635 Works

Hygiene in der Arztpraxis - Infektionsprävention in der ambulanten Versorgung

Tobias Kramer, Andreas Suck, Hedwig François-Kettner, Petra Gastmeier, Bernd Gruber, Katja Heinze, Elena Kortemeyer, Moritz Liewer, Pamela Reißner, Katharina Rubin, Cornelia Schmitz, Anke Westerberg, Cornelia Winten & Conny Wiebe-Franzen
Die Handlungsempfehlung wendet sich an Sie als Ärzte, Betreiber und Medizinische Fachangestellte (MFA) in ambulanten Praxen und Medizinischen Versorgungszentren (MVZ) sowie an zugehörige Ausbildungsbereiche. Durch ausgewählte praxisnahe Beispiele gibt Ihnen die Handlungsempfehlung die Möglichkeit, Infektionsrisiken im täglichen Umgang mit ihren Patienten zu identifizieren. Die Empfehlungen beleuchten eine Auswahl relevanter Aspekte zur Sicherung ihrer Patienten und Mitarbeitenden. Sie bilden den Stand des aktuellen Wissens ab und stellen in ihrer Umsetzung eine Mindestanforderung dar. Daher fokussiert die...

Does cumulative exposure to traumatic stressors predict treatment outcome of community-implemented exposure-based therapy for PTSD?

Anna Schneider, Anett Pfeiffer, Daniela Conrad, Thomas Elbert, Iris-Tatjana Kolassa & Sarah Wilker
Background: Posttraumatic Stress Disorder (PTSD) is associated with high levels of functional impairments such as difficulties in academic or occupational performance and in social relationships. With an increasing number of traumatic event types experienced (trauma load), PTSD risk increases in a dose-dependent manner. Accordingly, high rates of PTSD can impair the reconstruction process in post-conflict societies. In order to meet these high needs for mental health services in societies with little access to professional care,...

Does cumulative exposure to traumatic stressors predict treatment outcome of community-implemented exposure-based therapy for PTSD?

Anna Schneider, Anett Pfeiffer, Daniela Conrad, Thomas Elbert, Iris-Tatjana Kolassa & Sarah Wilker
Background: Posttraumatic Stress Disorder (PTSD) is associated with high levels of functional impairments such as difficulties in academic or occupational performance and in social relationships. With an increasing number of traumatic event types experienced (trauma load), PTSD risk increases in a dose-dependent manner. Accordingly, high rates of PTSD can impair the reconstruction process in post-conflict societies. In order to meet these high needs for mental health services in societies with little access to professional care,...

Data from: Clinical presentation and management of SMART syndrome

Sebastian F. Winter, Joshua P. Klein, Eugene J. Vaios, Philipp Karschnia, Eudocia Q. Lee, Helen A. Shih, Franziska Loebel & Jorg Dietrich
Stroke-like migraine attacks after radiation therapy (SMART) syndrome represents a rare but serious condition manifesting years after cranial radiation therapy (RT). Characterized by migraine-type headaches, stroke-like deficits and/or seizures and MR imaging abnormalities, including cortical gyriform enhancement in irradiated brain regions, SMART remains diagnostically and therapeutically challenging. Distinction from tumor progression is difficult and treatment options are limited. Although frequently reversible, SMART episodes can recur and effectuate persistent neurologic and/or imaging sequelae.

Data from: Predictors of new remote cerebral microbleeds after intravenous thrombolysis for ischemic stroke

Tim Bastian Braemswig, Kersten Villringer, Guillaume Turc, Hebun Erdur, Jochen B. Fiebach, Heinrich J. Audebert, Matthias Endres, Christian H. Nolte & Jan F. Scheitz
Objective: To assess the frequency, associated factors, and underlying vasculopathy of new remote cerebral microbleeds (CMB), as well as the risk of concomitant hemorrhagic complications related to new CMBs, after intravenous thrombolysis (IVT) in acute stroke patients. Methods: We conducted an observational study using data from our local thrombolysis registry. We included consecutive stroke patients with MRI (3-Tesla)-based IVT and a follow-up MRI the next day between 2008–2017 (n=396). Only CMBs located outside of the...

Data from: Hodge decomposition of wall shear stress vector fields characterizing biological flows

Faniry H. Razafindrazaka, Pavel Yevtushenko, Konstantin Poelke, Konrad Polthier & Leonid Goubergrits
A discrete boundary-sensitive Hodge decomposition is proposed as a central tool for the analysis of wall shear stress (WSS) vector fields in aortic blood flows. The method is based on novel results for the smooth and discrete Hodge-Morrey-Friedrichs decomposition on manifolds with boundary and subdivides the WSS vector field into five components: gradient (curl-free), co-gradient (divergence-free), and three harmonic fields induced from the boundary, which are called the center, Neumann and Dirichlet fields. First, an...

