6 Works

Data from: Restoring Study 329: efficacy and harms of paroxetine and imipramine in treatment of major depression in adolescence

Joanna C. Le Noury, John M. Nardo, David Healy, Jon Jureidini, Melissa Raven, Catalin Tufanaru & Elia Abi-Jaoude
Objectives: To reanalyse SmithKline Beecham’s Study 329 (published by Keller and colleagues in 2001), the primary objective of which was to compare the efficacy and safety of paroxetine and imipramine with placebo in the treatment of adolescents with unipolar major depression. The reanalysis under the restoring invisible and abandoned trials (RIAT) initiative was done to see whether access to and reanalysis of a full dataset from a randomised controlled trial would have clinically relevant implications...

Data from: Widespread parallel population adaptation to climate variation across a radiation: implications for adaptation to climate change.

Roger S. Thorpe, Axel Barlow, Anita Malhotra & Yann Surget-Groba
Global warming will impact species in a number of ways, and it is important to know the extent to which natural populations can adapt to anthropogenic climate change by natural selection. Parallel microevolution within separate species can demonstrate natural selection, but several studies of homoplasy have not yet revealed examples of widespread parallel evolution in a generic radiation. Taking into account primary phylogeographic divisions, we investigate numerous quantitative traits (size, shape, scalation, colour pattern and...

Data from: Transcriptomic analysis of the lesser spotted catshark (Scyliorhinus canicula) pancreas, liver and brain reveals molecular level conservation of vertebrate pancreas function

John F. Mulley, Adam D. Hargreaves, Matthew J. Hegarty, R. Scott Heller & Martin T. Swain
Background: Understanding the evolution of the vertebrate pancreas is key to understanding its functions. The chondrichthyes (cartilaginous fish such as sharks and rays) have often been suggested to possess the most ancient example of a distinct pancreas with both hormonal (endocrine) and digestive (exocrine) roles. The lack of genetic, genomic and transcriptomic data for cartilaginous fish has hindered a more thorough understanding of the molecular-level functions of the chondrichthyan pancreas, particularly with respect to their...

Coastal Biodiversity and Ecosystem Service Sustainability (CBESS) dry weight root biomass from three soil depths on salt marsh sites at Morecambe Bay and Essex

H. Ford, A. Garbutt & M. Skov
The dataset comprises of dry weight root biomass data collected from 0 cm to 10 cm, 10 cm to 20 cm and 20 cm to 30 cm soil depths from six salt marsh sites. Three of the sites were in Morecambe Bay, North West England and three of the sites were in Essex, South East England. The Morecambe Bay samples were taken during the winter and summer of 2013. The Essex samples were taken during...

Data from: Genomic islands of speciation separate cichlid ecomorphs in an East African crater lake

Milan Malinsky, Richard J. Challis, Alexandra M. Tyers, Stephan Schiffels, Yohey Terai, Benjamin P. Ngatunga, Eric A. Miska, Richard Durbin, Martin J. Genner & George F. Turner
The genomic causes and effects of divergent ecological selection during speciation are still poorly understood. Here we report the discovery and detailed characterization of early-stage adaptive divergence of two cichlid fish ecomorphs in a small (700 meters in diameter) isolated crater lake in Tanzania. The ecomorphs differ in depth preference, male breeding color, body shape, diet, and trophic morphology. With whole-genome sequences of 146 fish, we identified 98 clearly demarcated genomic “islands” of high differentiation...

Data from: The importance of being genomic: non-coding and coding sequences suggest different models of toxin multi-gene family evolution

Anita Malhotra, Simon Creer, John B. Harris & Roger S. Thorpe
Studies of multi-gene protein families, including many toxins, are crucial for understanding the role of gene duplication in generating protein diversity in general. However, many evolutionary analyses of gene families are based on coding sequences, and do not take into account many potentially confounding evolutionary factors, such as recombination and convergence due to selection. We illustrate this using snake venom gene sequences from the Phospholipase A2 (PLA2) subfamily. Novel gene sequences from 20 species of...

Registration Year

  • 2015
    6

Resource Types

  • Dataset
    6

Affiliations

  • Bangor University
    6
  • University of Adelaide
    1
  • Tanzania Fisheries Research Institute
    1
  • Centre for Ecology & Hydrology
    1
  • Newcastle University
    1
  • Emory University
    1
  • SickKids Foundation
    1
  • Institute of Biological, Environmental and Rural Sciences
    1
  • University of Bristol
    1
  • Wellcome Sanger Institute
    1