Previous fMRI research on conscious tactile perception has focused on activity amplitudes instead of utilizing the spatial patterns. In the visual domain, low (spatial) variability of neural responses has been discussed as a marker of stimulus awareness. Here, we take a similar approach to tactile stimulation by investigating trial-to-trial variability of activation patterns as a measure of variability in neural representation.

Albeit the social disapproval and stigmatization, romance is an incontrovertible feature of youth culture in Pakistan. This study generates a multifaceted understanding about the intimate relationship development and dissolution, in particular the pre-dissolution conditions and post-dissolution adjustment among unmarried, non-cohabiting emerging adults. Qualitative methods were applied, comprising 129 in-depth interviews and three focus group discussions among undergraduate students at XYZ university located in Lahore city, Pakistan. Despite the public disapproval of intimacy out of wedlock...

N6-methyladenosine (m6A) RNA modification impacts mRNA fate primarily via reader proteins, which dictate processes in development, stress, and disease. Yet little is known about m6A function in Saccharomyces cerevisiae, which occurs solely during early meiosis. Here we perform a multifaceted analysis of the m6A reader protein Pho92/Mrb1. Cross-linking immunoprecipitation analysis reveals that Pho92 associates with the 3'end of meiotic mRNAs in both an m6A-dependent and independent manner. Within cells, Pho92 transitions from the nucleus to...

Supplemental Material for The angio-architectural features of brain arteriovenous malformations: is it possible to predict the probability of rupture? by Arianna Rustici, Francesca Vari, Carmelo Sturiale, Alfredo Conti, Antonino Scibilia, Carlo Bortolotti, Raffaele Agati, Caterina Tonon, Raffaele Lodi, Diego Mazzatenta, Matteo Zoli, Ciro Princiotta, Massimo Dall’Olio and Luigi Cirillo in The Neuroradiology Journal

Additional file 1: Fig. S1. The proliferation of CNE-1 cells on different On-Surface 3D matrix stiffness. (A) After successful establishment of the hydrogel adjusting stiffness culture system, the proliferation of CNE-1 cells on different stiffness substrates by colony formation assay were observed. The colony formation on different stiffness substrates under the microscope on the 1st, 3rd, 5th and 7th day (scale bar 100 μm). (B) Colony diameters (*P < 0.05) of CNE-1 cells on different...

Abstract Purpose Radiotherapy is one of the essential treatment modalities for nasopharyngeal carcinoma (NPC), however, radioresistance still poses challenges. Three-dimensional (3D) tumor culture models mimic the in vivo growth conditions of cells more accurately than 2D models. This study is to compare the tumor biological behaviors of NPC cells in 2D, On-Surface 3D and Embedded 3D systems, and to investigate the correlation between radioresistance and extracellular matrix (ECM) stiffness. Methods The morphology and radioresistance of...

Supplement 1

Supplemental material, sj-docx-2-tam-10.1177_17588359221136759 for Immune checkpoint inhibitors plus chemotherapy in patients with locally advanced or metastatic pulmonary sarcomatoid carcinoma: a multicentric real-world study by Fei Zhou, Haoyue Guo, Xiaolong Zhou, Huikang Xie, Tian Tian, Wencheng Zhao, Guanghui Gao, Anwen Xiong, Lei Wang, Wei Li, Xiaoxia Chen, Yan Zhang, Jue Fan, Fengying Wu, Yongchang Zhang and Caicun Zhou in Therapeutic Advances in Medical Oncology

Supplemental material, sj-docx-1-tam-10.1177_17588359221136759 for Immune checkpoint inhibitors plus chemotherapy in patients with locally advanced or metastatic pulmonary sarcomatoid carcinoma: a multicentric real-world study by Fei Zhou, Haoyue Guo, Xiaolong Zhou, Huikang Xie, Tian Tian, Wencheng Zhao, Guanghui Gao, Anwen Xiong, Lei Wang, Wei Li, Xiaoxia Chen, Yan Zhang, Jue Fan, Fengying Wu, Yongchang Zhang and Caicun Zhou in Therapeutic Advances in Medical Oncology

Abstract Background Mobilisation and exercise intervention in general are safe and feasible in critically ill patients. For patients requiring catecholamines, however, doses of norepinephrine safe for mobilisation in the intensive care unit (ICU) are not defined. This study aimed to describe mobilisation practice in our hospital and identify doses of norepinephrine that allowed a safe mobilisation. Methods We conducted a retrospective single-centre cohort study of 16 ICUs at a university hospital in Germany with patients...

Triplet generation by QDs-sensitized molecules emerges great potential in many applications. However, the mechanism of triplet energy transfer (TET) is still fuzzy especially due to complicated energy level alignment of QDs and molecules or trap states in QDs. Here, CdSe QDs and 5-tetracene carboxylic acid (TCA) molecules are selected as the triplet donor and acceptor, respectively, to form a TET system. By tuning the band gap of CdSe, the CdSe-TCA complex is exactly designed to...

