2 Works

Autoantibodies against the prion protein in individuals with PRNP mutations

Karl Frontzek, Manfredi Carta, Marco Losa, Mirka Epskamp, Georg Meisl, Alice Anane, Jean-Philippe Brandel, Ulrike Camenisch, Joaquín Castilla, Stéphane Haïk, Tuomas Knowles, Ewald Lindner, Andreas Lutterotti, Eric Vallabh Minikel, Ignazio Roiter, Jiri G. Safar, Raquel Sanchez-Valle, Dana Žáková, Simone Hornemann & Adriano Aguzzi
Objective. To determine whether naturally occurring autoantibodies against the prion protein are present in individuals with genetic prion disease mutations and controls, and if so, whether they are protective against prion disease. Methods. In this case-control study, we collected 124 blood samples from individuals with a variety of pathogenicPRNPmutations and 78 control individuals with a positive family history of genetic prion disease but lacking disease-associatedPRNPmutations. Antibody reactivity was measured using an indirect ELISA for the...

Data from: Plasticity of promoter-core sequences allows bacteria to compensate for the loss of a key global regulatory gene

Otmane Lamrabet, Jacqueline Plumbridge, Mikaël Martin, Richard E. Lenski, Dominique Schneider & Thomas Hindré
Transcription regulatory networks (TRNs) are of central importance for both short-term phenotypic adaptation in response to environmental fluctuations and long-term evolutionary adaptation, with global regulatory genes often being targets of natural selection in laboratory experiments. Here, we combined evolution experiments, whole-genome resequencing, and molecular genetics to investigate the driving forces, genetic constraints, and molecular mechanisms that dictate how bacteria can cope with a drastic perturbation of their TRNs. The crp gene, encoding a major global...

Registration Year

  • 2019
    2

Resource Types

  • Dataset
    2

Affiliations

  • Sorbonne Paris Cité
    2
  • Institut de Physique
    1
  • University of Cambridge
    1
  • University of Graz
    1
  • Hospital Clinic of Barcelona
    1
  • University of Zurich
    1
  • CIC bioGUNE
    1
  • Treviso Tecnologia (Italy)
    1
  • Healthcare Foundation of New Jersey
    1
  • Case Western Reserve University
    1