1,300 Works

Protective effect of valerian extract capsule (VEC) on ethanol- and indomethacin-induced gastric mucosa injury and ameliorative effect of VEC on gastrointestinal motility disorder

Yuan Feng, Wan Dai, Junyu Ke, Yong Cui, Shuang Li, Jingjing Ma, Wenfeng Guo, Gang Chen, Ning Li & Yanwu Li
Valerian extract capsule (VEC) is an effective Chinese patent medicine used for gastrointestinal (GI) diseases. To investigate the detailed pharmacological activity for VEC clinical effects in GI diseases. Sprague-Dawley rats were divided into six groups: control, model, and drug-treated (VEC-L, VEC-M, VEC-H, and teprenone). Rats were orally administered VEC (124, 248, 496 mg/kg) and teprenone (21.43 mg/kg) for 3 consecutive days. After 1 h, the five groups (except the control group) were orally given ethanol...

A theoretical study on the electronically excited-state spectroscopic properties of phosphorus nitride

Hui Liu, Huihua Zhang, Deheng Shi & Zunlue Zhu
The potential energy curves of 103 Ω states generated from the 39 Λ–S states of PN have been calculated using the internally contracted multireference configuration interaction method with the Davidson modification. Core-valence correlation and scalar relativistic corrections, as well as the basis-set extrapolation to the complete basis set limit are considered. The spin–orbit coupling is computed using the state interaction approach with the Breit-Pauli Hamiltonian. The spectroscopic parameters and molecular constants of bound and quasibound...

A theoretical study on the electronically excited-state spectroscopic properties of phosphorus nitride

Hui Liu, Huihua Zhang, Deheng Shi & Zunlue Zhu
The potential energy curves of 103 Ω states generated from the 39 Λ–S states of PN have been calculated using the internally contracted multireference configuration interaction method with the Davidson modification. Core-valence correlation and scalar relativistic corrections, as well as the basis-set extrapolation to the complete basis set limit are considered. The spin–orbit coupling is computed using the state interaction approach with the Breit-Pauli Hamiltonian. The spectroscopic parameters and molecular constants of bound and quasibound...

Rational design of non-noble-metal-based alloy catalysts for hydrogen activation: a density functional theory study

Danyang Li, Zhili Chen, Kui Ren, Shuang Zhao, Haoxiang Xu & Dapeng Cao
The alloying of precious metals with non-noble metals in the active components for hydrogen activation during regeneration of the solid acid catalyst in hydrogenation conditions, can reduce the cost of the catalyst and improve the catalytic efficiency of precious metals. However, it lacks a theoretical method to guide the development of non-noble-metal-based alloy catalysts. In this work, the dependence of hydrogen adsorption and dissociation of alloy models on various non-noble-metal bases has been investigated by...

Methyl-Sensitive Amplification Polymorphism (MSAP) Analysis Provides Insights into the DNA Methylation Underlying Heterosis in Kenaf (Hibiscus Cannabinus L.) Drought Tolerance

Dengjie Luo, Shan Cao, Zengqiang Li, Meiqiong Tang, Caijin Wang, Enerand Mackon, Zhen Huang, Jiao Pan, Xia Wu, Qijing Wu, Hui Zhang, Renxue Li, Xin Li, Ru Li & Peng Chen
Kenaf (Hibiscus cannabinus L.) is an industrial fiber crop with significant heterosis and tolerance to abiotic stresses. However, the mechanism underlying heterosis in kenaf under drought conditions is completely unknown. In this study, F1 hybrids were remarkably tolerant to drought stress. Through methylation-sensitive amplification polymorphism (MSAP) analysis, we highlighted that total DNA methylation level under drought decreased by 11.2% in F1 and increased by 29.7% and 13.1% in parents CP079 and CP071, respectively. Unlike parents,...

Autophagy loss impedes cancer-associated fibroblast activation via downregulating proline biosynthesis

Jingru Bai, Tong Liu, Bo Tu, Meng Yuan, Zhaoqi Shu, Minghe Fan, Sihan Huo, Yuyao Guo, Lina Wang, Hua Wang & Ying Zhao
Cancer-associated fibroblasts (CAFs) are considered one of the most critical stromal cells that interact with pancreatic ductal adenocarcinoma (PDAC) and promote tumor growth, metastasis, and treatment resistance. Previous studies illustrated macroautophagy/autophagy contributes to CAF activation during tumor progression. Here in our study, we found that autophagy deficiency in CAFs impedes CAF activation by inhibiting proline biosynthesis and collagen production. Furthermore, we uncovered that autophagy promotes proline biosynthesis through mitophagy-mediated regulation of NADK2 (NAD kinase 2,...

