377 Works

Proteomic profiling of circulating plasma exosomes reveals novel biomarkers of Alzheimer’s disease

Huimin Cai, Yana Pang, Qi Wang, Wei Qin, Cuibai Wei, Ying Li, Tingting Li, Fangyu Li, Qigeng Wang, Yan Li, Yiping Wei & Longfei Jia
Abstract Background Neuronal- and astrocyte-derived exosomes have been identified as an optimal source for screening biomarkers for Alzheimer’s disease (AD). However, few studies focus on the bulk exosome population isolated from plasma of AD. This study investigated whether proteins in bulk exosomes can aid in the diagnosis of AD. Methods The plasma exosomes were collected by ultracentrifuge. Protein samples were extracted from exosomes. Cerebrospinal fluid levels of amyloid β (Aβ)42 and phosphorylated tau (P-tau)181 were...

Supplementary document for A polarization tunable transmitted full-color display with enhanced switchability - 6188181.pdf

Xufeng Gao, Qi Wang, Shijie Zhang, Ruijin Hong, Dawei Zhang & Songlin Zhuang
Clean revised manuscript

Supplementary document for Modeling of ring-core trench-assisted few-mode BDFA for 7-mode signal gain equalization - 6123854.pdf

Dingchen Wang, Li Pei, Jingjing Zheng, Jianshuai wang, Wenxuan Xu, Jing Li & Tigang NIng
Verify the applicability of three-level simulation to BDFA through experiments

Divergent mutational processes distinguish hypoxic and normoxic tumours

Vinayak Bhandari, Constance H Li, Robert G Bristow, Paul C Boutros, Lauri A Aaltonen, Federico Abascal, Adam Abeshouse, Hiroyuki Aburatani, David J Adams, Nishant Agrawal, Keun Soo Ahn, Sung-Min Ahn, Hiroshi Aikata, Rehan Akbani, Kadir C Akdemir, Hikmat Al-Ahmadie, Sultan T Al-Sedairy, Fatima Al-Shahrour, Malik Alawi, Monique Albert, Kenneth Aldape, Ludmil B Alexandrov, Adrian Ally, Kathryn Alsop, Eva G Alvarez … & Christian von Mering
Many primary tumours have low levels of molecular oxygen (hypoxia), and hypoxic tumours respond poorly to therapy. Pan-cancer molecular hallmarks of tumour hypoxia remain poorly understood, with limited comprehension of its associations with specific mutational processes, non-coding driver genes and evolutionary features. Here, as part of the ICGC/TCGA Pan-Cancer Analysis of Whole Genomes (PCAWG) Consortium, which aggregated whole genome sequencing data from 2658 cancers across 38 tumour types, we quantify hypoxia in 1188 tumours spanning...

Visualization 2.mp4

Yuhang Yin, Qilin Duan, Jing Li, Chengwei Qiu & Huanyang Chen
The dynamic evolution of rays in 3D geodesic lens.

Visualization 1.mp4

Yuhang Yin, Qilin Duan, Jing Li, Chengwei Qiu & Huanyang Chen
The dynamic evolution of waves in 2D MFE lens.

Supplementary document for Evolution of optical vortices in gradient media and curved spaces - 6196806.pdf

Yuhang Yin, Qilin Duan, Jing Li, Chengwei Qiu & Huanyang Chen
Supplemental Document

Development and validation of an LC-MS/MS method for pharmacokinetic study of lobetyolin in rats

Haitao Tian, Pan Zhao, Jing Li, Zhipeng Deng, Gaobin Pu & Hong Wang
Abstract A simple and selective liquid chromatography tandem with mass spectrometry (LC-MS/ MS) method for quantification of lobetyolin in rat plasma was developed and validated. Chromatographic separation was achieved on a Thermo ODS C18 reversed-phase column using 0.1% aqueous formic acid-methanol (50:50, v/v) in an isocratic elution mode at a flow rate of 0.4 mL.min-1. LC/MS performance was done in a positive ion ESI mode and the MS/MS transitions were monitored at m/z 419.3 [M+Na]+...

