10 Works

Data from: Natural selection in a post-glacial range expansion: the case of the colour cline in the European barn owl

Sylvain Antoniazza, Ricardo Kanitz, Samuel Neuenschwander, Reto Burri, Arnaud Gaigher, Alexandre Roulin & Jérôme Goudet
Gradients of variation – or clines – have always intrigued biologists. Classically, they have been interpreted as the outcomes of antagonistic interactions between selection and gene flow. Alternatively, clines may also establish neutrally with isolation-by-distance or secondary contact between previously isolated populations. The relative importance of natural selection and these two neutral processes in the establishment of clinal variation can be tested by comparing genetic differentiation at neutral genetic markers and at the studied trait....

Data from: Soil fungal communities of grasslands are environmentally structured at a regional scale in the Alps

Loic Pellissier, Hélène Niculita-Hirzel, Anne Dubuis, Marco Pagni, Nicolas Guex, Charlotte Ndiribe, Nicolas Salamin, Ioannis Xennarios, Jerome Goudet, Ian R. Sanders, Antoine Guisan & I. Xenarios
Studying patterns of species distributions along elevation gradients is frequently used to identify the primary factors that determine the distribution, diversity and assembly of species. However, despite their crucial role in ecosystem functioning, our understanding of the distribution of below-ground fungi is still limited, calling for more comprehensive studies of fungal biogeography along environmental gradients at various scales (from regional to global). Here, we investigated the richness of taxa of soil fungi and their phylogenetic...

Data from: Increased gene dosage plays a predominant role in the initial stages of evolution of duplicate TEM-1 beta lactamase genes

Riddhiman Dhar, Tobias Bergmiller & Andreas Wagner
Gene duplication is important in evolution, because it provides new raw material for evolutionary adaptations. Several existing hypotheses about the causes of duplicate retention and diversification differ in their emphasis on gene dosage, sub-functionalization, and neo-functionalization. Little experimental data exists on the relative importance of gene expression changes and changes in coding regions for the evolution of duplicate genes. Furthermore, we do not know how strongly the environment could affect this importance. To address these...

Data from: Identification of ZEB1 as a central component of the adipogenic gene regulatory network

Carine Gubelmann, Petra C. Schwalie, Sunil K. Raghav, Eva Röder, Delessa Tenagne, Elke Kiehlmann, Sebastian M. Waszak, Andrea Corsinotti, Gilles Udin, Wiebke Holcombe, Gottfried Rudowsky, Didier Trono, Christian Wolfrum & Bart Deplancke
Adipose tissue is a key determinant of whole body metabolism and energy homeostasis. Unraveling the regulatory mechanisms underlying adipogenesis is therefore highly relevant from a biomedical perspective. Our current understanding of fat cell differentiation is centered on the transcriptional cascades driven by the C/EBP protein family and the master regulator PPARγ. To elucidate further components of the adipogenic gene regulatory network, we performed a large-scale transcription factor (TF) screen overexpressing 734 TFs in mouse pre-adipocytes...

Data from: MicroRNAs Shape Circadian Hepatic Gene Expression on a Transcriptome-Wide Scale

David Gatfield, Ngoc-Hien Du, Alaaddin Bulak Arpat & Mara De Matos
A considerable proportion of mammalian gene expression undergoes circadian oscillations. Post-transcriptional mechanisms likely make important contributions to mRNA abundance rhythms. We have investigated how microRNAs (miRNAs) contribute to core clock and clock-controlled gene expression using mice in which miRNA biogenesis can be inactivated in the liver. While the hepatic core clock was surprisingly resilient to miRNA loss, whole transcriptome sequencing uncovered widespread effects on clock output gene expression. Cyclic transcription paired with miRNA-mediated regulation was...

