9 Works

Atlas of Bacterial and Archaeal Cell Structure

Catherine Oikonomou & Grant Jensen

Synthetic multistability in mammalian cells

Ronghui Zhu, Jesus M. del Rio-Salgado, Jordi García-Ojalvo & Michael B. Elowitz
Data and code repository for paper "Synthetic multistability in mammalian cells"

Prediction of clinical prognosis in cutaneous melanoma using an immune-related gene pair signature

Yu Yang, Xuan Long, Guiyun Li, Xiaohong Yu, Yu Liu, Kun Li & Xiaobin Tian
Cutaneous melanoma (CM) is a malignant and aggressive skin cancer that is the leading cause of skin cancer-related deaths. Increasing evidence shows that immunity plays a vital role in the prognosis of CM. In this study, we developed an immune-related gene pair (IRGP) signature to predict the clinical prognosis of patients with CM. Immune-related genes from The Cancer Genome Atlas (TCGA) and the Gene Expression Omnibus (GEO) databases were selected to construct the IRGPs, and...

Pinpointing the neural signatures of single-exposure visual recognition memory

Vahid Mehrpour, Travis Meyer, Eero P. Simoncelli & Nicole C. Rust
Memories of the images that we have seen are thought to be reflected in the reduction of neural responses in high-level visual areas such as inferotemporal (IT) cortex, a phenomenon known as repetition suppression (RS). We challenged this hypothesis with a task that required rhesus monkeys to report whether images were novel or repeated while ignoring variations in contrast, a stimulus attribute that is also known to modulate the overall IT response. The monkeys’ behavior...

A dominant-negative SOX18 mutant disrupts multiple regulatory layers essential to transcription factor activity

Jieqiong Lou, Alex McCann, Mehdi Moustaqil, Matthew Graus, Ailisa Blum, Frank Fontaine, Hui Liu, Winnie Luu, Peter Koopman, Emma Sierecki, Yann Gambin, Frédéric Meunier, Zhe Liu, Elizabeth Hinde & Mathias Francois
Few genetically dominant mutations involved in human disease have been fully explained at the molecular level. In cases where the mutant gene encodes a transcription factor, the dominant-negative mode of action of the mutant protein is particularly poorly understood. Here, we studied the genome-wide mechanism underlying a dominant-negative form of the SOX18 transcription factor (SOX18RaOp) responsible for both the classical mouse mutant Ragged Opossum and the human genetic disorder Hypotrichosis-Lymphedema-Telangiectasia-Renal Syndrome. Combining three single-molecule imaging...

Data supplement for: Disrupting cortico-cerebellar communication impairs dexterity

Britton Sauerbrei, Jian-Zhong Guo, Jeremy Cohen, Matteo Mischiati, Austin Graves, Ferruccio Pisanello, Kristin Branson & Adam Hantman
This dataset, along with the corresponding code, is a supplement to “Disrupting cortico-cerebellar communication impairs dexterity” (Guo*, Sauerbrei* et al., eLife 2021). It consists of single-unit electrophysiology data from the pontine nuclei, Purkinje cells, cerebellar nuclei, and motor cortex of awake mice, along with measurements of the hand position of mice performing reaching movements. These data address the question of how the dynamics of motor cortex and cerebellum interact to control skilled reaching. First, we...

Escherichia coli

&
Movie from the Atlas of Bacterial and Archaeal Cell Structure

A phase-separated nuclear GBPL circuit controls immunity in plants

Shuai Huang, Shiwei Zhu, Pradeep Kumar & John MacMicking
Liquid-liquid phase separation (LLPS) has emerged as a central paradigm for understanding how membrane-less organelles compartmentalize diverse cellular activities in eukaryotes. Here, we identified a new superfamily of plant Guanylate-Binding Protein-Like GTPases (GBPLs) that assemble LLPS-driven condensates within the nucleus to protect against infection and autoimmunity. In Arabidopsis thaliana, two family members - GBPL1 and GBPL3 - undergo phase transition behavior to control transcriptional responses as part of an allosteric switch triggered by exposure to...

Prediction of clinical prognosis in cutaneous melanoma using an immune-related gene pair signature

Yu Yang, Xuan Long, Guiyun Li, Xiaohong Yu, Yu Liu, Kun Li & Xiaobin Tian
Cutaneous melanoma (CM) is a malignant and aggressive skin cancer that is the leading cause of skin cancer-related deaths. Increasing evidence shows that immunity plays a vital role in the prognosis of CM. In this study, we developed an immune-related gene pair (IRGP) signature to predict the clinical prognosis of patients with CM. Immune-related genes from The Cancer Genome Atlas (TCGA) and the Gene Expression Omnibus (GEO) databases were selected to construct the IRGPs, and...

Registration Year

  • 2021
    9

Resource Types

  • Dataset
    5
  • Image
    2
  • Audiovisual
    1
  • Book
    1

Affiliations

  • Howard Hughes Medical Institute
    9
  • California Institute of Technology
    3
  • Shanghai University of Sport
    2
  • Sun Yat-sen University
    2
  • West China Second University Hospital of Sichuan University
    2
  • Zhejiang University
    2
  • Tri-Service General Hospital Beitou Branch
    2
  • Lanzhou Veterinary Research Institute
    2
  • Temple University
    2
  • Huazhong University of Science and Technology
    2