377 Works

Additional file 2 of Facilitators, barriers and strategies for health-system guidance implementation: a critical interpretive synthesis protocol

Qi Wang, Ying Zhu, Shitong Xie, Mohammad Golam Kibria, Qiangqiang Guo, Ahmed Atef Belal, Yanfei Li, Jingyi Zhang, Yaolong Chen, Holger J. Schünemann, Michael G. Wilson, Kehu Yang & John N. Lavis
Additional file 2. Databases and search strategies.

Topological inverse design of fabrication-constrained nanophotonic devices via adaptive projection method

Hao Liang, Qi Wang, Xueguang Yuan, Hao Liu, Jiyu Xu, Yangan Zhang, Kai Liu, Yongqing Huang & Xiaomin Ren
Topology optimization has been widely adopted in the inverse design of nanophotonic devices due to low computational cost, which unfortunately produces intermediate relative permittivity values that fail to meet fabrication constraints. Additionally, the postprocessing required inevitably increases the complexity of the inverse design. In this Letter, we propose an adaptive projection method for topology optimization, in which a two-level hierarchical hyperbolic tangent projection function with linear increment and differentiation was constructed and applied to eliminate...

Topological inverse design of fabrication-constrained nanophotonic devices via adaptive projection method

Hao Liang, Qi Wang, Xueguang Yuan, Hao Liu, Jiyu Xu, Yangan Zhang, Kai Liu, Yongqing Huang & Xiaomin Ren
Topology optimization has been widely adopted in the inverse design of nanophotonic devices due to low computational cost, which unfortunately produces intermediate relative permittivity values that fail to meet fabrication constraints. Additionally, the postprocessing required inevitably increases the complexity of the inverse design. In this Letter, we propose an adaptive projection method for topology optimization, in which a two-level hierarchical hyperbolic tangent projection function with linear increment and differentiation was constructed and applied to eliminate...

Topological inverse design of fabrication-constrained nanophotonic devices via adaptive projection method

Hao Liang, Qi Wang, Xueguang Yuan, Hao Liu, Jiyu Xu, Yangan Zhang, Kai Liu, Yongqing Huang & Xiaomin Ren
Topology optimization has been widely adopted in the inverse design of nanophotonic devices due to low computational cost, which unfortunately produces intermediate relative permittivity values that fail to meet fabrication constraints. Additionally, the postprocessing required inevitably increases the complexity of the inverse design. In this Letter, we propose an adaptive projection method for topology optimization, in which a two-level hierarchical hyperbolic tangent projection function with linear increment and differentiation was constructed and applied to eliminate...

Construction and validation of a revised satisfaction index model for the Chinese urban and rural resident-based basic medical insurance scheme

Wenwei Cheng, Shiwen Wang, Xiaofang Liu, Yanyan Wu, Jin Cheng, Weichu Sun, Xiaofang Yan, Qi Wang, Liai Peng, Xiaoli Liu, Tingting Sha, Jingcheng Shi & Fang Yang
Abstract Background Quality is the most important factor in satisfaction. However, the existing satisfaction index model of urban and rural resident-based basic medical insurance scheme (SIM_URRBMI) lacks the segmentation of perceived quality elements, it couldn’t provide a reference for quality improvement and satisfaction promotion. This study aims to construct a revised SIM_URRBMI that can accurately and detailly measure perceived quality and provide feasible and scientific suggestions for improving the satisfaction of urban and rural residents'...

SPRY4 promotes adipogenic differentiation of human mesenchymal stem cells through the MEK–ERK1/2 signaling pathway

Na Li, Yunfei Chen, Haiyan Wang, Jing Li & Robert Chunhua Zhao
Obesity is a chronic metabolic disorder characterized by the accumulation of excess fat in the body. Preventing and controlling obesity by inhibiting the adipogenic differentiation of mesenchymal stem cells (MSCs) and thereby avoiding the increase of white adipose tissue is safe and effective. Recent studies have demonstrated that Sprouty proteins (SPRYs) are involved in cell differentiation and related diseases. However, the role and mechanism of SPRY4 in MSC adipogenic differentiation remain to be explored. Here,...

