Data from: Empty conformers of HLA-B preferentially bind CD8 and regulate CD8+ T cell function

Jie Geng, John D. Altman, Sujatha Krishnakumar & Malini Raghavan
When complexed with antigenic peptides, human leukocyte antigen (HLA) class I (HLA-I) molecules initiate CD8+ T cell responses via interaction with the T cell receptor (TCR) and co-receptor CD8. Peptides are generally critical for the stable cell surface expression of HLA-I molecules. However, for HLA-I alleles such as HLA-B35:01, peptide-deficient (empty) heterodimers are thermostable and detectable on the cell surface. Additionally, peptide-deficient HLA-B35:01 tetramers preferentially bind CD8 and to a majority of blood-derived CD8+ T...

Registration Year

  • 2018
    1

Resource Types

  • Dataset
    1

Affiliations

  • Emory University School of Medicine
    1
  • University of Michigan-Ann Arbor
    1
  • Immucor (United States)
    1