47 Works

sj-docx-1-dhj-10.1177_20552076231152989 - Supplemental material for Driving time-based identification of gaps in specialised care coverage: An example of neuroinflammatory diseases in Germany

Lars Masanneck, Saskia Räuber, Christina B Schroeter, Sophie Lehnerer, Tjalf Ziemssen, Tobias Ruck, Sven G. Meuth & Marc Pawlitzki
Supplemental material, sj-docx-1-dhj-10.1177_20552076231152989 for Driving time-based identification of gaps in specialised care coverage: An example of neuroinflammatory diseases in Germany by Lars Masanneck, Saskia Räuber, Christina B Schroeter, Sophie Lehnerer, Tjalf Ziemssen, Tobias Ruck, Sven G. Meuth and Marc Pawlitzki in Digital Health

A genome-wide transcriptomic analysis of embryos fathered by obese males in a murine model of diet-induced obesity

Laura Bernhardt, Marcus Dittrich, Rabih El-Merahbi, Antoine-Emmanuel Saliba, Tobias Müller, Grzegorz Sumara, Jörg Vogel, Stefanie Nichols-Burns, Megan Mitchell, Thomas Haaf & Nady El Hajj
Paternal obesity is known to have a negative impact on the male’s reproductive health as well as the health of his offspring. Although epigenetic mechanisms have been implicated in the non-genetic transmission of acquired traits, the effect of paternal obesity on gene expression in the preimplantation embryo has not been fully studied. To this end, we investigated whether paternal obesity is associated with gene expression changes in eight-cell stage embryos fathered by males on a...

sj-docx-1-tan-10.1177_17562864221142924 – Supplemental material for Comparative effectiveness of natalizumab versus ocrelizumab in multiple sclerosis: a real-world propensity score–matched study

Katrin Pape, Leoni Rolfes, Falk Steffen, Muthuraman Muthuraman, Melanie Korsen, Sven G. Meuth, Frauke Zipp & Stefan Bittner
Supplemental material, sj-docx-1-tan-10.1177_17562864221142924 for Comparative effectiveness of natalizumab versus ocrelizumab in multiple sclerosis: a real-world propensity score–matched study by Katrin Pape, Leoni Rolfes, Falk Steffen, Muthuraman Muthuraman, Melanie Korsen, Sven G. Meuth, Frauke Zipp and Stefan Bittner in Therapeutic Advances in Neurological Disorders

Additional file 7 of Cladribine treatment improves cortical network functionality in a mouse model of autoimmune encephalomyelitis

Christina B. Schroeter, Leoni Rolfes, K. S. Sophie Gothan, Joel Gruchot, Alexander M. Herrmann, Stefanie Bock, Luca Fazio, Antonia Henes, Venu Narayanan, Steffen Pfeuffer, Christopher Nelke, Saskia Räuber, Niklas Huntemann, Eduardo Duarte-Silva, Vera Dobelmann, Petra Hundehege, Heinz Wiendl, Katharina Raba, Patrick Küry, David Kremer, Tobias Ruck, Thomas Müntefering, Thomas Budde, Manuela Cerina & Sven G. Meuth
Additional file 7: Figure S7. Proliferation assay of splenocytes from naïve wild-type mice, with and without cladribine treatment in vitro. A: Proliferated cells in % after cladribine treatment (with 0.1 or 1 μM cladribine) versus vehicle-treated cells. We compared the unstimulated to the stimulated setting (stimulated with 1 μg/mL anti-CD3 and 2 μg/mL anti-CD28 for 3 days) (n = 6 for both vehicle and cladribine treatment, two-way ANOVAs). B: Mean fluorescence intensities (MFIs) of migration...

sj-docx-1-tan-10.1177_17562864221142924 – Supplemental material for Comparative effectiveness of natalizumab versus ocrelizumab in multiple sclerosis: a real-world propensity score–matched study

Katrin Pape, Leoni Rolfes, Falk Steffen, Muthuraman Muthuraman, Melanie Korsen, Sven G. Meuth, Frauke Zipp & Stefan Bittner
Supplemental material, sj-docx-1-tan-10.1177_17562864221142924 for Comparative effectiveness of natalizumab versus ocrelizumab in multiple sclerosis: a real-world propensity score–matched study by Katrin Pape, Leoni Rolfes, Falk Steffen, Muthuraman Muthuraman, Melanie Korsen, Sven G. Meuth, Frauke Zipp and Stefan Bittner in Therapeutic Advances in Neurological Disorders

