14 Works

A Scalable Frequentist Model Averaging Method

Rong Zhu, Haiying Wang, Xinyu Zhang & Hua Liang
Frequentist model averaging is an effective technique to handle model uncertainty. However, calculation of the weights for averaging is extremely difficult, if not impossible, even when the dimension of the predictor vector, p, is moderate, because we may have2pcandidate models. The exponential size of the candidate model set makes it difficult to estimate all candidate models, and brings additional numeric errors when calculating the weights. This article proposes a scalable frequentist model averaging method, which...

A Scalable Frequentist Model Averaging Method

Rong Zhu, Haiying Wang, Xinyu Zhang & Hua Liang
Frequentist model averaging is an effective technique to handle model uncertainty. However, calculation of the weights for averaging is extremely difficult, if not impossible, even when the dimension of the predictor vector, p, is moderate, because we may have2pcandidate models. The exponential size of the candidate model set makes it difficult to estimate all candidate models, and brings additional numeric errors when calculating the weights. This article proposes a scalable frequentist model averaging method, which...

Denisovan and Neanderthal archaic introgression differentially impacted the genetics of complex traits in modern populations

Dora Koller, Frank R. Wendt, Gita A. Pathak, Antonella De Lillo, Flavio De Angelis, Brenda Cabrera-Mendoza, Serena Tucci & Renato Polimanti
Abstract Background Introgression from extinct Neanderthal and Denisovan human species has been shown to contribute to the genetic pool of modern human populations and their phenotypic spectrum. Evidence of how Neanderthal introgression shaped the genetics of human traits and diseases has been extensively studied in populations of European descent, with signatures of admixture reported for instance in genes associated with pigmentation, immunity, and metabolic traits. However, limited information is currently available about the impact of...

Thrombus-targeted nano-agents for NIR-II diagnostic fluorescence imaging-guided flap thromboembolism multi-model therapy

Zichen Cao, Xinyu Zhang, Zheng Wei, Chuanhui Song, Huihui Zou, Jianchuan Ran, Hongbo Zhang, Diya Xie, Shengwei Han, Yufeng Wang, Yu Cai & Wei Han
Abstract In oral and maxillofacial surgery, flap repair is essential to the quality of postoperative life. Still, thrombosis is fatal for the survival of the flaps. Besides, some postoperative thrombotic diseases, such as pulmonary embolism, also intimidate patients’ life. The traditional diagnostic methods are still limited by a large amount of hardware and suffer from inconvenience, delay, and subjectivity. Moreover, the treatments mainly rely upon thrombolytics, such as urokinase (UK) plasminogen activator, which may cause...

Impact of NAFLD on clinical outcomes in hepatocellular carcinoma treated with sorafenib: an international cohort study

Jessica Howell, Amit Samani, Binish Mannan, Saur Hajiev, Leila Motedayen Aval, Rebecca Abdelmalak, Vincent C. Tam, Dominik Bettinger, Robert Thimme, Tamar H. Taddei, David E. Kaplan, Max Seidensticker & Rohini Sharma
Background:The impact of nonalcoholic fatty liver disease (NAFLD) on overall survival (OS), treatment response and toxicity in patients with hepatocellular carcinoma (HCC) treated with sorafenib is unknown. We examined the impact of NAFLD on survival and toxicity in an international cohort of patients receiving sorafenib.Methods:Clinical and demographic data were collected from patients consecutively treated at specialist centres in Europe and North America. The impact of NAFLD on OS, sorafenib-specific survival and toxicity compared with other...