A CT-based nomogram for differentiating invasive fungal disease of the lung from bacterial pneumonia

Meilin Gong, Jingmei Xu, Kang Li, Ke Li, Yuwei Xia, Yang Jing, Jiafei Chen, Jing Li, Jing Yang, Mingshan Du, Wenjing Hou, Yuan Ou, Lian Li & Wei Chen
Abstract Background There is an annual increase in the incidence of invasive fungal disease (IFD) of the lung worldwide, but it is always a challenge for physicians to make an early diagnosis of IFD of the lung. Computed tomography (CT) may play a certain role in the diagnosis of IFD of the lung, however, there are no specific imaging signs for differentiating IFD of lung from bacterial pneumonia (BP). Methods A total of 214 patients...

5-Methoxyflavone-induced AMPKα activation inhibits NF-κB and P38 MAPK signaling to attenuate influenza A virus-mediated inflammation and lung injury in vitro and in vivo

Sushan Yang, Linxin Wang, Xiping Pan, Yueyun Liang, Yuehan Zhang, Jing Li & Beixian Zhou
Abstract Influenza-related acute lung injury (ALI) is a life-threatening condition that results mostly from uncontrolled replication of influenza virus (IV) and severe proinflammatory responses. The methoxy flavonoid compound 5-methoxyflavone (5-MF) is believed to have superior biological activity in the treatment of cancer. However, the effects and underlying mechanism of 5-MF on IV-mediated ALI are still unclear. Here, we showed that 5-MF significantly improved the survival of mice with lethal IV infection and ameliorated IV-mediated lung...

Additional file 3 of ETV2 promotes osteogenic differentiation of human dental pulp stem cells through the ERK/MAPK and PI3K-Akt signaling pathways

Jing Li, Haoran Du, Xin Ji, Yihan Chen, Yishuai Li, Boon Chin Heng & Jianguang Xu
Additional file 3: Figure S3. HE (scale bar = 200 μm) and Masson (scale bar = 50 μm) staining in the rat calvarial defect model (n = 6).

Additional file 1 of Patient perception of doctor communication skills and patient trust in rural primary health care: the mediating role of health service quality

Linni Gu, Bo Tian, Yujia Xin, Shengfa Zhang, Jing Li & Zhijun Sun
Additional file 1.

Additional file 1 of Patient perception of doctor communication skills and patient trust in rural primary health care: the mediating role of health service quality

Linni Gu, Bo Tian, Yujia Xin, Shengfa Zhang, Jing Li & Zhijun Sun
Additional file 1.

Additional file 2 of Construction and yield optimization of a cinnamylamine biosynthesis route in Escherichia coli

Qi Wang, Linlin Ma, Zhiguo Wang, Quan Chen, Qian Wang & Qingsheng Qi
Additional file 2: Table S2. Plasmids used in this study.

Additional file 6 of Construction and yield optimization of a cinnamylamine biosynthesis route in Escherichia coli

Qi Wang, Linlin Ma, Zhiguo Wang, Quan Chen, Qian Wang & Qingsheng Qi
Additional file 6: Figure S3. The petP and petE plasmids expression in E. coil by SDS-PAGE analysis of whole cell (WC), supernatant (S), and protein marker (M).

Enhanced stability of foot-and-mouth disease vaccine antigens with a novel formulation

Jing Li, Rong Zhang, Huiqing Yang & Yanming Wei
The structural instability of inactivated Foot-and-mouth disease virus antigen hinders the development of vaccine industry. The use of an inexpensive, biocompatible formulation to slow down the degradation of antigen would address the problem. Here, phosphate-buffered saline (PBS) was showed to be effective in stabilizing 146S and hence determined as basic solution buffer. Excipients such as trehalose, sucrose, arginine, cysteine, calcium chloride, BSA and ascorbic acid were found to protect 146S from massive structural breakdown. Using...

