82 Works

Data from: Spatial extinction or persistence: landscape-temperature interactions perturb predator-prey dynamics

Jason L. Salt, Celia Bulit, Wei Zhang, Hongli Qi, David J.S. Montagnes & David J. S. Montagnes
Recognising that species interact across a range of spatial scales, we explore how landscape structure interacts with temperature to influence persistence. Specifically, we recognise that few studies indicate thermal shifts as the proximal cause of species extinctions; rather, species interactions exacerbated by temperature result in extinctions. Using microcosm-based experiments, as models of larger landscape processes, we test hypotheses that would be problematic to address through field work. A text-book predator-prey system (the ciliates Didinium and...

Red and processed meat intakes and cardiovascular disease and type 2 diabetes mellitus: An umbrella systematic review and assessment of causal relations using Bradford Hill’s criteria

Erica R. Hill, Lauren E. O’Connor, Yu Wang, Caroline M. Clark, Bethany S. McGowan, Michele R. Forman & Wayne W. Campbell
Observational research suggests higher red and processed meat intakes predict greater risks of developing or dying from cardiovascular diseases (CVD) and type 2 diabetes mellitus (T2DM), but this research limits causal inference. This systematic review of reviews utilizes both observational and experimental research findings to infer causality of these relations. Reviews from four databases were screened by two researchers. Reviews included unprocessed red meat (URM), processed meat (PM), or mixed URM + PM intake, and...

Organoids from patient biopsy samples can predict the response of BC patients to neoadjuvant chemotherapy

Dan Shu, Meiying Shen, Kang Li, Xiaojian Han, Han Li, Zhaofu Tan, Yu Wang, Yang Peng, Zhenrong Tang, Chi Qu, Aishun Jin & Shengchun Liu
Neoadjuvant chemotherapy has been widely used in locally advanced and inflammatory breast cancer. Generally, complete pathological response after neoadjuvant chemotherapy treatment predicts survival. Studies have shown that patient-derived organoids can be used in cancer research and drug development. Therefore, we aimed to generate a living organoid biobank from biopsy samples to predict the response of patients to neoadjuvant chemotherapy. We generated a living organoid biobank from locally advanced breast cancer patients receiving neoadjuvant chemotherapy. When...

Organoids from patient biopsy samples can predict the response of BC patients to neoadjuvant chemotherapy

Dan Shu, Meiying Shen, Kang Li, Xiaojian Han, Han Li, Zhaofu Tan, Yu Wang, Yang Peng, Zhenrong Tang, Chi Qu, Aishun Jin & Shengchun Liu
Neoadjuvant chemotherapy has been widely used in locally advanced and inflammatory breast cancer. Generally, complete pathological response after neoadjuvant chemotherapy treatment predicts survival. Studies have shown that patient-derived organoids can be used in cancer research and drug development. Therefore, we aimed to generate a living organoid biobank from biopsy samples to predict the response of patients to neoadjuvant chemotherapy. We generated a living organoid biobank from locally advanced breast cancer patients receiving neoadjuvant chemotherapy. When...

Additional file 1 of Transcutaneous electrical acupoint stimulation for high-normal blood pressure: study protocol for a randomized controlled pilot trial

Yu Wang, Guang-Xia Shi, Zhong-Xue Tian, Jun-Hong Liu, You-Sheng Qi, Jian-Feng Tu, Jing-Wen Yang, Li-Qiong Wang & Cun-Zhi Liu
Additional file 1. Completed Standard Protocol Items: Recommendation for Interventional Trials (SPIRIT) 2013 Checklist: items addressed in this clinical trial protocol.

Integrative analysis of a novel 5 methylated snoRNA genes prognostic signature in patients with glioma

Bing Zhao, Erbao Bian, Deran Zhang, Zhiwei Wang, Yu Wang, Zhigang Cheng, Zhihao Yang, Lianxin Li, Yinfei Zheng & Xiaoyu Yue
Supplementary Table 1 | Genes associated with risk scores.
Supplementary Table 2 | Expression levels and methylation levels of SNORA71B in gliomas (TCGA Database). Supplementary Table 3 | Fold change values of the 5 methylated snoRNA genes (TCGA Database).
Supplementary Table 4 | Methylation levels of five snoRNAs in gliomas (TCGA Database).
Supplementary Table 5 Clinic-pathological characteristics of 13 glioma patients.