Supplementary document for Evolution of optical vortices in gradient media and curved spaces - 6196806.pdf

Yuhang Yin, Qilin Duan, Jing Li, Chengwei Qiu & Huanyang Chen
Supplemental Document

Supplementary document for A polarization tunable transmitted full-color display with enhanced switchability - 6213452.pdf

Xufeng Gao, Qi Wang, Shijie Zhang, Ruijin Hong, Dawei Zhang & Songlin Zhuang
Clean revised manuscript

A deep learning system accurately classifies primary and metastatic cancers using passenger mutation patterns

Wei Jiao, Gurnit Atwal, Paz Polak, Rosa Karlic, Edwin Cuppen, Fatima Al-Shahrour, Peter J Bailey, Andrew V Biankin, Paul C Boutros, Peter J Campbell, David K Chang, Susanna L Cooke, Vikram Deshpande, Bishoy M Faltas, William C Faquin, Levi Garraway, Gad Getz, Sean M Grimmond, Syed Haider, Katherine A Hoadley, Vera B Kaiser, Mamoru Kato, Kirsten Kübler, Alexander J Lazar, Constance H Li … & Christian von Mering
In cancer, the primary tumour’s organ of origin and histopathology are the strongest determinants of its clinical behaviour, but in 3% of cases a patient presents with a metastatic tumour and no obvious primary. Here, as part of the ICGC/TCGA Pan-Cancer Analysis of Whole Genomes (PCAWG) Consortium, we train a deep learning classifier to predict cancer type based on patterns of somatic passenger mutations detected in whole genome sequencing (WGS) of 2606 tumours representing 24...

A deep learning system accurately classifies primary and metastatic cancers using passenger mutation patterns

Wei Jiao, Gurnit Atwal, Paz Polak, Rosa Karlic, Edwin Cuppen, Fatima Al-Shahrour, Peter J Bailey, Andrew V Biankin, Paul C Boutros, Peter J Campbell, David K Chang, Susanna L Cooke, Vikram Deshpande, Bishoy M Faltas, William C Faquin, Levi Garraway, Gad Getz, Sean M Grimmond, Syed Haider, Katherine A Hoadley, Vera B Kaiser, Mamoru Kato, Kirsten Kübler, Alexander J Lazar, Constance H Li … & Christian von Mering
In cancer, the primary tumour’s organ of origin and histopathology are the strongest determinants of its clinical behaviour, but in 3% of cases a patient presents with a metastatic tumour and no obvious primary. Here, as part of the ICGC/TCGA Pan-Cancer Analysis of Whole Genomes (PCAWG) Consortium, we train a deep learning classifier to predict cancer type based on patterns of somatic passenger mutations detected in whole genome sequencing (WGS) of 2606 tumours representing 24...

Combined burden and functional impact tests for cancer driver discovery using DriverPower

Shimin Shuai, Federico Abascal, Samirkumar B Amin, Gary D Bader, Pratiti Bandopadhayay, Jonathan Barenboim, Rameen Beroukhim, Johanna Bertl, Keith A Boroevich, Søren Brunak, Peter J Campbell, Joana Carlevaro-Fita, Dimple Chakravarty, Calvin Wing Yiu Chan, Ken Chen, Jung Kyoon Choi, Jordi Deu-Pons, Priyanka Dhingra, Klev Diamanti, Lars Feuerbach, J Lynn Fink, Nuno A Fonseca, Joan Frigola, Carlo Gambacorti-Passerini, Dale W Garsed … & L van’t Veer
The discovery of driver mutations is one of the key motivations for cancer genome sequencing. Here, as part of the ICGC/TCGA Pan-Cancer Analysis of Whole Genomes (PCAWG) Consortium, which aggregated whole genome sequencing data from 2658 cancers across 38 tumour types, we describe DriverPower, a software package that uses mutational burden and functional impact evidence to identify driver mutations in coding and non-coding sites within cancer whole genomes. Using a total of 1373 genomic features...

