Data from: Simulation of the nodal flow of mutant embryos with small number of cilia: comparison of mechanosensing and vesicle transport hypotheses

Toshihiro Omori, Katja Winter, Kyosuke Shinohara, Hiroshi Hamada & Takuji Ishikawa
Left-right (L-R) asymmetry in the body plan is determined by nodal flow in vertebrate embryos. Shinohara et al. used Dpcd and Rfx3 mutant mouse embryos and showed that only a few cilia were sufficient to achieve L-R asymmetry. However, the mechanism underlying the breaking of symmetry by such weak ciliary flow is unclear. The flow-mediated signals related to L-R asymmetry have not been clarified; there are two models for L-R symmetry breaking: vesicle transport and...

Registration Year

  • 2018
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  • Dataset
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Affiliations

  • RIKEN Center for Developmental Biology
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  • Tokyo University of Agriculture and Technology
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  • Tohoku University
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  • University of Potsdam
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