Folic acid-modified ROS-responsive nanoparticles encapsulating luteolin for targeted breast cancer treatment

Yu Wang, Qianmei Wang, Wei Feng, Qian Yuan, Xiaowei Qi, Sheng Chen, Pu Yao, Qing Dai, Peiyuan Xia, Dinglin Zhang & Fengjun Sun
Luteolin (Lut) is a natural flavonoid polyphenolic compound with multiple pharmacological activities, such as anti-oxidant, anti-inflammatory, and anti-tumor effects. However, the poor aqueous solubility and low bioactivity of Lut restrict its clinical translation. Herein, we developed a reactive oxygen species (ROS)-responsive nanoplatforms to improve the bioactivity of Lut. Folic acid (FA) was employed to decorate the nanoparticles (NPs) to enhance its targeting ability. The size of Lut-loaded ROS-responsive nanoparticles (Lut/Oxi-αCD NPs) and FA-modified Lut/Oxi-αCD NPs...

MICALL2 as a substrate of ubiquitinase TRIM21 regulates tumorigenesis of colorectal cancer

Pushuai Wen, Huade Wang, Yi Li, Xinyao Sui, Zhijuan Hou, Xiaoyan Guo, Wanying Xue, Dahua Liu, Yu Wang & Jing Gao
Abstract Background Molecule interacting with CasL-like protein 2 (MICALL2) is believed to regulate cytoskeleton dynamics, tight junction formation, and neurite outgrowth. However, its biological role and the underlying mechanism in colorectal cancer (CRC) remain largely elusive. Methods qRT-PCR, Western blotting and immunohistochemistry assays were used to detect the expression levels of different genes. Next, mass spectrometry, co-immunoprecipitation and immunofluorescence staining were used to detect the interactions of proteins. Furthermore, MTT assay, colony formation assay, wound-healing...

Additional file 11 of Deficiency of exchange protein directly activated by cAMP (EPAC)-1 in mice augments glucose intolerance, inflammation, and gut dysbiosis associated with Western diet

Preeti Dinesh Virwani, Lin Cai, Patrick Ka Kit Yeung, Gordon Qian, Yingxian Chen, Lei Zhou, Jason Wing Hon Wong, Yu Wang, Joshua Wing Kei Ho, Kui Kai Lau, Pei-Yuan Qian & Sookja Kim Chung
Additional file 11: Table S9. KEGG orthology IDs.

Additional file 2 of Deficiency of exchange protein directly activated by cAMP (EPAC)-1 in mice augments glucose intolerance, inflammation, and gut dysbiosis associated with Western diet

Preeti Dinesh Virwani, Lin Cai, Patrick Ka Kit Yeung, Gordon Qian, Yingxian Chen, Lei Zhou, Jason Wing Hon Wong, Yu Wang, Joshua Wing Kei Ho, Kui Kai Lau, Pei-Yuan Qian & Sookja Kim Chung
Additional file 2. R scripts used for bioinformatics analysis.

The important role of NLRP6 inflammasome in Pasteurella multocida infection

Xingping Wu, Zheng Zeng, Hongliang Tian, Lianci Peng, Dongyi Xu, Yu Wang, Chao Ye, Yuanyi Peng & Rendong Fang
Abstract Pasteurella multocida (P. multocida) can cause severe respiratory disease in cattle, resulting in high mortality and morbidity. Inflammasomes are multiprotein complexes in the cytoplasm that recognize pathogens and play an important role in the host defense against microbial infection. In this study, the mechanism of P. multocida-induced NLRP6 inflammasome activation was investigated in vitro and in vivo. Firstly, P. multocida induced severe inflammation with a large number of inflammatory cells infiltrating the lungs of...