Current Advances, Challenges, and Opportunities in Stroke Research, Management, and Care

Julius Emmrich, Samuel Knauss & Matthias Endres
Stroke is the second leading cause of death (after heart disease) and a major cause of disability worldwide. Also called a brain attack, typical symptoms of stroke include sudden one-sided weakness and numbness in the face and arm as well as altered speech. Most strokes are ischaemic strokes where arterial blood flow to the brain is interrupted by an embolism or thrombosis. Strokes are less frequently caused by haemorrhage. Non-contrast cranial computed tomography (CT) imaging,...

A comprehensive survey among statistical members of medical ethics committees in Germany on their personal impression of completeness and correctness of biostatistical aspects of submitted study protocols

Geraldine Rauch
Original data of a comprehensive survey among statistical members of medical ethics committees in Germany on their personal impression of completeness and correctness of biostatistical aspects of submitted study protocols. To enable reproduction of the results presented in the corresponding paper, the final dataset is freely available here, without any information on the medical ethics committee’s federal state to avoid any risk of potential re-identification.

Accumulation and translocation of selenium in a soil–rice system in Guangxi, China

Zhen Wang, Fei Pang & Wei Huang
Selenium (Se) is an essential element for the human body. Humans meet their basic Se requirements primarily through food consumption. The largest Se-rich contiguous area in China is located in the southeast of Guangxi. In this study, the Se accumulation and translocation in the Guangxi rice–soil system was assessed. Organically bound Se (O-Se) was found to be the main type of soil Se (72.5%), and had a good linear relationship with soil total Se (TSe)...

Hyperthermia inhibits growth of nasopharyngeal carcinoma through degradation of c-Myc

Xiaole Li, Shichao Duan, Yingjuan Zheng, Yongqiang Yang, Lei Wang, Xinqiang Li, Qing Zhang, Rick F. Thorne, Wencai Li & Daoke Yang
Hyperthermia is a widely used adjunct treatment for different cancers including nasopharyngeal carcinoma (NPC). The protooncogene c-Myc is up-regulated in NPC and its expression is associated with poor prognosis. We hypothesized that c-Myc constitutes an important hyperthermia treatment target, and we investigated its contribution to hyperthermia responses in NPC. The growth of the human NPC cell lines CNE1 and CNE2 was analyzed using CCK-8 and clonogenicity assays after 43 °C hyperthermia, knockdown or overexpression of...

Original data for the manuscript \"Fault slip behaviors modulated by locally increased fluid pressure: Earthquake nucleation and slow slip events\"

Peng Dong, Ran Xu, Hongfeng Yang, Zhiyin Guo & Kaiwen Xia
Model results of four typical fault slip behaviors are presented in the form of time (T), displacement(U), slip rate(v), friction(f), and time increment(dt) at each step in numerical simulation. The collective results of numerical simulation are present in Data.xlsx

Additional file 2 of Association between in-ICU red blood cells transfusion and 1-year mortality in ICU survivors

Alice Blet, Joel B. McNeil, Julie Josse, Bernard Cholley, Raphaël Cinotti, Gad Cotter, Agnès Dauvergne, Beth Davison, Kévin Duarte, Jacques Duranteau, Marie-Céline Fournier, Etienne Gayat, Samir Jaber, Sigismond Lasocki, Thomas Merkling, Katell Peoc’h, Imke Mayer, Malha Sadoune, Pierre-François Laterre, Romain Sonneville, Lorraine Ware, Alexandre Mebazaa & Antoine Kimmoun
Additional file 2: Supplemental Text.

Additional file 1 of EVI1 expression in early-stage breast cancer patients treated with neoadjuvant chemotherapy

Jonas Leichsenring, Valentina Vladimirova, Christine Solbach, Thomas Karn, Beyhan Ataseven, Bruno Valentin Sinn, Jana Barinoff, Volkmar Müller, Jens-Uwe Blohmer, Christian Schem, Knut Engels, Frederik Marmé, Annette Fisseler-Eckhoff, Peter A. Fasching, Elmar Stickeler, Marion van Mackelenbergh, Carsten Denkert, Albrecht Stenzinger, Sibylle Loibl & Stefan Gröschel
Additional file 1: Supplementary Figure 1. Flow diagram of patients included in the analysis set from GeparTrio study.

