433 Works

Hyperthermia inhibits growth of nasopharyngeal carcinoma through degradation of c-Myc

Xiaole Li, Shichao Duan, Yingjuan Zheng, Yongqiang Yang, Lei Wang, Xinqiang Li, Qing Zhang, Rick F. Thorne, Wencai Li & Daoke Yang
Hyperthermia is a widely used adjunct treatment for different cancers including nasopharyngeal carcinoma (NPC). The protooncogene c-Myc is up-regulated in NPC and its expression is associated with poor prognosis. We hypothesized that c-Myc constitutes an important hyperthermia treatment target, and we investigated its contribution to hyperthermia responses in NPC. The growth of the human NPC cell lines CNE1 and CNE2 was analyzed using CCK-8 and clonogenicity assays after 43 °C hyperthermia, knockdown or overexpression of...

FROM-GLC Plus: toward near real-time and multi-resolution land cover mapping

Le Yu, Zhenrong Du, Runmin Dong, Juepeng Zheng, Ying Tu, Xin Chen, Pengyu Hao, Bo Zhong, Dailiang Peng, Jiyao Zhao, Xiyu Li, Jianyu Yang, Haohuan Fu, Guangwen Yang & Peng Gong
Global land cover has undergone extensive and rapid changes as a result of human activities and climate change. These changes have had a significant impact on biodiversity, the surface energy balance, and sustainable development. Global land cover data underpins research on the development of earth system models, resource management, and evaluation of the ecological environment. However, there are limitations in the classification detail, spatial resolution, and rapid change monitoring capability of global land cover change...

Knowledge, experiences, and practices of women affected by female genital schistosomiasis in rural Madagascar

Angela Schuster, Oliva Tiana Onintsoa Rabozakandraina, Bodo Sahondra Randrianasolo, Charles Emile Ramarokoto, Dorthe Brønnum & Hermann Feldmeier
Background: Female genital schistosomiasis (FGS) is a neglected manifestation of urogenital schistosomiasis caused by S. haematobium. The disease presents with symptoms such as pelvic pain, vaginal discharge and bleeding and menstruation disorders, and might lead to infertility and pregnancy complications. The perspectives of women with FGS have not been studied systematically. Methods: We performed a qualitative study in the Ambanja district in Northwest Madagascar. FGS was diagnosed by colposcopy. Seventy-six women with FGS participated either...

Original data for the manuscript \"Fault slip behaviors modulated by locally increased fluid pressure: Earthquake nucleation and slow slip events\"

Peng Dong, Ran Xu, Hongfeng Yang, Zhiyin Guo & Kaiwen Xia
Model results of four typical fault slip behaviors are presented in the form of time (T), displacement(U), slip rate(v), friction(f), and time increment(dt) at each step in numerical simulation. The collective results of numerical simulation are present in Data.xlsx

MEDICC2: whole-genome doubling aware copy-number phylogenies for cancer evolution

Tom L. Kaufmann, Marina Petkovic, Thomas B. K. Watkins, Emma C. Colliver, Sofya Laskina, Nisha Thapa, Darlan C. Minussi, Nicholas Navin, Charles Swanton, Peter Van Loo, Kerstin Haase, Maxime Tarabichi & Roland F. Schwarz
Abstract Aneuploidy, chromosomal instability, somatic copy-number alterations, and whole-genome doubling (WGD) play key roles in cancer evolution and provide information for the complex task of phylogenetic inference. We present MEDICC2, a method for inferring evolutionary trees and WGD using haplotype-specific somatic copy-number alterations from single-cell or bulk data. MEDICC2 eschews simplifications such as the infinite sites assumption, allowing multiple mutations and parallel evolution, and does not treat adjacent loci as independent, allowing overlapping copy-number events....

