12 Works

Data from: Delimiting tropical mountain ecoregions for conservation

Philip J. Platts, Neil D. Burgess, Roy E. Gereau, Jon C. Lovett, Andrew R. Marshall, Colin J. McClean, Petri K. E. Pellikka, Ruth D. Swetnam & Rob Marchant
Ecological regions aggregate habitats with similar biophysical characteristics within well-defined boundaries, providing spatially consistent platforms for monitoring, managing and forecasting the health of interrelated ecosystems. A major obstacle to the implementation of this approach is imprecise and inconsistent boundary placement. For globally important mountain regions such as the Eastern Arc (Tanzania and Kenya), where qualitative definitions of biophysical affinity are well established, rule-based methods for landform classification provide a straightforward solution to ambiguities in region...

The Information Market for Research and Higher Education. How to integrate all relevant information in a network of repositories?

Hans E. Roosendaal
The information market for research and Higher Education (HE) will in future be based on a federated network of repositories of information relating to research and education that conform to open standards, and an accommodating infrastructure that allows users the easiest and fastest possible access to information in all of these repositories. The information covered by such a network will not only comprise of information material for research and HE, including grey information, but also...

Data from: Exogenous α-synuclein hinders synaptic communication in cultured cortical primary rat neurons

Gerco C. Hassink, Christian C. Raiss, M.J. Segers-Nolten, Richard J.A. Van Wezel, Vinod Subramaniam, Joost Le Feber, Mireille M.A.E. Claessens, M. M. A. E. Claessens, R. J. A. Van Wezel & I. M. J. Segers-Nolten
Amyloid aggregates of the protein α-synuclein (αS) called Lewy Bodies (LB) and Lewy Neurites (LN) are the pathological hallmark of Parkinson's disease (PD) and other synucleinopathies. We have previously shown that high extracellular αS concentrations can be toxic to cells and that neurons take up αS. Here we aimed to get more insight into the toxicity mechanism associated with high extracellular αS concentrations (50-100 μM). High extracellular αS concentrations resulted in a reduction of the...

Experimental 3D Velocity Field in Random Sphere Packing

Mathieu Souzy, Henri Lhuissier, Yves Méheust, Tanguy Le Borgne & Bloen Metzger

The Chronological Development of Coaching and Mentoring: Side by Side Disciplines

Ruud Koopman, Paula Danskin Englis, Michel L. Ehgrenhard & Aard Groen

Maximum entropy model estimates functional connectivity

Martina Lamberti
Tools to estimate brain connectivity have been useful to improve our understanding of brain functioning. Reduced models ofcultured neurons are often used to study the behavior of neuronal networks, including functional connectivity and how it mightbe affected by external stimuli. Cultured neurons tend to be active in ensembles, and when pairs of neurons show significantsynchronicity in their firing patterns they are said to be functionally connected. The most common methods to infer functionalconnections are based...

Data from: 18F-fluorodeoxyglucose positron-emission tomography (FDG-PET)-Radiomics of metastatic lymph nodes and primary tumor in non-small cell lung cancer (NSCLC) – A prospective externally validated study

Sara Carvalho, Ralph T. H. Leijienaar, Esther G. C. Troost, Janna E. Van Timmeren, Cary Oberije, Wouter Van Elmpt, Lioe-Fee De Geus-Oei, Johan Bussink, Philippe Lambin & Ralph T. H. Leijenaar
Background: Lymph node stage prior to treatment is strongly related to disease progression and poor prognosis in non-small cell lung cancer (NSCLC). However, few studies have investigated metabolic imaging features derived from pre-radiotherapy 18F-fluorodeoxyglucose (FDG) positron-emission tomography (PET) of metastatic hilar/mediastinal lymph nodes (LNs). We hypothesized that these would provide complementary prognostic information to FDG-PET descriptors to only the primary tumor (tumor). Methods: Two independent cohorts of 262 and 50 node-positive NSCLC patients were used...

Photo-responsive Bioactive Surfaces Based on Cucurbit[8]uril-Mediated Host-Guest Interactions of Arylazopyrazoles

Bart Jan Ravoo, Maike Wiemann, Rebecca Niebuhr, Alberto Juan, Emanuela Cavatorta & Pascal Jonkheijm
Abstract A photoswitchable arylazopyrazole (AAP) derivative binds with cucurbit[8]uril (CB[8]) and methylviologen (MV2+) to form a 1:1:1 heteroternary host–guest complex with a binding constant of ...

Data from: Progression of neuronal damage in an in vitro model of the ischemic penumbra

Joost Le Feber, Stelina Tzafi Pavlidou, Niels Erkamp, Michel J. A. M. Van Putten & Jeannette Hofmeijer
Improvement of neuronal recovery in the ischemic penumbra around a brain infarct has a large potential to advance clinical recovery of patients with acute ischemic stroke. However, pathophysiological mechanisms leading to either recovery or secondary damage in the penumbra are not completely understood. We studied neuronal dynamics in a model system of the penumbra consisting of networks of cultured cortical neurons exposed to controlled levels and durations of hypoxia. Short periods of hypoxia (pO2≈20mmHg) reduced...

Data from: Past distribution of epiphyllous liverworts in China: the usability of historical data

Yanbin Jiang, Tiejun Wang, Yupeng Wu, Ronggui Hu, Ke Huang & Xiaoming Shao
Epiphyllous liverworts form a special group of bryophytes that primarily grow on the leaves of understory vascular plants in tropical and subtropical evergreen broadleaf forests. Being sensitive to moisture and temperature changes, epiphyllous liverworts are often consider to be good indicators of climate change and forest degradation. However, they are a poorly collected and taxonomically complicated group, with an only partly identified distribution pattern. In this study, we built four models based on 24 environmental...

Data from: Large birds travel farther in homogeneous environments

Marlee A. Tucker, Olga Alexandrou, , Keith L. Bildstein, Katrin Böhning-Gaese, Chloe Bracis, John N. Brzorad, Evan R. Buechley, David Cabot, Justin M. Calabrese, Carlos Carrapato, André Chiaradia, Lisa C. Davenport, Sarah C. Davidson, Mark Desholm, Christopher R. DeSorbo, Robert Domenech, Peter Enggist, William F. Fagan, Nina Farwig, Wolfgang Fiedler, Christen H. Fleming, Alastair Franke, John M. Fryxell, Clara García-Ripollés … & João Paulo Silva
Aim: Animal movement is an important determinant of individual survival, population dynamics, and ecosystem structure and function. Yet it is still unclear how local movements are related to resource availability and the spatial arrangement of resources. Using resident bird species and migratory bird species outside of the migratory period, we examined how the distribution of resources affect the movement patterns of both large terrestrial birds (e.g., raptors, bustards, hornbills) and waterbirds (e.g., cranes, storks, ducks,...

Data from: Deformability assessment of waterborne protozoa using a microfluidic-enabled force microscopy probe

John S. McGrath, Jos Quist, James R. T. Seddon, Stanley C. S. Lai, Serge G. Lemay & Helen L. Bridle
Many modern filtration technologies are incapable of the complete removal of Cryptosporidium oocysts from drinking-water. Consequently, Cryptosporidium-contaminated drinking-water supplies can severely implicate both water utilities and consumers. Existing methods for the detection of Cryptosporidium in drinking-water do not discern between non-pathogenic and pathogenic species, nor between viable and non-viable oocysts. Using FluidFM, a novel force spectroscopy method employing microchannelled cantilevers for single-cell level manipulation, we assessed the size and deformability properties of two species of...

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