Additional file 2 of EVI1 expression in early-stage breast cancer patients treated with neoadjuvant chemotherapy

Jonas Leichsenring, Valentina Vladimirova, Christine Solbach, Thomas Karn, Beyhan Ataseven, Bruno Valentin Sinn, Jana Barinoff, Volkmar Müller, Jens-Uwe Blohmer, Christian Schem, Knut Engels, Frederik Marmé, Annette Fisseler-Eckhoff, Peter A. Fasching, Elmar Stickeler, Marion van Mackelenbergh, Carsten Denkert, Albrecht Stenzinger, Sibylle Loibl & Stefan Gröschel
Additional file 2: Supplementary Figure 2. Distribution of EVI1 continuous expression in breast cancer: A: Histogram of EVI1 continuous expression in the entire cohort (N=993); B: Boxplots of EVI1 continuous expression within breast cancer subtypes. Note, 882/993 patients with available BC subtype information were included in this analysis. Horizontal bold lines present EVI1 median values of 116.65 in HR+/HER2-, 98.67 in HR+/HER2+, 114.77in HR-/HER2+, and 115.64 in TNBC; boxes present the interquartile range between first...

Shotgun-2: A Bayesian phase I/II basket trial design to identify indication-specific optimal biological doses

Xin Chen, Jingyi Zhang, Liyun Jianga & Fangrong Yan
For novel molecularly targeted agents and immunotherapies, the objective of dose-finding is often to identify the optimal biological dose, rather than the maximum tolerated dose. However, optimal biological doses may not be the same for different indications, challenging the traditional dose-finding framework. Therefore, we proposed a Bayesian phase I/II basket trial design, named “shotgun-2,” to identify indication-specific optimal biological doses. A dose-escalation part is conducted in stage I to identify the maximum tolerated dose and...

Additional file 3 of The dynamic changes and sex differences of 147 immune-related proteins during acute COVID-19 in 580 individuals

Guillaume Butler-Laporte, Edgar Gonzalez-Kozlova, Chen-Yang Su, Sirui Zhou, Tomoko Nakanishi, Elsa Brunet-Ratnasingham, David Morrison, Laetitia Laurent, Jonathan Afilalo, Marc Afilalo, Danielle Henry, Yiheng Chen, Julia Carrasco-Zanini, Yossi Farjoun, Maik Pietzner, Nofar Kimchi, Zaman Afrasiabi, Nardin Rezk, Meriem Bouab, Louis Petitjean, Charlotte Guzman, Xiaoqing Xue, Chris Tselios, Branka Vulesevic, Olumide Adeleye … & J Brent Richards
Additional file 3: Protein correlation heatmaps.

Additional file 4 of The dynamic changes and sex differences of 147 immune-related proteins during acute COVID-19 in 580 individuals

Guillaume Butler-Laporte, Edgar Gonzalez-Kozlova, Chen-Yang Su, Sirui Zhou, Tomoko Nakanishi, Elsa Brunet-Ratnasingham, David Morrison, Laetitia Laurent, Jonathan Afilalo, Marc Afilalo, Danielle Henry, Yiheng Chen, Julia Carrasco-Zanini, Yossi Farjoun, Maik Pietzner, Nofar Kimchi, Zaman Afrasiabi, Nardin Rezk, Meriem Bouab, Louis Petitjean, Charlotte Guzman, Xiaoqing Xue, Chris Tselios, Branka Vulesevic, Olumide Adeleye … & J Brent Richards
Additional file 4: Protein clusters.

Additional file 5 of The dynamic changes and sex differences of 147 immune-related proteins during acute COVID-19 in 580 individuals

Guillaume Butler-Laporte, Edgar Gonzalez-Kozlova, Chen-Yang Su, Sirui Zhou, Tomoko Nakanishi, Elsa Brunet-Ratnasingham, David Morrison, Laetitia Laurent, Jonathan Afilalo, Marc Afilalo, Danielle Henry, Yiheng Chen, Julia Carrasco-Zanini, Yossi Farjoun, Maik Pietzner, Nofar Kimchi, Zaman Afrasiabi, Nardin Rezk, Meriem Bouab, Louis Petitjean, Charlotte Guzman, Xiaoqing Xue, Chris Tselios, Branka Vulesevic, Olumide Adeleye … & J Brent Richards
Additional file 5: Inferred protein levels over time.

Additional file 1 of The dynamic changes and sex differences of 147 immune-related proteins during acute COVID-19 in 580 individuals

Guillaume Butler-Laporte, Edgar Gonzalez-Kozlova, Chen-Yang Su, Sirui Zhou, Tomoko Nakanishi, Elsa Brunet-Ratnasingham, David Morrison, Laetitia Laurent, Jonathan Afilalo, Marc Afilalo, Danielle Henry, Yiheng Chen, Julia Carrasco-Zanini, Yossi Farjoun, Maik Pietzner, Nofar Kimchi, Zaman Afrasiabi, Nardin Rezk, Meriem Bouab, Louis Petitjean, Charlotte Guzman, Xiaoqing Xue, Chris Tselios, Branka Vulesevic, Olumide Adeleye … & J Brent Richards
Additional file 1: List of immunity-related proteins measured.

