To assess whether people with an existing musculoskeletal painful condition (pain in the joints and the muscles around them) have worse outcomes following a diagnosis of another illness. These illnesses were heart attack, stroke, cancer, dementia, and pneumonia.

Mechanosensory transduction by vertebrate hair cells depends on a protein complex at the tips of shorter stereocilia associated with mechanoelectrical transduction channels activated by tip links in the hair bundle. In mammalian hair cells, this complex includes transmembrane channel-like protein subunit 1 (TMC1), lipoma HMGIC fusion partner-like 5 protein (LHFPL5) and protocadherin 15 (PCDH15), a lower-end component of the tip link. TMC1 interacts with LHFPL5 and PCDH15 but how the complex develops to maturity, and...

Authentic assessment is increasingly prized in all tiers of education. In order to inform and facilitate the design of such an assessment strategy a number of authors propose criteria or models of design that the educator can apply to their particular programme. In a review of the Level 4 module ‘The Foundations of Radiographic Science’ the current assessment strategy was found to test recollection and knowledge, but not to meet the criteria for an authentic...

Group-based teaching can be an effective means of promoting active learning. As part of a medical degree, these sessions often focus on a clinical case. The students work collaboratively to build on previous knowledge and gain a deeper understanding of the pathophysiological mechanisms causing disease. However, a student-led approach can lead to frustration (and consequently sacrifice engagement) if the sessions are not designed with enough guidance to enable students to “scaffold” their learning. This case...

How global is International Relations really? The discipline of International Relations (IR) has long been criticised for its Eurocentric foundations and perspectives. At the International Studies Association (ISA) Convention in 2014, the ISA President, Amitav Acharya, promoted the novel Global IR agenda. Constituted of six dimensions, the Agenda seeks to globalise the IR discipline. This article will first define International Relations, linking a broad definition to the root of Eurocentrism within the discipline. It provides...

The dataset contains measurements of fluorescein, dopachrome and nitrous oxide production from incubation experiments of streambed sediments. The sediments were collected in five pseudo-replicates from 0 to 10cm depth using a 5cm-diameter AMS slide hammer and trowel at two locations within the Wood Brook, Staffordshire, in June 2015. Samples were collected from two reaches within the stream, a mid-stream sandy reach and a downstream gravel reach. The sediment was used in laboratory incubation experiments to...

Supplemental Material, sj-pdf-1-ptd-10.1177_0896860819895364 for International Society for Peritoneal Dialysis practice recommendations: Prescribing high-quality goal-directed peritoneal dialysis by Edwina A Brown, Peter G Blake, Neil Boudville, Simon Davies, Javier de Arteaga, Jie Dong, Fred Finkelstein, Marjorie Foo, Helen Hurst, David W Johnson, Mark Johnson, Adrian Liew, Thyago Moraes, Jeff Perl, Rukshana Shroff, Isaac Teitelbaum, Angela Yee-Moon Wang and Bradley Warady in Peritoneal Dialysis International

The International Society for Peritoneal Dialysis last published a guideline on prescribing peritoneal dialysis (PD) in 2006. This focused on clearance of toxins and used a measure of waste product removal by dialysis using urea as an example. This guideline suggested that a specific quantity of small solute removal was needed to achieve dialysis ‘adequacy’. It is now generally accepted, however, that the well-being of the person on dialysis is related to many different factors...

Additional file 1: Supplementary Tables 1-6.

Supplemental Material, sj-pdf-2-ptd-10.1177_0896860819895364 for International Society for Peritoneal Dialysis practice recommendations: Prescribing high-quality goal-directed peritoneal dialysis by Edwina A Brown, Peter G Blake, Neil Boudville, Simon Davies, Javier de Arteaga, Jie Dong, Fred Finkelstein, Marjorie Foo, Helen Hurst, David W Johnson, Mark Johnson, Adrian Liew, Thyago Moraes, Jeff Perl, Rukshana Shroff, Isaac Teitelbaum, Angela Yee-Moon Wang and Bradley Warady in Peritoneal Dialysis International

The International Society for Peritoneal Dialysis last published a guideline on prescribing peritoneal dialysis (PD) in 2006. This focused on clearance of toxins and used a measure of waste product removal by dialysis using urea as an example. This guideline suggested that a specific quantity of small solute removal was needed to achieve dialysis ‘adequacy’. It is now generally accepted, however, that the well-being of the person on dialysis is related to many different factors...

