6,372 Works

Additional file 1 of Identification of the cuproptosis-related molecular subtypes and an immunotherapy prognostic model in hepatocellular carcinoma

Li Zhang, Jingwei Xu, Xiufeng Chu, Hongqiao Zhang, Xueyuan Yao, Jian Zhang & Yanwei Guo
Additional file1. Fig S1: The flow chart of this study. HCC, hepatocellular carcinoma. TMB, tumor mutation burden. TME, tumor microenvironment. GSVA, gene set variation analysis. GO, Gene Ontology. KEGG, Kyoto Encyclopedia.

Additional file 1 of The prognostic role of tumor mutation burden on survival of breast cancer: a systematic review and meta-analysis

Liyuan Ke, Su Li & Hongxia Cui
Additional file 1: Supplementary Figure 1. Forest plot of subgroup analysis for OS on type of therapy.

Additional file 1 of Characterization of key aroma compounds and regulation mechanism of aroma formation in local Binzi (Malus pumila × Malus asiatica) fruit

Qinghua Wang, Fan Gao, Xuexue Chen, Wenjiang Wu, Lei Wang, Jiangli Shi, Yun Huang, Yuanyue Shen, Guoliang Wu & Jiaxuan Guo
Additional file 1: Supplementary Fig. 1 Morphology of ‘HFBZ’ and ‘LFBZ’ fruit at harvest. a ‘HFBZ’ fruit (Left) and ‘LFBZ’ (Right) fruit. b Transverse and longitudinal diameter, and weight of ‘HFBZ’ and ‘LFBZ’ fruit. c Anthocyanin content of ‘HFBZ’ and ‘LFBZ’ fruit. The scale bar is 1 cm in a. Supplementary Fig. 2 Liquid chromatography profiles of sucrose, glucose, and fructose standards. Supplementary Fig. 3 Chromatograms of free amino acid standard (a) and free amino...

Assessing the feasibility of sustaining SARS-CoV-2 local containment in China in the era of highly transmissible variants

Yan Wang, Kaiyuan Sun, Zhaomin Feng, Lan Yi, Yanpeng Wu, Hengcong Liu, Quanyi Wang, Marco Ajelli, Cécile Viboud & Hongjie Yu
Abstract Background The SARS-CoV-2 containment strategy has been successful in mainland China prior to the emergence of Omicron. However, in the era of highly transmissible variants, whether it is possible for China to sustain a local containment policy and under what conditions China could transition away from it are of paramount importance at the current stage of the pandemic. Methods We developed a spatially structured, fully stochastic, individual-based SARS-CoV-2 transmission model to evaluate the feasibility...

Additional file 23 of Beneficial effect of the short-chain fatty acid propionate on vascular calcification through intestinal microbiota remodelling

Jianlong Yan, Yanbin Pan, Wenming Shao, Caiping Wang, Rongning Wang, Yaqiong He, Min Zhang, Yongshun Wang, Tangzhiming Li, Zhefeng Wang, Wenxing Liu, Zhenmin Wang, Xin Sun & Shaohong Dong
Additional file 23: Supplementary Figure 12. SCFAs for external standard curves and control environmental acetate contamination. (a), (b) and (c) External standard curves of short-chain fatty acids (acetic acid, propionate, butyrate) standards in plasma samples. (d), (e) and (f) External standard curves of short-chain fatty acids (acetic acid, propionate, butyrate) standards in faecal samples. (g) Peak time of acetonitrile. (h) Peak time of acetic acid.

Additional file 24 of Beneficial effect of the short-chain fatty acid propionate on vascular calcification through intestinal microbiota remodelling

Jianlong Yan, Yanbin Pan, Wenming Shao, Caiping Wang, Rongning Wang, Yaqiong He, Min Zhang, Yongshun Wang, Tangzhiming Li, Zhefeng Wang, Wenxing Liu, Zhenmin Wang, Xin Sun & Shaohong Dong
Additional file 24: Supplementary Table 12. Univariate and multivariate regression analysis of risk factors for vascular calcification in the participants with plasma samples.

