5,308 Works

Pro-thrombotic changes associated with exposure to ambient ultrafine particles in patients with chronic obstructive pulmonary disease: roles of lipid peroxidation and systemic inflammation

Teng Wang, Xi Chen, Haonan Li, Wu Chen, Yifan Xu, Yuan Yao, Hanxiyue Zhang, Yiqun Han, Lina Zhang, Chengli Que, Jicheng Gong, Xinghua Qiu & Tong Zhu
Abstract Background Exposure to particulate matter air pollution is associated with an increased risk of cardiovascular mortality in patients with chronic obstructive pulmonary disease (COPD), but the underlying mechanisms are not yet understood. Enhanced platelet and pro-thrombotic activity in COPD patients may explain their increased cardiovascular risk. We aim to explore whether short-term exposure to ambient particulate matter is associated with pro-thrombotic changes in adults with and without COPD, and investigate the underlying biological mechanisms...

Additional file 1 of Deciphering chloramphenicol biotransformation mechanisms and microbial interactions via integrated multi-omics and cultivation-dependent approaches

Jiayu Zhang, Xiaoyan Li, Uli Klümper, Huaxin Lei, Thomas U. Berendonk, Fangliang Guo, Ke Yu, Chao Yang & Bing Li
Additional file 1: Table S1. The taxonomy, quality, and genome size of 18 MAGs. Table S2. The taxonomy, quality, and genomic information of seven isolated strains. Table S3. The information of proteins related to CAP biotransformation in Sphingomonas sp. CL5.1 revealed by proteomics.

Effect of Multi-Pass Rolling on the Performance of AZ31 Magnesium Alloy Anode in Mg-Air Battery

Jinchao Zou, Junpeng Wang, Zhiquan Huang & Tao Zhang
In this work, the influence of rolling passes on microstructure, corrosion behavior, electrochemical performance, and battery performance of AZ31 magnesium alloy was studied. The experimental results show that the grain size decreases first and then increases with rolling passes. Among them, the grain size of three passes rolled sample is the smallest, while the grain size of the four passes rolled sample is obviously refined and evenly distributed, accompanied by a small number of twins....

Additional file 1 of An optimized exosome production strategy for enhanced yield while without sacrificing cargo loading efficiency

Rongxin Zhang, Te Bu, Ruidan Cao, Zhelong Li, Chen Wang, Bing Huang, Mengying Wei, Lijun Yuan & Guodong Yang
Additional file 1: Figure S1. qPCR analysis of knockdown efficiency. A-L AML12 cells were transfected with siRNA against genes of interest and relative expression of Rab33b (A), Nfs (B), Rab9 (C), Vps18 (D), Rab22a (E), Rab35 (F), Rab24 (G), Vps39 (H), Rab14 (I), Rab4 (J), Rab11a (K) and Tfeb (L). Gapdh served as an internal reference gene. Data are expressed as mean $$\pm$$ ± SEM of three independent experiments. * p < 0.05 by t-test....

Additional file 1 of An optimized exosome production strategy for enhanced yield while without sacrificing cargo loading efficiency

Rongxin Zhang, Te Bu, Ruidan Cao, Zhelong Li, Chen Wang, Bing Huang, Mengying Wei, Lijun Yuan & Guodong Yang
Additional file 1: Figure S1. qPCR analysis of knockdown efficiency. A-L AML12 cells were transfected with siRNA against genes of interest and relative expression of Rab33b (A), Nfs (B), Rab9 (C), Vps18 (D), Rab22a (E), Rab35 (F), Rab24 (G), Vps39 (H), Rab14 (I), Rab4 (J), Rab11a (K) and Tfeb (L). Gapdh served as an internal reference gene. Data are expressed as mean $$\pm$$ ± SEM of three independent experiments. * p < 0.05 by t-test....

Coexistence of chronic hyperalgesia and multilevel neuroinflammatory responses after experimental SCI: a systematic approach to profiling neuropathic pain

Lei Wang, Mehmet A. Gunduz, Ana T. Semeano, Enis C. Yılmaz, Feras A. H. Alanazi, Ozan B. Imir, Ulas Yener, Christian A. Arbelaez, Esteban Usuga & Yang D. Teng
Abstract Background People with spinal cord injury (SCI) frequently develop neuropathic pain (NP) that worsens disability and diminishes rehabilitation efficacy. Chronic NP is presently incurable due to poor understanding of underlying mechanisms. We hypothesized that multilocus neuroinflammation (NIF) might be a driver of SCI NP, and tested it by investigating whether NP coexisted with central NIF, neurotransmission (NTM), neuromodulation (NML) and neuroplasticity (NPL) changes post-SCI. Methods Female Sprague–Dawley rats (230–250 g) with T10 compression or...

