Supplementary Material 6

Background: A multidisciplinary collaboration investigated the world's largest, most catastrophic epidemic thunderstorm asthma event that took place in Melbourne, Australia, on Nov 21, 2016, to inform mechanisms and preventive strategies. Methods: Meteorological and airborne pollen data, satellite-derived vegetation index, ambulance callouts, emergency department presentations, and data on hospital admissions for Nov 21, 2016, as well as leading up to and following the event were collected between Nov 21, 2016, and March 31, 2017, and analysed....

Background: A multidisciplinary collaboration investigated the world's largest, most catastrophic epidemic thunderstorm asthma event that took place in Melbourne, Australia, on Nov 21, 2016, to inform mechanisms and preventive strategies. Methods: Meteorological and airborne pollen data, satellite-derived vegetation index, ambulance callouts, emergency department presentations, and data on hospital admissions for Nov 21, 2016, as well as leading up to and following the event were collected between Nov 21, 2016, and March 31, 2017, and analysed....

Abstract Objective To compare colorectal cancer (CRC) incidences in carriers of pathogenic variants of the MMR genes in the PLSD and IMRC cohorts, of which only the former included mandatory colonoscopy surveillance for all participants. Methods CRC incidences were calculated in an intervention group comprising a cohort of confirmed carriers of pathogenic or likely pathogenic variants in mismatch repair genes (path_MMR) followed prospectively by the Prospective Lynch Syndrome Database (PLSD). All had colonoscopy surveillance, with...

Abstract Background MicroRNAs (miRNAs) have been confirmed to be inextricably linked to the emergence of human complex diseases. The identification of the disease-related miRNAs has gradually become a routine way to unveil the genetic mechanisms of examined disorders. Methods In this study, a method BLNIMDA based on a weighted bi-level network was proposed for predicting hidden associations between miRNAs and diseases. For this purpose, the known associations between miRNAs and diseases as well as integrated...

Additional file 1: Figure S1. An example of data processing, including the calculation of GIP kernel similarity and the process of integrating similarity. Figure S2. A BLNIMDA calculation example, including the generation of two side information properties, the calculation of two affinity weights for each MDP and the MDA score.

Additional file 4:

Additional file 2: Supplementary Table 1. Independent sample test of age.

Abstract Objective The unknown aetiology of Serrated Polyposis Syndrome (SPS) impedes risk prediction and prevention. We investigated risk factors for SPS, overall and stratified by World Health Organization (WHO)2010 clinical criteria and by colorectal cancer (CRC). Method A retrospective case-control study involving a cross-sectional analysis from 350 unrelated individuals with SPS from the Genetics of Colonic Polyposis Study and 714 controls from the Australasian Colorectal Cancer Family Registry. Univariate and multivariate logistic regression modelling was...

Screening for primary aldosteronism on and off interfering medications Appendix

Additional file 1. Carer Needs Assessment.

Supplementary Material 1

Additional file 1: Finite element analysis of Case 1.

Abstract Open reduction and internal fixation of pelvic acetabular fractures are challenging due to the limited surgical exposure from surrounding abdominal tissue. There have been a number of recent trials using metallic 3D-printed pelvic fracture plates to simplify and improve various elements of these fracture fixation surgeries; however, the amount of time and accuracy involved in the design and implantation of customised plates have not been well characterised. This study recorded the amount of time...

Abstract Open reduction and internal fixation of pelvic acetabular fractures are challenging due to the limited surgical exposure from surrounding abdominal tissue. There have been a number of recent trials using metallic 3D-printed pelvic fracture plates to simplify and improve various elements of these fracture fixation surgeries; however, the amount of time and accuracy involved in the design and implantation of customised plates have not been well characterised. This study recorded the amount of time...

Supplemental material, sj-docx-2-tct-10.1177_15330338231175735 for The Differential Diagnostic Value of Radiomics Signatures Between Single-Nodule Pulmonary Metastases and Second Primary Lung Cancer in Patients with Colorectal Cancer by Yu Yu, Jiaqing Tan, Yi Yang, Bin Zhang, Xiaodong Yao, Shibiao Sang and Shengming Deng in Technology in Cancer Research & Treatment

Supplemental material, sj-png-1-tct-10.1177_15330338231175735 for The Differential Diagnostic Value of Radiomics Signatures Between Single-Nodule Pulmonary Metastases and Second Primary Lung Cancer in Patients with Colorectal Cancer by Yu Yu, Jiaqing Tan, Yi Yang, Bin Zhang, Xiaodong Yao, Shibiao Sang and Shengming Deng in Technology in Cancer Research & Treatment

BackgroundDifferential diagnosis of single-nodule pulmonary metastasis (SNPM) and second primary lung cancer (SPLC) in patients with colorectal cancer (CRC) prior to lung surgery is relatively complex. Radiomics is an emerging technique for image information analysis, while it has not yet been applied to construct a differential diagnostic model between SNPM and SPLC in patients with CRC. In the present study, we aimed to extract radiomics signatures from thin-section computed tomography (CT) images of the chest....

Objectives: To examine the personal and social experiences of younger adults after stroke. Design: Qualitative study design involving in-depth semi-structured interviews and rigorous qualitative descriptive analysis informed by social constructionism. Participants: Nineteen young stroke survivors aged 18 to 55 at the time of their first-ever stroke. Setting: Participants were recruited from urban and rural settings across Australia. Interviews took place in a clinic room of the Florey Institute of Neuroscience and Mental Health (Melbourne, Australia),...

Additional file 1: Supplementary Material A. Table S1. Overview of source population (ORIMA) and comparable census demographics. Table S2. Percentage of respondents willing to undertake each dementia testing modality by age group and gender. Table S3. Percentage of respondents endorsing items pertaining to dementia testing by age group and gender. Supplementary Material B. Information pertaining to individual survey items.

Abstract Background Acute respiratory distress syndrome (ARDS) patients with different lung morphology have distinct pulmonary mechanical dysfunction and outcomes. Whether lung morphology impacts the association between ventilatory variables and mortality remains unclear. Moreover, the impact of a novel combined ventilator variable [(4×DP) + RR] on morality in ARDS patients needs external validation. Methods We obtained data from the Chinese Database in Intensive Care (CDIC), which included adult ARDS patients who received invasive mechanical ventilation for...

Additional file 1: Table S1. Different multivariate Cox proportional hazards regression models; Table S2. Percentage of missing data in the variables of interest at baseline; Table S3. The impact of Driving pressure and respiratory rate on 28-day mortality in Model D; Table S4. Association between time-varying ventilatory variables and mortality in ARDS patients with different lung morphology after excluding patients receiving ECMO (n=352); Fig. S1. Lung morphology of ARDS patients based on lung CT: non-focal...

Abstract Background Celiac disease (CD) is an autoimmune disorder triggered by gluten consumption. Almost all CD patients possess human leukocyte antigen (HLA) DQ2/DQ8 haplotypes; however, only a small subset of individuals carrying these alleles develop CD, indicating the role of environmental factors in CD pathogenesis. The main objective of this study was to determine the contributory role of gut microbiota and microbial metabolites in CD onset. To this end, we obtained fecal samples from a...

Additional file 1. Semi-Structured Moderator’s Guide. Used for the focus groups and interviews conducted in the study.

Abstract Background For decades, the research community has called for participant information sheets/consent forms (PICFs) to be improved. Recommendations include simplifying content, reducing length, presenting information in layers and using multimedia. However, there are relatively few studies that have evaluated health consumers’ (patients/carers) perspectives on the type and organisation of information, and the level of detail to be included in a PICF to optimise an informed decision to enter a trial. We aimed to elicit...