Supplemental Material - A diffuse reflectance portable near infrared spectroscopy system for the determination of biuret content in urea fertilizer

Jing Liu, Shaohui Yu, Shupeng Hu, Ziyang Ling, Jiguang Gao, Binmei Liu, Lixiang Yu, Yang Yang, Ye Yang, Qi Wang, Xiaoyu Ni, Liping Zhao & Yuejin Wu
Supplemental Material for A diffuse reflectance portable near infrared spectroscopy system for the determination of biuret content in urea fertilizer by Jing Liu, Shaohui Yu, Shupeng Hu, Ziyang Ling, Jiguang Gao, Binmei Liu, Lixiang Yu, Yang Yang, Ye Yang, Qi Wang, Xiaoyu Ni, Liping Zhao and Yuejin Wu in Journal of Near Infrared Spectroscopy

A polarization tunable transmitted full-color display enabling switchable bright and dark states

Xufeng Gao, Qi Wang, Shijie Zhang, Ruijin Hong, Dawei Zhang & Songlin Zhuang
Although structural colors based on nanostructures have attracted many researchers’ attentions due to their superior durability and high resolution, most previous reports focused on the static and dynamic structural colors in reflection mode and few researchers focus on the static and dynamic transmission colors for high-saturation RGB models. Here, the hybrid Al-Si3N4 nanogratings with the top SiO2 capping layer and the bottom MgF2 layer that can switch full-hue and high-saturation transmitted structural colors on and...

Supplementary document for A polarization tunable transmitted full-color display with enhanced switchability - 6213452.pdf

Xufeng Gao, Qi Wang, Shijie Zhang, Ruijin Hong, Dawei Zhang & Songlin Zhuang
Clean revised manuscript

Modeling of a ring-core trench-assisted few-mode BDFA for seven-mode signal gain equalization

Dingchen Wang, Li Pei, Jingjing Zheng, Jianshuai wang, Wenxuan Xu, Jing Li & Tigang NIng
In this paper, a ring-core trench-assisted few-mode bismuth-doped fiber amplifier (FM-BDFA) is simulated on the basis of the threeenergy level. The fiber is designed to support four modes of signal group transmission for practical considerations, including LP01, LP11, LP21, and LP31. The results suggest that (1) it is possible to obtain gain equalization of the three signal groups by using the LP21 mode pump independently, where the maximum difference in modal gain (MAX DMG) is...

Modeling of a ring-core trench-assisted few-mode BDFA for seven-mode signal gain equalization

Dingchen Wang, Li Pei, Jingjing Zheng, Jianshuai wang, Wenxuan Xu, Jing Li & Tigang NIng
In this paper, a ring-core trench-assisted few-mode bismuth-doped fiber amplifier (FM-BDFA) is simulated on the basis of the threeenergy level. The fiber is designed to support four modes of signal group transmission for practical considerations, including LP01, LP11, LP21, and LP31. The results suggest that (1) it is possible to obtain gain equalization of the three signal groups by using the LP21 mode pump independently, where the maximum difference in modal gain (MAX DMG) is...

Nanowire-in-Bowl-shaped Piezoelectric Cavity Structure for SERS Directional Detection of Nanoplastics less than 50 nm

Enze Lv, Junkun Wang, Jing Li, Xiaofei Zhao, Yu Jing, shicai xu, Zhen Li, yuan man, Mei xue & JiHua Xu
The accurate detection of nanoplastics is crucial due to their harmful effects on the environment and human beings. In this research, we successfully constructed an Ag/CuO nanowire (NW)/BaTiO3@PVDF Bowl-shaped substrate with a nanowire-in-Bowl-shaped piezoelectric cavity structure that can modulate surface-enhanced Raman scattering (SERS) by the piezoelectric effect by the virtue of the molecular gripper of the CuO NW and optical field amplifier of the Bowl-shaped cavity. Due to its unique nanowire-in-Bowl-shaped structure and piezoelectrically modifiable...