Mental health among adolescents exposed to social inequality in Latin America and the Caribbean: a scoping review protocol

Johanna Carolina Sánchez Castro, Laura Pilz González, Christiane Stock & Katherina Heinrichs
This protocol describes the methodology of a scoping review that aims to explore the available knowledge about the mental health of adolescents in Latin America and the Caribbean exposed to social inequality.

Mental health among adolescents exposed to social inequality in Latin America and the Caribbean: a scoping review protocol

Johanna Carolina Sánchez Castro, Laura Pilz González, Christiane Stock & Katherina Heinrichs
This protocol describes the methodology of a scoping review that aims to explore the available knowledge about the mental health of adolescents in Latin America and the Caribbean exposed to social inequality.

Spatiotemporal dynamics and potential ecological drivers of acute respiratory infectious diseases: an example of scarlet fever in Sichuan Province

Cheng Li, Rujun Liao, Wenhui Zhu, Guiyu Jiang, Yumeng Wang, Ling Li, Tao Zhang & Qiang Lv
Abstract Object Scarlet fever is an acute respiratory infectious disease that endangers public health and imposes a huge economic burden. In this paper, we systematically studied its spatial and temporal evolution and explore its potential ecological drivers. The goal of this research is to provide a reference for analysis based on surveillance data of scarlet fever and other acute respiratory infectious illnesses, and offer suggestions for prevention and control. Method This research is based on...

Reversible photochromic effect in natural gemstone sapphires

Tsung-Han Tsai, Zhen Wang & Hiroshi Takahashi
Photochromic sapphires show an optically controllable orange coloration under ambient temperature, which strongly affects the color appearance and market value of gemstone sapphires. An in-situ absorption spectroscopy combined with a tunable excitation light source has been developed to investigate the wavelength- and time dependence of sapphire’s photochromism. An excitation of ≤370 nm and ≥410 nm introduces and removes the orange coloration, respectively, accompanied by a stable absorption band at 470 nm. Both the color enhancement...

Additional file 1 of Automated classification of protein expression levels in immunohistochemistry images to improve the detection of cancer biomarkers

Zhen-Zhen Xue, Cheng Li, Zhuo-Ming Luo, Shan-Shan Wang & Ying-Ying Xu
Additional file 1. Table S-1. Comparison of different architectures of deep neural networks. Table S-2. Results of deep learning features.

Automated classification of protein expression levels in immunohistochemistry images to improve the detection of cancer biomarkers

Zhen-Zhen Xue, Cheng Li, Zhuo-Ming Luo, Shan-Shan Wang & Ying-Ying Xu
Abstract Background The expression changes of some proteins are associated with cancer progression, and can be used as biomarkers in cancer diagnosis. Automated systems have been frequently applied in the large-scale detection of protein biomarkers and have provided a valuable complement for wet-laboratory experiments. For example, our previous work used an immunohistochemical image-based machine learning classifier of protein subcellular locations to screen biomarker proteins that change locations in colon cancer tissues. The tool could recognize...

Additional file 1 of Smartphone-RCCT: an online repository of randomized controlled clinical trials of smartphone applications for chronic conditions

Jürgen Barth, Jiani Wang, Jesus Lopez-Alcalde, Christoph Kramm, Daniel Pach, Noelia Álvarez-Díaz, Eulàlia Grifol-Clar & Claudia M. Witt
Additional file 1. Chronic health conditions

Smartphone-RCCT: an online repository of randomized controlled clinical trials of smartphone applications for chronic conditions

Jürgen Barth, Jiani Wang, Jesus Lopez-Alcalde, Christoph Kramm, Daniel Pach, Noelia Álvarez-Díaz, Eulàlia Grifol-Clar & Claudia M. Witt
Abstract Background Chronic health conditions have a big impact on disability, morbidity, and mortality worldwide. Smartphone health applications (apps) can improve the health of patients with chronic conditions and enhance the quality and efficiency of healthcare. The number of randomized controlled trials (RCTs) of smartphone health apps is increasing, but a collection of the available evidence into a single database is still missing. The purpose of this study is to describe Smartphone-RCCT, which is an...

