One novel naphthalene derivative and other constituents with anti-complementary activities from the aerial parts of Dracocephalum moldavicaJia-Ming Wang, Jin-Feng Sun, Long Jin, Meng-Jie Wang, Yan-Yan Huang, Mei Jin, Wei Zhou & Gao Li
One novel naphthalene derivative, 2-octa-2′,4′,6′-atriynenaphthalene (1), together with eighteen known compounds (2–19) were isolated from the aerial parts of Dracocephalum moldavica L. Compounds 2, 8, 10, 13, 15–17 and 19 were obtained from the family Lamiaceae for the first time, and compounds 11 and 18 were firstly identified from the genus of Dracocephalum. All the isolates were evaluated for anti-complementary activities through the classical and alternative pathways, and the targets of the most active compounds...
Maternal Mediterranean diet in pregnancy and newborn DNA methylation: a meta-analysis in the PACE ConsortiumLeanne K. Küpers, Sílvia Fernández-Barrés, Aayah Nounu, Chloe Friedman, Ruby Fore, Giulia Mancano, Dana Dabelea, Sheryl L. Rifas-Shiman, Rosa H. Mulder, Emily Oken, Laura Johnson, Mariona Bustamante, Vincent W.V. Jaddoe, Marie-France Hivert, Anne P. Starling, Jeanne H.M. de Vries, Gemma C. Sharp, Martine Vrijheid & Janine F. Felix
Higher adherence to the Mediterranean diet during pregnancy is related to a lower risk of preterm birth and to better offspring cardiometabolic health. DNA methylation may be an underlying biological mechanism. We evaluated whether maternal adherence to the Mediterranean diet was associated with offspring cord blood DNA methylation. We meta-analysed epigenome-wide association studies (EWAS) of maternal adherence to the Mediterranean diet during pregnancy and offspring cord blood DNA methylation in 2802 mother–child pairs from five...
Efficient Learning of Quadratic Variance Function Directed Acyclic Graphs via Topological LayersWei Zhou, Xin He, Wei Zhong & Junhui Wang
Directed acyclic graph (DAG) models are widely used to represent casual relationships among random variables in many application domains. This article studies a special class of non-Gaussian DAG models, where the conditional variance of each node given its parents is a quadratic function of its conditional mean. Such a class of non-Gaussian DAG models are fairly flexible and admit many popular distributions as special cases, including Poisson, Binomial, Geometric, Exponential, and Gamma. To facilitate learning,...
Telerobotic neurovascular interventions with magnetic manipulationYoonho Kim, Emily Genevriere, Pablo Harker, Jaehun Choe, Marcin Balicki, Robert W. Regenhardt, Justin E. Vranic, Adam A. Dmytriw, Aman B. Patel & Xuanhe Zhao
Advances in robotic technology have been adopted in various subspecialties of both open and minimally invasive surgery, offering benefits such as enhanced surgical precision and accuracy with reduced fatigue of the surgeon. Despite the advantages, robotic applications to endovascular neurosurgery have remained largely unexplored because of technical challenges such as the miniaturization of robotic devices that can reach the complex and tortuous vasculature of the brain. Although some commercial systems enable robotic manipulation of conventional...
Continuous glucose monitoring in cystic fibrosis: glycemic relationships, clinical correlations, and implications for CFRD diagnosisMelissa Putman & Scully Kevin
Context: The clinical utility and implications of continuous glucose monitoring (CGM) in cystic fibrosis (CF) are unclear. Objective: We examined the correlation between CGM measures and clinical outcomes in adults with CF, investigated the relationship between hemoglobin A1c (HbA1c) and CGM-derived average glucose (AG), and explored CGM measures that distinguish cystic fibrosis–related diabetes (CFRD) from normal and abnormal glucose tolerance. Methods: This prospective observational study included 77 adults with CF who had CGM and HbA1c...
Long non-coding RNA PCAT1 drives clear cell renal cell carcinoma by upregulating YAP via sponging miR-656 and miR-539Rui Wang, Bin Zheng, Hongyan Liu & Xiuxian Wan
Clear cell renal cell carcinoma (ccRCC) is the most common RCC subtype with high metastasis, poor prognosis and conventional chemotherapy resistance. Prostate cancer associated transcript 1 (PCAT1) is an important lncRNA that was reported to be involved in cell proliferation, migration and invasion of several types of cancer cells. However, its role in ccRCC is still undetermined. This study found that PCAT1 levels were elevated in ccRCC tumors as well as several ccRCC cells, and...
