225 Works

Genome-wide identification of the SWEET gene family in Phaseolus vulgaris L. and their patterns of expression under abiotic stress

Yanli Du, Weijia Li, Jing Geng, Siqi Li, Wenjing Zhang, Xianxian Liu, Minghui Hu, Zhaoning Zhang, Yaru Fan, Xiankai Yuan, Jidao Du & Qiang Zhao
Sugar Will Eventually be Exported Transporters (SWEET) proteins function as sugar transporters that play key roles in plant growth, development, and biotic and abiotic stress responses. However, little is known about the SWEET gene family in common bean (Phaseolus vulgaris L.). In this study, 24 putative PvSWEET genes were identified. They can be categorized into four subgroups based on a phylogenetic analysis, exon–intron structure, cis-regulatory elements, and MEME motifs. A collinearity analysis showed that three...

Long non-coding RNA TRPM2 antisense RNA as a potential therapeutic target promotes tumorigenesis and metastasis in esophageal cancer

Wei Wang, Yukai Dai, Xin Yang & Xinming Xiong
Esophageal cancer (EC) is one type of aggressive gastrointestinal cancers. The treatment of EC is challenging. Effective therapeutic targets require development. Long non-coding RNA TRPM2 antisense RNA (LncRNA TRPM2-AS) is considering a novel biomarker and therapeutic target for various types of cancer. However, the role of lncRNA TRPM2-AS in EC remains unknown. This study aimed to illustrate effects of LncRNA TRPM2-AS on EC growth and metastasis and potential underlying molecular mechanisms. LncRNA TRPM2-AS expression was...

Response to immune checkpoint blockade improved in pre-clinical model of breast cancer after bariatric surgery

Laura Sipe, Mehdi Chaib, Emily Korba, Mary Lovely, Heejoon Jo, Brittany Counts, Ubaid Tanveer, Jared Clements, Neena John, Deidre Daria, Tony Marion, Radhika Sekhri, Ajeeth Pingili, Bin Teng, James Carson, D Hayes, Matthew Davis, Joseph Pierre & Liza Makowski
Bariatric surgery is becoming more prevalent as a sustainable weight loss approach, with vertical sleeve gastrectomy (VSG) being the first line of surgical intervention. We and others have shown that obesity exacerbates tumor growth while diet-induced weight loss impairs obesity-driven progression. It remains unknown how bariatric surgery-induced weight loss impacts cancer progression or alters responses to therapy. Using a pre-clinical model of diet induced obesity followed by VSG or diet-induced weight loss, breast cancer progression...

The antimicrobial systems of Streptococcus suis promote niche competition in pig tonsils

Zijing Liang, Huizhen Wu, Chen Bian, Hao Chen, Yanling Shen, Xueping Gao, Jiale Ma, Huochun Yao, Liping Wang & Zongfu Wu
Streptococcus suis can cause severe infections in pigs and humans. The tonsils of pigs are major niches for S. suis, and different serotypes of S. suis can be found in the same tonsil. Pig tonsil colonization by S. suis is believed to be an important source of infection for humans and pigs. However, how S. suis competes for a stable tonsil niche is unknown. Here, we found that S. suis strain WUSS351, isolated from a...

The antimicrobial systems of Streptococcus suis promote niche competition in pig tonsils

Zijing Liang, Huizhen Wu, Chen Bian, Hao Chen, Yanling Shen, Xueping Gao, Jiale Ma, Huochun Yao, Liping Wang & Zongfu Wu
Streptococcus suis can cause severe infections in pigs and humans. The tonsils of pigs are major niches for S. suis, and different serotypes of S. suis can be found in the same tonsil. Pig tonsil colonization by S. suis is believed to be an important source of infection for humans and pigs. However, how S. suis competes for a stable tonsil niche is unknown. Here, we found that S. suis strain WUSS351, isolated from a...

STEAP3 can predict the prognosis and shape the tumor microenvironment of clear cell renal cell carcinoma

Jiyue Wu, Qing Bi, Xiang Zheng, Huawei Cao, Changzhen Hao, Zejia Sun & Wei Wang
Abstract Clear cell renal cell carcinoma (ccRCC) is a common malignant tumor of the urinary system characterized by poor prognosis and difficult treatment. It has been reported that iron metabolism dysregulation is a common phenomenon in ccRCC and is closely related to the process of ccRCC. But still now, the exact function and underlying mechanisms of iron metabolism dysregulation in ccRCC have not been fully elucidated. In this study, we comprehensively investigated the prognostic value...