Bias reduction by transformed flat-top Fourier series estimator of density on compact support

Liang Wang & Dimitris N. Politis
The problem of nonparametric estimation of a univariate density with rth continuous derivative on compact support is addressed (r≥2). If the density function has compact support and is non-zero at either boundary, regular kernel estimator will be completely biased at such boundary. Although several correction methods were proposed to improve the bias at the boundary to h2 in the last decades, this paper initiates a way to further improve bias to higher order (hr) for...

DAR-PCR: a new tool for efficient retrieval of unknown flanking genomic DNA

Tianyi Sun, Mengya Jia, Lingqin Wang, Zhaoqin Li, Zhiyu Lin, Cheng Wei, Jinfeng Pei & Haixing Li
Abstract Various PCR-based genome-walking methods have been developed to acquire unknown flanking DNA sequences. However, the specificity and efficacy levels, and the operational processes, of the available methods are unsatisfactory. This work proposes a novel walking approach, termed differential annealing-mediated racket PCR (DAR-PCR). The key to DAR-PCR is the use of primer-mediated intra-strand annealing (ISA). An ISA primer consists of a 5’ root homologous to the known sequence and a heterologous 3’ bud. In the...

DAR-PCR: a new tool for efficient retrieval of unknown flanking genomic DNA

Tianyi Sun, Mengya Jia, Lingqin Wang, Zhaoqin Li, Zhiyu Lin, Cheng Wei, Jinfeng Pei & Haixing Li
Abstract Various PCR-based genome-walking methods have been developed to acquire unknown flanking DNA sequences. However, the specificity and efficacy levels, and the operational processes, of the available methods are unsatisfactory. This work proposes a novel walking approach, termed differential annealing-mediated racket PCR (DAR-PCR). The key to DAR-PCR is the use of primer-mediated intra-strand annealing (ISA). An ISA primer consists of a 5’ root homologous to the known sequence and a heterologous 3’ bud. In the...

Additional file 2 of FOXD1-dependent RalA-ANXA2-Src complex promotes CTC formation in breast cancer

Yufei Long, Tuotuo Chong, Xiaoming Lyu, Lujia Chen, Xiaomin Luo, Oluwasijibomi Damola Faleti, Simin Deng, Fei Wang, Mingliang He, Zhipeng Qian, Hongli Zhao, Wenyan Zhou, Xia Guo, Ceshi Chen & Xin Li
Additional file 2. Predicted binding sites through JASPAR database, and the sequences of the constructed Luciferase activity reporter assays.

sj-pdf-1-imr-10.1177_03000605221132711 - Supplemental material for New onset atrial fibrillation during orthotopic liver transplantation induced by iced saline injection for transpulmonary thermodilution: a case report

Xin Li, Xu Wang & Zheng Guan
Supplemental material, sj-pdf-1-imr-10.1177_03000605221132711 for New onset atrial fibrillation during orthotopic liver transplantation induced by iced saline injection for transpulmonary thermodilution: a case report by Xin Li, Xu Wang and Zheng Guan in Journal of International Medical Research

Unraveling the structures, functions and mechanisms of epithelial membrane protein family in human cancers

Nan Zhang, Hong‑Ping Zhu, Wei Huang, Xiang Wen, Xin Xie, Xian Jiang, Cheng Peng, Bo Han & Gu He
Abstract Peripheral myelin protein 22 (PMP22) and epithelial membrane proteins (EMP-1, -2, and -3) belong to a small hydrophobic membrane protein subfamily, with four transmembrane structures. PMP22 and EMPs are widely expressed in various tissues and play important roles in cell growth, differentiation, programmed cell death, and metastasis. PMP22 presents its highest expression in the peripheral nerve and participates in normal physiological and pathological processes of the peripheral nervous system. The progress of molecular genetics...

Molecular characteristics of a coxsackievirus A12 strain in Zhejiang of China, 2019

Linjie Hu, Lu Zhou, Pingping Wang, Hairenguli Maimaiti & Yihan Lu
Abstract Background Enterovirus A (EV-A), such as enterovirus A71 (EV-A71), generally causes hand, foot, and mouth disease (HFMD). However, limited studies focused on uncommon enterovirus serotypes such as coxsackievirus A12 (CV-A12). This study aimed to provide evidence to determine the molecular characteristics of a CV-A12 strain isolated in Zhejiang province, China. Methods In routine surveillance of HFMD, we identified a child case with CV-A12 infection in 2019 in Zhejiang province, China. Enterovirus was examined by...

