1,736 Works

Additional file 2 of Proteogenomic insights into the biology and treatment of pancreatic ductal adenocarcinoma

Yexin Tong, Mingjun Sun, Lingli Chen, Yunzhi Wang, Yan Li, Lingling Li, Xuan Zhang, Yumeng Cai, Jingbo Qie, Yanrui Pang, Ziyan Xu, Jiangyan Zhao, Xiaolei Zhang, Yang Liu, Sha Tian, Zhaoyu Qin, Jinwen Feng, Fan Zhang, Jiajun Zhu, Yifan Xu, Wenhui Lou, Yuan Ji, Jianyuan Zhao, Fuchu He, Yingyong Hou … & Chen Ding
Additional file 2: Fig. S2. Phosphoproteomic characterization, related to Fig. 1. A. MS2 spectrums of the YAP1 at S109 and RB1 at S807. B. IHC staining of YAP1 at S109 and RB1 at S807 in PDAC tumor tissues and NATs. C. Boxplot indicting the phosphosite expression of YAP1_pS109 and RB1_pS807 between tumors and NATs.

Obesity promotes lipid accumulation in lymph node metastasis of gastric cancer: a retrospective case‒control study

Jian Xiao, Kuan Shen, Kanghui Liu, Yuanhang Wang, Hao Fan, Quan Cheng, Xinyi Zhou, Li Hu, Gang Wang, Zekuan Xu & Li Yang
Abstract Background The connection between obesity, lipid accumulation, and lymph node metastasis (LNM) in gastric cancer (GC) is unclear. Methods The association of body mass index (BMI) and serum lipid levels with LNM was measured by calculating the odds ratio (OR) and 95% confidence interval (CI) in 1,058 eligible GC patients with a mean age of 61.4 years. Meanwhile, differentially expressed genes (DEGs) were identified between lymph node metastasis-positive (N +) and -negative (N0) groups...

The beneficial effect of growth mindset intervention for adolescents in economically disadvantaged areas of China

Ruixue Xia, Peiying Zhang, Ruiyang Liu, Junwei Xue, Huijing Zhu, Guaiguai Guo, Min Zhang & Yang Liu
The existing research has explored the effects of growth mindset intervention on individuals in Western culture. This study sought to determine whether growth mindset intervention has a positive impact on adolescents in economically disadvantaged areas of China. Participants in this study were 324 junior high school students who were randomly divided into the intervention group and the control group. The intervention group received six weeks of intervention classes designed to help students learn, internalize, and...

Analysis of dephasing time of plasmonic 1 hybridization modes using a quasi-normal mode method

Lun Wang, Boyu Ji, Yang Xu, peng lang, xiaowei song & Jingquan Lin
Near field coupling between different localized surface plasmon (LSP) modes supported by nanoparticles may result in two hybridization modes, namely bonding and antibonding modes. The antibonding mode is similar to the higher-order mode and has a longer dephasing time; the bonding mode has strong locality and higher near-field enhancement. It makes them very attractive in many applications, such as light-emitting electron sources, solar cells, sensors, etc. Measuring and regulating the LSP dephasing time (lifetime) is...

Analysis of dephasing time of plasmonic 1 hybridization modes using a quasi-normal mode method

Lun Wang, Boyu Ji, Yang Xu, peng lang, xiaowei song & Jingquan Lin
Near field coupling between different localized surface plasmon (LSP) modes supported by nanoparticles may result in two hybridization modes, namely bonding and antibonding modes. The antibonding mode is similar to the higher-order mode and has a longer dephasing time; the bonding mode has strong locality and higher near-field enhancement. It makes them very attractive in many applications, such as light-emitting electron sources, solar cells, sensors, etc. Measuring and regulating the LSP dephasing time (lifetime) is...

sj-docx-5-taj-10.1177_20406223221143245 – Supplemental material for Chest X-ray features facilitate screening for pulmonary hypertension caused by fibrosing mediastinitis

Mingfang Zhou, Bo Li, Yaling Chen, Aqian Wang, Yining Zhu, Yu Li, Hongling Su, Jingchun Fan, Yan Zhang & Yunshan Cao
Supplemental material, sj-docx-5-taj-10.1177_20406223221143245 for Chest X-ray features facilitate screening for pulmonary hypertension caused by fibrosing mediastinitis by Mingfang Zhou, Bo Li, Yaling Chen, Aqian Wang, Yining Zhu, Yu Li, Hongling Su, Jingchun Fan, Yan Zhang and Yunshan Cao in Therapeutic Advances in Chronic Disease

sj-docx-7-taj-10.1177_20406223221143245 – Supplemental material for Chest X-ray features facilitate screening for pulmonary hypertension caused by fibrosing mediastinitis