Integrated dose–response metabolomics with therapeutic effects and adverse reactions may demystify the dosage of traditional Chinese medicine

Yan-Yan Chen, Jia-Qian Chen, Yu-Ping Tang, Er-Xin Shang, Qi Zhao, Jun-Bo Zou, Ding-Qiao Xu, Shi-Jun Yue, Jie Yang, Rui-Jia Fu, Gui-Sheng Zhou & Jin-Ao Duan
Abstract Background Traditional Chinese medicine (TCM) has been used to treat various diseases for thousands of years. However, the uncertainty of dosage as well as the lack of systemic evaluation of pharmacology and toxicology is one major reason why TCM remains mysterious and is not accepted worldwide. Hence, we aimed to propose an integrated dose–response metabolomics strategy based on both therapeutic effects and adverse reactions to guide the TCM dosage in treatment. Methods The proposed...

Additional file 2 of The landscape of hervRNAs transcribed from human endogenous retroviruses across human body sites

Jianqi She, Minghao Du, Zhanzhan Xu, Yueqi Jin, Yu Li, Daoning Zhang, Changyu Tao, Jian Chen, Jiadong Wang & Ence Yang
Additional file 2: Table S1-S15. Supplementary tables.

Additional file 3 of The landscape of hervRNAs transcribed from human endogenous retroviruses across human body sites

Jianqi She, Minghao Du, Zhanzhan Xu, Yueqi Jin, Yu Li, Daoning Zhang, Changyu Tao, Jian Chen, Jiadong Wang & Ence Yang
Additional file 3. Peer review history.

Phylogenomics, plastome degradation and mycoheterotrophy evolution of Neottieae (Orchidaceae), with emphasis on the systematic position and Loess Plateau-Changbai Mountains disjunction of Diplandrorchis

Huan-Wen Peng, Lian Lian, Jun Zhang, Andrey S. Erst & Wei Wang
Abstract Background Mycoheterotrophy is a unique survival strategy adapted to dense forests and has attracted biologists’ attention for centuries. However, its evolutionary origin and related plastome degradation are poorly understood. The tribe Neottieae contains various nutrition types, i.e., autotrophy, mixotrophy, and mycoheterotrophy. Here, we present a comprehensive phylogenetic analysis of the tribe based on plastome and nuclear ITS data. We inferred the evolutionary shift of nutrition types, constructed the patterns of plastome degradation, and estimated...

An examination of health care utilization during the COVID-19 pandemic among women with early-stage hormone receptor-positive breast cancer

Andrew J. Paladino, Kinsey Pebley, Mehmet Kocak, Rebecca A. Krukowski, Teresa M. Waters, Gregory Vidal, Lee S. Schwartzberg, Andrea N. Curry & Ilana Graetz
Abstract Background Women undergoing treatment for breast cancer require frequent clinic visits for maintenance of therapy. With COVID-19 causing health care disruptions, it is important to learn about how this population’s access to health care has changed. This study compares self-reported health care utilization and changes in factors related to health care access among women treated at a cancer center in the mid-South US before and during the pandemic. Methods Participants (N = 306) part...

An examination of health care utilization during the COVID-19 pandemic among women with early-stage hormone receptor-positive breast cancer

Andrew J. Paladino, Kinsey Pebley, Mehmet Kocak, Rebecca A. Krukowski, Teresa M. Waters, Gregory Vidal, Lee S. Schwartzberg, Andrea N. Curry & Ilana Graetz
Abstract Background Women undergoing treatment for breast cancer require frequent clinic visits for maintenance of therapy. With COVID-19 causing health care disruptions, it is important to learn about how this population’s access to health care has changed. This study compares self-reported health care utilization and changes in factors related to health care access among women treated at a cancer center in the mid-South US before and during the pandemic. Methods Participants (N = 306) part...

Additional file 1 of A machine learning-based data mining in medical examination data: a biological features-based biological age prediction model

Qing Yang, Sunan Gao, Junfen Lin, Ke Lyu, Zexu Wu, Yuhao Chen, Yinwei Qiu, Yanrong Zhao, Wei Wang, Tianxiang Lin, Huiyun Pan & Ming Chen
Additional file 1. Fig. S1. Optimized lambda selection (A) and feature selection (B) in Lasso regression. Fig. S2. Feature importance values in the Stacking model. Fig. S3. Schematic diagrams of the process for introducing missing values and interpolation in MCAR (A) and MNAR (B). Table S1. Parameter optimization results of KNN and MICE in MCAR. Table S2. Parameter optimization results of KNN and MICE in MNAR. Table S3. The optimized parameters of AE and RRLR....