Supplementary document for Nanowire-in-Bowl-shaped Piezoelectric Cavity Structure for SERS Directional Detection of Nanoplastics less than 50 nm - 6228293.pdf

Enze Lv, Junkun Wang, Jing Li, Xiaofei Zhao, Yu Jing, shicai xu, Zhen Li, yuan man, Mei xue & JiHua Xu
Supplementary Material

Long-term response to sintilimab, bevacizumab and chemotherapy in heavily pretreated microsatellite stable colon cancer. Supplementary Figure.

Quanli Han, Beifang Niu, Sheng Liu, Erhong Meng, Muhong Deng, Qi Wang & Zhi Cui
Supplmentary figure 1

Additional file 1 of CEF3 is involved in membrane trafficking and essential for secondary cell wall biosynthesis and its mutation enhanced biomass enzymatic saccharification in rice

Hongrui Jiang, Yan Ren, Junyao Guo, Huijie Yang, Xiaotong Zhu, Wenhao Li, Liangzhi Tao, Yue Zhan, Qi Wang, Yuejin Wu, Binmei Liu & Yafeng Ye
Additional file 1: Figure S1. Phenotype of wild-type (WT), cef3 and cesa9 plants at seedling stage. The seedling of cesa9 is easily broken, while seedlings of WT and cef3 are normal after hand flexing

Additional file 3 of Genome-wide identification and characterization of lncRNAs in sunflower endosperm

Shuai Yu, Zhichao Zhang, Jing Li, Yanbin Zhu, Yanzhe Yin, Xiaoyu Zhang, Yuxin Dai, Ao Zhang, Cong Li, Yanshu Zhu, Jinjuan Fan, Yanye Ruan & Xiaomei Dong
Additional file 3: Table S3. GO Gene Ontology analysis of co-expressed protein-coding genes with all candidate lncRNAs.

Additional file 4 of Genome-wide identification and characterization of lncRNAs in sunflower endosperm

Shuai Yu, Zhichao Zhang, Jing Li, Yanbin Zhu, Yanzhe Yin, Xiaoyu Zhang, Yuxin Dai, Ao Zhang, Cong Li, Yanshu Zhu, Jinjuan Fan, Yanye Ruan & Xiaomei Dong
Additional file 4: Fig. S1. Expressed lncRNAs in two crosses.

Additional file 5 of Genome-wide identification and characterization of lncRNAs in sunflower endosperm

Shuai Yu, Zhichao Zhang, Jing Li, Yanbin Zhu, Yanzhe Yin, Xiaoyu Zhang, Yuxin Dai, Ao Zhang, Cong Li, Yanshu Zhu, Jinjuan Fan, Yanye Ruan & Xiaomei Dong
Additional file 5: Fig. S2. Expression levels of lncRNAs and PCgenes in sunflower endosperm.

Registration Year

  • 2023
    58
  • 2022
    293
  • 2021
    13
  • 2020
    11
  • 2019
    2

Resource Types

  • Text
    154
  • Collection
    82
  • Dataset
    76
  • Image
    58
  • Audiovisual
    4
  • Other
    3

Affiliations

  • State Administration of Traditional Chinese Medicine of the People's Republic of China
    377
  • Sichuan University
    377
  • Fudan University
    377
  • Capital Medical University
    377
  • Nanjing University
    377
  • Chinese Academy of Medical Sciences & Peking Union Medical College
    377
  • Guangzhou University of Chinese Medicine
    377
  • Xuzhou Medical College
    377
  • Zhejiang University
    369
  • Shandong University
    369