Data from: Computed tomography shows high fracture prevalence among physically active forager-horticulturalists with high fertilityJonathan Stieglitz, Benjamin C. Trumble, Study Team HORUS, Caleb Finch, Dong Li, Matthew J. Budoff, Hillard Kaplan & Michael Gurven
Modern humans have more fragile skeletons than other hominins, which may result from physical inactivity. Here we test whether reproductive effort also compromises bone strength, by measuring using computed tomography thoracic vertebral bone mineral density (BMD) and fracture prevalence among physically active Tsimane forager-horticulturalists. Earlier onset of reproduction and shorter interbirth intervals are associated with reduced BMD for women. Tsimane BMD is lower versus Americans, but only for women, contrary to simple predictions relying on...
Data from: Automatic segmentation of multiple cardiovascular structures from cardiac computed tomography angiography images using deep learningLohendran Baskaran, Subhi J. Al’Aref, Gabriel Maliakal, Benjamin C. Lee, Zhuoran Xu, Jeong W. Choi, Sang-Eun Lee, Ji Min Sung, Fay Y. Lin, Simon Dunham, Bobak Mosadegh, Yong-Jin Kim, Ilan Gottlieb, Byoung Kwon Lee, Eun Ju Chun, Filippo Cademartiri, Erica Maffei, Hugo Marques, Sanghoon Shin, Jung Hyun Choi, Kavitha Chinnaiyan, Martin Hadamitzky, Edoardo Conte, Daniele Andreini, Gianluca Pontone … & Leslee J. Shaw
Objectives: To develop, demonstrate and evaluate an automated deep learning method for multiple cardiovascular structure segmentation. Background: Segmentation of cardiovascular images is resource-intensive. We design an automated deep learning method for the segmentation of multiple structures from Coronary Computed Tomography Angiography (CCTA) images. Methods: Images from a multicenter registry of patients that underwent clinically-indicated CCTA were used. The proximal ascending and descending aorta (PAA, DA), superior and inferior vena cavae (SVC, IVC), pulmonary artery (PA),...
Untargeted high-resolution plasma metabolomic profiling among patients with coronary artery disease. Patients recruited from the Emory Cardiovascular Biobank into independent discovery and validation cohorts.
Data from: Association of serum neurofilament light (sNfL) and disease severity in patients with spinocerebellar ataxia type 3Yun Peng, Youming Zhang, Zhao Chen, Huirong Peng, Na Wan, Jennifer Zhang, Jingyi Tang, Puzhi Wang, Yue Xie, Qiyong Cai, Shaohui Liu, Xuewei Zhang, Chunrong Wang, Hongyu Yuan, Tianjiao Li, Linlin Wan, Yuting Shi, Rong Qiu, Thomas Klockgether, Beisha Tang, Weihua Liao & Hong Jiang
Objective: To investigate serum neurofilament light protein (sNfL) levels in patients with spinocerebellar ataxia type 3 (SCA3) and to determine whether they are associated with disease severity. Methods: This cross-sectional study enrolled 185 healthy controls and 235 ATXN3 mutation carriers (17 asymptomatic stage, 20 preclinical stage, and 198 ataxic stage). We measured sNfL levels with the single molecule array (Simoa) platform. Clinical disease severity was assessed using the scale of assessment and rating of ataxia...
When complexed with antigenic peptides, human leukocyte antigen (HLA) class I (HLA-I) molecules initiate CD8+ T cell responses via interaction with the T cell receptor (TCR) and co-receptor CD8. Peptides are generally critical for the stable cell surface expression of HLA-I molecules. However, for HLA-I alleles such as HLA-B35:01, peptide-deficient (empty) heterodimers are thermostable and detectable on the cell surface. Additionally, peptide-deficient HLA-B35:01 tetramers preferentially bind CD8 and to a majority of blood-derived CD8+ T...
The subcellular localization of objects, such as organelles, proteins, or other molecules, instructs cellular form and function. Understanding the underlying spatial relationships between objects through colocalization analysis of microscopy images is a fundamental approach used to inform biological mechanisms. We generated an automated and customizable computational tool, the SubcellularDistribution pipeline, to facilitate object-based image analysis from 3D fluorescence microcopy images. To test the utility of the SubcellularDistribution pipeline, we examined the subcellular distribution of mRNA...
Objective: The objectives of this study were to measure the global impact of the pandemic on the volumes for intravenous thrombolysis (IVT), IVT transfers, and stroke hospitalizations over 4 months at the height of the pandemic (March 1 to June 30, 2020) compared with two control 4-month periods. Methods: We conducted a cross-sectional, observational, retrospective study across 6 continents, 70 countries, and 457 stroke centers. Diagnoses were identified by their ICD-10 codes and/or classifications in...
Data from: Observational study of hemostatic dysfunction and bleeding in neonates with hypoxic-ischemic encephalopathyMitali A. Pakvasa, Anne M. Winkler, Shannon E. Hamrick, Cassandra D. Josephson & Ravi M. Patel
Objective: Evaluate the relationship between initial haemostatic parameters and the frequency and severity of bleeding in neonates with hypoxic–ischaemic encephalopathy (HIE). Design: Retrospective observational cohort study. Setting: 2 academically affiliated level III neonatal intensive care units in Atlanta, Georgia. Participants: 98 neonates with moderate-to-severe HIE who underwent haemostatic testing within 12 hours of birth and were born from 1 January 2008 to 31 December 2013. Primary and secondary outcome measures: Initial haemostatic dysfunction was defined...
Objective: The primary objective of this study was to evaluate the correlation of large mitochondrial DNA deletions in skin samples of people with HIV with measure of neuropathy and prior exposure to therapy. We hypothesized that deletions would be associated with the presence of neuropathy. As secondary objectives we determined the correlation of deletion burden with demographic data and neuropathy measures. Methods: In this retrospective cohort study we measured the accumulation of large mtDNA deletions...
Krabbe disease (KD) is a rare autosomal recessive lysosomal storage disorder (LSD) associated with severe neurodegeneration and high mortality and is one of most prevalent LSDs at a recent estimate of 1 in 12,080 live births. The disease pathogenesis is related to low/undetectable galactocerebrosidase (GALC) activity resulting in an accumulation of a cytotoxic GALC substrate, psychosine (Psy), that leads to diffuse demyelination, psychomotor delays, and high morbidity/mortality across the disease spectrum. Although phenotypic prediction in...
Data from: Flightin maintains myofilament lattice organization required for optimal flight power and courtship song quality in DrosophilaSamya Chakravorty, Bertrand C. W. Tanner, Veronica Lee Foelber, Hien Vu, Matthew Rosenthal, Teresa Ruiz & Jim O. Vigoreaux
The indirect flight muscles (IFMs) of Drosophila and other insects with asynchronous flight muscles are characterized by a crystalline myofilament lattice structure. The high-order lattice regularity is considered an adaptation for enhanced power output, but supporting evidence for this claim is lacking. We show that IFMs from transgenic flies expressing flightin with a deletion of its poorly conserved N-terminal domain (flnΔN62) have reduced inter-thick filament spacing and a less regular lattice. This resulted in a...
Emory University School of Medicine11
Brigham and Women's Hospital2
New York University Langone Medical Center1
Centro Cardiologico Monzino1
Kwame Nkrumah University of Science and Technology1
Seoul National University Bundang Hospital1
Ain Shams University1
Central South University1
University of Michigan-Ann Arbor1
Ain Shams University Hospital1