Colorectal cancer incidences in Lynch syndrome: a comparison of results from the prospective lynch syndrome database and the international mismatch repair consortium

Pål Møller, Toni Seppälä, James G. Dowty, Saskia Haupt, Mev Dominguez-Valentin, Lone Sunde, Inge Bernstein, Christoph Engel, Stefan Aretz, Maartje Nielsen, Gabriel Capella, Dafydd Gareth Evans, John Burn, Elke Holinski-Feder, Lucio Bertario, Bernardo Bonanni, Annika Lindblom, Zohar Levi, Finlay Macrae, Ingrid Winship, John-Paul Plazzer, Rolf Sijmons, Luigi Laghi, Adriana Della Valle, Karl Heinimann … & Mark A. Jenkins
Abstract Objective To compare colorectal cancer (CRC) incidences in carriers of pathogenic variants of the MMR genes in the PLSD and IMRC cohorts, of which only the former included mandatory colonoscopy surveillance for all participants. Methods CRC incidences were calculated in an intervention group comprising a cohort of confirmed carriers of pathogenic or likely pathogenic variants in mismatch repair genes (path_MMR) followed prospectively by the Prospective Lynch Syndrome Database (PLSD). All had colonoscopy surveillance, with...

sj-docx-1-dhj-10.1177_20552076231152989 - Supplemental material for Driving time-based identification of gaps in specialised care coverage: An example of neuroinflammatory diseases in Germany

Lars Masanneck, Saskia Räuber, Christina B Schroeter, Sophie Lehnerer, Tjalf Ziemssen, Tobias Ruck, Sven G. Meuth & Marc Pawlitzki
Supplemental material, sj-docx-1-dhj-10.1177_20552076231152989 for Driving time-based identification of gaps in specialised care coverage: An example of neuroinflammatory diseases in Germany by Lars Masanneck, Saskia Räuber, Christina B Schroeter, Sophie Lehnerer, Tjalf Ziemssen, Tobias Ruck, Sven G. Meuth and Marc Pawlitzki in Digital Health

Additional file 2 of Cladribine treatment improves cortical network functionality in a mouse model of autoimmune encephalomyelitis

Christina B. Schroeter, Leoni Rolfes, K. S. Sophie Gothan, Joel Gruchot, Alexander M. Herrmann, Stefanie Bock, Luca Fazio, Antonia Henes, Venu Narayanan, Steffen Pfeuffer, Christopher Nelke, Saskia Räuber, Niklas Huntemann, Eduardo Duarte-Silva, Vera Dobelmann, Petra Hundehege, Heinz Wiendl, Katharina Raba, Patrick Küry, David Kremer, Tobias Ruck, Thomas Müntefering, Thomas Budde, Manuela Cerina & Sven G. Meuth
Additional file 2: Figure S2. Titration curves of oral cladribine treatment in mice. In preliminary experiments, we analyzed the plasma [ng/ml] and brain concentrations [ng/g] of oral cladribine treatment with different doses (3.25, 5 and 10 mg/kg bodyweight) over a time period of 2.5 h. Every 30 min blood was drawn and a proportion of animals was killed to obtain brain tissue for titration analyses. Curves show the maximal concentration of cladribine in blood and...

Additional file 5 of Cladribine treatment improves cortical network functionality in a mouse model of autoimmune encephalomyelitis

Christina B. Schroeter, Leoni Rolfes, K. S. Sophie Gothan, Joel Gruchot, Alexander M. Herrmann, Stefanie Bock, Luca Fazio, Antonia Henes, Venu Narayanan, Steffen Pfeuffer, Christopher Nelke, Saskia Räuber, Niklas Huntemann, Eduardo Duarte-Silva, Vera Dobelmann, Petra Hundehege, Heinz Wiendl, Katharina Raba, Patrick Küry, David Kremer, Tobias Ruck, Thomas Müntefering, Thomas Budde, Manuela Cerina & Sven G. Meuth
Additional file 5: Figure S5. Migration assay of leukocytes in organ cultures of cervical LNs from naïve wild-type mice, with and without cladribine treatment in vitro. A: Migration ratios (number of migrated cells: total cell count) of viable (live), CD4+ or CD8+ T cells and B cells after cladribine treatment (vehicle (migration) versus cladribine 0.1 µM (migration)) (n = 6 for both vehicle and cladribine treatment, two-way ANOVAs, p-values > 0.05). B: Flow cytometric analysis...