Additional file 1 of The impact of medically tailored meals and nutrition therapy on biometric and dietary outcomes among food-insecure patients with congestive heart failure: a matched cohort studyLauren Belak, Caroline Owens, Margaret Smith, Eric Calloway, Laura Samnadda, Heartley Egwuogu & Stacie Schmidt
Additional file 1: SupplementalTable 1. Demographics for individuals with pre- and post- weight and BMI data.
Additional file 2 of The impact of medically tailored meals and nutrition therapy on biometric and dietary outcomes among food-insecure patients with congestive heart failure: a matched cohort studyLauren Belak, Caroline Owens, Margaret Smith, Eric Calloway, Laura Samnadda, Heartley Egwuogu & Stacie Schmidt
Additional file 2: SupplementalTable 2. Demographics for individuals with pre- and post- blood pressure data.
Multiple Sclerosis immunotherapies and COVID-19 mortality: an analysis of the FDA Adverse Event Reporting SystemMaximilian Pistor, Robert Hoepner, Andreas G.F. Hoepner, Yanan Lin, Simon Jung, Claudio L. Bassetti, Andrew Chan & Anke Salmen
Background:Evidence on mortality risks associated with MS-immunotherapies during the SARS-CoV2 pandemic derived thus far mainly from single country experiences.Objective:In this analysis, we aim to determine the frequency of COVID-19 associated fatality reports of patients receiving an MS-immunotherapy as reported to the international Food and Drug Administration (FDA) Adverse Event Reporting System (FAERS) from February 2020 to March 2021.Methods:In all, 1071 cases for this cross-sectional analysis were retrieved from FAERS and a multivariable logistic regression was...
Antibody correlates of protection from SARS-CoV-2 reinfection prior to vaccination: a nested case-control within the SIREN study.Ana Atti, Ferdinando Insalata, Edward J Carr, Ashley D Otter, Javier Castillo-Olivares, Mary Wu, Ruth Harvey, Michael Howell, Andrew Chan, Jonathan Lyall, Nigel Temperton, Diego Cantoni, Kelly da Costa, Angalee Nadesalingam, Andrew Taylor-Kerr, Nipunadi Hettiarachchi, Caio Tranquillini, Jacqueline Hewson, Michelle J Cole, Sarah Foulkes, Katie Munro, Edward JM Monk, Iain D Milligan, Ezra Linley, Meera A Chand … & The Crick COVID Immunity Pipeline Consortium
OBJECTIVES: To investigate serological differences between SARS-CoV-2 reinfection cases and contemporary controls, to identify antibody correlates of protection against reinfection. METHODS: We performed a case-control study, comparing reinfection cases with singly infected individuals pre-vaccination, matched by gender, age, region and timing of first infection. Serum samples were tested for anti-SARS-CoV-2 spike (anti-S), anti-SARS-CoV-2 nucleocapsid (anti-N), live virus microneutralisation (LV-N) and pseudovirus microneutralisation (PV-N). Results were analysed using fixed effect linear regression and fitted into conditional...
Additional file 1 of Natural language processing for identification of hypertrophic cardiomyopathy patients from cardiac magnetic resonance reportsNakeya Dewaswala, David Chen, Huzefa Bhopalwala, Vinod C. Kaggal, Sean P. Murphy, J. Martijn Bos, Jeffrey B. Geske, Bernard J. Gersh, Steve R. Ommen, Philip A. Araoz, Michael J. Ackerman & Adelaide M. Arruda-Olson
Additional file 1. Supplemental Table 1. Sample of NLP system errors.
Analysis of shared cognitive tasks in the application of non-invasive ventilation to patients with COPD exacerbationAshley M. Hughes, Karen Riska, Mary Jo S. Farmer, Divya Krishnakumar, Christopher M. Shea, Dean R. Hess, Peter K. Lindenauer & Mihaela S. Stefan
Interprofessional teamwork plays a key role in the uptake of evidence-based interventions, such as noninvasive ventilation (NIV) for patients with exacerbated Chronic Obstructive Pulmonary Disease (COPD). We aimed to identify the shared cognitive tasks in interprofessional teams using NIV for patients with COPD exacerbation. We used a cognitive task analysis approach (CTA) to engage nurses, rapid response team members, respiratory therapists, and physicians involved in the use of NIV to treat patients with COPD exacerbation....
