12 Works

Data from: Task shifting interventions for cardiovascular risk reduction in low-and middle-income countries: a systematic review of randomized controlled trials

Joyce Gyamfi, Gbenga Ogedegbe, Jacob Plange-Rhule, Alisa Surkis, Diana Margot Rosenthal, Collins Airhihenbuwa, Juliet Iwelunmor & Richard Cooper
Objective: To evaluate evidence from published randomised controlled trials (RCTs) for the use of task-shifting strategies for cardiovascular disease (CVD) risk reduction in low-income and middle-income countries (LMICs). Design: Systematic review of RCTs that utilised a task-shifting strategy in the management of CVD in LMICs. Data Sources: We searched the following databases for relevant RCTs: PubMed from the 1940s, EMBASE from 1974, Global Health from 1910, Ovid Health Star from 1966, Web of Knowledge from...

Data from: Elementary sensory-motor transformations underlying olfactory navigation in walking fruit flies

Efrén Álvarez-Salvado, Angela M. Licata, Erin G. Connor, Margaret K. McHugh, Benjamin M.N. King, Nicholas Stavropoulos, Jonathan D. Victor, John P. Crimaldi, Katherine I. Nagel & Benjamin MN King
Odor attraction in walking Drosophila melanogaster is commonly used to relate neural function to behavior, but the algorithms underlying attraction are unclear. Here we develop a high-throughput assay to measure olfactory behavior in response to well-controlled sensory stimuli. We show that odor evokes two behaviors: an upwind run during odor (ON response), and a local search at odor offset (OFF response). Wind orientation requires antennal mechanoreceptors, but search is driven solely by odor. Using dynamic...

Distinct population code for movement kinematics and changes of ongoing movements in human subthalamic nucleus

Dennis London, Arash Fazl, Kalman Katlowitz, Marisol Soula, Michael Pourfar, Alon Mogilner & Roozbeh Kiani
The subthalamic nucleus (STN) is theorized to globally suppress movement through connections with downstream basal ganglia structures. Current theories are supported by increased STN activity when subjects withhold an uninitiated action plan, but a critical test of these theories requires studying STN responses when an ongoing action is replaced with an alternative. We perform this test in subjects with Parkinson’s disease using an extended reaching task where the movement trajectory changes mid-action. We show that...

Proteomics and Transcriptomics of the Hippocampus and Cortex in SUDEP and High-Risk SUDEP Patients

Dominique Leitner, James D. Mills, Geoffrey Pires, Arline Faustin, Eleanor Drummond, Evgeny Kanshin, Shruti Nayak, Manor Askenazi, Chloe Verducci, Bei Jun Chen, Michael Janitz, Jasper J. Anink, Johannes C. Baayen, Sander Idema, Erwin A. Van Vliet, Sasha Devore, Daniel Friedman, Beate Diehl, Catherine Scott, Roland Thijs, Thomas Wisniewski, Beatrix Ueberheide, Maria Thom, Eleonora Aronica & Orrin Devinsky
To identify the molecular signaling pathways underlying sudden unexpected death in epilepsy (SUDEP) and high-risk SUDEP compared to control patients with epilepsy. For proteomics analyses, we evaluated the hippocampus and frontal cortex from microdissected postmortem brain tissue of 12 patients with SUDEP and 14 with non-SUDEP epilepsy. For transcriptomics analyses, we evaluated hippocampus and temporal cortex surgical brain tissue from patients with mesial temporal lobe epilepsy: 6 low-risk and 8 high-risk SUDEP as determined by...

Supplemental figures: Calcium response behaviors and biomarker expression in human parathyroid tumors

James Koh, Run Zhang, Sanziana Roman, Quan-Yang Duh, Jessica Gosnell, Wen Shen, Insoo Suh & Julie Sosa
Context. The biochemical basis for clinical variability in primary hyperparathyroidism (PHPT) is poorly understood. Objectives. To define parathyroid tumor biochemical properties associated with calcium sensing failure in PHPT patients, and to relate differences in these profiles to variations in clinical presentation. Design. Pre-operative clinical data were evaluated for correlation to parathyroid tumor biochemical behavior. Setting. An endocrine surgery referral center at a large, public university hospital. Patients and Other Participants. A sequential series of 39...

Sudden Unexpected Death in Epilepsy: A Personalized Prediction Tool

Ashwani Jha, Cheongeun Oh, Dale Hesdorffer, Beate Diehl, Sasha Devore, Martin Brodie, Torbjörn Tomson, Josemir W. Sander, Thaddeus S. Walczak & Orrin Devinsky
Objective: To develop and validate a tool for individualised prediction of Sudden Unexpected Death in Epilepsy (SUDEP) risk, we re-analysed data from one cohort and three case-control studies undertaken 1980-2005. Methods: We entered 1273 epilepsy cases (287 SUDEP, 986 controls) and 22 clinical predictor variables into a Bayesian logistic regression model. Results: Cross-validated individualized model predictions were superior to baseline models developed from only average population risk or from generalised tonic-clonic seizure frequency (pairwise difference...

