For malaria elimination efforts, it is important to better understand parasite transmission to mosquitoes and to develop models to allow early clinical evaluation of transmission-blocking interventions. We previously described a Controlled Human Malaria Infection protocol for induction of gametocytemia in malaria naïve volunteers by mosquito bite (CHMI-trans) (Reuling et al., 2018). Here, we compared gametocyte production and infectivity in the CHMI-trans model after bites of Plasmodium falciparum (Pf)- infected mosquitoes to that after intravenous administration...

Diagnosis of attention deficit hyperactive disorder (ADHD) has been associated with increased risk of mortality in large register samples. However, there is less known about the association between symptoms of ADHD in adolescents and risk of mortality in general population samples. The Northern Finland Birth Cohort 1986 (n = 9432 at recruitment in early pregnancy) linked to nationwide register data for deaths was utilized to study the association between parent-rated ADHD symptoms assessed using Strengths...

Supplemental material, sj-docx-2-dhj-10.1177_20552076221144104 for Understanding what we know so far about young people's engagement with wellbeing apps. A scoping review and narrative synthesis by Gaston Antezana, Anthony Venning, David Smith and Niranjan Bidargaddi in Digital Health

Abstract Background Inflammatory bowel disease (IBD) is a chronic idiopathic disease characterized by inflammation-related epithelial barrier damage in the intestinal tract. Helminth infection reduces autoimmune disease symptoms through regulation of inflammatory responses based on hygiene theory. However, the underlying mechanisms remain unclear. Methods BALB/c mice were infected with microcysts of E. granulosus sensu stricto and drank water containing 3.5% dextran sodium sulfate (DSS) at the 100th day post-infection. After 7 days of drinking DSS, the...

Additional file 1: Database S1. The B. glabrata protein database used in the proteomic data analysis.

Additional file 5: Table S4. A list of the total proteins, unique proteins and corresponding peptides identified in susceptible B. glabrata with reference to the B. glabrata proteome.

Additional file 6: Figure S1. The representative MS/MS spectrum of LTGMAFR, supporting both B. glabrata and S. mansoni glyceraldehyde-3-phosphate dehydrogenase (G3PDH).

Additional file 9: Table S6. The results of PPIs shown in Fig. 5 and the co-expression data export from STRING to support the PPI of S. mansoni proteins.

Additional file 8: Table S5. A list of the total proteins, unique proteins and corresponding peptides identified in susceptible B. glabrata SCW with reference to the S. mansoni proteome, and enriched GO terms related to the proteins.

Talk given at the TDWG 2022 conference titled Towards a next-gen collections management system as part of the institutional and community data ecosystems

Additional file 1: Table S1. Genome-wide significant independent SNPs for Body Mass Index in women (Pulit 2018). Table S2. Genome-wide significant independent SNPs for Years Ovulating (Hg19). Table S3. Genome-wide significant independent SNPs for age at menarche downloaded from the ReproGen Consortium Website (Perry et al., 2014; Hg19). Table S4. Genome-wide significant independent SNPs for age at menopause downloaded from the ReproGen Consortium Website (Hg19; Day et al., 2015). Table S5. Genome-wide significant independent SNPs...

Long non-coding RNAs (lncRNAs) are crucial drivers in the progression of human diseases such as myocardial infarction (MI). However, the impact of lncRNA MCM3AP antisense RNA 1 (MCM3AP-AS1) on MI remains unknown. This research was determined to explore the effect of MCM3AP-AS1 modulating microRNA-24-3p (miR-24-3p) and eukaryotic translation initiation factor 4 gamma 2 (EIF4G2) on MI. The rat MI models were constructed and, respectively, treated with altered MCM3AP-AS1, miR-24-3p or/and EIF4G2. Subsequently, the cardiac function,...