Additional file 2 of Beneficial effect of the short-chain fatty acid propionate on vascular calcification through intestinal microbiota remodelling

Jianlong Yan, Yanbin Pan, Wenming Shao, Caiping Wang, Rongning Wang, Yaqiong He, Min Zhang, Yongshun Wang, Tangzhiming Li, Zhefeng Wang, Wenxing Liu, Zhenmin Wang, Xin Sun & Shaohong Dong
Additional file 2: Supplementary Table 2. Characteristics of the participants at baseline in faecal samples.

Additional file 5 of Beneficial effect of the short-chain fatty acid propionate on vascular calcification through intestinal microbiota remodelling

Jianlong Yan, Yanbin Pan, Wenming Shao, Caiping Wang, Rongning Wang, Yaqiong He, Min Zhang, Yongshun Wang, Tangzhiming Li, Zhefeng Wang, Wenxing Liu, Zhenmin Wang, Xin Sun & Shaohong Dong
Additional file 5: Supplementary Figure 1. Amelioration of VND-induced rat vascular calcification and reduction of inflammation by rectal propionate administration. (a) A flow diagram of the rectal propionate administration experiment. (b) Macroscopic observation of arterial vascular calcification based on alizarin red staining. (c) Quantitative evaluation of calcium content in whole aortas. (d) Observation of vascular calcification of the ascending aorta through alizarin red staining of tissue sections (original magnification ×40). (e) Relative quantification of calcium...

Additional file 4 of Chronic constriction injury-induced changes in circular RNA expression profiling of the dorsal root ganglion in a rat model of neuropathic pain

Wanxia Xiong, Min Wei, Li Zhang, Jie Wang, Fan Liu & Zhiyao Wang
Additional file 4: Table S4. List of circRNAs and miRNA predicted by using miRanda and TargetScan. Potential connections between circRNAs and microRNAs were predicted by using TargetScan and miRanda, and the interaction results were displayed by Cytoscape. All the circRNAs and miRNAs were listed.

Chronic constriction injury-induced changes in circular RNA expression profiling of the dorsal root ganglion in a rat model of neuropathic pain

Wanxia Xiong, Min Wei, Li Zhang, Jie Wang, Fan Liu & Zhiyao Wang
Abstract Background The pathogenesis of neuropathic pain (NP) has not been fully elucidated. Gene changes in dorsal root ganglia (DRG) may contribute to the development of NP. Circular RNAs (circRNAs) are a class of endogenous noncoding RNAs that form covalently closed loop structures and are crucial for genetic and epigenetic regulation. However, little is known about circRNA changes in DRG neurons after peripheral nerve injury. Methods A sciatic nerve chronic constriction injury (CCI) model was...

Chronic constriction injury-induced changes in circular RNA expression profiling of the dorsal root ganglion in a rat model of neuropathic pain

Wanxia Xiong, Min Wei, Li Zhang, Jie Wang, Fan Liu & Zhiyao Wang
Abstract Background The pathogenesis of neuropathic pain (NP) has not been fully elucidated. Gene changes in dorsal root ganglia (DRG) may contribute to the development of NP. Circular RNAs (circRNAs) are a class of endogenous noncoding RNAs that form covalently closed loop structures and are crucial for genetic and epigenetic regulation. However, little is known about circRNA changes in DRG neurons after peripheral nerve injury. Methods A sciatic nerve chronic constriction injury (CCI) model was...

Sleep apnea is associated with the increase of certain genera of Ruminococcaceae and Lachnospiraceae in the gut microbiome of hypertensive patients

Cheng Zhang, Fengwei Chen, Yane Shen, Yuqing Chen & Jing Ma
Obstructive sleep apnea (OSA) and hypertension are interrelated diseases linked to gut dysbiosis. This study aimed to investigate the effect of OSA on the gut microbiome in the context of hypertension and vice versa. Of 211 consecutively screened patients, 52 completed polysomnography study, medical history questionnaires, and fecal sample collection. 16S rRNA gene sequencing was performed on fecal samples, and diversity, richness, and microbial taxa were analyzed using bioinformatics. Alpha diversity showed slightly decreased diversity...

