225 Works

Gestational diabetes mellitus, prenatal maternal depression, and risk for postpartum depression: an Environmental influences on Child Health Outcomes (ECHO) Study

Lauren C. Shuffrey, Maristella Lucchini, Santiago Morales, Ayesha Sania, Christine Hockett, Emily Barrett, Kecia N. Carroll, Camille C. Cioffi, Dana Dabelea, Sean Deoni, Anne L. Dunlop, Arielle Deutsch, William P. Fifer, Morgan R. Firestein, Monique M. Hedderson, Melanie Jacobson, Rachel S. Kelly, Jean M. Kerver, W. Alex Mason, Hooman Mirzakhani, Thomas G. O’Connor, Leonardo Trasande, Scott Weiss, Rosalind Wright, Yeyi Zhu … & Catherine Monk
Abstract Background Prior research has demonstrated bidirectional associations between gestational diabetes mellitus (GDM) and perinatal maternal depression. However, the association between GDM, prenatal depression, and postpartum depression (PPD) has not been examined in a prospective cohort longitudinally. Methods Participants in the current analysis included 5,822 women from the National Institutes of Health’s Environmental influences on Child Health Outcomes (ECHO) Research Program: N = 4,606 with Neither GDM nor Prenatal Maternal Depression (Reference Category); N =...

PDE12 expression data from diabetes patients and controls

Knud Josefsen, Karsten Buschard, Hasim Tekin, Lars Krogvold, Ivan Gerling & Flemming Poicot
Type 1 diabetes (T1D) incidence is increased after COVID-19 infection in children under 18 years of age. Interferon-α-activated oligoadenylate synthetase and downstream RNAseL activation degrade pathogen RNA, but can also damage host RNA when RNAseL activity is poorly regulated. One such regulator is PDE12 which degrades 2′-5′ oligoadenylate units, thereby decreasing RNAseL activity. We analyzed PDE12 expression in islets from non-diabetic donors, individuals with newly (median disease duration 35 days) and recently (5 years) diagnosed...

Additional file 1 of Emergency department-based, nurse-initiated, serious illness conversation intervention for older adults: a protocol for a randomized controlled trial

Thidathit Prachanukool, Susan D. Block, Donna Berry, Rachel S. Lee, Sarah Rossmassler, Mohammad A. Hasdianda, Wei Wang, Rebecca Sudore, Mara A. Schonberg, James A. Tulsky & Kei Ouchi
Additional file 1: Supplemental file 1. Study information sheet for patients.

Additional file 1 of The distribution of bioactive gibberellins along peach annual shoots is closely associated with PpGA20ox and PpGA2ox expression profiles

Mengmeng Zhang, Yangtao Ma, Xianbo Zheng, Bin Tan, Xia Ye, Wei Wang, Langlang Zhang, Jidong Li, Zhiqian Li, Jun Cheng & Jiancan Feng
Additional file 1: Figure S1. Verification of PpKO gene structure using the alignment results of reads obtained from the transcriptome of peach flowers, stems, fruits and pits. Figure S2. Sequence alignment of GA20ox from Arabidopsis and peach. The LPWKET motif are underlined. Figure S3. The phylogenetic trees of CPS (A), KS (B), KO (C), KAO (D) and GA3ox (E). The amino acid sequences were downloaded from Phytozome database and the Gene ID are listed after...

Vascular endothelial growth factor and the risk of venous thromboembolism: a genetic correlation and two-sample Mendelian randomization study

Qiaoyun Zhang, Xiaoyu Zhang, Jie Zhang, Biyan Wang, Qiuyue Tian, Xiaoni Meng, Jinxia Zhang, Mengyang Jiang, Yiqiang Zhang, Deqiang Zheng, Lijuan Wu, Wei Wang, Baoguo Wang & Youxin Wang
Abstract Background The relationship between vascular endothelial growth factor (VEGF) and the risk of venous thromboembolism (VTE) has always been one of the concerns in the medical field. However, the causal inferences from published observational studies on this issue may be affected by confounders or reverse causality. We performed a two-sample bidirectional Mendelian randomization (MR) to infer the associations between VEGF and VTE. Methods Summary statistics from genome-wide association studies (GWAS) for VEGF and VTE...