Additional file 1 of Molecular characteristics of a coxsackievirus A12 strain in Zhejiang of China, 2019

Linjie Hu, Lu Zhou, Pingping Wang, Hairenguli Maimaiti & Yihan Lu
Additional file 1. Supplementary tables showing the information of sequences analyzed.

Additional file 2 of Diagnostic and prognostic value of ventilatory power in pulmonary hypertension

Xin Li, Yi Zhang, Qi Jin, Zhihui Zhao, Qing Zhao, Lu Yan, Anqi Duan, Zhihua Huang, Meixi Hu, Changming Xiong, Qin Luo & Zhihong Liu
Additional file 2: Supplementary tables.

Supplementary document for Topological inverse design of fabrication-constrained nanophotonic devices via adaptive projection method - 6063130.pdf

Hao Liang, Qi Wang, Xueguang Yuan, Hao Liu, Jiyu Xu, Yangan Zhang, Kai Liu, Yongqing Huang & Xiaomin Ren
Topological inverse design of fabrication-constrained nanophotonic devices via adaptive projection method: supplemental document

Psoriasis complicated with metabolic disorder is associated with traditional Chinese medicine syndrome types: a hospital-based retrospective case–control study

Xiaoying Sun, Huaibo Zhao, Ruiping Wang, Hongjin Li, Yong Wu, Kan Ze, Yonghua Su, Bin Li & Xin Li
To explore the distribution law of traditional Chinese medicine (TCM) syndrome types in patients with psoriasis vulgaris complicated by metabolic disorders based on the same pathogenic factors as blood-heat and blood-stasis in the pathogenesis of psoriasis and metabolic disorders and to further analyze the correlation between adiponectin and the distribution law. From 1 January 2018 to 31 December 2019, patients diagnosed with psoriasis in the inpatient or outpatient department of Dermatology Ward of Shanghai Yueyang...

sj-tif-3-onc-10.1177_11795549221127161 – Supplemental material for Effect of Number of Retrieved Lymph Nodes on Prognosis in FIGO Stage IA1-IIA2 Cervical Cancer Patients Treated With Primary Radical Surgery

Shan Jiang, Peng Jiang, Tingting Jiang, Yuan Tu, Jingni Zhang, Ning Li, Wei Kong, Yuzhen Huang & Rui Yuan
Supplemental material, sj-tif-3-onc-10.1177_11795549221127161 for Effect of Number of Retrieved Lymph Nodes on Prognosis in FIGO Stage IA1-IIA2 Cervical Cancer Patients Treated With Primary Radical Surgery by Shan Jiang, Peng Jiang, Tingting Jiang, Yuan Tu, Jingni Zhang, Ning Li, Wei Kong, Yuzhen Huang and Rui Yuan in Clinical Medicine Insights: Oncology

Supplementary document for High energy Q-switched Yb-doped fiber laser based on ternary layered structured Ti2AlC saturable absorber - 6077484.pdf

KANG ZHANG, Jinyue Xie, Xu Sang, Guoqing Sun, Ye Tian, Ming Feng, Feng Song & Wei Huang
Fig. S1. The RF spectrum of Q-switched pulses

High-energy Q switched Yb-doped fiber laser based on a ternary layered structured Ti2AlC saturable absorber

KANG ZHANG, Ming Feng, Jinyue Xie, Xu Sang, Guoqing Sun, Ye Tian, Feng Song & Wei Huang
Ti₂AlC is a kind of ternary layered structured ceramic metal compound, combing advantages of both ceramic and metal. Herein, the saturable absorption performance of Ti₂AlC at 1 μm waveband is investigated for the first time. The Ti₂AlC behaves with excellent saturable absorption, which has a modulation depth of 14.53% and a saturable intensity of 13.27 MW/cm². An all-normal dispersion fiber laser based on the Ti₂AlC saturable absorber (SA) is constructed. The repetition frequency of the...