Additional file 1 of Degree of protection provided by poverty alleviation policies for the middle-aged and older in China: evaluation of effectiveness of medical insurance system tools and vulnerable target recognition

Wanxin Tian, Bing Wu, Yahong Yang, Yongqiang Lai, Wenqing Miao, Xiyu Zhang, Chenxi Zhang, Qi Xia, Linghan Shan, Huiying Yang, Huiqi Yang, Zhipeng Huang, Yuze Li, Yiyun Zhang, Fan Ding, Yulu Tian, Hongyu Li, Xinwei Liu, Ye Li & Qunhong Wu
Additional file 1. Comparison of major basic medical insurance systems in China.

Additional file 23 of Evolution of different rice ecotypes and genetic basis of flooding adaptability in Deepwater rice by GWAS

Xueqiang Wang, Yan Zhao, Conghui Jiang, Libing Wang, Lei Chen, Fengmei Li, Yanhong Zhang, Yinghua Pan & Tianzhen Zhang
Additional file 23 Table S22. The cloned genes for deepwater and heat map of the ratio of RPKM.

Additional file 24 of Evolution of different rice ecotypes and genetic basis of flooding adaptability in Deepwater rice by GWAS

Xueqiang Wang, Yan Zhao, Conghui Jiang, Libing Wang, Lei Chen, Fengmei Li, Yanhong Zhang, Yinghua Pan & Tianzhen Zhang
Additional file 24 Table S23. Haplotype analysis of the candidate genes for deepwater QTLs.

Additional file 3 of Evolution of different rice ecotypes and genetic basis of flooding adaptability in Deepwater rice by GWAS

Xueqiang Wang, Yan Zhao, Conghui Jiang, Libing Wang, Lei Chen, Fengmei Li, Yanhong Zhang, Yinghua Pan & Tianzhen Zhang
Additional file 3 Fig. S1 PCA plot of the first two eigenvectors (a) and two and three eigenvectors (b) of rice accessions. Additional file 2. Fig. S2 Maximum-likelihood tree of rice assuming 0 to 3 migration edges. Additional file 2. Fig. S3 Corresponding residual of rice assuming 0 to 10 migration edges. Additional file 2. Fig. S4 Genome-wide detection of positive selection in different rice ecotypes. Additional file 2. Fig. S5 Selective sweep regions identified...

Additional file 9 of Evolution of different rice ecotypes and genetic basis of flooding adaptability in Deepwater rice by GWAS

Xueqiang Wang, Yan Zhao, Conghui Jiang, Libing Wang, Lei Chen, Fengmei Li, Yanhong Zhang, Yinghua Pan & Tianzhen Zhang
Additional file 9 Table S8. Genome-wide detection of positive selection in upland GJ rice.

Impact of antiretroviral therapy (ART) duration on ART adherence among men who have sex with men (MSM) living with HIV in Jinan of China

Kedi Jiao, Meizhen Liao, Guangmei Liu, Yanmei Bi, Xiuhong Zhao, Qian Chen, Jing Ma, Yu Yan, Chunxiao Cheng, Yijun Li, Wenwen Jia, Lina Wang, Yanwen Cao, Zhonghui Zhao, Xuan Yang, Jing Meng, Jianzhuo Li, Xinrui Li, Chunmei Wang, Dianmin Kang & Wei Ma
Abstract Background Consistent and complete adherence is considered an essential requirement for patients on antiretroviral therapy (ART). This study aimed to evaluate the impact of ART duration on ART adherence, identify the trend of complete adherence, and compare the factors associated with ART adherence between short-term and long-term ART group among men who have sex with men (MSM) living with HIV in Jinan of China. Methods MSM living with HIV aged 18 or above and...