Additional file 1 of Identification of the origin of tumor in vein: comparison between CEUS LI-RADS v2017 and v2016 for patients at high risk

Wen-juan Tong, Mei-qing Cheng, Man-xia Lin, Hang-tong Hu, Jia-min Pan, Hui Huang, Ying Wang, Xiao-yan Xie, Ming-de Lu, Ming Kuang, Yang Huang & Wei Wang
Additional file 1. Section S1: The specific process of Focal liver lesion puncture biopsy procedure. Section S2: Image archiving and scanning parameters of CT and MRI. Table S1: FLLs with TIV images characteristics. Except where indicated, data are numbers of nodules or TIV cases and numbers in parentheses are percentages. * datas are Mean ± SD. / means NA. AP: Arterial phase; APHE: Arterial phase hyperenhancement; CEUS: Contrast-enhanced ultrasound; FLLs: Focal liver lesions; HCC: Hepatocellular...

Activation of arcuate nucleus glucagon-like peptide-1 receptor-expressing neurons suppresses food intake

Ishnoor Singh, Le Wang, Baijuan Xia, Ji Liu, Azeddine Tahiri, Abdelfattah El Ouaamari, Michael B. Wheeler & Zhiping P. Pang
Abstract Background Central nervous system (CNS) control of metabolism plays a pivotal role in maintaining energy balance. In the brain, Glucagon-like peptide 1 (GLP-1), encoded by the proglucagon ‘Gcg’ gene, produced in a distinct population of neurons in the nucleus tractus solitarius (NTS), has been shown to regulate feeding behavior leading to the suppression of appetite. However, neuronal networks that mediate endogenous GLP-1 action in the CNS on feeding and energy balance are not well...

Activation of arcuate nucleus glucagon-like peptide-1 receptor-expressing neurons suppresses food intake

Ishnoor Singh, Le Wang, Baijuan Xia, Ji Liu, Azeddine Tahiri, Abdelfattah El Ouaamari, Michael B. Wheeler & Zhiping P. Pang
Abstract Background Central nervous system (CNS) control of metabolism plays a pivotal role in maintaining energy balance. In the brain, Glucagon-like peptide 1 (GLP-1), encoded by the proglucagon ‘Gcg’ gene, produced in a distinct population of neurons in the nucleus tractus solitarius (NTS), has been shown to regulate feeding behavior leading to the suppression of appetite. However, neuronal networks that mediate endogenous GLP-1 action in the CNS on feeding and energy balance are not well...

Application of exome sequencing for prenatal diagnosis of fetal structural anomalies: clinical experience and lessons learned from a cohort of 1618 fetuses

Fang Fu, Ru Li, Qiuxia Yu, Dan Wang, Qiong Deng, Lushan Li, Tingying Lei, Guilan Chen, Zhiqiang Nie, Xin Yang, Jin Han, Min Pan, Li Zhen, Yongling Zhang, Xiangyi Jing, Fucheng Li, Fatao Li, Lina Zhang, Cuixing Yi, Yingsi Li, Yan Lu, Hang Zhou, Ken Cheng, Jian Li, Lina Xiang … & Can Liao
Abstract Background Exome sequencing (ES) is becoming more widely available in prenatal diagnosis. However, data on its clinical utility and integration into clinical management remain limited in practice. Herein, we report our experience implementing prenatal ES (pES) in a large cohort of fetuses with anomalies detected by ultrasonography using a hospital-based in-house multidisciplinary team (MDT) facilitated by a three-step genotype-driven followed by phenotype-driven analysis framework. Methods We performed pES in 1618 fetal cases with positive...

Additional file 2 of The causal associations of circulating amino acids with blood pressure: a Mendelian randomization study

Chenhao Lin, Zhonghan Sun, Zhendong Mei, Hailuan Zeng, Manying Zhao, Jianying Hu, Mingfeng Xia, Tao Huang, Chaolong Wang, Xin Gao & Yan Zheng
Additional file 2. STROBE-MR checklist.