Efficacy and safety of adding bevacizumab biosimilar or original drug to platinum-based chemotherapy as first-line treatment in patients with advanced NSCLC: a systematic review and meta-analysisLiu Yang, Maobai Liu, Xueqiong Cao, Na Li, Bin Zheng, Jianhao Deng & Hongfu Cai
Introduction:The role of bevacizumab combined with paclitaxel and carboplatin in the first-line treatment of advanced non-squamous non-small-cell lung cancer (NSCLC) has been supported by a large number of data. However, whether bevacizumab biosimilars have the same efficacy and safety as the original drug is still controversial. This meta-analysis was designed to evaluate whether bevacizumab biosimilars have the same clinical efficacy and safety as the original drug in patients with advanced non-squamous NSCLC.Methods:Electronic databases (PubMed, Embase,...
Prognostic value of coronary microvascular dysfunction assessed by coronary angiography-derived index of microcirculatory resistance in diabetic patients with chronic coronary syndromeWen Zhang, Shekhar Singh, Lu Liu, Abdul-Quddus Mohammed, Guoqing Yin, Siling Xu, Xian Lv, Tingting Shi, Cailin Feng, Rong Jiang, Ayman A. Mohammed, Redhwan M. Mareai, Yawei Xu, Xuejing Yu, Fuad A. Abdu & Wenliang Che
Abstract Background Coronary microvascular dysfunction (CMD) is common and is associated with unfavorable cardiovascular events in patients with diabetes mellitus (DM). Coronary angiography-derived index of microcirculatory resistance (caIMR) is a recently developed wire- and hyperemic agent-free method to assess CMD. We aimed to investigate the prognostic impact of CMD assessed by caIMR on clinical outcomes in patients with DM and chronic coronary syndrome (CCS). Methods CCS patients who underwent coronary angiography between June 2015 to...
Clinical, radiologic, and pathologic features of the globular glial tauopathy subtype of frontotemporal lobar degeneration in right temporal variant frontotemporal dementia with salient features of Geschwind syndromeSylvia Josephy-Hernandez, Michael Brickhouse, Samantha Champion, David Dongkyung Kim, Alexandra Touroutoglou, Matthew Frosch & Bradford C. Dickerson
Globular Glial Tauopathy (GGT) is a rare form of Frontotemporal Lobar Degeneration (FTLD) consisting of 4-repeat tau globular inclusions in astrocytes and oligodendrocytes. We present the pathological findings of GGT in a previously published case of a 73-year-old woman with behavioral symptoms concerning for right temporal variant frontotemporal dementia with initial and salient features of Geschwind syndrome. Clinically, she lacked motor abnormalities otherwise common in previously published GGT cases. Brain MRI showed focal right anterior...
Additional file 1 of Association of co-occurring mental health problems with hepatitis C status among young people who inject drugs in rural New Mexico, 2016–2018Akash Gupta, Fatma M. Shebl, Yao Tong, Katherine Wagner, Ingrid V. Bassett, Kimberly Page & Erin L. Winstanley
Additional file 1: Table S1. Baseline population characteristics. Table S2. Mental health problems and engagement in care.
Additional file 2 of Association of co-occurring mental health problems with hepatitis C status among young people who inject drugs in rural New Mexico, 2016–2018Akash Gupta, Fatma M. Shebl, Yao Tong, Katherine Wagner, Ingrid V. Bassett, Kimberly Page & Erin L. Winstanley
Additional file 2: Table S3. Adjusted modified (robust) Poisson regression models for history of HCV infection, PTSD, and any mental health problems
Additional file 4 of Association of co-occurring mental health problems with hepatitis C status among young people who inject drugs in rural New Mexico, 2016–2018Akash Gupta, Fatma M. Shebl, Yao Tong, Katherine Wagner, Ingrid V. Bassett, Kimberly Page & Erin L. Winstanley
Additional file 4: Table S5. Adjusted modified (robust) Poisson regression models for history of HCV infection, PTSD, and any mental health problems.