Abstract Background More people with rare diseases likely receive disease education and emotional and practical support from peer-led support groups than any other way. Most rare-disease support groups are delivered outside of the health care system by untrained leaders. Potential benefits may not be achieved and harms, such as dissemination of inaccurate information, may occur. Our primary objective was to evaluate the effects of a rare-disease support group leader education program, which was developed collaboratively...

These files contain the lists of CPRD medical and product codes used to define all variables in the paper “Trends in gabapentinoid prescribing in UK primary care using the Clinical Practice Research Datalink: an observational study“ by Ashworth et al published in Lancet Regional Health Europe 2023. Code lists are different for the two CPRD datasets GOLD and Aurum and the correct code list must be used in each.

Supplemental material, sj-pdf-1-ajs-10.1177_03635465221136547 for Moderators, Mediators, and Prognostic Indicators of Treatment With Hip Arthroscopy or Physical Therapy for Femoroacetabular Impingement Syndrome: Secondary Analyses From the Australian FASHIoN Trial by Nicholas J. Murphy, Jillian Eyles, Libby Spiers, Emily Davidson, Young Jo Kim, James M. Linklater, Onur Afacan, Kim L. Bennell, Alexander Burns, Laura E. Diamond, Edward Dickenson, Camdon Fary, Nadine E. Foster, Jurgen Fripp, Stuart M. Grieve, Damian R. Griffin, Gillian Heller, Robert Molnar, Ales Neubert,...

Background:Although randomized controlled trials comparing hip arthroscopy with physical therapy for the treatment of femoroacetabular impingement (FAI) syndrome have emerged, no studies have investigated potential moderators or mediators of change in hip-related quality of life.Purpose:To explore potential moderators, mediators, and prognostic indicators of the effect of hip arthroscopy and physical therapy on change in 33-item international Hip Outcome Tool (iHOT-33) score for FAI syndrome.Study Design:Cohort study; Level of evidence, 2.Methods:Overall, 99 participants were recruited from...

Supplemental material, sj-pdf-1-ajs-10.1177_03635465221136547 for Moderators, Mediators, and Prognostic Indicators of Treatment With Hip Arthroscopy or Physical Therapy for Femoroacetabular Impingement Syndrome: Secondary Analyses From the Australian FASHIoN Trial by Nicholas J. Murphy, Jillian Eyles, Libby Spiers, Emily Davidson, Young Jo Kim, James M. Linklater, Onur Afacan, Kim L. Bennell, Alexander Burns, Laura E. Diamond, Edward Dickenson, Camdon Fary, Nadine E. Foster, Jurgen Fripp, Stuart M. Grieve, Damian R. Griffin, Gillian Heller, Robert Molnar, Ales Neubert,...

Background:The association between cholesterol levels and cerebral edema (CED) or hemorrhagic transformation (HT) as an expressions of blood-brain barrier (BBB) dysfunction after ischemic stroke is not well established. The aim of this study is to determine the association of total cholesterol (TC) levels with the incidence of HT and CED after reperfusion therapies.Methods:We analyzed SITS Thrombolysis and Thrombectomy Registry data from January 2011 to December 2017. We identified patients with data on TC levels at...

Background:The association between cholesterol levels and cerebral edema (CED) or hemorrhagic transformation (HT) as an expressions of blood-brain barrier (BBB) dysfunction after ischemic stroke is not well established. The aim of this study is to determine the association of total cholesterol (TC) levels with the incidence of HT and CED after reperfusion therapies.Methods:We analyzed SITS Thrombolysis and Thrombectomy Registry data from January 2011 to December 2017. We identified patients with data on TC levels at...