Long non-coding RNAs (lncRNAs) are crucial drivers in the progression of human diseases such as myocardial infarction (MI). However, the impact of lncRNA MCM3AP antisense RNA 1 (MCM3AP-AS1) on MI remains unknown. This research was determined to explore the effect of MCM3AP-AS1 modulating microRNA-24-3p (miR-24-3p) and eukaryotic translation initiation factor 4 gamma 2 (EIF4G2) on MI. The rat MI models were constructed and, respectively, treated with altered MCM3AP-AS1, miR-24-3p or/and EIF4G2. Subsequently, the cardiac function,...

Supplemental material, sj-docx-2-dhj-10.1177_20552076221144104 for Understanding what we know so far about young people's engagement with wellbeing apps. A scoping review and narrative synthesis by Gaston Antezana, Anthony Venning, David Smith and Niranjan Bidargaddi in Digital Health

Because little is known about cataract in pilots, we estimated prevalence by anonymously ascertaining all commercial airline pilots diagnosed with cataract 2011–2016 using the electronic Medical Records System of the Australian Civil Aviation Safety Authority. Of 14,163 Australian male commercial pilots licensed in 2011, 1286 aged ≥60 had biennial eye examinations showing a cataract prevalence of 11.6%. Among 12,877 pilots aged <60, based on compulsory eye examinations only when first licensed, prevalence was 0.5%. There...

Additional file 2.

Abstract Background Observational epidemiological studies suggest a link between several factors related to ovulation and reproductive function and endometrial cancer (EC) risk; however, it is not clear whether these relationships are causal, and whether the risk factors act independently of each other. The aim of this study was to investigate putative causal relationships between the number of live births, age at last live birth, and years ovulating and EC risk. Methods We conducted a series...

Additional file 1: Figure S1. ECF showed no effect on mice with DSS-induced colitis. ECF was intraperitoneally injected into mice, which were then administered DSS for 7 days. The differences in parameters between the DSS and ECF-DSS groups are shown: (A) body weight change, (B) DAI score, and (C) colon length (8–10 mice per group). The experiment was repeated independently.

Additional file 1: Figure S1. ECF showed no effect on mice with DSS-induced colitis. ECF was intraperitoneally injected into mice, which were then administered DSS for 7 days. The differences in parameters between the DSS and ECF-DSS groups are shown: (A) body weight change, (B) DAI score, and (C) colon length (8–10 mice per group). The experiment was repeated independently.

Latex for a supplemental document with expanded experimental methods

Diagnosis of attention deficit hyperactive disorder (ADHD) has been associated with increased risk of mortality in large register samples. However, there is less known about the association between symptoms of ADHD in adolescents and risk of mortality in general population samples. The Northern Finland Birth Cohort 1986 (n = 9432 at recruitment in early pregnancy) linked to nationwide register data for deaths was utilized to study the association between parent-rated ADHD symptoms assessed using Strengths...

Successful gene therapy for brain tumors are often limited by two important factors, the existence of blood brain barrier (BBB) and inefficient transfection of brain tumor cells. In this study, we designed a series of peptide-based gene delivery vectors decorated with T7 segment for binding the transferrin (Tf) receptors which were highly expressed on brain tumor cells, and evaluated their ability of gene delivery. The physicochemical properties of peptide vectors or peptide/DNA complexes were studied...

Abstract Background Inflammatory bowel disease (IBD) is a chronic idiopathic disease characterized by inflammation-related epithelial barrier damage in the intestinal tract. Helminth infection reduces autoimmune disease symptoms through regulation of inflammatory responses based on hygiene theory. However, the underlying mechanisms remain unclear. Methods BALB/c mice were infected with microcysts of E. granulosus sensu stricto and drank water containing 3.5% dextran sodium sulfate (DSS) at the 100th day post-infection. After 7 days of drinking DSS, the...

Additional file 3: Table S2. A list of the total proteins, unique proteins and corresponding peptides identified in naïve B. glabrata with reference to the B. glabrata proteome.

Additional file 4: Table S3. A list of the total proteins, unique proteins and corresponding peptides identified resistant B. glabrata with reference to the B. glabrata proteome.