Additional file 2 of Oral health and depressive symptoms among older adults in urban China: a moderated mediation model analysis

Qian Sun, Youwei Wang & Qingsong Chang
Additional file 2.

Oral health and depressive symptoms among older adults in urban China: a moderated mediation model analysis

Qian Sun, Youwei Wang & Qingsong Chang
Abstract Background This study explored the association between oral health and depression occurs via daily dietary satisfaction as a mediator, and that body mass index could moderate the path between daily dietary satisfaction and depression. Methods Data for this research were derived from a community survey adopting quota sampling in the cities of Tianjin and Shijiazhuang in mainland China in 2020 (N = 781). The moderated mediation model was tested by using bootstrapping with resampling...

Additional file 1 of Application of exome sequencing for prenatal diagnosis of fetal structural anomalies: clinical experience and lessons learned from a cohort of 1618 fetuses

Fang Fu, Ru Li, Qiuxia Yu, Dan Wang, Qiong Deng, Lushan Li, Tingying Lei, Guilan Chen, Zhiqiang Nie, Xin Yang, Jin Han, Min Pan, Li Zhen, Yongling Zhang, Xiangyi Jing, Fucheng Li, Fatao Li, Lina Zhang, Cuixing Yi, Yingsi Li, Yan Lu, Hang Zhou, Ken Cheng, Jian Li, Lina Xiang … & Can Liao
Additional file 1. Analysis and interpretation process of fetal ES data.

C9orf16 represents the aberrant genetic programs and drives the progression of PDAC

Xiaojun Chen, Hong Zhang & Bo Xiao
Abstract Background Pancreatic ductal adenocarcinoma (PDAC), constituting 90% of pancreatic cancers, is the fourth leading cause of cancer-related deaths in the world. Lack of early detection of PDAC contributes to its poor prognosis as patients are often diagnosed at an advanced stage of disease. This is mostly due to the lack of promising diagnostic and therapeutic targets and corresponding drugs. Methods and results Here, by bioinformatic analysis of single cell RNA-sequencing data on normal pancreas...

Additional file 3 of Identification of tumor-associated antigens and immune subtypes of lower-grade glioma and glioblastoma for mRNA vaccine development

Zhi-liang Wang, Ruo-yu Huang, Bo Han, Fan Wu, Zhi-yan Sun, Guan-zhang Li, Wei Zhang, Zheng Zhao & Xing Liu
Additional file 3: Supplementary Figure 3.

Additional file 4 of Identification of tumor-associated antigens and immune subtypes of lower-grade glioma and glioblastoma for mRNA vaccine development

Zhi-liang Wang, Ruo-yu Huang, Bo Han, Fan Wu, Zhi-yan Sun, Guan-zhang Li, Wei Zhang, Zheng Zhao & Xing Liu
Additional file 4: Supplementary Figure 4.

Additional file 5 of Identification of tumor-associated antigens and immune subtypes of lower-grade glioma and glioblastoma for mRNA vaccine development

Zhi-liang Wang, Ruo-yu Huang, Bo Han, Fan Wu, Zhi-yan Sun, Guan-zhang Li, Wei Zhang, Zheng Zhao & Xing Liu
Additional file 5: Supplementary Figure 5.

Identification of tumor-associated antigens and immune subtypes of lower-grade glioma and glioblastoma for mRNA vaccine development

Zhi-liang Wang, Ruo-yu Huang, Bo Han, Fan Wu, Zhi-yan Sun, Guan-zhang Li, Wei Zhang, Zheng Zhao & Xing Liu
Abstract Background mRNA became a promising therapeutic approach in many diseases. This study aimed to identify the tumor antigens specifically expressed in tumor cells for lower-grade glioma (LGG) and glioblastoma (GBM) patients. Methods In this work, the mRNA microarray expression profile and clinical data were obtained from 301 samples in the Chinese Glioma Genome Atlas (CGGA) database, the mRNA sequencing data and clinical data of 701 samples were downloaded from The Cancer Genome Atlas (TCGA)...

