3 Works

Data from: Levels of 8-oxodG predict hepatobiliary-pathology in Opisthorchis viverrini endemic settings in Thailand

Prasert Saichua, Anna Yakovleva, Christine Kamamia, Amar R. Jariwala, Jiraporn Sithithaworn, Banchop Sripa, Paul J. Brindley, Thewarach Laha, Eimorn Mairiang, Chawalit Pairojkul, Narong Khuntikeo, Jason P. Mulvenna, Paiboon Sithithaworn, Jeffrey Michael Bethony, Banchob Sripa & Jason Mulvenna
Opisthorchis viverrini is distinct among helminth infections as it drives a chronic inflammatory response in the intrahepatic bile duct that progresses from advanced periductal fibrosis (APF) to cholangiocarcinoma (CCA). Extensive research shows that oxidative stress (OS) plays a critical role in the transition from chronic O. viverrini infection to CCA. OS also results in the excision of a modified DNA lesion (8-oxodG) into urine, the levels of which can be detected by immunoassay. Herein, we...

Data from: Less is more: extreme genome complexity reduction with ddRAD using Ion Torrent semiconductor technology

Lilian Pukk, Freed Ahmad, Shihab Hasan, Veljo Kisand, Riho Gross & Anti Vasem├Ągi
Massively parallel sequencing a small proportion of the whole genome at high coverage enables answering a wide range of questions from molecular evolution and evolutionary biology to animal and plant breeding and forensics. In this study, we describe the development of restriction-site associated DNA (RAD) sequencing approach for Ion Torrent PGM platform. Our protocol results in extreme genome complexity reduction using two rare-cutting restriction enzymes and strict size selection of the library allowing sequencing of...

Data from: Impact of an ivermectin mass drug administration on scabies prevalence in a remote Australian Aboriginal community

Therese M. Kearns, Linda Ward, Deborah C. Holt, Bart J. Currie, Roslyn Gundjirryirr, Leanne Bundhala, Mark Chatfield, Ross M. Andrews, Richard Speare, Allen C. Cheng, James McCarthy, Jonathan R. Carapetis & Jennifer Shield
Background: Scabies is endemic in many Aboriginal and Torres Strait Islander communities, with 69% of infants infected in the first year of life. We report the outcomes against scabies of two oral ivermectin mass drug administrations (MDAs) delivered 12 months apart in a remote Australian Aboriginal community. Methods: Utilizing a before and after study design, we measured scabies prevalence through population census with sequential MDAs at baseline and month 12. Surveys at months 6 and...

Registration Year

  • 2015
    3

Resource Types

  • Dataset
    3

Affiliations

  • QIMR Berghofer Medical Research Institute
    3
  • Thammasat University
    1
  • University of Queensland
    1
  • Estonian University of Life Sciences
    1
  • George Washington University
    1
  • La Trobe University
    1
  • Monash University
    1
  • Khon Kaen University
    1
  • University of Tartu
    1
  • University of Western Australia
    1