Additional file 1 of Aligned nanofibrous collagen membranes from fish swim bladder as a tough and acid-resistant suture for pH-regulated stomach perforation and tendon rupture

Zhaohui Luan, Shuang Liu, Wei Wang, Kaige Xu, Shaosong Ye, Ruijue Dan, Hong Zhang, Zhenzhen Shu, Tongchuan Wang, Chaoqiang Fan, Malcolm Xing & Shiming Yang
Additional file 1: Supplementary Fig. S1. PGA with highly complex structure under SEM. Supplementary Fig. S2. Two other crosslinking methods. Supplementary Fig. S3. The detailed process of fabricating DCDS suture with standardization. Supplementary Fig. S4. The tensile strength of double-layers swim bladder with and without crosslinking.

Aligned nanofibrous collagen membranes from fish swim bladder as a tough and acid-resistant suture for pH-regulated stomach perforation and tendon rupture

Zhaohui Luan, Shuang Liu, Wei Wang, Kaige Xu, Shaosong Ye, Ruijue Dan, Hong Zhang, Zhenzhen Shu, Tongchuan Wang, Chaoqiang Fan, Malcolm Xing & Shiming Yang
Abstract Background Wound closure in the complex body environment places higher requirements on suture’s mechanical and biological performance. In the scenario of frequent mechanical gastric motility and extremely low pH, single functional sutures have limitations in dealing with stomach bleeding trauma where the normal healing will get deteriorated in acid. It necessitates to advance suture, which can regulate wounds, resist acid and intelligently sense stomach pH. Methods Based on fish swim bladder, a double-stranded drug-loaded...

Additional file 1 of Identification of the origin of tumor in vein: comparison between CEUS LI-RADS v2017 and v2016 for patients at high risk

Wen-juan Tong, Mei-qing Cheng, Man-xia Lin, Hang-tong Hu, Jia-min Pan, Hui Huang, Ying Wang, Xiao-yan Xie, Ming-de Lu, Ming Kuang, Yang Huang & Wei Wang
Additional file 1. Section S1: The specific process of Focal liver lesion puncture biopsy procedure. Section S2: Image archiving and scanning parameters of CT and MRI. Table S1: FLLs with TIV images characteristics. Except where indicated, data are numbers of nodules or TIV cases and numbers in parentheses are percentages. * datas are Mean ± SD. / means NA. AP: Arterial phase; APHE: Arterial phase hyperenhancement; CEUS: Contrast-enhanced ultrasound; FLLs: Focal liver lesions; HCC: Hepatocellular...

Additional file 2 of Phylogenomics, plastome degradation and mycoheterotrophy evolution of Neottieae (Orchidaceae), with emphasis on the systematic position and Loess Plateau-Changbai Mountains disjunction of Diplandrorchis

Huan-Wen Peng, Lian Lian, Jun Zhang, Andrey S. Erst & Wei Wang
Additional file 2: Fig. S1. Evolutionary inference of nutrition types for Neottieae. Numbers in bold near branches indicate the node number, as referred to Fig. 3. Large pie charts show the relative probabilities of alternative ancestral states obtained by BayesTraits. Fig. S2. Ancestral range reconstruction for Neottieae using BioGeoBEARS under the statistical DEC model. Numbers in bold near branches indicate the node number, as referred to Fig. 3. Large pie charts show the relative probabilities...