Additional file 6 of Cladribine treatment improves cortical network functionality in a mouse model of autoimmune encephalomyelitis

Christina B. Schroeter, Leoni Rolfes, K. S. Sophie Gothan, Joel Gruchot, Alexander M. Herrmann, Stefanie Bock, Luca Fazio, Antonia Henes, Venu Narayanan, Steffen Pfeuffer, Christopher Nelke, Saskia Räuber, Niklas Huntemann, Eduardo Duarte-Silva, Vera Dobelmann, Petra Hundehege, Heinz Wiendl, Katharina Raba, Patrick Küry, David Kremer, Tobias Ruck, Thomas Müntefering, Thomas Budde, Manuela Cerina & Sven G. Meuth
Additional file 6: Figure S6. Migration assay of leukocytes in organ cultures of spleens from naïve wild-type mice, with and without cladribine treatment in vitro. A: Migration ratios (number of migrated cells: total cell count) of viable (live), CD4+ or CD8+ T cells and B cells upon cladribine treatment (vehicle (migration) versus cladribine 0.1 µM (migration)) (n = 6 for both vehicle and cladribine treatment, two-way ANOVAs, p-values > 0.05). B: Flow cytometric analysis of...

Additional file 1 of Prognostic markers for the clinical course in the blood of patients with SARS-CoV-2 infection

Johannes C. Fischer, Vera Balz, Danny Jazmati, Edwin Bölke, Noemi F. Freise, Verena Keitel, Torsten Feldt, Björn-Erik Ole Jensen, Johannes Bode, Tom Lüdde, Dieter Häussinger, Ortwin Adams, E. Marion Schneider, Jürgen Enczmann, Jutta M. Rox, Derik Hermsen, Karin Schulze-Bosse, Detlef Kindgen-Milles, Wolfram Trudo Knoefel, Martijn van Griensven, Jan Haussmann, Balint Tamaskovics, Christian Plettenberg, Kathrin Scheckenbach, Stefanie Corradini … & Christiane Matuschek
Additional file 1: Table S1. Tests for deviation and tests for association from Hardy Weinberg equilibration.

Additional file 1 of Prognostic markers for the clinical course in the blood of patients with SARS-CoV-2 infection

Johannes C. Fischer, Vera Balz, Danny Jazmati, Edwin Bölke, Noemi F. Freise, Verena Keitel, Torsten Feldt, Björn-Erik Ole Jensen, Johannes Bode, Tom Lüdde, Dieter Häussinger, Ortwin Adams, E. Marion Schneider, Jürgen Enczmann, Jutta M. Rox, Derik Hermsen, Karin Schulze-Bosse, Detlef Kindgen-Milles, Wolfram Trudo Knoefel, Martijn van Griensven, Jan Haussmann, Balint Tamaskovics, Christian Plettenberg, Kathrin Scheckenbach, Stefanie Corradini … & Christiane Matuschek
Additional file 1: Table S1. Tests for deviation and tests for association from Hardy Weinberg equilibration.

Prognostic markers for the clinical course in the blood of patients with SARS-CoV-2 infection

Johannes C. Fischer, Vera Balz, Danny Jazmati, Edwin Bölke, Noemi F. Freise, Verena Keitel, Torsten Feldt, Björn-Erik Ole Jensen, Johannes Bode, Tom Lüdde, Dieter Häussinger, Ortwin Adams, E. Marion Schneider, Jürgen Enczmann, Jutta M. Rox, Derik Hermsen, Karin Schulze-Bosse, Detlef Kindgen-Milles, Wolfram Trudo Knoefel, Martijn van Griensven, Jan Haussmann, Balint Tamaskovics, Christian Plettenberg, Kathrin Scheckenbach, Stefanie Corradini … & Christiane Matuschek
Abstract Background The presentation of peptides and the subsequent immune response depend on the MHC characteristics and influence the specificity of the immune response. Several studies have found an association between HLA variants and differential COVID-19 outcomes and have shown that HLA genotypes are associated with differential immune responses against SARS-CoV-2, particularly in severely ill patients. Information, whether HLA haplotypes are associated with the severity or length of the disease in moderately diseased individuals is...