Mingfang Zhou, Bo Li, Yaling Chen, Aqian Wang, Yining Zhu, Yu Li, Hongling Su, Jingchun Fan, Yan Zhang & Yunshan Cao
Supplemental material, sj-docx-7-taj-10.1177_20406223221143245 for Chest X-ray features facilitate screening for pulmonary hypertension caused by fibrosing mediastinitis by Mingfang Zhou, Bo Li, Yaling Chen, Aqian Wang, Yining Zhu, Yu Li, Hongling Su, Jingchun Fan, Yan Zhang and Yunshan Cao in Therapeutic Advances in Chronic Disease

Allelic and haplotypic polymorphisms and paternal genetic analysis of Chinese Shaanxi Han population utilizing a multiplex Y-STR set

Hui Xu, Ming Zhao, Shuyan Mei, Yunying Zhang, Meiming Cai, Fanzhang Lei & Bofeng Zhu
The analysis of Y chromosomal genetic markers is of great significance in human genetic fields related to male individuals. The Han nationality is the most populous ethnic group. It is critical to investigate the Y-chromosome short tandem repeat (Y-STR) genetic informativeness of Han nationalities in different Chinese regions in order to gain a comprehensive understanding of their paternal genetic relationships and origin. To assess the allelic and haplotypic polymorphisms of the novel AGCU Y SUPP...

sj-docx-1-tag-10.1177_17562848221142913 – Supplemental material for Hereditary hemorrhagic telangiectasis with juvenile polyposis syndrome: a case report

Meng-Yu Tao, Kai-Yi Wang, Xin Li, Chen Yu, Qin-Si Wan, Xu Shu, You-Xiang Chen & Wang-Di Liao
Supplemental material, sj-docx-1-tag-10.1177_17562848221142913 for Hereditary hemorrhagic telangiectasis with juvenile polyposis syndrome: a case report by Meng-Yu Tao, Kai-Yi Wang, Xin Li, Chen Yu, Qin-Si Wan, Xu Shu, You-Xiang Chen and Wang-Di Liao in Therapeutic Advances in Gastroenterology

Two unusual novel iridoid glycosides from Cornus officinalis fruit and their biological activities

Bin Li, Xin Wang, Peng-Cheng Lin, Jin-Jie Li, Na Luan, Yun-Qin Wang & Xiao-Ya Shang
Two unusual novel iridoid glycosides, cornsecoside A (1) and cornsecoside B (2), were isolated from a 40% ethanol elution fraction of a 50% ethanol extract of Cornus officinalis fruit. Their structures were determined by spectroscopic data analysis combined with hydrolysis and ECD spectroscopy. In addition, compounds 1 and 2 exhibited cytotoxic activity against Bel-7402 cells with IC50 values of 8.12 and 9.31 µM, and were neuroprotective against H2O2-induced SH-SY5Y cell injure at a concentration of...

Lack of bombesin receptor-activated protein homologous protein impairs hippocampal synaptic plasticity and promotes chronic unpredictable mild stress induced behavioral changes in mice

Xueping Yao, Xiaoqun Qin, Hui Wang, Jiaoyun Zheng, Zhi Peng, Jie Wang, Horst Christian Weber, Rujiao Liu, Wenrui Zhang, Ji Zeng, Suhui Zuo, Hui Chen, Yang Xiang, Chi Liu, Huijun Liu, Lang Pan & Xiangping Qu
Bombesin receptor-activated protein (BRAP) and its homologous protein in mice, which is encoded by bc004004 gene, were expressed abundantly in brain tissues with unknown functions. We treated bc004004-/- mice with chronic unpredictable mild stress (CUMS) to test whether those mice were more vulnerable to stress-related disorders. The results of forced swimming test, sucrose preference test, and open field test showed that after being treated with CUMS for 28 days or 35 days both bc004004-/- and...