Supplementary document for Temporal modulation of nonlinear ionization process in femtosecond laser pulse induced periodic surface structures - 6117294.pdf

Ying Sun, Weiyi Yin, Qian Yao, Xiangyu Ren, Juan Song & Ye Dai
supplement 1

Additional file 1 of Change lifestyle modification plan/transtheoretical model in non-alcoholic simple fatty liver disease: a pilot randomized study

Lijuan Li, Kun Hou, Mengya Yuan, Yan Zhang & Yang Zhang
Supplementary Material 1. Supplementary Table 1. Transtheoretical Model and stages of change-oriented lifestyle intervention strategies and measures for simple fatty liver disease patients. Supplementary Table 2. Comparison of healthy behavior levels of the 2 groups (controls vs. transtheoretical model and stages of change) before and after intervention.

Additional file 5 of Effectiveness of WeChat-group-based parental health education in preventing unintentional injuries among children aged 0–3: randomized controlled trial in Shanghai

Yuheng Feng, Xueqi Ma, Qi Zhang, Ruo Jiang, Jun Lu, Kaiyue Chen, Huiping Wang, Qinghua Xia, Jicui Zheng, Jingwei Xia & Xiaohong Li
Additional file 5: Table S2. The details of questionnaire.

Additional file 1 of Triclosan exposure induced disturbance of gut microbiota and exaggerated experimental colitis in mice

Jing Liu, Yang Tao, Wang Haikun, Yang Lanfang, Lu Jingyi & Yao Ping
Supplementary Material 1

Additional file 3 of CX3CL1 promotes cell sensitivity to ferroptosis and is associated with the tumor microenvironment in clear cell renal cell carcinoma

Qiming Gong, Zhiting Guo, Wenjuan Sun, Xiuri Du, Yan Jiang & Fahui Liu
Additional file 3: Supplementary Fig. 2. The relationship between CX3CL1 and necroptosis, autophagy, and apoptosis. (A) 786-O cells were incubated with Necrostatin-1 (0, 5, 10, 15 μM/ml) for 6, 12, and 24 h. Then cell viability was estimated using the CCK-8 assay. (B) 786-O cells were incubated with CQ (0, 5, 15, 25 and 35 μM/ml) for 12, 24, and 48 h. Then cell viability was estimated using the CCK-8 assay. (C) 786-O cells were...

CX3CL1 promotes cell sensitivity to ferroptosis and is associated with the tumor microenvironment in clear cell renal cell carcinoma

Qiming Gong, Zhiting Guo, Wenjuan Sun, Xiuri Du, Yan Jiang & Fahui Liu
Abstract Background An increasing number of studies have demonstrated that CX3CL1 is involved in the development of tumors and may thus be considered a new potential therapeutic target for them. However, the function of CX3CL1 in clear cell renal cell carcinoma (ccRCC) remains poorly defined. Methods The pan-cancer expression pattern and prognostic value of CX3CL1 were evaluated in this study. Moreover, the relationship of CX3CL1 expression with the tumor microenvironment, especially the tumor immune microenvironment,...

Opposing effects of apoE2 and apoE4 on microglial activation and lipid metabolism in response to demyelination

Na Wang, Minghui Wang, Suren Jeevaratnam, Cassandra Rosenberg, Tadafumi C. Ikezu, Francis Shue, Sydney V. Doss, Alla Alnobani, Yuka A. Martens, Melissa Wren, Yan W. Asmann, Bin Zhang, Guojun Bu & Chia-Chen Liu
Abstract Background Abnormal lipid accumulation has been recognized as a key element of immune dysregulation in microglia whose dysfunction contributes to neurodegenerative diseases. Microglia play essential roles in the clearance of lipid-rich cellular debris upon myelin damage or demyelination, a common pathogenic event in neuronal disorders. Apolipoprotein E (apoE) plays a pivotal role in brain lipid homeostasis; however, the apoE isoform-dependent mechanisms regulating microglial response upon demyelination remain unclear. Methods To determine how apoE isoforms...

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