Response to immune checkpoint blockade improved in pre-clinical model of breast cancer after bariatric surgeryLaura Sipe, Mehdi Chaib, Emily Korba, Mary Lovely, Heejoon Jo, Brittany Counts, Ubaid Tanveer, Jared Clements, Neena John, Deidre Daria, Tony Marion, Radhika Sekhri, Ajeeth Pingili, Bin Teng, James Carson, D Hayes, Matthew Davis, Joseph Pierre & Liza Makowski
Bariatric surgery is becoming more prevalent as a sustainable weight loss approach, with vertical sleeve gastrectomy (VSG) being the first line of surgical intervention. We and others have shown that obesity exacerbates tumor growth while diet-induced weight loss impairs obesity-driven progression. It remains unknown how bariatric surgery-induced weight loss impacts cancer progression or alters responses to therapy. Using a pre-clinical model of diet induced obesity followed by VSG or diet-induced weight loss, breast cancer progression...
Data from: A whole methylome study of ethanol exposure in brain and blood: an exploration of the utility of peripheral blood as proxy tissue for brain in alcohol methylation studiesShaunna L. Clark, Blair N. Costin, Robin F. Chan, Alexander W. Johnson, Linying Xie, Jessica L. Jurmain, Gaurav Kumar, Andrey A. Shabalin, Ashutosh K. Pandey, Karolina A. Aberg, Michael F. Miles & Edwin Van Den Oord
Background: Recent reviews have highlighted the potential use of blood‐based methylation biomarkers as diagnostic and prognostic tools of current and future alcohol use and addiction. Due to the substantial overlap that often exists between methylation patterns across different tissues, including blood and brain, blood‐based methylation may track methylation changes in brain; however, little work has explored the overlap in alcohol‐related methylation in these tissues. Methods: To study the effects of alcohol on the brain methylome...
Background: Duplications of 15q11.2-q13.1 (Dup15q syndrome) are highly penetrant for autism spectrum disorder (ASD). A distinct electrophysiological (EEG) pattern characterized by excessive activity in the beta band has been noted in clinical reports. We asked whether EEG power in the beta band, as well as in other frequency bands, distinguished children with Dup15q syndrome from those with non-syndromic ASD and then examined the clinical correlates of this electrophysiological biomarker in Dup15q syndrome. Methods: In the...
Supplemental tables from: Antifibrogenic activities of CYP11A1-derived vitamin D3-hydroxyderivatives are dependent on RORγZorica Janjetovic, Arnold Postlethwaite Postlethwaite, Hong Soon Kang, Tae Kang Kim, Robert Tuckey, David Crossman, Anton Jetten & Andrzej Alominski
Previous studies showed that non-calcemic 20(OH)D3, a product of CYP11A1 action on vitamin D3, has antifibrotic activity in human dermal fibroblasts and in a bleomycin mouse model of scleroderma. In this study we tested the role of RORγ, which is expressed in skin, in the action of CYP11A1-derived secosteroids using murine fibroblasts isolated from the skin of wild type (RORg+/+), knock out (RORg-/-) and heterozygote (RORg+/-) mice. CYP11A1-derived 20(OH)D3, 20,23(OH)2D3, 1,20(OH)2D3, and 1,20,23(OH)3D3 inhibited proliferation...
Data from: Oral anticoagulation in patients with chronic kidney disease: a systematic review and meta-analysisKonark Malhotra, Muhammad Fawad Ishfaq, Nitin Goyal, Aristeidis H. Katsanos, John Parissis, Anne W Alexandrov, Andrei V. Alexandrov & Georgios Tsivgoulis
Objective: Data regarding the efficacy and safety of warfarin and Non-Vitamin K Antagonist Oral Anticoagulant (NOAC) among patients with chronic kidney disease (CKD) remain scarce. Methods: Systematic review and meta-analysis of studies involving CKD patients treated on OACs was conducted to evaluate following outcomes: ischemic stroke, intracerebral hemorrhage (ICH), combined ischemic and hemorrhagic stroke (strokecombined), stroke or systemic embolism, mortality, and major bleeding events. CKD was defined based on creatinine clearance (CrCl) ranging from mild...
Data from: Telemedicine in neurology: telemedicine work group of the American Academy of Neurology updateJaime M. Hatcher-Martin, Jamie Lynn Adams, Eric R Anderson, Riley Bove, Tamika M. Burrus, Mahan Chehrenama, Mary Dolan O'Brien, Dawn S. Eliashiv, Deniz Erten-Lyons, Barbara S. Giesser, Lauren Moo, Pushpa Narayanaswami, Marvin A. Rossi, Madhu Soni, Nauman Tariq, Jack W. Tsao, Bert Vargas, Scott Vota, Scott Wessels, Hannah Planalp & Raghav Govindarajan
ABSTRACT Purpose: While there is strong evidence supporting the importance of telemedicine in stroke, its role in other areas of neurology is not as clear. The goal of this review is to provide an overview of evidence-based data regarding the role of teleneurology in the care of patients with neurologic disorders other than stroke. Recent findings: Studies across multiple specialties report noninferiority of evaluations by telemedicine compared with traditional, in-person evaluations in terms of patient...
University of Tennessee Health Science Center6
Massachusetts General Hospital2
Virginia Commonwealth University2
University of Alabama at Birmingham1
Oregon Health & Science University1
David Geffen School of Medicine at UCLA1
American Academy of Neurology1
University of Rochester Medical Center1
West Virginia University1
National Institutes of Health1