AGI grade-guided chaiqin chengqi decoction treatment for predicted moderately severe and severe acute pancreatitis (CAP trial): study protocol of a randomised, double-blind, placebo-controlled, parallel-group, pragmatic clinical trial

Zhiyao Chen, Xiaonan Yang, Jia Guo, Tao Jin, Ziqi Lin, Ping Zhu, Jing Li, Ling Li, Xin Sun, Dan Du, Kun Jiang, Yanqiu He, Fei Cai, Lan Li, Cheng Hu, Qingyuan Tan, Wei Huang, Lihui Deng & Qing Xia
Abstract Background Acute pancreatitis (AP) is a common digestive disease with increased incidence globally but without internationally licenced pharmacological therapy. Moderately severe and severe acute pancreatitis (MSAP/SAP) contributes predominately for its morbidities and mortality and has been managed in West China Hospital for decades using the traditional Chinese medicinal formula chaiqin chengqi decoction (CQCQD). The current study tests whether the early administration of CQCQD will result in improved clinical outcomes in predicted MSAP/SAP patients. Methods...

AGI grade-guided chaiqin chengqi decoction treatment for predicted moderately severe and severe acute pancreatitis (CAP trial): study protocol of a randomised, double-blind, placebo-controlled, parallel-group, pragmatic clinical trial

Zhiyao Chen, Xiaonan Yang, Jia Guo, Tao Jin, Ziqi Lin, Ping Zhu, Jing Li, Ling Li, Xin Sun, Dan Du, Kun Jiang, Yanqiu He, Fei Cai, Lan Li, Cheng Hu, Qingyuan Tan, Wei Huang, Lihui Deng & Qing Xia
Abstract Background Acute pancreatitis (AP) is a common digestive disease with increased incidence globally but without internationally licenced pharmacological therapy. Moderately severe and severe acute pancreatitis (MSAP/SAP) contributes predominately for its morbidities and mortality and has been managed in West China Hospital for decades using the traditional Chinese medicinal formula chaiqin chengqi decoction (CQCQD). The current study tests whether the early administration of CQCQD will result in improved clinical outcomes in predicted MSAP/SAP patients. Methods...

Additional file 2 of AGI grade-guided chaiqin chengqi decoction treatment for predicted moderately severe and severe acute pancreatitis (CAP trial): study protocol of a randomised, double-blind, placebo-controlled, parallel-group, pragmatic clinical trial

Zhiyao Chen, Xiaonan Yang, Jia Guo, Tao Jin, Ziqi Lin, Ping Zhu, Jing Li, Ling Li, Xin Sun, Dan Du, Kun Jiang, Yanqiu He, Fei Cai, Lan Li, Cheng Hu, Qingyuan Tan, Wei Huang, Lihui Deng & Qing Xia
Additional file 2. PRECIS-2 scores of chaiqin chengqi decoction for predicted moderately severe and severe acute pancreatitis (CAP trial) domains.

Additional file 1 of Clinical application of artificial neural network (ANN) modeling to predict BRCA1/2 germline deleterious variants in Chinese bilateral primary breast cancer patients

Yan Li, Lili Chen, Jinxing Lv, Xiaobin Chen, Bangwei Zeng, Minyan Chen, Wenhui Guo, Yuxiang Lin, Liuwen Yu, Jialin Hou, Jing Li, Peng Zhou, Wenzhe Zhang, Shengmei Li, Xuan Jin, Weifeng Cai, Kun Zhang, Yeyuan Huang, Chuan Wang & Fangmeng Fu
Supplementary Material 1

Clinical application of artificial neural network (ANN) modeling to predict BRCA1/2 germline deleterious variants in Chinese bilateral primary breast cancer patients

Yan Li, Lili Chen, Jinxing Lv, Xiaobin Chen, Bangwei Zeng, Minyan Chen, Wenhui Guo, Yuxiang Lin, Liuwen Yu, Jialin Hou, Jing Li, Peng Zhou, Wenzhe Zhang, Shengmei Li, Xuan Jin, Weifeng Cai, Kun Zhang, Yeyuan Huang, Chuan Wang & Fangmeng Fu
Abstract Background Bilateral breast cancer (BBC), as well as ovarian cancer, are significantly associated with germline deleterious variants in BRCA1/2, while BRCA1/2 germline deleterious variants carriers can exquisitely benefit from poly (ADP-ribose) polymerase (PARP) inhibitors. However, formal genetic testing could not be carried out for all patients due to extensive use of healthcare resources, which in turn results in high medical costs. To date, existing BRCA1/2 deleterious variants prediction models have been developed in women...