Additional file 1 of The important role of NLRP6 inflammasome in Pasteurella multocida infection

Xingping Wu, Zheng Zeng, Hongliang Tian, Lianci Peng, Dongyi Xu, Yu Wang, Chao Ye, Yuanyi Peng & Rendong Fang
Additional file 1: NLRP6 is involved in the recruitment of macrophages and neutrophils in pulmonary infection with P. multocida. WT and Nlrp6-/- mice were intranasally infected with 20 µL P. multocida (1000 CFU) and the same volume of sterilized PBS were used as control. Flow cytometry was used to analyze the recruitment of neutrophils and macrophages after 24 h infection. (A, B, E, F). Aseptic PBS infection group (control group). (C, D, G, H). P....

Autologous stem cell transplantation in tandem with Anti-CD30 CAR T-cell infusion in relapsed/refractory CD30+ lymphoma

Peiling Zhang, Xiuxiu Yang, Yang Cao, Jue Wang, Mi Zhou, Liting Chen, Jia Wei, Zekai Mao, Di Wang, Yi Xiao, Haichuan Zhu, Shangkun Zhang, Tongcun Zhang, Yicheng Zhang, Jianfeng Zhou & Liang Huang
Abstract Background Long-term outcome is unfavourable for relapsed/refractory (r/r) lymphoma patients who are resistant to salvage chemotherapy, even after subsequent autologous stem-cell transplantation (ASCT). Although anti-CD30 chimeric antigen receptor (CAR30) T-cell therapy induces high response rates in these patients, the duration of response is relatively limited. Methods This open-label, single-center and single-arm pilot study investigated the safety and efficacy of ASCT in tandem with CAR30 T-cell infusion in r/r CD30+ lymphoma. The primary endpoint was...

Additional file 2 of MICALL2 as a substrate of ubiquitinase TRIM21 regulates tumorigenesis of colorectal cancer

Pushuai Wen, Huade Wang, Yi Li, Xinyao Sui, Zhijuan Hou, Xiaoyan Guo, Wanying Xue, Dahua Liu, Yu Wang & Jing Gao
Additional file 1. Supplementary Figure.

Additional file 3 of MICALL2 as a substrate of ubiquitinase TRIM21 regulates tumorigenesis of colorectal cancer

Pushuai Wen, Huade Wang, Yi Li, Xinyao Sui, Zhijuan Hou, Xiaoyan Guo, Wanying Xue, Dahua Liu, Yu Wang & Jing Gao
Additional file 2. Supplementary Table.

Additional file 1 of Deficiency of exchange protein directly activated by cAMP (EPAC)-1 in mice augments glucose intolerance, inflammation, and gut dysbiosis associated with Western diet

Preeti Dinesh Virwani, Lin Cai, Patrick Ka Kit Yeung, Gordon Qian, Yingxian Chen, Lei Zhou, Jason Wing Hon Wong, Yu Wang, Joshua Wing Kei Ho, Kui Kai Lau, Pei-Yuan Qian & Sookja Kim Chung
Additional file 1: Table S1. RT-qPCR primer sequences for the targeted mouse genes.

Additional file 1 of Deficiency of exchange protein directly activated by cAMP (EPAC)-1 in mice augments glucose intolerance, inflammation, and gut dysbiosis associated with Western diet

Preeti Dinesh Virwani, Lin Cai, Patrick Ka Kit Yeung, Gordon Qian, Yingxian Chen, Lei Zhou, Jason Wing Hon Wong, Yu Wang, Joshua Wing Kei Ho, Kui Kai Lau, Pei-Yuan Qian & Sookja Kim Chung
Additional file 1: Table S1. RT-qPCR primer sequences for the targeted mouse genes.

Additional file 2 of Deficiency of exchange protein directly activated by cAMP (EPAC)-1 in mice augments glucose intolerance, inflammation, and gut dysbiosis associated with Western diet

Preeti Dinesh Virwani, Lin Cai, Patrick Ka Kit Yeung, Gordon Qian, Yingxian Chen, Lei Zhou, Jason Wing Hon Wong, Yu Wang, Joshua Wing Kei Ho, Kui Kai Lau, Pei-Yuan Qian & Sookja Kim Chung
Additional file 2. R scripts used for bioinformatics analysis.