Additional file 1 of Multiomics analyses reveals Anaplasma phagocytophilum Ats-1 induces anti-apoptosis and energy metabolism by upregulating the respiratory chain-mPTP axis in eukaryotic mitochondria

Ruirui Li, Zhongchen Ma, Wei Zheng, Zhen Wang, Jihai Yi, Yangyang Xiao, Yong Wang & Chuangfu Chen
Supplementary Material 1

Additional file 1 of Multiomics analyses reveals Anaplasma phagocytophilum Ats-1 induces anti-apoptosis and energy metabolism by upregulating the respiratory chain-mPTP axis in eukaryotic mitochondria

Ruirui Li, Zhongchen Ma, Wei Zheng, Zhen Wang, Jihai Yi, Yangyang Xiao, Yong Wang & Chuangfu Chen
Supplementary Material 1

sj-docx-1-pss-10.1177_09567976221118541 – Supplemental material for Today’s Older Adults Are Cognitively Fitter Than Older Adults Were 20 Years Ago, but When and How They Decline Is No Different Than in the Past

Denis Gerstorf, Nilam Ram, Johanna Drewelies, Sandra Duezel, Peter Eibich, Elisabeth Steinhagen-Thiessen, Stefan Liebig, Jan Goebel, Ilja Demuth, Arno Villringer, Gert G. Wagner, Ulman Lindenberger & Paolo Ghisletta
Supplemental material, sj-docx-1-pss-10.1177_09567976221118541 for Today’s Older Adults Are Cognitively Fitter Than Older Adults Were 20 Years Ago, but When and How They Decline Is No Different Than in the Past by Denis Gerstorf, Nilam Ram, Johanna Drewelies, Sandra Duezel, Peter Eibich, Elisabeth Steinhagen-Thiessen, Stefan Liebig, Jan Goebel, Ilja Demuth, Arno Villringer, Gert G. Wagner, Ulman Lindenberger and Paolo Ghisletta in Psychological Science

Additional file 2 of The use of video consultations to support orthopedic patients' treatment at the interface of a clinic and general practitioners

Estel K, Richter L, Weber G, Fellmer F, Märdian S, Willy C & Back DA
Additional file 2. Questionnaire of the general practitioners.

Additional file 3 of The use of video consultations to support orthopedic patients' treatment at the interface of a clinic and general practitioners

Estel K, Richter L, Weber G, Fellmer F, Märdian S, Willy C & Back DA
Additional file 3. Questionnaire of the patients.

Additional file 1 of Mobilisation of critically ill patients receiving norepinephrine: a retrospective cohort study

Maximilian Lindholz, Clara M. Schellenberg, Julius J. Grunow, Simone Kagerbauer, Annette Milnik, Daniel Zickler, Stefan Angermair, Anett Reißhauer, Martin Witzenrath, Mario Menk, Sebastian Boie, Felix Balzer & Stefan J. Schaller
Additional file 1. Table S1. Individual elements of the Elixhauser index. Table S2. All Admission diagnoses with n > 50.

Additional file 1 of Association between in-ICU red blood cells transfusion and 1-year mortality in ICU survivors

Alice Blet, Joel B. McNeil, Julie Josse, Bernard Cholley, Raphaël Cinotti, Gad Cotter, Agnès Dauvergne, Beth Davison, Kévin Duarte, Jacques Duranteau, Marie-Céline Fournier, Etienne Gayat, Samir Jaber, Sigismond Lasocki, Thomas Merkling, Katell Peoc’h, Imke Mayer, Malha Sadoune, Pierre-François Laterre, Romain Sonneville, Lorraine Ware, Alexandre Mebazaa & Antoine Kimmoun
Additional file 1: Figures and Tables.