Prognostic markers for the clinical course in the blood of patients with SARS-CoV-2 infection

Johannes C. Fischer, Vera Balz, Danny Jazmati, Edwin Bölke, Noemi F. Freise, Verena Keitel, Torsten Feldt, Björn-Erik Ole Jensen, Johannes Bode, Tom Lüdde, Dieter Häussinger, Ortwin Adams, E. Marion Schneider, Jürgen Enczmann, Jutta M. Rox, Derik Hermsen, Karin Schulze-Bosse, Detlef Kindgen-Milles, Wolfram Trudo Knoefel, Martijn van Griensven, Jan Haussmann, Balint Tamaskovics, Christian Plettenberg, Kathrin Scheckenbach, Stefanie Corradini … & Christiane Matuschek
Abstract Background The presentation of peptides and the subsequent immune response depend on the MHC characteristics and influence the specificity of the immune response. Several studies have found an association between HLA variants and differential COVID-19 outcomes and have shown that HLA genotypes are associated with differential immune responses against SARS-CoV-2, particularly in severely ill patients. Information, whether HLA haplotypes are associated with the severity or length of the disease in moderately diseased individuals is...

Traumatic experiences, alexithymia, and posttraumatic symptomatology: a cross-sectional population-based study in Germany

Svenja Eichhorn, Elmar Brähler, Matthias Franz, Michael Friedrich & Heide Glaesmer
Previous studies have established an association between number of traumatic experiences and alexithymia. The present study examines this relationship in a large-scale representative sample of the German general population (N=2,507) and explores the potential mediating effects of posttraumatic symptomatology, particularly avoidance/numbing. Alexithymia was assessed with the German version of the Toronto Alexithymia Scale (TAS-20). Posttraumatic symptomatology was operationalized by the symptom score of the modified German version of the Posttraumatic Symptom Scale, and traumatic experiences...

sj-docx-1-mso-10.1177_20552173221142741 - Supplemental material for Endocrine and multiple sclerosis outcomes in patients with autoimmune thyroid events in the alemtuzumab CARE-MS studies

Colin M. Dayan, Beatriz Lecumberri, Ilaria Muller, Sashiananthan Ganesananthan, Samuel F. Hunter, Krzysztof W. Selmaj, Hans-Peter Hartung, Eva K. Havrdova, Christopher C. LaGanke, Tjalf Ziemssen, Bart Van Wijmeersch, Sven G. Meuth, David H. Margolin, Elizabeth M. Poole, Darren P. Baker & Peter A. Senior
Supplemental material, sj-docx-1-mso-10.1177_20552173221142741 for Endocrine and multiple sclerosis outcomes in patients with autoimmune thyroid events in the alemtuzumab CARE-MS studies by Colin M. Dayan, Beatriz Lecumberri, Ilaria Muller, Sashiananthan Ganesananthan, Samuel F. Hunter, Krzysztof W. Selmaj, Hans-Peter Hartung, Eva K. Havrdova, Christopher C. LaGanke, Tjalf Ziemssen, Bart Van Wijmeersch, Sven G. Meuth, David H. Margolin, Elizabeth M. Poole, Darren P. Baker and Peter A. Senior in Multiple Sclerosis Journal – Experimental, Translational and Clinical

Driving time-based identification of gaps in specialised care coverage: An example of neuroinflammatory diseases in Germany

Lars Masanneck, Saskia Räuber, Christina B Schroeter, Sophie Lehnerer, Tjalf Ziemssen, Tobias Ruck, Sven G. Meuth & Marc Pawlitzki
ObjectiveDue to the growing complexity in monitoring and treatment of many disorders, disease-specific care and research networks offer patients certified healthcare. However, the networks’ ability to provide health services close to patients’ homes usually remains vague. Digital Health Technologies (DHTs) help to provide better care, especially if implemented in a targeted manner in regions undersupplied by specialised networks. Therefore, we used a car travel time-based isochrone approach to identify care gaps using the example of...

