Additional file 2: Table S1. Detected gene levels upon methionine restriction in livers of HCC mouce models.

Abstract Background Exploiting cancer metabolism during nutrient availability holds immense potential for the clinical and therapeutic benefits of hepatocellular carcinoma (HCC) patients. Dietary methionine is a metabolic dependence of cancer development, but how the signal transduction integrates methionine status to achieve the physiological demand of cancer cells remains unknown. Methods Low or high levels of dietary methionine was fed to mouse models with patient-derived xenograft or diethyl-nitrosamine induced liver cancer. RNA sequence and metabolomics were...

Understanding and mastering the light-light and light-matter interactions in coupled structures have become a significant subject, as it provides versatile tools for manipulating light in both classical and quantum regimes. Mimicking quantum interference effects in pure photonic nanostructures, from weak Fano dip to intense electromagnetically induced transparency, usually requires strong asymmetries in complex geometries and larger interactions between resonances, i.e., in the intermediate coupling regime. Here, we numerically demonstrate a simple and chemically feasible plasmonic...

Whether long non-coding RNA Mir-99a-Let-7c Cluster Host Gene (LncRNA MIR99AHG) is involved in osteoporosis (OP) remains vague, so we hereby center on its implication. Old C57BL/6J mice were injected with the silencing lentivirus of MIR99AHG and subjected to microCT analysis and immunohistochemistry on osteogenic cells. The osteogenic differentiation of bone marrow mesenchymal stem cells (BMSCs) with or without transfection was determined by alkaline phosphatase (ALP) and Alizarin Red S staining. Total N(6)-methyladenosine (m6A) on the...

Additional file 1. Supplemental methods, tables, and figures.

Abstract Background Artificial intelligence (AI) algorithms are capable of automatically detecting contouring boundaries in medical images. However, the algorithms impact on clinical practice of cervical cancer are unclear. We aimed to develop an AI-assisted system for automatic contouring of the clinical target volume (CTV) and organs-at-risk (OARs) in cervical cancer radiotherapy and conduct clinical-based observations. Methods We first retrospectively collected data of 203 patients with cervical cancer from West China Hospital. The proposed method named...

Cascaded operations play an important role in traditional electronic computing systems for the realization of advanced strategies. Here, we introduce the idea of cascaded operations into all-optical spatial analog computing. The single function of the first-order operation is difficult to meet the requirements of practical applications in image recognition. The all-optical second-order spatial differentiators are implemented by cascading two first-order differential operation units, and the image edge detection of amplitude and phase objects are demonstrated....

Clinical application of autophagy proteins as prognostic biomarkers in colorectal cancer: a meta-analysis Supplementary tables 1-3

Supplemental material, sj-docx-1-jcc-10.1177_00220221221132810 for Unsociability and Psychological and School Adjustment in Chinese Children: The Moderating Effects of Peer Group Cultural Orientations by Siman Zhao, Mengting Liu, Xinyin Chen, Dan Li, Junsheng Liu and Shihong Liu in Journal of Cross-Cultural Psychology

This study examined the moderating effects of cultural orientations of peer groups on the relations between unsociability and psychological and school adjustment in Chinese children. Participants included 1,092 students (527 boys, M age = 12.21 years) in the sixth grade in elementary schools. Data on individualistic and collectivistic cultural orientations, unsociability, and adjustment were obtained from multiple sources including peer nominations, teacher ratings, self-reports, and school records. Using the Social Cognitive Map method, 193 peer...

Additional file 1: Figure S1. The AR−/− mice genotyping and the expression level of AR in AR−/− mice. (A) AR null allele were identified by northern blot analysis. The expected bands of ∼119 bp is observed in the wild-type mice while not seen in AR−/− mice. (B) Western blot analyze the AR expression in the AR−/− mice. (C) Immunofluorescence analyze the AR expression in the spinal cord of AR−/− mice at 3 day following BPRA...

Abstract Brachial plexus root avulsion (BPRA) is frequently caused by high-energy trauma including traffic accident and birth trauma, which will induces massive motoneurons (MNs) death as well as loss of motor and sensory function in the upper limb. The death of MNs is attributed to energy deficiency, neuroinflammation and oxidative stress at the injured ventral horn of spinal cord triggered by BPRA injury. It has been reported which aldose reductase (AR), an endogenous enzyme that...

Source_Data_Figure_2 and 3

Additional file 3: Figure S3. The funnel plots of Lp(a) on CVD.

We propose and experimentally demonstrate the generation of a circular polarization detector based on planar polarization holography. The detector is designed by constructing the interference field according to the null reconstruction effect (NRE). We create the multiplexed holograms which feature the combination of two sets of hologram patterns and operate with opposite circular polarization beams. In a few seconds, the exposure operation allows the polarization multiplexed holograms element to be generated, with functionality equivalent to...

Supplemental material, sj-docx-4-cre-10.1177_02692155221135729 for Effect of respiratory muscle training in patients with chronic kidney disease: A systematic review and meta-analysis of randomized controlled trials by Fan Zhang, Hui Wang, Yan Bai, Liuyan Huang and Huachun Zhang in Clinical Rehabilitation

Four new ferulic acid sucrose esters, β-D-(1-O-acetyl-6-O-trans-feruloyl)fructofuranosyl-a-D-2',6'-O-diacetylglucopyranoside (1), β-D-(1-O-acetyl-6-O-trans-feruloyl)fructofuranosyl-a-D-2',4'-O-diacetylglucopyranoside (2), β-D-(6-O-trans-feruloyl)fructofuranosyl-a-D-2',4',6'-O-triacetylglucopyranoside (3), β-D-(1-O-acetyl-6-O-trans-feruloyl)fructofuranosyl-a-D-4',6'-O-diacetylglucopyranoside (4), together with four known phenylpropanoids (5–8) were isolated from the rhizome of Sparganium stoloniferum (Graebn.) Buch.-Ham. ex Juz. Their structures were elucidated by chemical evidence and spectral analysis. Compounds 1–8 exhibited obvious inhibitory effects on ADP-induced platelet aggregation.

Additional file 10: Table S5. Spearman correlations significance (P-value) between ASVs and testicular genes in the photoperiod experiment.

Additional file 13: Table S8. Spearman correlation coefficients (r) between ASVs and testicular genes in the FMT experiment.

Additional file 1. Fitting parameters of HFRS, shigellosis, mumps, HFMD and scarlet fever by the LDE model in Jilin Province. (N is the upper limit of cumulative infectious disease cases; k is the correlation coefficient; c is a constant).

Additional file 15: Table S10. Spearman correlations of aggressive behavior with hormones and genes in the photoperiod experiment.

Additional file 15: Table S10. Spearman correlations of aggressive behavior with hormones and genes in the photoperiod experiment.

Two new isoquinoline alkaloids, hypecocarpinine (1) and leptocaramine (2) along with five known ones including leptopidine (3), corydamine (4), protopine (5), dihydroprotopine (6) and oxohydrastinine (7), were isolated from Hypecoum leptocarpum Hook. f. et Thoms. Structures of the compounds were elucidated using spectroscopic methods, including UV, IR, HR-ESI-MS, 1 D and 2 D NMR. The cytotoxic activities of these compounds were evaluated using MTT assay. The results showed that compounds 2, 4, and 7 have...

This file provides the data for figures in this paper, as well as the code that generates the data.

This file provides the data for figures in this paper, as well as the code that generates the data.