Additional file 1 of EVI1 expression in early-stage breast cancer patients treated with neoadjuvant chemotherapy

Jonas Leichsenring, Valentina Vladimirova, Christine Solbach, Thomas Karn, Beyhan Ataseven, Bruno Valentin Sinn, Jana Barinoff, Volkmar Müller, Jens-Uwe Blohmer, Christian Schem, Knut Engels, Frederik Marmé, Annette Fisseler-Eckhoff, Peter A. Fasching, Elmar Stickeler, Marion van Mackelenbergh, Carsten Denkert, Albrecht Stenzinger, Sibylle Loibl & Stefan Gröschel
Additional file 1: Supplementary Figure 1. Flow diagram of patients included in the analysis set from GeparTrio study.

Additional file 2 of EVI1 expression in early-stage breast cancer patients treated with neoadjuvant chemotherapy

Jonas Leichsenring, Valentina Vladimirova, Christine Solbach, Thomas Karn, Beyhan Ataseven, Bruno Valentin Sinn, Jana Barinoff, Volkmar Müller, Jens-Uwe Blohmer, Christian Schem, Knut Engels, Frederik Marmé, Annette Fisseler-Eckhoff, Peter A. Fasching, Elmar Stickeler, Marion van Mackelenbergh, Carsten Denkert, Albrecht Stenzinger, Sibylle Loibl & Stefan Gröschel
Additional file 2: Supplementary Figure 2. Distribution of EVI1 continuous expression in breast cancer: A: Histogram of EVI1 continuous expression in the entire cohort (N=993); B: Boxplots of EVI1 continuous expression within breast cancer subtypes. Note, 882/993 patients with available BC subtype information were included in this analysis. Horizontal bold lines present EVI1 median values of 116.65 in HR+/HER2-, 98.67 in HR+/HER2+, 114.77in HR-/HER2+, and 115.64 in TNBC; boxes present the interquartile range between first...

Shotgun-2: A Bayesian phase I/II basket trial design to identify indication-specific optimal biological doses

Xin Chen, Jingyi Zhang, Liyun Jianga & Fangrong Yan
For novel molecularly targeted agents and immunotherapies, the objective of dose-finding is often to identify the optimal biological dose, rather than the maximum tolerated dose. However, optimal biological doses may not be the same for different indications, challenging the traditional dose-finding framework. Therefore, we proposed a Bayesian phase I/II basket trial design, named “shotgun-2,” to identify indication-specific optimal biological doses. A dose-escalation part is conducted in stage I to identify the maximum tolerated dose and...

Combining QTL mapping and RNA-Seq Unravels candidate genes for Alfalfa (Medicago sativa L.) leaf development

Xueqian Jiang, Xijiang Yang, Fan Zhang, Tianhui Yang, Changfu Yang, Fei He, Ting Gao, Chuan Wang, Qingchuan Yang, Zhen Wang & Junmei Kang
Abstract Background Leaf size affects crop canopy morphology and photosynthetic efficiency, which can influence forage yield and quality. It is of great significance to mine the key genes controlling leaf development for breeding new alfalfa varieties. In this study, we mapped leaf length (LL), leaf width (LW), and leaf area (LA) in an F1 mapping population derived from a cultivar named ZhongmuNo.1 with larger leaf area and a landrace named Cangzhou with smaller leaf area....

Additional file 2 of Digitally-supported patient-centered asynchronous outpatient follow-up in rheumatoid arthritis - an explorative qualitative study

Ramona Stenzel, Katharina Hadaschik, Susann May, Manuel Grahammer, Hannah Labinsky, Martin Welcker, Johannes Hornig, Gerlinde Bendzuck, Corinna Elling-Audersch, Ulrike Erstling, Patricia Steffens Korbanka, Nicolas Vuillerme, Martin Heinze, Gerhard Krönke, Georg Schett, Ann-Christin Pecher, Martin Krusche, Johanna Mucke, Johannes Knitza & Felix Muehlensiepen
Supplementary Material 2

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  • Charité - University Medicine Berlin
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