Data from: Quantitative time-resolved analysis reveals intricate, differential regulation of standard- and immuno-proteasomes

Juliane Liepe, Hermann-Georg Holzhütter, Elena Bellavista, Peter M. Kloetzel, Michael P. H. Stumpf & Michele Mishto
Proteasomal protein degradation is a key determinant of protein half-life and hence of cellular processes ranging from basic metabolism to a host of immunological processes. Despite its importance the mechanisms regulating proteasome activity are only incompletely understood. Here we use an iterative and tightly integrated experimental and modelling approach to develop, explore and validate mechanistic models of proteasomal peptide-hydrolysis dynamics. The 20S proteasome is a dynamic enzyme and its activity varies over time because of...

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  • University of Bologna
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