Additional file 1 of Denisovan and Neanderthal archaic introgression differentially impacted the genetics of complex traits in modern populations

Dora Koller, Frank R. Wendt, Gita A. Pathak, Antonella De Lillo, Flavio De Angelis, Brenda Cabrera-Mendoza, Serena Tucci & Renato Polimanti
Additional file 1: Table S1. Description of all phenotypes derived from each GWAS of East Asian and European individuals. Table S2. Comparison of the equivalent phenotypes derived from each GWAS of East Asian and European individuals. Table S3. Description of all phenotypes and statistics for baseline annotations derived from each GWAS of East Asian and European individuals. Table S4. Description of all phenotypes and statistics for evolutionary annotations derived from each GWAS of East Asian...

sj-docx-1-tag-10.1177_17562848221100106 – Supplemental material for Impact of NAFLD on clinical outcomes in hepatocellular carcinoma treated with sorafenib: an international cohort study

Jessica Howell, Amit Samani, Binish Mannan, Saur Hajiev, Leila Motedayen Aval, Rebecca Abdelmalak, Vincent C. Tam, Dominik Bettinger, Robert Thimme, Tamar H. Taddei, David E. Kaplan, Max Seidensticker & Rohini Sharma
Supplemental material, sj-docx-1-tag-10.1177_17562848221100106 for Impact of NAFLD on clinical outcomes in hepatocellular carcinoma treated with sorafenib: an international cohort study by Jessica Howell, Amit Samani, Binish Mannan, Saur Hajiev, Leila Motedayen Aval, Rebecca Abdelmalak, Vincent C. Tam, Dominik Bettinger, Robert Thimme, Tamar H. Taddei, David E. Kaplan, Max Seidensticker and Rohini Sharma in Therapeutic Advances in Gastroenterology

Impact of NAFLD on clinical outcomes in hepatocellular carcinoma treated with sorafenib: an international cohort study

Jessica Howell, Amit Samani, Binish Mannan, Saur Hajiev, Leila Motedayen Aval, Rebecca Abdelmalak, Vincent C. Tam, Dominik Bettinger, Robert Thimme, Tamar H. Taddei, David E. Kaplan, Max Seidensticker & Rohini Sharma
Background:The impact of nonalcoholic fatty liver disease (NAFLD) on overall survival (OS), treatment response and toxicity in patients with hepatocellular carcinoma (HCC) treated with sorafenib is unknown. We examined the impact of NAFLD on survival and toxicity in an international cohort of patients receiving sorafenib.Methods:Clinical and demographic data were collected from patients consecutively treated at specialist centres in Europe and North America. The impact of NAFLD on OS, sorafenib-specific survival and toxicity compared with other...

Additional file 1 of Denisovan and Neanderthal archaic introgression differentially impacted the genetics of complex traits in modern populations

Dora Koller, Frank R. Wendt, Gita A. Pathak, Antonella De Lillo, Flavio De Angelis, Brenda Cabrera-Mendoza, Serena Tucci & Renato Polimanti
Additional file 1: Table S1. Description of all phenotypes derived from each GWAS of East Asian and European individuals. Table S2. Comparison of the equivalent phenotypes derived from each GWAS of East Asian and European individuals. Table S3. Description of all phenotypes and statistics for baseline annotations derived from each GWAS of East Asian and European individuals. Table S4. Description of all phenotypes and statistics for evolutionary annotations derived from each GWAS of East Asian...

Denisovan and Neanderthal archaic introgression differentially impacted the genetics of complex traits in modern populations

Dora Koller, Frank R. Wendt, Gita A. Pathak, Antonella De Lillo, Flavio De Angelis, Brenda Cabrera-Mendoza, Serena Tucci & Renato Polimanti
Abstract Background Introgression from extinct Neanderthal and Denisovan human species has been shown to contribute to the genetic pool of modern human populations and their phenotypic spectrum. Evidence of how Neanderthal introgression shaped the genetics of human traits and diseases has been extensively studied in populations of European descent, with signatures of admixture reported for instance in genes associated with pigmentation, immunity, and metabolic traits. However, limited information is currently available about the impact of...

sj-docx-1-tag-10.1177_17562848221100106 – Supplemental material for Impact of NAFLD on clinical outcomes in hepatocellular carcinoma treated with sorafenib: an international cohort study