Additional file 1 of The distribution of bioactive gibberellins along peach annual shoots is closely associated with PpGA20ox and PpGA2ox expression profiles

Mengmeng Zhang, Yangtao Ma, Xianbo Zheng, Bin Tan, Xia Ye, Wei Wang, Langlang Zhang, Jidong Li, Zhiqian Li, Jun Cheng & Jiancan Feng
Additional file 1: Figure S1. Verification of PpKO gene structure using the alignment results of reads obtained from the transcriptome of peach flowers, stems, fruits and pits. Figure S2. Sequence alignment of GA20ox from Arabidopsis and peach. The LPWKET motif are underlined. Figure S3. The phylogenetic trees of CPS (A), KS (B), KO (C), KAO (D) and GA3ox (E). The amino acid sequences were downloaded from Phytozome database and the Gene ID are listed after...

Additional file 2 of Activation of arcuate nucleus glucagon-like peptide-1 receptor-expressing neurons suppresses food intake

Ishnoor Singh, Le Wang, Baijuan Xia, Ji Liu, Azeddine Tahiri, Abdelfattah El Ouaamari, Michael B. Wheeler & Zhiping P. Pang
Additional file 2: Figure S2. GLP-1 receptor neuron distribution in the whole brain. Representative images of GLP-1R-ires-cre mouse crossed with Ai14 tdTomato reporter mice line.

sj-docx-1-tah-10.1177_20406207221134409 – Supplemental material for Association between haploidentical hematopoietic stem cell transplantation combined with an umbilical cord blood unit and graft-versus-host disease in pediatric patients with acquired severe aplastic anemia

Di Yao, Yuanyuan Tian, Jie Li, Bohan Li, Jun Lu, Jing Ling, Defei Zheng, Yanhua Yao, Peifang Xiao, Lijun Meng & Shaoyan Hu
Supplemental material, sj-docx-1-tah-10.1177_20406207221134409 for Association between haploidentical hematopoietic stem cell transplantation combined with an umbilical cord blood unit and graft-versus-host disease in pediatric patients with acquired severe aplastic anemia by Di Yao, Yuanyuan Tian, Jie Li, Bohan Li, Jun Lu, Jing Ling, Defei Zheng, Yanhua Yao, Peifang Xiao, Lijun Meng and Shaoyan Hu in Therapeutic Advances in Hematology

Association between haploidentical hematopoietic stem cell transplantation combined with an umbilical cord blood unit and graft-versus-host disease in pediatric patients with acquired severe aplastic anemia

Di Yao, Yuanyuan Tian, Jie Li, Bohan Li, Jun Lu, Jing Ling, Defei Zheng, Yanhua Yao, Peifang Xiao, Lijun Meng & Shaoyan Hu
Background:Haploidentical hematopoietic stem cell transplantation (haplo-HSCT) based on granulocyte colony-stimulating factor plus anti-thymocyte regimens (‘Beijing Protocol’) provides a salvage treatment for patients of acquired severe aplastic anemia (SAA) in China. However, graft-versus-host disease (GVHD) is a major impediment of haplo-HSCT due to human leukocyte antigen disparity. Recently, haplo-HSCT combined with umbilical cord blood (UCB) (haplo-cord HSCT) is performed in clinical trials to potentially reduce the risk of severe GVHD. Nevertheless, studies comparing GVHD in pediatric...

In search of the ‘buffering’ effect in the job demands–control model: The role of teamwork HRM practices and occupations

Min Zou, Ying Zhou & Mark Williams
The job demands–control/support (JDC/JDCS) models are highly influential in the HRM and employee well-being literature. Despite the high face validity, however, research has failed to find convincing empirical support for the ‘buffer’ hypothesis suggested by the JDC/JDCS models. In this article the authors explore this issue from three perspectives. First, they test the controversial ‘buffer’ hypothesis using a large nationally representative matched employer–employee sample from Britain. Second, they examine the role of teamwork HRM practices...

Additional file 1 of Facile approach for surfactant-free synthesis of Au@ginsenoside Rh2 nanoparticles and researches on anticancer activity

Hua Yao, Xupeng Mu, Zhenhong Wei, Xiuying Li, Liya Wu, Yongri Jin, Xuwen Li, Jing Li & Jinlan Jiang
Additional file 1: Characterization of Au@ginsenoside Rh2 NPs and results of cell uptake and cell proliferation.

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