Additional file 1: Figure S1. Progression-free survival for the DEmiRNAsrelated to prognosis in PRAD. Figure S2: Progression-free survival for the DEmRNAsrelated to prognosis in PRAD. Figure S3: Progression-free survival for the DElncRNAsrelated to prognosis in PRAD. Figure S4: A correlation heatmap which exhibits the correlation among AC005154.6, hsa-miR-29c-3p and CCNL2. Figure S5: Progression-free survival of high-and low-risk groups in PRAD: (A) the cut-off obtained by the “survminer” package. (B) the Kaplan-Meier survival curve of high-and...

Additional file 3: Table S1. siRNA sequence.

Additional file 1: Table A1. The meaning and value of covariates. Table A2. Demographic characteristics of scarlet fever in Sichuan Province, 2016–2019. Fig. A1. Time series of scarlet fever counts in 21 cities (/prefectures) of Sichuan province from 2016 to 2019. Figure A2. The fitted values for 21 cities (/prefectures) in Sichuan Province during 2016–2019. Fig. A3. The estimated multiplicative effect of seasonality on the endemic mean. Table A3. Model selection and comparison. Table A4....

Additional file 1. The additional file provides statistical comparison of gene expression between wildtype and Cx3cr1GFP/GFP mice at the different time points, control data for human FoxP3 staining, the growth rate of ARPE-19 to compare with Crisp/Cas treated ARPE-19 cells and uncropped dot plots.

Abstract Background and aim The role of dietary protein and glycemic index on insulin resistance (based on TyG index) within a nutritional program for weight loss and weight maintenance was examined. Methods This study analyzed 744 adults with overweight/obesity within the DIOGenes project. Patients who lost at least 8% of their initial weight (0–8 weeks) after a low-calorie diet (LCD) were randomly assigned to one of five ad libitum diets designed for weight maintenance (8–34...

Additional file 1: Supplementary table 1. TyG index correlation with BMI changes within complete nutritional program and weight maintenance stage.

more details about the experiment

detailed description of some measurements

detailed description of some measurements

Mid-infrared (MIR) single-photon detection is emerging as an important technology for various applications. Superconducting nanowire single photon detectors (SNSPDs) fabricated with superconducting films with energy gaps of a few meV are natural broadband single-photon detectors. Recently, extending SNSPDs’ operation wavelengths into the MIR region is highly attractive. γ-Nb₄N₃ has a reduced N content and lower energy gap than the commonly used δ-NbN, making SNSPDs based on γ-Nb₄N₃ film more sensitive to low energy photons. We...

Reinforcements in metal composites are usually dispersed at grain boundaries. We here show that the rapid solidification during laser additive manufacturing enables the spontaneous engulfment of reinforcing particles inside aluminum grains, which helps to decouple the stress concentration induced by grain boundaries and reinforcements. The additively manufactured TiB2-Al composite possesses 30% increase in tensile strength and nearly tripled ductility as compared with composite obtained by the traditional method. Our experimental investigations indicate that the intragranular...

ObjectivesIn adult aortic arch surgery, moderate hypothermic circulatory arrest (HCA) with selective antegrade cerebral perfusion (SACP) (MoHACP) is widely used, but the application of mild HCA with SACP (MiHACP) is still controversial. This meta-analysis aimed to compare clinical outcomes using MiHACP or MoHACP.MethodsStudies comparing outcomes of MiHACP or MoHACP in adult aortic arch surgery were searched from four databases from inception through April 2022. Primary outcomes were postoperative permanent neurological deficit (PND), temporary neurological deficit...

Supplemental material, sj-docx-2-dhj-10.1177_20552076221143903 for The medical profession transformed by artificial intelligence: Qualitative study by Lina Mosch, Daniel Fürstenau, Jenny Brandt, Jasper Wagnitz, Sophie AI Klopfenstein, Akira-Sebastian Poncette and Felix Balzer in Digital Health

Supplement 1

The possibility to record proteomes in high throughput and at high quality has opened new avenues for biomedical research, drug discovery, systems biology, and clinical translation. However, high-throughput proteomic experiments often require high sample amounts and can be less sensitive compared to conventional proteomic experiments. Here, we introduce and benchmark Zeno SWATH MS, a data-independent acquisition technique that employs a linear ion trap pulsing (Zeno trap pulsing) to increase the sensitivity in high-throughput proteomic experiments....