Jessica Howell, Amit Samani, Binish Mannan, Saur Hajiev, Leila Motedayen Aval, Rebecca Abdelmalak, Vincent C. Tam, Dominik Bettinger, Robert Thimme, Tamar H. Taddei, David E. Kaplan, Max Seidensticker & Rohini Sharma
Supplemental material, sj-docx-1-tag-10.1177_17562848221100106 for Impact of NAFLD on clinical outcomes in hepatocellular carcinoma treated with sorafenib: an international cohort study by Jessica Howell, Amit Samani, Binish Mannan, Saur Hajiev, Leila Motedayen Aval, Rebecca Abdelmalak, Vincent C. Tam, Dominik Bettinger, Robert Thimme, Tamar H. Taddei, David E. Kaplan, Max Seidensticker and Rohini Sharma in Therapeutic Advances in Gastroenterology

Additional file 1 of Thrombus-targeted nano-agents for NIR-II diagnostic fluorescence imaging-guided flap thromboembolism multi-model therapy

Zichen Cao, Xinyu Zhang, Zheng Wei, Chuanhui Song, Huihui Zou, Jianchuan Ran, Hongbo Zhang, Diya Xie, Shengwei Han, Yufeng Wang, Yu Cai & Wei Han
Additional file 1: Figure S1. The Molecular Structure of Y8. Figure S2. (a) The TEM image and DLS of Y8U@P. (b) The standard curve of Y8 in DCM at 600 nm. (c) The absorption spectrum of GPRPP-Y8U@P in DCM. (d) The BCA standard curve in the supernatant to calculate the UK loading rate. Figure S3. The cumulative release of UK under NIR irradiation (0 and 0.6 w/cm2). Figure S4. (a) Raw264.7 viability after simple co-incubation...

Thrombus-targeted nano-agents for NIR-II diagnostic fluorescence imaging-guided flap thromboembolism multi-model therapy

Zichen Cao, Xinyu Zhang, Zheng Wei, Chuanhui Song, Huihui Zou, Jianchuan Ran, Hongbo Zhang, Diya Xie, Shengwei Han, Yufeng Wang, Yu Cai & Wei Han
Abstract In oral and maxillofacial surgery, flap repair is essential to the quality of postoperative life. Still, thrombosis is fatal for the survival of the flaps. Besides, some postoperative thrombotic diseases, such as pulmonary embolism, also intimidate patients’ life. The traditional diagnostic methods are still limited by a large amount of hardware and suffer from inconvenience, delay, and subjectivity. Moreover, the treatments mainly rely upon thrombolytics, such as urokinase (UK) plasminogen activator, which may cause...

Additional file 1 of Thrombus-targeted nano-agents for NIR-II diagnostic fluorescence imaging-guided flap thromboembolism multi-model therapy

Zichen Cao, Xinyu Zhang, Zheng Wei, Chuanhui Song, Huihui Zou, Jianchuan Ran, Hongbo Zhang, Diya Xie, Shengwei Han, Yufeng Wang, Yu Cai & Wei Han
Additional file 1: Figure S1. The Molecular Structure of Y8. Figure S2. (a) The TEM image and DLS of Y8U@P. (b) The standard curve of Y8 in DCM at 600 nm. (c) The absorption spectrum of GPRPP-Y8U@P in DCM. (d) The BCA standard curve in the supernatant to calculate the UK loading rate. Figure S3. The cumulative release of UK under NIR irradiation (0 and 0.6 w/cm2). Figure S4. (a) Raw264.7 viability after simple co-incubation...

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  • VA Connecticut Healthcare System
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  • Hangzhou Normal University
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  • Nanjing University
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  • Nantong University
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  • Fourth Affiliated Hospital of Harbin Medical University
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  • Guangdong Provincial People's Hospital
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  • Shanghai First People's Hospital
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