Data from: The role of climatic tolerances and seed traits in reduced extinction rates of temperate Polygonaceae

Anna Kostikova, Nicolas Salamin & Peter B. Pearman
The latitudinal diversity gradient (LDG) is one of the most striking and consistent biodiversity patterns across taxonomic groups. We investigate the species richness gradient in the buckwheat family, Polygonaceae, which exhibits a reverse LDG and is, thus, decoupled from dominant gradients of energy and environmental stability that increase towards the tropics and confound mechanistic interpretations. We test competing age and evolutionary diversification hypotheses, which may explain the diversification of this plant family over the past...

Data from: Genomics of the divergence continuum in an African plant biodiversity hotspot, I: drivers of population divergence in Restio capensis (Restionaceae)

Christian Lexer, Rafael O. Wüest, Sofia Mangili, Myriam Heuertz, Kai N. Stolting, Peter B. Pearman, Felix Forest, Nicolas Salamin, Niklaus E. Zimmermann & Eligio Bossolini
Understanding the drivers of population divergence, speciation and species persistence is of great interest to molecular ecology, especially for species-rich radiations inhabiting the world’s biodiversity hotspots. The toolbox of population genomics holds great promise for addressing these key issues, especially if genomic data are analyzed within a spatially and ecologically explicit context. We have studied the earliest stages of the divergence continuum in the Restionaceae, a species-rich and ecologically important plant family of the Cape...

Data from: Adaptive, convergent origins of the pygmy phenotype in African rainforest hunter-gatherers

George H. Perry, Matthieu Foll, Jean-Christophe Grenier, Etienne Patin, Yohann Nédélec, Alain Pacis, Maxime Barakatt, Simon Gravel, Xiang Zhou, Sam L. Nsobya, Laurent Excoffier, Lluis Quintana-Murci, Nathaniel J. Dominy & Luis B. Barreiro
The evolutionary history of the human pygmy phenotype (small body size), a characteristic of African and Southeast Asian rainforest hunter-gatherers, is largely unknown. Here we use a genome-wide admixture mapping analysis to identify 16 genomic regions that are significantly associated with the pygmy phenotype in the Batwa, a rainforest hunter-gatherer population from Uganda (east central Africa). The identified genomic regions have multiple attributes that provide supporting evidence of genuine association with the pygmy phenotype, including...

Data from: De novo assembly and comparative analysis of the Ceratodon purpureus transcriptome

Péter Szövényi, Pierre-François Perroud, Aikaterini Symeonidi, Sean Stevenson, Ralph S. Quatrano, Stefan A. Rensing, Andrew C. Cuming & Stuart F. McDaniel
The bryophytes are a morphologically and ecologically diverse group of plants that have recently emerged as major model systems for a variety of biological processes. In particular, the genome sequence of the moss, Physcomitrella patens, has significantly enhanced our understanding of the evolution of developmental processes in land plants. However, to fully explore the diversity within bryophytes, we need additional genomic resources. Here we describe analyses of the transcriptomes of a male and a female...

Data from: Automated quantitative histology reveals vascular morphodynamics during Arabidopsis hypocotyl secondary growth

Martial Sankar, Kaisa Nieminen, Laura Ragni, Ioannis Xenarios & Christian S. Hardtke
Among various advantages, their small size makes model organisms preferred subjects of investigation. Yet, even in model systems detailed analysis of numerous developmental processes at cellular level is severely hampered by their scale. For instance, secondary growth of Arabidopsis hypocotyls creates a radial pattern of highly specialized tissues that comprises several thousand cells starting from a few dozen. This dynamic process is difficult to follow because of its scale and because it can only be...

Registration Year

  • 2014

Resource Types

  • Dataset


  • Swiss Institute of Bioinformatics
  • University of Lausanne
  • University of Zurich
  • École Polytechnique Fédérale de Lausanne
  • Swiss Federal Institute for Forest, Snow and Landscape Research
  • Royal Botanic Gardens
  • Santa Fe Institute
  • McGill University
  • Philipp University of Marburg
  • Washington University in St. Louis