Lack of bombesin receptor-activated protein homologous protein impairs hippocampal synaptic plasticity and promotes chronic unpredictable mild stress induced behavioral changes in mice

Xueping Yao, Xiaoqun Qin, Hui Wang, Jiaoyun Zheng, Zhi Peng, Jie Wang, Horst Christian Weber, Rujiao Liu, Wenrui Zhang, Ji Zeng, Suhui Zuo, Hui Chen, Yang Xiang, Chi Liu, Huijun Liu, Lang Pan & Xiangping Qu
Bombesin receptor-activated protein (BRAP) and its homologous protein in mice, which is encoded by bc004004 gene, were expressed abundantly in brain tissues with unknown functions. We treated bc004004-/- mice with chronic unpredictable mild stress (CUMS) to test whether those mice were more vulnerable to stress-related disorders. The results of forced swimming test, sucrose preference test, and open field test showed that after being treated with CUMS for 28 days or 35 days both bc004004-/- and...

sj-docx-1-cat-10.1177_10760296221139258 - Supplemental material for Establishment of a Predictive Model for Poor Prognosis of Incomplete Revascularization in Patients with Coronary Heart Disease and Multivessel Disease

Huan Lian, Zhuoyan Zhao, Kelin Ma, Zhenjiang Ding, Lixian Sun & Ying Zhang
Supplemental material, sj-docx-1-cat-10.1177_10760296221139258 for Establishment of a Predictive Model for Poor Prognosis of Incomplete Revascularization in Patients with Coronary Heart Disease and Multivessel Disease by Huan Lian, Zhuoyan Zhao, Kelin Ma, Zhenjiang Ding, Lixian Sun and Ying Zhang in Clinical and Applied Thrombosis/Hemostasis

Additional file 4 of The effect of SNPs in lncRNA as ceRNA on the risk and prognosis of hepatocellular carcinoma

Han Mo, Xi Wang, Guohua Ji, Xiao Liang, Yi Yang, Wenjing Sun, Xueyuan Jia, Lidan Xu, Yuandong Qiao, Henan Zhou, Wenhui Zhao, Songbin Fu & Xuelong Zhang
Additional file 4:

Additional file 3 of The effect of SNPs in lncRNA as ceRNA on the risk and prognosis of hepatocellular carcinoma

Han Mo, Xi Wang, Guohua Ji, Xiao Liang, Yi Yang, Wenjing Sun, Xueyuan Jia, Lidan Xu, Yuandong Qiao, Henan Zhou, Wenhui Zhao, Songbin Fu & Xuelong Zhang
Additional file 3:

Additional file 2 of The effect of SNPs in lncRNA as ceRNA on the risk and prognosis of hepatocellular carcinoma

Han Mo, Xi Wang, Guohua Ji, Xiao Liang, Yi Yang, Wenjing Sun, Xueyuan Jia, Lidan Xu, Yuandong Qiao, Henan Zhou, Wenhui Zhao, Songbin Fu & Xuelong Zhang
Additional file 2: Supplementary Table 1. Independent sample test of age.

Additional file 1 of Water extract from artichoke ameliorates high-fat diet-induced non-alcoholic fatty liver disease in rats

Aihua Deng, Fengying Liu, Xuchong Tang, Yun Wang, Peng Xie, Qifu Yang & Bing Xiao
Additional file 1.

sj-pdf-1-eae-10.1177_0958305X221140567 - Supplemental material for Reduce carbon emissions efficiently: The influencing factors and decoupling relationships of carbon emission from high-energy consumption and high-emission industries in China

Xiaopeng Guo, Rong Shi & Dongfang Ren
Supplemental material, sj-pdf-1-eae-10.1177_0958305X221140567 for Reduce carbon emissions efficiently: The influencing factors and decoupling relationships of carbon emission from high-energy consumption and high-emission industries in China by Xiaopeng Guo, Rong Shi and Dongfang Ren in Energy & Environment

Reduce carbon emissions efficiently: The influencing factors and decoupling relationships of carbon emission from high-energy consumption and high-emission industries in China

Xiaopeng Guo, Rong Shi & Dongfang Ren
High-energy consumption and high-emission industries contribute a lot to economic development, but their carbon emissions are also huge. In order to achieve the dual-carbon target as early as possible, it is necessary to reduce the carbon emissions of high-energy consumption and high-emission industries. This paper selected five representative factors (population, per capita gross domestic product (GDP), energy intensity, energy structure and carbon emission coefficient) and adopted the logarithmic mean divisia index (LMDI) method to decompose...