Supplement to: Global impact of the COVID-19 pandemic on stroke care and intravenous thrombolysis

Raul Nogueira, Muhammed Qureshi, Mohamad Abdalkader, Sheila Martins, Hiroshi Yamagami, Zhongming Qiu, Ossama Mansour, Anvitha Sathya, Anna Czlonkowska, Georgios Tsivgoulis, Diana Aguiar De Sousa, Jelle Demeestere, Robert Mikulik, Peter Vanacker, James Siegler, Janika Korv, Jose Biller, Conrad Liang, Navdeep Sangha, Alicia Zha, Alexandra Czap, Christine Holmstedt, Tanya Turan, George Ntaios, Konark Malhotra … & Thanh Nguyen
Objective: The objectives of this study were to measure the global impact of the pandemic on the volumes for intravenous thrombolysis (IVT), IVT transfers, and stroke hospitalizations over 4 months at the height of the pandemic (March 1 to June 30, 2020) compared with two control 4-month periods. Methods: We conducted a cross-sectional, observational, retrospective study across 6 continents, 70 countries, and 457 stroke centers. Diagnoses were identified by their ICD-10 codes and/or classifications in...

Multi-contrast MRI and histology datasets used to train and validate MRH networks to generate virtual mouse brain histology

Zifei Liang & Jiangyang Zhang
H MRI maps brain structure and function non-invasively through versatile contrasts that exploit inhomogeneity in tissue micro-environments. Inferring histopathological information from MRI findings, however, remains challenging due to absence of direct links between MRI signals and cellular structures. Here, we provided deep convolutional neural networks, called MRH-Nets, developed using co-registered multi-contrast MRI and histological data of the mouse brain, can estimate histological staining intensity directly from MRI signals at each voxel. The results provide three-dimensional...

Data from: Clinical trial registration, reporting, publication and FDAAA compliance: a cross-sectional analysis and ranking of new drugs approved by the FDA in 2012

Jennifer E. Miller, David Korn & Joseph S. Ross
Objective: To evaluate clinical trial registration, reporting and publication rates for new drugs by: (1) legal requirements and (2) the ethical standard that all human subjects research should be publicly accessible to contribute to generalisable knowledge. Design: Cross-sectional analysis of all clinical trials submitted to the Food and Drug Administration (FDA) for drugs approved in 2012, sponsored by large biopharmaceutical companies. Data sources: Information from Drugs@FDA, ClinicalTrials.gov, MEDLINE-indexed journals and drug company communications. Main outcome...

Data from: Information-theoretic analysis of realistic odor plumes: what cues are useful for determining location?

Sebastian D. Boie, Erin G. Connor, Margaret McHugh, Katherine I. Nagel, G. Bard Ermentrout, John P. Crimaldi & Jonathan D. Victor
Many species rely on olfaction to navigate towards food sources or mates. Olfactory navigation is a challenging task since odor environments are typically turbulent. While time-averaged odor concentration varies smoothly with the distance to the source, instaneous concentrations are intermittent and obtaining stable averages takes longer than the typical intervals between animals’ navigation decisions. How to effectively sample from the odor distribution to determine sampling location is the focus on this article. To investigate which...

Prospective Quantification of CSF Biomarkers in Antibody-Mediated Encephalitis

Gregory Day, Melanie L. Yarbrough, Peter Körtvelyessy, Harald Prüss, Robert C. Bucelli, Marvin J. Fritzler, Warren Mason, David F. Tang-Wai, Claude Steriade, Julien Hébert, Rachel L. Henson, Elizabeth M. Herries, Jack H. Ladenson, A. Sebastian Lopez-Chiriboga, Neill R. Graff-Radford, John C. Morris & Anne Fagan
Objective: To determine whether neuronal and neuroaxonal injury, neuroinflammation, and synaptic dysfunction associate with clinical course and outcomes in antibody-mediated encephalitis (AME), we measured biomarkers of these processes in CSF from patients presenting with AME and cognitively normal individuals. Methods: Biomarkers of neuronal (total tau, VILIP-1) and neuroaxonal damage (neurofilament light chain [NfL]), inflammation (YKL-40), and synaptic function (neurogranin, SNAP-25) were measured in CSF obtained from 45 patients at the time of diagnosis of NMDA...

Noninvasive quantification of axon radii using diffusion MRI

Jelle Veraart
Axon size plays a crucial role in determining conductance velocity and, consequently, in the the timing and synchronization of neural activation. Noninvasive measurement of axon radii could have significant impact on the understanding of healthy and diseased neural processes. However, until now, accurate axon radius mapping has eluded in vivo neuroimaging, mainly due to a lack of sensitivity of the MRI signal to micron-sized axons. Here, we show how -- when confounding factors such as...

Registration Year

  • 2022
  • 2021
  • 2020
  • 2018
  • 2016
  • 2014

Resource Types

  • Dataset


  • New York University Langone Medical Center
  • Kwame Nkrumah University of Science and Technology
  • University of Colorado Boulder
  • Emory University School of Medicine
  • Charité
  • Massachusetts General Hospital
  • Ain Shams University
  • Ain Shams University Hospital
  • Kaiser Permanente
  • University of Glasgow