A genome-wide transcriptomic analysis of embryos fathered by obese males in a murine model of diet-induced obesity

Laura Bernhardt, Marcus Dittrich, Rabih El-Merahbi, Antoine-Emmanuel Saliba, Tobias Müller, Grzegorz Sumara, Jörg Vogel, Stefanie Nichols-Burns, Megan Mitchell, Thomas Haaf & Nady El Hajj
Paternal obesity is known to have a negative impact on the male’s reproductive health as well as the health of his offspring. Although epigenetic mechanisms have been implicated in the non-genetic transmission of acquired traits, the effect of paternal obesity on gene expression in the preimplantation embryo has not been fully studied. To this end, we investigated whether paternal obesity is associated with gene expression changes in eight-cell stage embryos fathered by males on a...

Additional file 1 of Cladribine treatment improves cortical network functionality in a mouse model of autoimmune encephalomyelitis

Christina B. Schroeter, Leoni Rolfes, K. S. Sophie Gothan, Joel Gruchot, Alexander M. Herrmann, Stefanie Bock, Luca Fazio, Antonia Henes, Venu Narayanan, Steffen Pfeuffer, Christopher Nelke, Saskia Räuber, Niklas Huntemann, Eduardo Duarte-Silva, Vera Dobelmann, Petra Hundehege, Heinz Wiendl, Katharina Raba, Patrick Küry, David Kremer, Tobias Ruck, Thomas Müntefering, Thomas Budde, Manuela Cerina & Sven G. Meuth
Additional file 1: Figure S1. Experimental scheme. Active MOG EAE was induced as previously described by immunization (day 0) of C57BL/6J mice with MOG35–55 peptide, followed by pertussis toxin (PTX) injections (day 0 and day 2) (15). Mice were divided into two experimental groups: Group 1 received cladribine via oral gavage (10 mg/kg from day 5 to day 9), while group 2 received only the vehicle for the same period of time. On day 10...

Cladribine treatment improves cortical network functionality in a mouse model of autoimmune encephalomyelitis

Christina B. Schroeter, Leoni Rolfes, K. S. Sophie Gothan, Joel Gruchot, Alexander M. Herrmann, Stefanie Bock, Luca Fazio, Antonia Henes, Venu Narayanan, Steffen Pfeuffer, Christopher Nelke, Saskia Räuber, Niklas Huntemann, Eduardo Duarte-Silva, Vera Dobelmann, Petra Hundehege, Heinz Wiendl, Katharina Raba, Patrick Küry, David Kremer, Tobias Ruck, Thomas Müntefering, Thomas Budde, Manuela Cerina & Sven G. Meuth
Abstract Background Cladribine is a synthetic purine analogue that interferes with DNA synthesis and repair next to disrupting cellular proliferation in actively dividing lymphocytes. The compound is approved for the treatment of multiple sclerosis (MS). Cladribine can cross the blood–brain barrier, suggesting a potential effect on central nervous system (CNS) resident cells. Here, we explored compartment-specific immunosuppressive as well as potential direct neuroprotective effects of oral cladribine treatment in experimental autoimmune encephalomyelitis (EAE) mice. Methods...

Cladribine treatment improves cortical network functionality in a mouse model of autoimmune encephalomyelitis

Christina B. Schroeter, Leoni Rolfes, K. S. Sophie Gothan, Joel Gruchot, Alexander M. Herrmann, Stefanie Bock, Luca Fazio, Antonia Henes, Venu Narayanan, Steffen Pfeuffer, Christopher Nelke, Saskia Räuber, Niklas Huntemann, Eduardo Duarte-Silva, Vera Dobelmann, Petra Hundehege, Heinz Wiendl, Katharina Raba, Patrick Küry, David Kremer, Tobias Ruck, Thomas Müntefering, Thomas Budde, Manuela Cerina & Sven G. Meuth
Abstract Background Cladribine is a synthetic purine analogue that interferes with DNA synthesis and repair next to disrupting cellular proliferation in actively dividing lymphocytes. The compound is approved for the treatment of multiple sclerosis (MS). Cladribine can cross the blood–brain barrier, suggesting a potential effect on central nervous system (CNS) resident cells. Here, we explored compartment-specific immunosuppressive as well as potential direct neuroprotective effects of oral cladribine treatment in experimental autoimmune encephalomyelitis (EAE) mice. Methods...