Protective effects of psoralen polymer lipid nanoparticles on doxorubicin - induced myocardial toxicity

Fansu Meng, Yong Ouyang, Qianqian Ma, Manling Du, Hui Liu, Yong Zhuang, Mujuan Pang, Tiange Cai & Yu Cai
Abstract Doxorubicin (DOX) induced myocardial toxicity may limit its therapeutic use in clinic. Psoralen (PSO), a major active tricyclic furocoumarin extracted from Psoralea corylifolia, is widely used as an antineoplastic agent in treatment of leukemia and other cancers. This study is aim to find the protective effect of psoralen polymer lipid nanoparticles (PSO-PLN) on doxorubicin-induced myocardial toxicity in mice. The model of myocardial toxicity induced by DOX was established. The experiment was divided into 6...

The presence of ovarian endometrioma adversely affect ovarian reserve and response to stimulation but not oocyte quality or IVF/ICSI outcomes: a retrospective cohort study

Cheng Zeng, Ruihui Lu, Xin Li, Yanrong Kuai, Sheng Wang & Qing Xue
Abstract Background The possible impact of ovarian endometriomas (OMAs) on in vitro fertilization (IVF) outcomes remains controversial. Therefore, this study aimed to assess the impact of OMAs on IVF cycle parameters, including ovarian reserve and response to stimulation, embryo quality and pregnancy outcomes. Methods This retrospective cohort study included 2067 patients undergoing their first IVF/ICSI cycles between January 2018 and December 2020. The study group included 154 infertile women who had OMAs. The control group...

Additional file 2 of CXCL12/CXCR7/β-arrestin1 biased signal promotes epithelial-to-mesenchymal transition of colorectal cancer by repressing miRNAs through YAP1 nuclear translocation

Mahan Si, Yujia Song, Xiaohui Wang, Dong Wang, Xiaohui Liu, Xianjun Qu, Zhiyu Song & Xinfeng Yu
Additional file 2: Table S1. The significantly upregulated genes in HCT116LV-CXCR7 vs. HCT116Control. Table S2. The significantly upregulated and downregulated miRNAs in HCT116LV-CXCR7 vs. HCT116Control. Table S3. The sequences of siRNAs and miRNAs. Table S4. The sequences of primers for RT-qPCR.

Additional file 2 of CXCL12/CXCR7/β-arrestin1 biased signal promotes epithelial-to-mesenchymal transition of colorectal cancer by repressing miRNAs through YAP1 nuclear translocation

Mahan Si, Yujia Song, Xiaohui Wang, Dong Wang, Xiaohui Liu, Xianjun Qu, Zhiyu Song & Xinfeng Yu
Additional file 2: Table S1. The significantly upregulated genes in HCT116LV-CXCR7 vs. HCT116Control. Table S2. The significantly upregulated and downregulated miRNAs in HCT116LV-CXCR7 vs. HCT116Control. Table S3. The sequences of siRNAs and miRNAs. Table S4. The sequences of primers for RT-qPCR.

3D-printed hemipelvic prosthesis combined with a dual mobility bearing in patients with primary malignant neoplasm involving the acetabulum: clinical outcomes and finite element analysis

Miao Wang, Tianze Liu, Changli Xu, Chang Liu, Bo Li, Qiujian Lian, Tongjiang Chen, Suchi Qiao & Zhiwei Wang
Abstract Background Limb salvage reconstruction for pelvic tumors, especially periacetabular tumors, is challenging. We combined the use of dual mobility bearing and 3D-printed hemipelvic prosthesis to improve function and reduce the probability of complications after hemi-pelvic resection in patients with primary acetabular malignancy. The purpose of this study was to evaluate the efficacy and safety of this combination. Methods Between October 2011 and May 2021, 11 patients with malignancies involving the acetabulum received hemipelvic replacement...

Registration Year

  • 2023
    70
  • 2022
    1,130
  • 2021
    57
  • 2020
    24
  • 2019
    14
  • 2018
    5

Resource Types

  • Text
    639
  • Collection
    274
  • Dataset
    241
  • Image
    131
  • Other
    9
  • Audiovisual
    6

Affiliations

  • Tianjin Medical University General Hospital
    1,300
  • Zhejiang University
    770
  • Chinese Academy of Medical Sciences & Peking Union Medical College
    750
  • Sun Yat-sen University
    745
  • Fudan University
    719
  • Shanghai Jiao Tong University
    683
  • Sichuan University
    645
  • Chinese Academy of Sciences
    631
  • Nanjing Medical University
    568
  • Huazhong University of Science and Technology
    549