Antibody persistence and safety after heterologous boosting with orally aerosolised Ad5-nCoV in individuals primed with two-dose CoronaVac previously: 12-month analyses of a randomized controlled trial

Lairun Jin, Rong Tang, Shipo Wu, Xiling Guo, Haitao Huang, Lihua Hou, Xiaoqin Chen, Tao Zhu, Jinbo Gou, Jin Zhong, Hongxing Pan, Lunbiao Cui, Yin Chen, Xin Xia, Jialu Feng, Xue Wang, Qi Zhao, XiaoYu Xu, Zhuopei Li, Xiaoyin Zhang, Wei Chen, Jingxin Li & Fengcai Zhu
Antibody persistence and safety up to 12 months of heterologous orally administered adenovirus type-5 vector-based COVID-19 vaccine (Ad5-nCoV) in individuals who were primed with two-dose inactivated SARS-CoV-2 vaccine (CoronaVac) previously, has not been reported yet. This randomized, open-label, single-centre trial included Chinese adults who have received two-dose CoronaVac randomized to low-dose or high-dose aerosolised Ad5-nCoV group, or CoronaVac group. In this report, we mainly evaluated the geometric mean titres (GMTs) of neutralizing antibodies (NAbs) against...

sj-docx-6-taj-10.1177_20406223221143245 – Supplemental material for Chest X-ray features facilitate screening for pulmonary hypertension caused by fibrosing mediastinitis

Mingfang Zhou, Bo Li, Yaling Chen, Aqian Wang, Yining Zhu, Yu Li, Hongling Su, Jingchun Fan, Yan Zhang & Yunshan Cao
Supplemental material, sj-docx-6-taj-10.1177_20406223221143245 for Chest X-ray features facilitate screening for pulmonary hypertension caused by fibrosing mediastinitis by Mingfang Zhou, Bo Li, Yaling Chen, Aqian Wang, Yining Zhu, Yu Li, Hongling Su, Jingchun Fan, Yan Zhang and Yunshan Cao in Therapeutic Advances in Chronic Disease

sj-png-2-taj-10.1177_20406223221143245 – Supplemental material for Chest X-ray features facilitate screening for pulmonary hypertension caused by fibrosing mediastinitis

Mingfang Zhou, Bo Li, Yaling Chen, Aqian Wang, Yining Zhu, Yu Li, Hongling Su, Jingchun Fan, Yan Zhang & Yunshan Cao
Supplemental material, sj-png-2-taj-10.1177_20406223221143245 for Chest X-ray features facilitate screening for pulmonary hypertension caused by fibrosing mediastinitis by Mingfang Zhou, Bo Li, Yaling Chen, Aqian Wang, Yining Zhu, Yu Li, Hongling Su, Jingchun Fan, Yan Zhang and Yunshan Cao in Therapeutic Advances in Chronic Disease

Chest X-ray features facilitate screening for pulmonary hypertension caused by fibrosing mediastinitis

Mingfang Zhou, Bo Li, Yaling Chen, Aqian Wang, Yining Zhu, Yu Li, Hongling Su, Jingchun Fan, Yan Zhang & Yunshan Cao
Background:Misdiagnosis and underdiagnosis of pulmonary hypertension caused by fibrosing mediastinitis (PH-FM) are considerably prevalent due to unspecific symptoms and as well as the lack of awareness of this fatal disease.Objectives:The aim of this study was to evaluate the diagnostic accuracy of the chest X-ray (CXR) for screening the patients with PH-FM from those with pulmonary hypertension (PH).Design:This was a retrospective observational cohort study.Methods:The patients with suspected PH were recruited between October 2014 and October 2020....

Long non-coding RNA TRPM2 antisense RNA as a potential therapeutic target promotes tumorigenesis and metastasis in esophageal cancer

Wei Wang, Yukai Dai, Xin Yang & Xinming Xiong
Esophageal cancer (EC) is one type of aggressive gastrointestinal cancers. The treatment of EC is challenging. Effective therapeutic targets require development. Long non-coding RNA TRPM2 antisense RNA (LncRNA TRPM2-AS) is considering a novel biomarker and therapeutic target for various types of cancer. However, the role of lncRNA TRPM2-AS in EC remains unknown. This study aimed to illustrate effects of LncRNA TRPM2-AS on EC growth and metastasis and potential underlying molecular mechanisms. LncRNA TRPM2-AS expression was...