S2_Measuring Facial Mimicry Automated Facial Coding vs. EMG_EMG Data

Jan Westermann, Marc A. Nordmann, Tobias Müller, Ralf Schäfer & Matthias Franz
EMG data

Additional file 1 of Cladribine treatment improves cortical network functionality in a mouse model of autoimmune encephalomyelitis

Christina B. Schroeter, Leoni Rolfes, K. S. Sophie Gothan, Joel Gruchot, Alexander M. Herrmann, Stefanie Bock, Luca Fazio, Antonia Henes, Venu Narayanan, Steffen Pfeuffer, Christopher Nelke, Saskia Räuber, Niklas Huntemann, Eduardo Duarte-Silva, Vera Dobelmann, Petra Hundehege, Heinz Wiendl, Katharina Raba, Patrick Küry, David Kremer, Tobias Ruck, Thomas Müntefering, Thomas Budde, Manuela Cerina & Sven G. Meuth
Additional file 1: Figure S1. Experimental scheme. Active MOG EAE was induced as previously described by immunization (day 0) of C57BL/6J mice with MOG35–55 peptide, followed by pertussis toxin (PTX) injections (day 0 and day 2) (15). Mice were divided into two experimental groups: Group 1 received cladribine via oral gavage (10 mg/kg from day 5 to day 9), while group 2 received only the vehicle for the same period of time. On day 10...

Additional file 2 of Cladribine treatment improves cortical network functionality in a mouse model of autoimmune encephalomyelitis

Christina B. Schroeter, Leoni Rolfes, K. S. Sophie Gothan, Joel Gruchot, Alexander M. Herrmann, Stefanie Bock, Luca Fazio, Antonia Henes, Venu Narayanan, Steffen Pfeuffer, Christopher Nelke, Saskia Räuber, Niklas Huntemann, Eduardo Duarte-Silva, Vera Dobelmann, Petra Hundehege, Heinz Wiendl, Katharina Raba, Patrick Küry, David Kremer, Tobias Ruck, Thomas Müntefering, Thomas Budde, Manuela Cerina & Sven G. Meuth
Additional file 2: Figure S2. Titration curves of oral cladribine treatment in mice. In preliminary experiments, we analyzed the plasma [ng/ml] and brain concentrations [ng/g] of oral cladribine treatment with different doses (3.25, 5 and 10 mg/kg bodyweight) over a time period of 2.5 h. Every 30 min blood was drawn and a proportion of animals was killed to obtain brain tissue for titration analyses. Curves show the maximal concentration of cladribine in blood and...

Additional file 3 of Cladribine treatment improves cortical network functionality in a mouse model of autoimmune encephalomyelitis

Christina B. Schroeter, Leoni Rolfes, K. S. Sophie Gothan, Joel Gruchot, Alexander M. Herrmann, Stefanie Bock, Luca Fazio, Antonia Henes, Venu Narayanan, Steffen Pfeuffer, Christopher Nelke, Saskia Räuber, Niklas Huntemann, Eduardo Duarte-Silva, Vera Dobelmann, Petra Hundehege, Heinz Wiendl, Katharina Raba, Patrick Küry, David Kremer, Tobias Ruck, Thomas Müntefering, Thomas Budde, Manuela Cerina & Sven G. Meuth
Additional file 3: Figure S3. Gating strategy for flow cytometry. Single immune cells from the periphery (A, here exemplary shown with spleen tissue) and the central nervous system (CNS; B, here exemplary shown with spinal cord tissue) were simultaneously analyzed by flow cytometry. Total leukocytes were identified by forward scatter (FSC) and sideward scatter (SSC) and cell-doublets were removed by FSC width and FSC height gating. From these cells, we identified leukocytes subsets based on...

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  • Düsseldorf University Hospital
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  • Heinrich Heine University Düsseldorf
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  • University Hospital Münster
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  • University of Münster
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  • University Medical Center of the Johannes Gutenberg University Mainz
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