Additional file 1 of Emergency department-based, nurse-initiated, serious illness conversation intervention for older adults: a protocol for a randomized controlled trial

Thidathit Prachanukool, Susan D. Block, Donna Berry, Rachel S. Lee, Sarah Rossmassler, Mohammad A. Hasdianda, Wei Wang, Rebecca Sudore, Mara A. Schonberg, James A. Tulsky & Kei Ouchi
Additional file 1: Supplemental file 1. Study information sheet for patients.

Additional file 1 of Gestational diabetes mellitus, prenatal maternal depression, and risk for postpartum depression: an Environmental influences on Child Health Outcomes (ECHO) Study

Lauren C. Shuffrey, Maristella Lucchini, Santiago Morales, Ayesha Sania, Christine Hockett, Emily Barrett, Kecia N. Carroll, Camille C. Cioffi, Dana Dabelea, Sean Deoni, Anne L. Dunlop, Arielle Deutsch, William P. Fifer, Morgan R. Firestein, Monique M. Hedderson, Melanie Jacobson, Rachel S. Kelly, Jean M. Kerver, W. Alex Mason, Hooman Mirzakhani, Thomas G. O’Connor, Leonardo Trasande, Scott Weiss, Rosalind Wright, Yeyi Zhu … & Catherine Monk
Additional file 1.

Additional file 1 of Predictive worth of estimated glucose disposal rate: evaluation in patients with non-ST-segment elevation acute coronary syndrome and non-diabetic patients after percutaneous coronary intervention

Chi Liu, Xiaoli Liu, Xiaoteng Ma, Yujing Cheng, Yan Sun, Dai Zhang, Qi Zhao & Yujie Zhou
Additional file 1: Table S1. Unadjusted Cox regression analysis investigating predictors of MACCE. Figure S1. Calculation of Gensini score of representative case.

Association between hyperglycemia on admission and preoperative deep venous thrombosis in patients with femoral neck fractures

Wei Yao, Wanyun Tang, Wei Wang, Qiaomei Lv & Wenbo Ding
Abstract Background Elevated blood glucose is the most frequent electrolyte disturbance in acutely ill patients. This study aimed to determine whether admission hyperglycemia is associated with the incidence of preoperative deep venous thrombosis (DVT) in patients with femoral neck fractures. Methods This retrospective study was conducted on consecutive patients with femoral neck fractures admitted to our institution from March 2018 to March 2022. Blood glucose levels were measured within 24 h of admission and categorized...

Booster vaccination is required to elicit and maintain COVID-19 vaccine-induced immunity in SIV-infected macaques

Pingchao Li, Qian Wang, Yizi He, Chenchen Yang, Zhengyuan Zhang, Zijian Liu, Bo Liu, Li Yin, Yilan Cui, Peiyu Hu, Yichu Liu, Pingqian Zheng, Wei Wang, Linbing Qu, Caijun Sun, Suhua Guan, Liqiang Feng & Ling Chen
Prolonged infection and possible evolution of SARS-CoV-2 in patients living with uncontrolled HIV-1 infection highlight the importance of an effective vaccination regimen, yet the immunogenicity of COVID-19 vaccines and predictive immune biomarkers have not been well investigated. Herein, we report that the magnitude and persistence of antibody and cell-mediated immunity (CMI) elicited by an Ad5-vectored COVID-19 vaccine are impaired in SIV-infected macaques with high viral loads (> 105 genome copies per ml plasma, SIVhi) but...

