Abstract Background More people with rare diseases likely receive disease education and emotional and practical support from peer-led support groups than any other way. Most rare-disease support groups are delivered outside of the health care system by untrained leaders. Potential benefits may not be achieved and harms, such as dissemination of inaccurate information, may occur. Our primary objective was to evaluate the effects of a rare-disease support group leader education program, which was developed collaboratively...

Additional file 1: COREQ checklist for ‘Recommendations for improving the working conditions and cultures of distressed junior doctors, based on a qualitative study and stakeholder perspectives’.

Abstract Background Doctors, including junior doctors, are vulnerable to greater levels of distress and mental health difficulties than the public. This is exacerbated by their working conditions and cultures. While this vulnerability has been known for many years, little action has been taken to protect and support junior doctors working in the NHS. As such, we present a series of recommendations from the perspective of junior doctors and other relevant stakeholders, designed to improve junior...

Objectives The nature of the relationship between baseline platelet count and clinical outcomes following percutaneous coronary intervention (PCI) is unclear. We undertook dose–response and pairwise meta-analyses to better describe the prognostic value of the initial platelet count and clinical endpoints in patients after PCI. Methods A search of PubMed, Scopus and Web of Science (up to 9 October 2021) was performed to identify studies that evaluated the association between platelet count and clinical outcomes following...

Objectives. Health systems with strong primary care tend to have better population outcomes, but in many countries demand for care is growing. We sought to identify mechanisms of primary care that influence premature mortality. Design. We developed a conceptual model of the mechanisms by which primary care influences premature mortality, and undertook a cross-sectional study in which population and primary care variables reflecting the model were used to explain variations in mortality under aged 75...

Supplemental Material, sj-pdf-1-ptd-10.1177_0896860819895364 for International Society for Peritoneal Dialysis practice recommendations: Prescribing high-quality goal-directed peritoneal dialysis by Edwina A Brown, Peter G Blake, Neil Boudville, Simon Davies, Javier de Arteaga, Jie Dong, Fred Finkelstein, Marjorie Foo, Helen Hurst, David W Johnson, Mark Johnson, Adrian Liew, Thyago Moraes, Jeff Perl, Rukshana Shroff, Isaac Teitelbaum, Angela Yee-Moon Wang and Bradley Warady in Peritoneal Dialysis International

The International Society for Peritoneal Dialysis last published a guideline on prescribing peritoneal dialysis (PD) in 2006. This focused on clearance of toxins and used a measure of waste product removal by dialysis using urea as an example. This guideline suggested that a specific quantity of small solute removal was needed to achieve dialysis ‘adequacy’. It is now generally accepted, however, that the well-being of the person on dialysis is related to many different factors...

Computers and Programming is a core module for Foundation Year students at Keele University intending to progress on to study Computer Science. This paper details a three-year reflection on how this module could be better delivered. After several areas for address were identified, it was found that changes to the structure, teaching activities and assessment of the module, in keeping with the principles of constructive alignment, led to significant improvement in student assessment performance. This...

The Gascon Rolls CKAN Dataset makes available the following resources: - The set of rolls in TEI-XML format; - An Eatsml file in XML containing the set of entity records (for persons, places, etc.) out of which the indexes and search available on the project site are generated; - The project guidelines for encoding the calendared versions of the rolls into TEI-XML.

In Bangladesh, energy poverty in small and remote coastal communities inhibits development and exacerbates livelihood and migration pressures, social changes, and gender disparities. Climate change threatens low lying coastal areas, bringing sea level rise and increasing salinity. Cyclones and flash floods are having increasing impacts on coastal terrains, habitats, and associated livelihoods. Such challenges are faced by similar communities globally and represent significant barriers to addressing multiple UN Sustainable Development Goals (SDGs) - in particular...

Screencasts and other video content offer an innovative means of improving communication between tutors and students and addressing student concerns about limited contact hours, which can be particularly pressing in English Literature. Our students’ comments make it clear they require further guidance and support, despite extensive feedback provided on written work and guidance provided in module handbooks. This likely results from the nature of the subject which foregrounds self-reflective learning and has fewer contact hours...

Anthropomorphism refers to the assignation of human characteristics to inanimate or non-human objects; whilst this concept is not new with relation to artificial intelligence in science fiction, post-2010 science fiction media provides an examination of this concept within the context of modern society, where artificial intelligence is arguably prevalent in our everyday lives. As we map out our lives with the addition of artificial intelligence, science fiction can help us understand how we can move...

This is a reflective piece from an individual who attended the Becoming Well Read Symposium 2021. The reflections are centred around three interlinked considerations regarding the challenges and opportunities for cultivating a reading culture within Higher Education. These reflections were inspired from listening to the keynote speaker of the event.

From a multidisciplinary scientific Investigation of the 1916 Hawthorn Mine Crater, Beaumont Hamel, Somme, Northern France,. Hawthorn Crater is a prominent feature of the former Somme battlefield near Beaumont Hamel, Northern France. It resulted from the detonation of what is arguably the most famous of the nine mines that the British had prepared below the German lines on 1 July 1916, as part of the opening day of the Battle of the Somme. This mine...

Additional file 1: Supplementary Tables 1-6.

Additional file 1: Supplementary Tables 1-6.

Additional file 3: Supplementary Figs. 1-8, Notes 1-3.

Background:Although randomized controlled trials comparing hip arthroscopy with physical therapy for the treatment of femoroacetabular impingement (FAI) syndrome have emerged, no studies have investigated potential moderators or mediators of change in hip-related quality of life.Purpose:To explore potential moderators, mediators, and prognostic indicators of the effect of hip arthroscopy and physical therapy on change in 33-item international Hip Outcome Tool (iHOT-33) score for FAI syndrome.Study Design:Cohort study; Level of evidence, 2.Methods:Overall, 99 participants were recruited from...

Explore trial participants’ and research team members’ perceptions of the impact of the videoconference-based, supportive care program (SPIN-CHAT Program) during early COVID-19 for individuals with systemic sclerosis (SSc). Data were collected cross-sectionally. A social constructivist paradigm was adopted, and one-on-one videoconference-based, semi-structured interviews were conducted with SPIN-CHAT Trial participants and research team members. A hybrid inductive-deductive approach and reflexive thematic analysis were used. Of the 40 SPIN-CHAT Trial participants and 28 research team members approached,...

Supplemental Material, sj-pdf-2-ptd-10.1177_0896860819895364 for International Society for Peritoneal Dialysis practice recommendations: Prescribing high-quality goal-directed peritoneal dialysis by Edwina A Brown, Peter G Blake, Neil Boudville, Simon Davies, Javier de Arteaga, Jie Dong, Fred Finkelstein, Marjorie Foo, Helen Hurst, David W Johnson, Mark Johnson, Adrian Liew, Thyago Moraes, Jeff Perl, Rukshana Shroff, Isaac Teitelbaum, Angela Yee-Moon Wang and Bradley Warady in Peritoneal Dialysis International

This paper offers a critical reflection about how undertaking an MSc Advanced Clinical Practice (ACP) programme, led to a greater understanding about how cognitive processes impact on making complex clinical judgements and decisions. Insights are offered about how using this understanding can ensure safe clinical decisions are made, especially if the clinician is stuck in the corridor of clinical uncertainty. Driscoll’s (2007) ‘what’, ‘so what’, ‘now what’ model is used to facilitate this reflection. To...

Additional file 1: Plain English Summary.