Additional file 1. Table S1. Individual elements of the Elixhauser index. Table S2. All Admission diagnoses with n > 50.

Additional file 1: Figures and Tables.

Additional file 1: Supplementary Figure 1. Flow diagram of patients included in the analysis set from GeparTrio study.

Additional file 2: Supplementary Figure 2. Distribution of EVI1 continuous expression in breast cancer: A: Histogram of EVI1 continuous expression in the entire cohort (N=993); B: Boxplots of EVI1 continuous expression within breast cancer subtypes. Note, 882/993 patients with available BC subtype information were included in this analysis. Horizontal bold lines present EVI1 median values of 116.65 in HR+/HER2-, 98.67 in HR+/HER2+, 114.77in HR-/HER2+, and 115.64 in TNBC; boxes present the interquartile range between first...

For novel molecularly targeted agents and immunotherapies, the objective of dose-finding is often to identify the optimal biological dose, rather than the maximum tolerated dose. However, optimal biological doses may not be the same for different indications, challenging the traditional dose-finding framework. Therefore, we proposed a Bayesian phase I/II basket trial design, named “shotgun-2,” to identify indication-specific optimal biological doses. A dose-escalation part is conducted in stage I to identify the maximum tolerated dose and...

Abstract Background Leaf size affects crop canopy morphology and photosynthetic efficiency, which can influence forage yield and quality. It is of great significance to mine the key genes controlling leaf development for breeding new alfalfa varieties. In this study, we mapped leaf length (LL), leaf width (LW), and leaf area (LA) in an F1 mapping population derived from a cultivar named ZhongmuNo.1 with larger leaf area and a landrace named Cangzhou with smaller leaf area....

Supplementary Material 2

Supplementary Material 3

Additional file 1: TableS1. General information of 16 newly sequenced Sorbus s.s. chloroplast genomes

Additional file 1: TableS1. General information of 16 newly sequenced Sorbus s.s. chloroplast genomes

Additional file 4: Table S4. The comparison of SSRs among 16 Sorbus s.s. chloroplast genomes

Additional file 5: Table S5. Comparison of dispersed repeats among 16 Sorbus s.s. chloroplast genomes

Additional file 5: Table S5. Comparison of dispersed repeats among 16 Sorbus s.s. chloroplast genomes

Additional file 7: Table S7. Information of species included in phylogenetic analyses

Supplemental material, sj-docx-1-jic-10.1177_08850666221132246 for Comparison of Different Ultrasound Methods to Assess Changes in Muscle Mass in Critically ill Patients by Kristina E. Fuest, Hugo Lanz, Jana Schulz, Bernhard Ulm, Victoria A. Bennett, Julius J. Grunow, Björn Weiss, Manfred Blobner and Stefan J. Schaller in Journal of Intensive Care Medicine

BackgroundMuscle ultrasound represents a promising approach to aid diagnoses of neuromuscular diseases in critically ill patients. Unfortunately, standardization of ultrasound measurements in clinical research is lacking, making direct comparisons between studies difficult. Protocols are required to assess qualitative muscle changes during an ICU stay in patients at high risk for the development of neuromuscular acquired weakness (ICUAW).MethodsWe conducted a retrospective, observational analysis comprised of three prospective observational studies with the aim of diagnosing muscle changes...

Introduction:Immune checkpoint inhibitors (ICIs) have demonstrated promising efficacy as monotherapy in patients with pulmonary sarcomatoid carcinoma (PSC). We performed the current multi-institutional, real-world study to assess the efficacy of ICIs plus chemotherapy in patients with PSC.Methods:All consecutive patients with locally advanced or metastatic PSC from three centers treated with ICIs between January 2018 and July 2021 were enrolled. Programmed death ligand 1 (PD-L1) expression was stained and evaluated using immunohistochemical with 22C3. Single-cell RNA sequencing...

Additional file 5. Thirteen ceRNA networks correlated with patient survival.

Additional file 5. Thirteen ceRNA networks correlated with patient survival.

Additional file 7. Drugs significantly associated with the expression of CCNL2.

Additional file 8. Twenty-nine small molecules identified from CMap.

Additional file 1: Table S1. Patient´s consent on the application of different blood products.

Additional file 3: Supplementary Table 2a. Baseline characteristics of the sample, according to Lp(a) below and above upper quintile (50mg/dL ≈ 107 nmol/L). Supplementary Table 2b. Lipid profile of the sample, according to Lp(a)below and above upper quintile (50mg/dL ≈ 107 nmol/L).

Additional file 2. Partial plots for continuous candidate predictors of the global logistic generalized additive model. The y-axis contains the REST outcome on the log-odds scale $$(ln(\frac{\hat{y}}{1-\hat{y}}))$$ ( l n ( y ^ 1 - y ^ ) ) , with the patient's predicted probability $$\hat{y}$$ y ^ of developing REST symptoms.

Supplementary Material 2