Additional file 5 of Population structure discovery in meta-analyzed microbial communities and inflammatory bowel disease using MMUPHinSiyuan Ma, Dmitry Shungin, Himel Mallick, Melanie Schirmer, Long H. Nguyen, Raivo Kolde, Eric Franzosa, Hera Vlamakis, Ramnik Xavier & Curtis Huttenhower
Additional file 5: Supplemental Table 3. Detailed specification for omnibus and per-feature differential abundance testing models.
Additional file 8 of Population structure discovery in meta-analyzed microbial communities and inflammatory bowel disease using MMUPHinSiyuan Ma, Dmitry Shungin, Himel Mallick, Melanie Schirmer, Long H. Nguyen, Raivo Kolde, Eric Franzosa, Hera Vlamakis, Ramnik Xavier & Curtis Huttenhower
Additional file 8: Supplemental Table 6. Per-study and meta-analytically aggregated effect sizes of tests on the interaction between disease/treatment and sample type/disease on per-feature abundances.
Population structure discovery in meta-analyzed microbial communities and inflammatory bowel disease using MMUPHinSiyuan Ma, Dmitry Shungin, Himel Mallick, Melanie Schirmer, Long H. Nguyen, Raivo Kolde, Eric Franzosa, Hera Vlamakis, Ramnik Xavier & Curtis Huttenhower
Abstract Microbiome studies of inflammatory bowel diseases (IBD) have achieved a scale for meta-analysis of dysbioses among populations. To enable microbial community meta-analyses generally, we develop MMUPHin for normalization, statistical meta-analysis, and population structure discovery using microbial taxonomic and functional profiles. Applying it to ten IBD cohorts, we identify consistent associations, including novel taxa such as Acinetobacter and Turicibacter, and additional exposure and interaction effects. A single gradient of dysbiosis severity is favored over discrete...
Additional file 1 of The prognostic value of early measures of the ventilatory ratio in the ARDS ROSE trialAna Carolina Costa Monteiro, Sitaram Vangala, Katherine D. Wick, Kevin L. Delucchi, Emily R. Siegel, B. Taylor Thompson, Kathleen D. Liu, Anil Sapru, Pratik Sinha & Michael A. Matthay
Additional file 1: Figure S1. Kaplan–Meier survival curves for patients with VR equal to or below 2 versus those with VR above 2. The outcome measured was 90-day survival. Left, 90-day survival for baseline VR values (n = 874, p = NS, log-rank test), Right, 90-day survival for day 1 VR. Values (n = 808, p < 0.01, log-rank test). Table S1. Interaction term analysis, baseline VR (n = 790).
Additional file 1 of Patient and provider perspectives on polygenic risk scores: implications for clinical reporting and utilizationAnna C. F. Lewis, Emma F. Perez, Anya E. R. Prince, Hana R. Flaxman, Lizbeth Gomez, Deanna G. Brockman, Paulette D. Chandler, Benjamin J. Kerman, Matthew S. Lebo, Jordan W. Smoller, Scott T. Weiss, Carrie L. Blout Zawatksy, James B. Meigs, Robert C. Green, Jason L. Vassy & Elizabeth W. Karlson
Additional file 1: Tables S1 and S2. Further information on patient survey items; Patient interview guide, with mock report designs; Primary Care Physician interview guide, with mock report designs.
Onset of depression and anxiety among patients with gout after diagnosis: a population-based incident cohort studyAlyssa Howren, Eric C. Sayre, Hyon K. Choi, J. Antonio Avina-Zubieta, Kam Shojania, Jamie Y. Park & Mary A. De Vera
Abstract Background Gout may be associated with an increased incidence of mental health disorders, however, published findings have been limited and inconsistent. Therefore, our objective was to conduct a population-based cohort study to evaluate the incidence of depression and anxiety after gout diagnosis. Methods We used linked population-based administrative health data in British Columbia, Canada that includes information on demographics, outpatient visits, and inpatient visits from the period of January 1, 1990 to March 31,...
Additional file 1 of Gender differences in health protective behaviours and its implications for COVID-19 pandemic in Taiwan: a population-based studyJasmine Tan, Yilin Yoshida, Kevin Sheng-Kai Ma, Franck Mauvais-Jarvis & Chien-Chang Lee
Supplementary Material 1
Massachusetts General Hospital322
Shanghai Jiao Tong University83
Chinese Academy of Medical Sciences & Peking Union Medical College57
Nanjing Medical University56
Fujian Medical University52
Zhongnan Hospital of Wuhan University49