8 Works

Minor neuropsychological deficits in patients with subjective cognitive decline

Steffen Wolfsgruber, Luca Kleineidam, Jannis Guski, Alexandra Polcher, Ingo Frommann, Sandra Roeske, Eike Jakob Spruth, Christina Franke, Josef Priller, Ingo Kilimann, Stefan Teipel, Katharina Buerger, Daniel Janowitz, Christoph Laske, Martina Buchmann, Oliver Peters, Felix Menne, Manuel Fuentes Casan, Jens Wiltfang, Claudia Bartels, Emrah Düzel, Coraline Metzger, Wenzel Glanz, Manuela Thelen, Annika Spottke … & Michael Wagner
Objective: To determine the nature and extent of minor neuropsychological deficits in patients with subjective cognitive decline (SCD) and their association with cerebrospinal fluid (CSF) biomarkers of Alzheimer’s disease (AD). Method: We analyzed data from n=449 cognitively normal participants (n=209 healthy controls, n=240 SCD patients) from an interim data release of the German Center for Neurodegenerative Diseases Longitudinal Cognitive Impairment and Dementia Study (DELCODE). An extensive neuropsychological test battery was applied at baseline for which...

Hygiene in der Arztpraxis - Infektionsprävention in der ambulanten Versorgung

Tobias Kramer, Andreas Suck, Hedwig François-Kettner, Petra Gastmeier, Bernd Gruber, Katja Heinze, Elena Kortemeyer, Moritz Liewer, Pamela Reißner, Katharina Rubin, Cornelia Schmitz, Anke Westerberg, Cornelia Winten & Conny Wiebe-Franzen
Die Handlungsempfehlung wendet sich an Sie als Ärzte, Betreiber und Medizinische Fachangestellte (MFA) in ambulanten Praxen und Medizinischen Versorgungszentren (MVZ) sowie an zugehörige Ausbildungsbereiche. Durch ausgewählte praxisnahe Beispiele gibt Ihnen die Handlungsempfehlung die Möglichkeit, Infektionsrisiken im täglichen Umgang mit ihren Patienten zu identifizieren. Die Empfehlungen beleuchten eine Auswahl relevanter Aspekte zur Sicherung ihrer Patienten und Mitarbeitenden. Sie bilden den Stand des aktuellen Wissens ab und stellen in ihrer Umsetzung eine Mindestanforderung dar. Daher fokussiert die...

Sepsis geht alle an! Handlungsempfehlung für Ärztinnen und Ärzte, Pflegekräfte und Angehörige anderer Gesundheitsberufe

, Rainer Petzina, Antje Erler, Ruth Hecker, Manuela Forster, Christiane Hartog, Frank Köhler, Hervig Gerlach, Delia Strunz, Susanne Eberl, Heinrich Geiss, Matthias Gründling, Iris Juditzki, Andreas Podbielski & Arbe Trumann
1. Auflage, Juni 2020

Der Kinder-und Jugendgesundheitsdienst

Peter Tinnemann & Ute Teichert

Sepsis geht alle an! Was Sie darüber wissen sollten

Rainer Petzina, , Antje Erler, Ruth Hecker, Christiane Hartog, Frank Köhler, Manuela Forster, Herwig Gerlach, Delia Strunz, Susanne Ebert, Eike Eymers, Jutta F. Maywald Kessel & Arne Tumann
1. Auflage, Juni 2020

Data from: Presynaptic GABAB receptors functionally uncouple somatostatin interneurons from the active hippocampal network

Sam A. Booker, Harumi Harada, Claudio Elguate, Julia Bank, Bartos Marlene, Akos Kulik & Imre Vida
Information processing in cortical neuronal networks relies on properly balanced excitatory and inhibitory neurotransmission. A ubiquitous motif for maintaining this balance is the somatostatin interneuron (SOM-IN) feedback microcircuit. Here, we investigate the modulation of this microcircuit by presynaptic GABAB receptors (GABABRs) in the rat hippocampus. Whole-cell recordings from SOM-INs reveal that both excitatory and inhibitory synaptic inputs are strongly inhibited by GABABRs, while optogenetic activation of the interneurons shows that their inhibitory output is also...

Endothelial and leukocyte-derived microvesicles and cardiovascular risk after stroke: PROSCIS-B

Shufan Huo, Nicolle Kränkel, Alexander H. Nave, Pia Sophie Sperber, Jessica Rohmann, Sophie K. Piper, Peter Heuschmann, Ulf Landmesser, Matthias Endres, Bob Siegerink & Thomas G. Liman
Objective: To determine the role of circulating endothelial microvesicles (EMV) and microvesicles (MV) of other origins on long-term cardiovascular outcomes after stroke, we measured them in a cohort of first-ever stroke patients and observed them for three years. Methods: In the PROSpective Cohort with Incident Stroke Berlin (PROSCIS-B), patients with first-ever ischemic stroke were followed for three years. The primary combined endpoint consisted of recurrent stroke, myocardial infarction, and all-cause mortality. Levels of EMV, leukocyte-derived...

Sex differences in response to triptans: a systematic review and meta-analysis

Daphne Van Casteren, Tobias Kurth, A.H. Jan Danser, Gisela M. Terwindt & Antoinette MaassenVanDenBrink
Objective: To examine the effect of sex on clinical response to triptans and to determine whether these differences are related to pharmacokinetics of triptans in men and women, we performed a systematic review and meta-analysis. Methods: We searched clinical trials distinguishing clinical response to or pharmacokinetic parameters of triptans between sexes in PubMed, MEDLINE, Cochrane Library, Embase and Web of Science up to Dec 12, 2019. Analysis was based on data extracted from published reports....

Registration Year

  • 2020
    8

Resource Types

  • Dataset
    4
  • Text
    4

Affiliations

  • Charité
    4
  • Charité - University Medicine Berlin
    4
  • Sana Klinikum
    2
  • University Hospital Schleswig-Holstein
    2
  • Vivantes Klinikum
    2
  • Johnson & Johnson (Germany)
    2
  • Klinik Bavaria
    2
  • Becton Dickinson (Germany)
    2
  • Universitätsmedizin Rostock
    2
  • Techniker Krankenkasse (Germany)
    1