. Sensitive probes for the esterase activity need to be developed. However, the currently reported fluorescence probes for esterase have drawbacks, such as long response times, low sensitivity, and high dosages. In this work, three fluorophores with the cyano group were designed and synthesized. The optical properties of these fluorophores were measured. A turn-on fluorescence detector for the determination of...

Additional file 4. The reference publications for the PPI network in the STRING database.

Additional file 5. The list of relevant proteins in the PPI network.

Additional file 6. The interaction scores in the PPI network.

Additional file 2: Table S1. Variation in growth inhibition of different strains under the indicated stress agents. Table S2. Summary statistics of reads mapping outcomes for individual RNA-seq libraries against the Colletotrichum fructicola and apple (Malus domestica) reference genomes.

TFEB (transcription factor EB) regulates multiple genes involved in the process of macroautophagy/autophagy and plays a critical role in lifespan determination. However, the detailed mechanisms that regulate TFEB activity are not fully clear. In this study, we identified a role for HSP90AA1 in modulating TFEB. HSP90AA1 was phosphorylated by CDK5 at Ser 595 under basal condition. This phosphorylation inhibited HSP90AA1, disrupted its binding to TFEB, and impeded TFEB’s nuclear localization and subsequent autophagy induction. Pro-autophagy...

The present study aimed to assess the effects of epileptic treatment of the aerial part of Bupleurum chinense DC. in kainic acid (KA)-induced epilepsy rats and LPS-induced BV2 cells, as well as to identify the active chemical constituents. The in vivo and vitro results showed that 20% ethanol elution fractions of the aerial part of B. chinense DC. (BCE-20) and 70% ethanol elution fractions of the aerial part of B. chinense DC. (BCE-70) could improve...