Set2 family regulates mycotoxin metabolism and virulence via H3K36 methylation in pathogenic fungus Aspergillus flavus

Zhenhong Zhuang, Xiaohua Pan, Mengjuan Zhang, Yaju Liu, Chuanzhong Huang, Yu Li, Ling Hao & Shihua Wang
Aspergillus flavus infects various crops with aflatoxins, and leads to aspergillosis opportunistically. Though H3K36 methylation plays an important role in fungal toxin metabolism and virulence, no data about the biological function of H3K36 methylation in A. flavus virulence has been reported. Our study showed that the Set2 histone methyltransferase family, AshA and SetB, involves in morphogenesis and mycotoxin anabolism by regulating related transcriptional factors, and they are important for fungal virulence to crops and animals....

Additional file 1 of Non-prescribed antibiotic use for children at community levels in low- and middle-income countries: a systematic review and meta-analysis

Dumessa Edessa, Nega Assefa, Yadeta Dessie, Fekede Asefa, Girmaye Dinsa & Lemessa Oljira
Additional file 1. Completed PRISMA checklist.

Additional file 3 of Non-prescribed antibiotic use for children at community levels in low- and middle-income countries: a systematic review and meta-analysis

Dumessa Edessa, Nega Assefa, Yadeta Dessie, Fekede Asefa, Girmaye Dinsa & Lemessa Oljira
Additional file 3. Risk of bias assessed for the included individual studies.

Additional file 1 of Non-prescribed antibiotic use for children at community levels in low- and middle-income countries: a systematic review and meta-analysis

Dumessa Edessa, Nega Assefa, Yadeta Dessie, Fekede Asefa, Girmaye Dinsa & Lemessa Oljira
Additional file 1. Completed PRISMA checklist.

Non-prescribed antibiotic use for children at community levels in low- and middle-income countries: a systematic review and meta-analysis

Dumessa Edessa, Nega Assefa, Yadeta Dessie, Fekede Asefa, Girmaye Dinsa & Lemessa Oljira
Abstract Background Non-prescribed antibiotic use is an emerging risky practice around the globe. An inappropriate use involving nonprescription access is one cause of the rapid increase in antibiotic resistance. Children commonly encounter many self-limiting illnesses for which they frequently use antibiotics without prescription. However, no specific and conclusive evidence exists to inform actions against this unsafe practice. We thus aimed to estimate the pooled proportion of non-prescribed antibiotic use for children at community levels in...

Design, synthesis, biological evaluation and molecular docking studies of novel pleuromutilin derivatives containing nitrogen heterocycle and alkylamine groups

Qi Wang, Jie Liu, Zi-Dan Zhou, Ke-Xin Zhou, Fei Li, Qi-Wen Zhang, Shou-Kai Wang, Wei Wang, Zhen Jin & You-Zhi Tang
A series of pleuromutilin derivatives containing alkylamine and nitrogen heterocycle groups were designed and synthesised under mild conditions. The in vitro antibacterial activity of these semisynthetic derivatives against four strains of Staphylococcus aureus (MRSA ATCC 43300, S.aureus ATCC 29213, S.aureus AD3, and S.aureus 144) were evaluated by the broth dilution method. Compound 13 was found to have excellent antibacterial activity against MRSA (MIC = 0.0625 μg/mL). Furthermore, compound 13 was further studied by the time-killing...