Objective:To compare organ involvement and disease severity between male and female patients with juvenile onset systemic sclerosis.Methods:Demographics, organ involvement, laboratory evaluation, patient-reported outcomes and physician assessment variables were compared between male and female juvenile onset systemic sclerosis patients enrolled in the prospective international juvenile systemic sclerosis cohort at their baseline visit and after 12 months.Results:One hundred and seventy-five juvenile onset systemic sclerosis patients were evaluated, 142 females and 33 males. Race, age of onset, disease...

Supplementary Material 1

Abstract Background Entrustable professional activities (EPAs) have been defined to promote the workplace participation of undergraduate medical students, generally in the context of high-income countries with a focus on the secondary and tertiary health care sectors. These EPAs have limited applicability to training and health care contexts in low- to middle-income countries that have a focus on primary health care, for instance, the context of community medicine. The purpose of this article is to report...

Age-related macular degeneration (AMD), the leading cause of blindness among the elderly, is without treatment for early disease. Degenerative retinal pigment epithelial (RPE) cell heterogeneity is a well-recognized but understudied pathogenic factor. Due to the daily phagocytosis of photoreceptor outer segments, unique photo-oxidative stress, and high metabolism for maintaining vision, the RPE has robust macroautophagy/autophagy, and mitochondrial and antioxidant networks. However, the autophagy subtype, mitophagy, in the RPE and AMD is understudied. Here, we found...

Bariatric surgery (BS) is an effective treatment for obesity. Adipose tissue, liver tissue and skeletal muscle are important metabolic tissues. This study investigated hub genes and their association with immune infiltration in these metabolic tissues of obese patients after BS by bioinformatic analysis with Gene Expression Omnibus datasets. Differentially expressed genes (DEGs) were identified, and a protein–protein interaction network was constructed to identify hub genes. As a result, 121 common DEGs were identified and mainly...

Bariatric surgery (BS) is an effective treatment for obesity. Adipose tissue, liver tissue and skeletal muscle are important metabolic tissues. This study investigated hub genes and their association with immune infiltration in these metabolic tissues of obese patients after BS by bioinformatic analysis with Gene Expression Omnibus datasets. Differentially expressed genes (DEGs) were identified, and a protein–protein interaction network was constructed to identify hub genes. As a result, 121 common DEGs were identified and mainly...

The aim of the present study was to investigate the injuries of spleen and intestinal immune system induced by 2 Gy 60Co γ ray in mice. A total of 120 Balb/c mice were randomly divided into two groups: blank control (Ctrl) and model (IR). The IR mice were exposed to a single dose of total body irradiation (2 Gy, dose rate: 1 Gy/min) and sacrificed on 1st, 3rd, 7th, 14th and 21st day after irradiation....

This is the third version of the guideline of the World Federation of Societies of Biological Psychiatry (WFSBP) Task Force for the Pharmacological Treatment of Anxiety, Obsessive–Compulsive and Posttraumatic Stress Disorders which was published in 2002 and revised in 2008. A consensus panel of 34 international experts representing 22 countries developed recommendations based on efficacy and acceptability of the treatments. In this version, not only medications but also psychotherapies and other non-pharmacological interventions were evaluated,...

The objective of this study is to investigate the incidence of low lean tissue index (LTI) and the risk factors for low LTI in peritoneal dialysis (PD) patients, including to establish risk prediction models. A total of 104 PD patients were enrolled from October 2019 to 2021. LTI was measured by bioimpedance spectroscopy. Multivariate logistic regression and machine learning were used to analyze the risk factors for low LTI in PD patients. Kaplan–Meier analysis was...

Obesity, one of the major public health problems worldwide, has attracted increasing attention. Ginsenoside Rb1 is the most abundant active component of Panax ginseng C.A.Mey (Araliaceae) and is reported to have beneficial effects on obesity and diabetes. However, the mechanisms by which Rb1 regulates obesity remain to be explored. This paper intends to further explore the mechanism of Rb1 in regulating obesity. The C57BL/6 obese mice were divided into two groups: the control (CTR) and...