Efficient synthesis of 3-hydroxy chromones via oxidative cyclization mediated by lipase

Jiapeng Li, Yue Yu, Yaning Xu, Fengxi Li, Yuqi Liu, Yifei Sun, Chunyu Wang, Peng Chen & Lei Wang
In this work, an efficient synthesis of 3-hydroxy chromones was accomplished through oxidative cyclization mediated by lipase. This enzymatic process has salient features of environmental friendliness, mild reaction condition, satisfactory yield, green reusable biocatalyst, and short reaction time. The proposed method expands the application of lipase in organic synthesis.

Additional file 3 of EVI1 expression in early-stage breast cancer patients treated with neoadjuvant chemotherapy

Jonas Leichsenring, Valentina Vladimirova, Christine Solbach, Thomas Karn, Beyhan Ataseven, Bruno Valentin Sinn, Jana Barinoff, Volkmar Müller, Jens-Uwe Blohmer, Christian Schem, Knut Engels, Frederik Marmé, Annette Fisseler-Eckhoff, Peter A. Fasching, Elmar Stickeler, Marion van Mackelenbergh, Carsten Denkert, Albrecht Stenzinger, Sibylle Loibl & Stefan Gröschel
Additional file 3: Supplementary Figure 3. Kaplan-Meier estimates of DFS (A) and OS (B) according to EVI1 expression in the non-pCR subgroup. Abbreviations:pCR, pathological complete response; DFS, disease-free survival; OS, overallsurvival.

Additional file 1 of Early clinical course of biopsy-proven IgA vasculitis nephritis

Sarina Butzer, Imke Hennies, Charlotte Gimpel, Jutta Gellermann, Gesa Schalk, Sabine König, Anja K. Büscher, Anja Lemke & Martin Pohl
Additional file 1. Comparative subgroup analysis. Of 66 patients, we identified 28 children with crescentic glomeruli and/or nephrotic syndrome at onset of IgAVN. Referring to the German Society of Pediatric Nephology, a corticosteroid pulse therapy only would have been recommended. Of these 28 children, 17 received corticosteroid pulse therapy per protocol, 11 did not receive any immunosuppressive therapy. We therefore performed a comparative subgroup analysis which showed similar improvements of clinical symptoms and proteinuria.

Utility of standard diffusion-weighted magnetic resonance imaging for the identification of ischemic optic neuropathy in giant cell arteritis

Leon Alexander Danyel
Purpose: To assess diffusion abnormalities of the optic nerve (ON) in giant cell arteritis (GCA) patients with acute onset of visual impairment (VI) using diffusion-weighted magnetic resonance imaging (DWI). Methods: DWI scans of GCA patients with acute VI were evaluated in a case-control study. Two blinded neuroradiologists assessed randomized DWI scans of GCA and controls for ON restricted diffusion. Statistical quality criteria and inter-rater reliability (IRR) were calculated. DWI findings were compared to ophthalmological assessments....

FROM-GLC Plus: toward near real-time and multi-resolution land cover mapping

Le Yu, Zhenrong Du, Runmin Dong, Juepeng Zheng, Ying Tu, Xin Chen, Pengyu Hao, Bo Zhong, Dailiang Peng, Jiyao Zhao, Xiyu Li, Jianyu Yang, Haohuan Fu, Guangwen Yang & Peng Gong
Global land cover has undergone extensive and rapid changes as a result of human activities and climate change. These changes have had a significant impact on biodiversity, the surface energy balance, and sustainable development. Global land cover data underpins research on the development of earth system models, resource management, and evaluation of the ecological environment. However, there are limitations in the classification detail, spatial resolution, and rapid change monitoring capability of global land cover change...

Knowledge, experiences, and practices of women affected by female genital schistosomiasis in rural Madagascar

Angela Schuster, Oliva Tiana Onintsoa Rabozakandraina, Bodo Sahondra Randrianasolo, Charles Emile Ramarokoto, Dorthe Brønnum & Hermann Feldmeier
Background: Female genital schistosomiasis (FGS) is a neglected manifestation of urogenital schistosomiasis caused by S. haematobium. The disease presents with symptoms such as pelvic pain, vaginal discharge and bleeding and menstruation disorders, and might lead to infertility and pregnancy complications. The perspectives of women with FGS have not been studied systematically. Methods: We performed a qualitative study in the Ambanja district in Northwest Madagascar. FGS was diagnosed by colposcopy. Seventy-six women with FGS participated either...

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