Supplemental material, sj-docx-1-dhj-10.1177_20552076221143903 for The medical profession transformed by artificial intelligence: Qualitative study by Lina Mosch, Daniel Fürstenau, Jenny Brandt, Jasper Wagnitz, Sophie AI Klopfenstein, Akira-Sebastian Poncette and Felix Balzer in Digital Health

BackgroundHealthcaare delivery will change through the increasing use of artificial intelligence (AI). Physicians are likely to be among the professions most affected, though to what extent is not yet clear.ObjectiveWe analyzed physicians’ and AI experts’ stances towards AI-induced changes. This concerned (1) physicians’ tasks, (2) job replacement risk, and (3) implications for the ways of working, including human–AI interaction, changes in job profiles, and hierarchical and cross-professional collaboration patterns.MethodsWe adopted an exploratory, qualitative research approach,...

BackgroundHealthcaare delivery will change through the increasing use of artificial intelligence (AI). Physicians are likely to be among the professions most affected, though to what extent is not yet clear.ObjectiveWe analyzed physicians’ and AI experts’ stances towards AI-induced changes. This concerned (1) physicians’ tasks, (2) job replacement risk, and (3) implications for the ways of working, including human–AI interaction, changes in job profiles, and hierarchical and cross-professional collaboration patterns.MethodsWe adopted an exploratory, qualitative research approach,...

Objective:To compare organ involvement and disease severity between male and female patients with juvenile onset systemic sclerosis.Methods:Demographics, organ involvement, laboratory evaluation, patient-reported outcomes and physician assessment variables were compared between male and female juvenile onset systemic sclerosis patients enrolled in the prospective international juvenile systemic sclerosis cohort at their baseline visit and after 12 months.Results:One hundred and seventy-five juvenile onset systemic sclerosis patients were evaluated, 142 females and 33 males. Race, age of onset, disease...

Additional file 1. Questionnaire of the orthopedic specialists.

Bortezomib (BTZ) is a first-generation proteasome inhibitor with anti-tumor properties for multiple myeloma and mantle cell lymphoma. Increasing evidence has shown that BTZ exhibits toxic effects on diverse tumor cells, including non-small cell lung cancer (NSCLC) cells. However, the mechanism has not been fully evaluated. Here, we examined the regulatory effect of BTZ on cellular senescence, a potent tumor suppressive mechanism, in NSCLC cell lines. SA-β-gal staining assay showed that BTZ caused a significant increase...

Additional file 1: Supplementary Figure 1. severity of CAD for (A) patients with a positive family history of premature CAD in first degree relatives (men <55years, women < 65 years) *. (B) Lp(a) ≥ 50mg/dL (107nmol/L). Percentages of patients with no CAD, non-obstructive CAD, 1-vessel, 2-vessel, and 3-vessel CAD. *Participants not knowing family history were excluded (n=77).

Additional file 2: Supplementary Table 1. Calculated LDL cholesterol reduction by LLT.

Abstract Background Although potent lipid-lowering therapies are available, patients commonly fall short of recommended low-density lipoprotein cholesterol (LDL-C) levels. The aim of this study was to examine the relationship between familial hypercholesterolemia (FH) and elevated lipoprotein(a) [Lp(a)] and LDL-C goal attainment, as well as the prevalence and severity of coronary artery disease (CAD). Moreover, we characterized patients failing to meet recommended LDL-C goals. Methods We performed a cross-sectional analysis in a cohort of patients undergoing...

3D printing technology has significant advantages in the processing field of vascular tissue engineering. We have developed KCMA/SA hydrogels based on methacrylated carrageenan (KCMA) and sodium alginate (SA), which have low viscosity and shear thinning properties and can be used for 3D printing. The physicochemical double cross-linked network structure leads to good mechanical properties. The composite hydrogels maintain the liquid crystallinity of KC, which causes the HUVECs to align. The KCMA/SA gel filaments printed by...

Additional file 6: Mount Sinai investigators.

Additional file 1: Table Supplementary. Logistic regression analysis for postoperative strokes in clipping sub-group.

Abstract Background The Hypotension Prediction Index (HPI) displays an innovative monitoring tool which predicts intraoperative hypotension before its onset. Case presentation We report the case of an 84-year-old Caucasian woman undergoing major spinal surgery with no possibility for the transfer of blood products given her status as a Jehovah’s Witness. The hemodynamic treatment algorithm we employed was based on HPI and resulted in a high degree of hemodynamic stability during the surgical procedure. Further, the...

Additional file 1: Figure S 1. Composition of workshop participants as per field of expertise. The organizing team mainly consists of meta-researchers with a clinical or preclinical background. Other refers to e.g., stakeholders from funding agencies that also attended the workshop. Methods S1. Multi-stakeholder workshop method-Workshop design. Glossary. Glossary of terms.