Comparative clinical outcome following individualized follitropin delta dosing in Chinese women undergoing ovarian stimulation for in vitro fertilization /intracytoplasmic sperm injection

Rui Yang, Yunshan Zhang, Xiaoyan Liang, Xueru Song, Zhaolian Wei, Jianqiao Liu, Yezhou Yang, Jichun Tan, Qingxue Zhang, Yingpu Sun, Wei Wang, Weiping Qian, Lei Jin, Shuyu Wang, Yang Xu, Jing Yang, Marie Goethberg, Bernadette Mannaerts, Wen Wu, Zugeng Zheng & Jie Qiao
Abstract Background To compare the efficacy and safety of follitropin delta in its individualized fixed-dose regimen with follitropin alfa in a conventional adjustable dosing regimen in Chinese women. Methods This was a subgroup analysis of the randomized, multi-center, assessor-blind, non-inferiority trial (GRAPE) including 759 Chinese women (aged 20–40 years) recruited in 16 reproductive medicine clinics in China. Women were randomized in a 1:1 ratio to be treated with either follitropin delta dose based on anti-Müllerian...

Additional file 2 of Non-prescribed antibiotic use for children at community levels in low- and middle-income countries: a systematic review and meta-analysis

Dumessa Edessa, Nega Assefa, Yadeta Dessie, Fekede Asefa, Girmaye Dinsa & Lemessa Oljira
Additional file 2. Methodological quality assessment of individual studies.

Additional file 4 of Non-prescribed antibiotic use for children at community levels in low- and middle-income countries: a systematic review and meta-analysis

Dumessa Edessa, Nega Assefa, Yadeta Dessie, Fekede Asefa, Girmaye Dinsa & Lemessa Oljira
Additional file 4. Nonprescription antibiotic use for children by region.

Non-prescribed antibiotic use for children at community levels in low- and middle-income countries: a systematic review and meta-analysis

Dumessa Edessa, Nega Assefa, Yadeta Dessie, Fekede Asefa, Girmaye Dinsa & Lemessa Oljira
Abstract Background Non-prescribed antibiotic use is an emerging risky practice around the globe. An inappropriate use involving nonprescription access is one cause of the rapid increase in antibiotic resistance. Children commonly encounter many self-limiting illnesses for which they frequently use antibiotics without prescription. However, no specific and conclusive evidence exists to inform actions against this unsafe practice. We thus aimed to estimate the pooled proportion of non-prescribed antibiotic use for children at community levels in...

The driver’s instantaneous situation awareness when the alarm rings during the take-over of vehicle control in automated driving

Jianwei Niu, Zhen Zhang, Yipin Sun, Xiai Wang, Jie Ni & Hua Qin
The driver’s instantaneous situation awareness in the process of take-over of vehicle control in automated driving has not yet been thoroughly investigated. The proposed research can provide a better understanding of the driver’s perceived characteristics and identify the most urgent information requirements of the on-site scenario when the driver’s eye sight returns from other distractors to the driving scene. We conducted an experiment in simulated automated driving to study the participants’ ability of instantaneous hazard...

Additional file 1 of AADAC protects colorectal cancer liver colonization from ferroptosis through SLC7A11-dependent inhibition of lipid peroxidation

Rongquan Sun, Zhifei Lin, Xiangyu Wang, Lu Liu, Meisi Huo, Rui Zhang, Jing Lin, Chao Xiao, Yitong Li, Wenwei Zhu, Lu Lu, Jubo Zhang & Jinhong Chen
Additional file 1.

Al₂O₃-YAG:Ce/YAG composite ceramic phosphor in a transmissive configuration for high-brightness laser-driven lighting

Pengfei Sang, Le Zhang, Jian Kang, yanbin li, shiwei chen, peng yang, Bingheng Sun, Yang Li & Hao Chen
High-power, high-brightness laser lighting promotes new requirements for light-conversion materials, such as high thermal conductivity, high saturation threshold and compact encapsulation. In this paper, we designed and fabricated a novel composite structure ceramic including a 1.0×1.0 mm2 Al₂O₃-YAG:Ce ceramic and a φ=16.0 mm transparent YAG ceramic for the transmissive configuration in laser lighting. When pumped by blue laser from 0~60 W mm2, all the samples exhibited no luminous saturation phenomenon, and the 10.0 wt.%Al₂O₃-YAG:Ce/YAG composite...

Registration Year

  • 2022
    225

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Affiliations

  • University of Tennessee Health Science Center
    225
  • Sun Yat-sen University
    181
  • Fudan University
    177
  • Capital Medical University
    170
  • Sichuan University
    165
  • Huazhong University of Science and Technology
    162
  • Chinese Academy of Medical Sciences & Peking Union Medical College
    152
  • Shanghai Jiao Tong University
    151
  • Air Force Medical University
    149
  • Fudan University Shanghai Cancer Center
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