Clinical application of artificial neural network (ANN) modeling to predict BRCA1/2 germline deleterious variants in Chinese bilateral primary breast cancer patients

Yan Li, Lili Chen, Jinxing Lv, Xiaobin Chen, Bangwei Zeng, Minyan Chen, Wenhui Guo, Yuxiang Lin, Liuwen Yu, Jialin Hou, Jing Li, Peng Zhou, Wenzhe Zhang, Shengmei Li, Xuan Jin, Weifeng Cai, Kun Zhang, Yeyuan Huang, Chuan Wang & Fangmeng Fu
Abstract Background Bilateral breast cancer (BBC), as well as ovarian cancer, are significantly associated with germline deleterious variants in BRCA1/2, while BRCA1/2 germline deleterious variants carriers can exquisitely benefit from poly (ADP-ribose) polymerase (PARP) inhibitors. However, formal genetic testing could not be carried out for all patients due to extensive use of healthcare resources, which in turn results in high medical costs. To date, existing BRCA1/2 deleterious variants prediction models have been developed in women...

Biomechanical analysis of stress around the tilted implants with different cantilever lengths in all-on-4 concept

Qi Wang, Zhen-zhen Zhang, Shi-zhu Bai & Shao-feng Zhang
Abstract Background Many clinical studies have reported the high success rate of the All-on-4 concept. In the present study, we aimed to compare the stress distribution with different tilted distal implants and cantilever lengths in an All-on-4 system using the two-dimensional photoelastic method and to establish the All-on-4 implant photoelastic model by computer-aided design (CAD) and rapid prototyping (RP). Methods The data of the human edentulous mandible were acquired by computed tomography (CT). Three human...

Additional file 1 of Biomechanical analysis of stress around the tilted implants with different cantilever lengths in all-on-4 concept

Qi Wang, Zhen-zhen Zhang, Shi-zhu Bai & Shao-feng Zhang
Additional file 1.

Additional file 5 of The H2A.Z-KDM1A complex promotes tumorigenesis by localizing in the nucleus to promote SFRP1 promoter methylation in cholangiocarcinoma cells

Qi Wang, Yongqiang Qi, Fei Xiong, Da Wang, Bing Wang & Yongjun Chen
Additional file 5. Supplement.

Machine Learning Radiomics Model for External and Internal Respiratory Motion Correlation Prediction in Lung Tumor

Xiangyu Zhang, Xinyu Song, Guangjun Li, Lian Duan, Guangyu Wang, Guyu Dai, Ying Song, Jing Li & Sen Bai
Objectives: The complexity and specificity of lung tumor motion render it necessary to determine the external and internal correlation individually before applying indirect tumor tracking. However, the correlation cannot be determined from patient respiratory and tumor clinical characteristics before treatment. The purpose of this study is to present a machine learning model for an external/internal correlation prediction that is based on computed tomography (CT) radiomic features. Methods: 4-dimensional computed tomography (4DCT) images of 67 patients...

Additional file 1 of Facile approach for surfactant-free synthesis of Au@ginsenoside Rh2 nanoparticles and researches on anticancer activity

Hua Yao, Xupeng Mu, Zhenhong Wei, Xiuying Li, Liya Wu, Yongri Jin, Xuwen Li, Jing Li & Jinlan Jiang
Additional file 1: Characterization of Au@ginsenoside Rh2 NPs and results of cell uptake and cell proliferation.

Registration Year

  • 2023
    58
  • 2022
    293
  • 2021
    13
  • 2020
    11
  • 2019
    2

Resource Types

  • Text
    154
  • Collection
    82
  • Dataset
    76
  • Image
    58
  • Audiovisual
    4
  • Other
    3

Affiliations

  • State Administration of Traditional Chinese Medicine of the People's Republic of China
    377
  • Sichuan University
    377
  • Fudan University
    377
  • Capital Medical University
    377
  • Nanjing University
    377
  • Chinese Academy of Medical Sciences & Peking Union Medical College
    377
  • Guangzhou University of Chinese Medicine
    377
  • Xuzhou Medical College
    377
  • Zhejiang University
    369
  • Shandong University
    369