Additional file 1 of A machine learning-based data mining in medical examination data: a biological features-based biological age prediction model

Qing Yang, Sunan Gao, Junfen Lin, Ke Lyu, Zexu Wu, Yuhao Chen, Yinwei Qiu, Yanrong Zhao, Wei Wang, Tianxiang Lin, Huiyun Pan & Ming Chen
Additional file 1. Fig. S1. Optimized lambda selection (A) and feature selection (B) in Lasso regression. Fig. S2. Feature importance values in the Stacking model. Fig. S3. Schematic diagrams of the process for introducing missing values and interpolation in MCAR (A) and MNAR (B). Table S1. Parameter optimization results of KNN and MICE in MCAR. Table S2. Parameter optimization results of KNN and MICE in MNAR. Table S3. The optimized parameters of AE and RRLR....

AADAC protects colorectal cancer liver colonization from ferroptosis through SLC7A11-dependent inhibition of lipid peroxidation

Rongquan Sun, Zhifei Lin, Xiangyu Wang, Lu Liu, Meisi Huo, Rui Zhang, Jing Lin, Chao Xiao, Yitong Li, Wenwei Zhu, Lu Lu, Jubo Zhang & Jinhong Chen
Abstract Background Oxidative stress is a highly active metabolic process in the liver, that poses great threats to disseminated tumor cells during their colonization. Here, we aimed to investigate how colorectal cancer (CRC) cells overcome lipid peroxidation to sustain their metastatic colonization in the liver. Methods Orthotopic colorectal liver metastasis (CRLM) and CRC liver colonization mouse models were constructed to determine the roles of lipid peroxidation and AADAC in CRC liver colonization. The levels of...

Additional file 1 of Impact of the national hepatitis B immunization program in China: a modeling study

Zhixi Liu, Mengying Li, David W. Hutton, Abram L. Wagner, Ye Yao, Wenlong Zhu, Lingsheng Cao, Shenglan Tang, Jinhua Pan, Yesheng Wang, Qi Zhao, Hong Ren, Ying Wang & Weibing Wang
Additional file 1: Fig: S1. Transmission structure of the HBV mathematical model. Fig. S2. HBV infection and progression structure of Markov model. Fig. S3. Process of acute HBV infection. Fig. S4. Dynamic model fitting and prediction results. The blue points represent the observed incidence data, while the black cross represents the incidence data fitted by the model. Red triangles represent the predicted incidence data. Fig. S5. Exploration of feasible vaccination interventions on HBV. A: the...

Additional file 1 of Integrated dose–response metabolomics with therapeutic effects and adverse reactions may demystify the dosage of traditional Chinese medicine

Yan-Yan Chen, Jia-Qian Chen, Yu-Ping Tang, Er-Xin Shang, Qi Zhao, Jun-Bo Zou, Ding-Qiao Xu, Shi-Jun Yue, Jie Yang, Rui-Jia Fu, Gui-Sheng Zhou & Jin-Ao Duan
Additional file 1: Quality Control of Rhubarb, Figure S1 Multicomponent quantification of the rhubarb, Table S1 Calibration curve of 15 analytes. Animal Experiments, Figure S2 Average food intake (A), weight (B), fecal pellet numbers (C) and fecal water content (D) of the normal group and model group, Figure S3 Evacuation index (A) and fecal water content (B) of the normal group, model group and rhubarb groups, Figure S4 Pathological sections of colons in the normal...

Additional file 1 of Comparative clinical outcome following individualized follitropin delta dosing in Chinese women undergoing ovarian stimulation for in vitro fertilization /intracytoplasmic sperm injection

Rui Yang, Yunshan Zhang, Xiaoyan Liang, Xueru Song, Zhaolian Wei, Jianqiao Liu, Yezhou Yang, Jichun Tan, Qingxue Zhang, Yingpu Sun, Wei Wang, Weiping Qian, Lei Jin, Shuyu Wang, Yang Xu, Jing Yang, Marie Goethberg, Bernadette Mannaerts, Wen Wu, Zugeng Zheng & Jie Qiao
Additional file 1: Additional Figure 1. Study design and study timeline. AE, adverse event; OHSS, ovarian hyperstimulation syndrome; GnRH, gonadotropin-releasing hormone

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  • University of Tennessee Health Science Center
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