Additional file 4 of Deficiency of exchange protein directly activated by cAMP (EPAC)-1 in mice augments glucose intolerance, inflammation, and gut dysbiosis associated with Western diet

Preeti Dinesh Virwani, Lin Cai, Patrick Ka Kit Yeung, Gordon Qian, Yingxian Chen, Lei Zhou, Jason Wing Hon Wong, Yu Wang, Joshua Wing Kei Ho, Kui Kai Lau, Pei-Yuan Qian & Sookja Kim Chung
Additional file 4: Table S3. Relative abundance of classes detected through 16S rRNA gene sequencing using fecal DNA.

Additional file 7 of Deficiency of exchange protein directly activated by cAMP (EPAC)-1 in mice augments glucose intolerance, inflammation, and gut dysbiosis associated with Western diet

Preeti Dinesh Virwani, Lin Cai, Patrick Ka Kit Yeung, Gordon Qian, Yingxian Chen, Lei Zhou, Jason Wing Hon Wong, Yu Wang, Joshua Wing Kei Ho, Kui Kai Lau, Pei-Yuan Qian & Sookja Kim Chung
Additional file 7: Table S6. Relative abundance of genera detected through 16S rRNA gene sequencing using fecal DNA.

Additional file 8 of Deficiency of exchange protein directly activated by cAMP (EPAC)-1 in mice augments glucose intolerance, inflammation, and gut dysbiosis associated with Western diet

Preeti Dinesh Virwani, Lin Cai, Patrick Ka Kit Yeung, Gordon Qian, Yingxian Chen, Lei Zhou, Jason Wing Hon Wong, Yu Wang, Joshua Wing Kei Ho, Kui Kai Lau, Pei-Yuan Qian & Sookja Kim Chung
Additional file 8: Fig. S1. Characterization of baseline GM of WT, Epac1–/–, and Epac2–/– mice at the class and order levels. Fig. S2. Characterization of baseline GM of WT, Epac1–/–, and Epac2–/– mice at the family and genus levels. Fig. S3. GM alterations at the class and order levels in the WT, Epac1–/– and Epac2–/– mice induced by an 8-week WD. Fig. S4. GM alterations at the family level in the WT, Epac1–/– and Epac2–/–...

Expression status and prognostic value of autophagy-related lncRNAs in prostate cancer

Guo Chen, Xiaoping Qin, Yu Wang, Biyun Gao, Muan Ling, Wenjun Yin, Yutong Li & Bin Pan
LncRNAs involve in the autophagy to regulate prostate cancer (PCA) initiation and progression. Therefore, it urges to explore more significant AR-lncRNAs in PCa. mRNA data and clinical information of PCa were achieved from TCGA database, and ARGs were obtained from the HADb. AR-lncRNAs were identified by correlation analysis of DE ARGs and lncRNAs. Univariate Cox regression, LASSO regression, and multivariate Cox regression were used to identify the prognostic AR-lncRNA signature and constructed a risk model....

Accurate Determination of Trace Cadmium in Soil Samples with Graphite Furnace Atomic Absorption Spectrometry Using Metal–Organic Frameworks as Matrix Modifiers

Hanyi Liu, Hao Cui, Yu Wang, Zhenmao Jiang, Lidan Lei & Shiqiang Wei
Cadmium (Cd) is a highly toxic heavy metal that is widely distributed in soils at low concentrations. Its volatilization loss occurs at an ashing temperature higher than 350 °C. Accordingly, the accurate determination of its concentration in soils often requires the addition of chemical modifiers by graphite furnace atomic absorption spectrometry (GFAAS) to improve the thermal stability of Cd. In this work, a metal–organic framework (MOF, UIO-66-NH2) was utilized as a matrix modifier to improve...

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Affiliations

  • Tianjin Agricultural University
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  • Zhejiang University
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  • Chongqing University
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  • Nanjing Drum Tower Hospital
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  • Nantong University
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  • Chinese Academy of Medical Sciences & Peking Union Medical College
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  • Hainan Medical University
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  • West China Hospital of Sichuan University
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  • Xuan Wu Hospital of the Capital Medical University
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  • Wenzhou Medical University
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