An icaritin-loaded microemulsion based on coix oil for improved pharmacokinetics and enhanced antitumor efficacy

Huating Zeng, Xiaoqi Li, Yuping Liu, Xia Li, Ding Qu & Yan Chen
Combinational icaritin (IC) and coix seed oil (CSO) holds promising potential in the treatment of hepatocellular carcinoma. However, traditional cocktail therapy is facing difficulties to optimize the synergistic antitumor efficacy due to the asynchronous pharmacokinetics. Therefore, we developed an icaritin-loaded microemulsion based on coix seed oil (IC-MEs) for improved pharmacokinetics and enhanced antitumor efficacy. The preparation technology of IC-MEs was optimized by the Box–Behnken design and the pharmaceutical properties were characterized in detail. IC-MEs show...

Synthesis of spirocyclopropanes via iodine-promoted bimolecular cyclization of 2-benzylidene 1,3-indandiones

Zeng-Yang He, Yong Ning, Yu-Fei Zhao, Hong-Lin Diao, Peng Zou, Wen-Bin Wang, Jun-Sheng Shu & Hui Xu
A novel and efficient iodine-promoted bimolecular annulation of 2-benzylidene 1,3-indandiones has been developed. Following this protocol, a series of spirocyclopropane derivatives were furnished in good to excellent yields. The present protocol features mild conditions, short reaction time, high efficiency, good chemoselectivity and remarkable functional group tolerance.

Design and synthesis of a new bioactive compound for marine antifouling inspired by natural products

Jiyong Zheng, Haiping Gao, Guanglong Zhang, Zhiyong Sun, Jinwei Zhang, Li Wang & Cunguo Lin
A marine antifouling compound, N-octyl-2-hydroxybenzamide (OHBA), inspired by ceramide and paeonol molecules, was created. First, methyl salicylate was synthesized with salicylic acid and methanol, followed by n-octylamine through an ester-amine condensation reaction. Fourier transform infrared spectroscopy, nuclear magnetic resonance spectroscopy, and mass spectrometry confirmed the characteristic structure of the OHBA compound. Bioassays showed that OHBA inhibits the growth of typical marine fouling organisms, such as Vibrio azureus, Navicula subminuscula, Ulva pertusa, Mytilus edulis, and Amphibalanus...

sj-pdf-1-jcb-10.1177_0271678X221135841 - Supplemental material for Endothelial progenitor cell transplantation attenuates synaptic loss associated with enhancing complement receptor 3-dependent microglial/macrophage phagocytosis in ischemic mice

Yuanyuan Ma, Ze Liu, Lu Jiang, Liping Wang, Yongfang Li, Yanqun Liu, Yongting Wang, Guo-Yuan Yang, Jing Ding & Zhijun Zhang
Supplemental material, sj-pdf-1-jcb-10.1177_0271678X221135841 for Endothelial progenitor cell transplantation attenuates synaptic loss associated with enhancing complement receptor 3-dependent microglial/macrophage phagocytosis in ischemic mice by Yuanyuan Ma, Ze Liu, Lu Jiang, Liping Wang, Yongfang Li, Yanqun Liu, Yongting Wang, Guo-Yuan Yang, Jing Ding and Zhijun Zhang in Journal of Cerebral Blood Flow & Metabolism

Endothelial progenitor cell transplantation attenuates synaptic loss associated with enhancing complement receptor 3-dependent microglial/macrophage phagocytosis in ischemic mice

Yuanyuan Ma, Ze Liu, Lu Jiang, Liping Wang, Yongfang Li, Yanqun Liu, Yongting Wang, Guo-Yuan Yang, Jing Ding & Zhijun Zhang
Endothelial progenitor cell (EPC) transplantation has therapeutic effects in cerebral ischemia. However, how EPCs modulate microglial activity remains unclear. In the study, we explored whether EPCs modulated microglial/macrophage activity and facilitated injured brain repair. Adult male mice (n = 184) underwent transient middle cerebral artery occlusion, and EPCs were transplanted into the brain immediately after ischemia. Microglial/macrophage activity and complement receptor 3 (CR3) expression were evaluated in ischemic brains and cultured microglia. CR3 agonist leukadherin-1...

An Optimal Hybrid Approach to Calculate Conditional Power

Jian Zhu, Xin Li & Yi Liu
When used in clinical trial adaptive designs, conditional power (CP) is most commonly calculated assuming the current trend, but this approach has been criticized for substantially deviating from the actual CP due to “double-dipping” the interim data (i.e., using the interim data as part of the final analysis test statistic and as the assumption for the remainder of the trial). By contrast, CP assuming the design assumption preserves the shape of the CP curve by...

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