71 Works

Data from: Variation in seasonal timing traits and life history along a latitudinal transect in Mimulus ringens

James Sobel & Kelly Vest
Seasonal timing traits are commonly under recurrent, spatially-variable selection, and are therefore predicted to exhibit clinal variation. Temperate perennial plants often require vernalization to prompt growth and reproduction; however, little is known about whether vernalization requirements change across the range of a broadly distributed species. We performed a critical vernalization duration study in Mimulus ringens, coupled with population genomic analysis. Plants from 8 populations spanning the latitudinal range were exposed to varying durations of 4°C...

Retention fraction of 15N-labelled deposited ammonium and nitrate in forests

Geshere Abdisa Gurmesa, Ang Wang, Shanlong Li, Shushi Peng, Wim De Vries, Per Gundersen, Philippe Ciais, Oliver L Phillips, Erik Hobbie, Weixing Zhu, Knute Nadelhoffer, Yi Xi, Edith Bai, Tao Sun, Dexiang Chen, Wenjun Zhou, Yiping Zhang, Yingrong Guo, Jiaojun Zhu, Lei Duan, Dejun Li, Keisuke Koba, Enzai Du, Guoyi Zhou, Xingguo Han … & Yunting Fang
The impacts of enhanced nitrogen (N) deposition on global forest carbon (C) sink and other ecosystem services may depend on whether N is deposited in reduced (mainly as ammonium) or oxidized forms (mainly as nitrate) and the subsequent fate of each. However, the fates of the two key reactive N forms and its contribution to forest C sink is unclear. We conducted ecosystem-scale paired 15N-labelling experiments in nine forests across China to quantify N retention...

E74 Like ETS Transcription Factor 3 is a Negative Regulator of Pathogenic Lamina Propria T Helper 17.1 Cells in Murine Colitis

Bo Hu, Hao Wang & Fei Xiao
Interleukin-17A (IL-17A)-expressing T cells, including T helper 17 (Th17) and T helper 17.1 (Th17.1) cells, play a significant role in inflammatory bowel diseases (IBDs). Identifying the mechanisms underlying the heterogeneity and plasticity of IL-17A-expressing T cells is crucial for understanding and controlling their pathogenicity. The role of E74 like ETS transcription factor 3 (ELF3) in regulating the pathogenicity of IL-17A-expressing T cells has not been studied before. Dextran sulfate sodium was used to induce acute...

Additional file 1 of Association between frequency of dairy product consumption and hypertension: a cross-sectional study in Zhejiang Province, China

Hao Wang, Lingli Chen, Yuan Cao, Kaixu Xie, Chunmei Wang, Pei Pei, Yu Guo, Fiona Bragg, Min Yu, Zhengming Chen & Liming Li
Additional file 1. Table S1. Unadjusted and adjusted β coefficients for SBP and DBP associated with frequency of dairy product consumption among adults without self-reported physician-diagnosed hypertension in Zhejiang. Table S2. Unadjusted and adjusted prevalence ratios for hypertension associated with frequency of dairy product consumption among adults in Zhejiang. Table S3. Adjusted odds ratios for hypertension associated with consuming dairy products weekly vs. never according to participant characteristics.

Additional file 1 of Aberrant methylation of Serpine1 mediates lung injury in neonatal mice prenatally exposed to intrauterine inflammation

Dongting Yao, Jiuru Zhao, Qianqian Zhang, Tao Wang, Meng Ni, Sudong Qi, Qianwen Shen, Wei Li, Baihe Li, Xiya Ding & Zhiwei Liu
Additional file 1: Figure S1. Enrichment of differentially expressed genes in lung tissues of neonatal mice with intrauterine inflammation. A Immunofluorescence detection of Pro-SFTPC in the lung tissues of neonatal mice (green, DAPI: blue). C, D GO and KEGG enrichment of the upregulated genes. E, F GO and KEGG enrichment of the downregulated genes.Q-value ≤ 0.05 and fold-change ≥ 2 were used as the thresholds for screening the differentially expressed genes. Data show mean ±...

Additional file 1 of Aberrant methylation of Serpine1 mediates lung injury in neonatal mice prenatally exposed to intrauterine inflammation

Dongting Yao, Jiuru Zhao, Qianqian Zhang, Tao Wang, Meng Ni, Sudong Qi, Qianwen Shen, Wei Li, Baihe Li, Xiya Ding & Zhiwei Liu
Additional file 1: Figure S1. Enrichment of differentially expressed genes in lung tissues of neonatal mice with intrauterine inflammation. A Immunofluorescence detection of Pro-SFTPC in the lung tissues of neonatal mice (green, DAPI: blue). C, D GO and KEGG enrichment of the upregulated genes. E, F GO and KEGG enrichment of the downregulated genes.Q-value ≤ 0.05 and fold-change ≥ 2 were used as the thresholds for screening the differentially expressed genes. Data show mean ±...

Additional file 5 of Aberrant methylation of Serpine1 mediates lung injury in neonatal mice prenatally exposed to intrauterine inflammation

Dongting Yao, Jiuru Zhao, Qianqian Zhang, Tao Wang, Meng Ni, Sudong Qi, Qianwen Shen, Wei Li, Baihe Li, Xiya Ding & Zhiwei Liu
Additional file 5: Figure S5. The expression of DNA methylation related enzymes in lung tissues and TNF-α-treated MLE-12 cells. A Dnmt1, Dnmt3a, Mbd1, and Tet1 expression analysed using RT-qPCR in lung tissues of neonatal mice. B TNF-α expression analysed using RT-qPCR in lung tissues of neonatal mice. C Dnmt1, Dnmt3a, Mbd1, and Tet1 expression analysed using RT-qPCR in TNF-α-treated MLE-12 cells. D Serpine1 expression analysed using RT-qPCR in TNF-α-treated MLE-12 cells. Data show mean ±...

Psychometric validation of a chinese version of COVID-19 vaccine hesitancy scale: a cross-sectional study

Yiman Huang, Yijin Wu, Zhenwei Dai, Weijun Xiao, Hao Wang, Mingyu Si, Wenjun Wang, Xiaofen Gu, Li Ma, Li Li, Shaokai Zhang, Chunxia Yang, Yanqin Yu, Youlin Qiao & Xiaoyou Su
Abstract Background COVID-19 vaccines have been administered in many countries; however, a sufficient vaccine coverage rate is not guaranteed due to vaccine hesitancy. To improve the uptake rate of COVID-19 vaccine, it is essential to evaluate the rate of vaccine hesitancy and explore relevant factors in different populations. An urgent need is to measure COVID-19 vaccine hesitancy among different population groups, hence a validated scale for measuring COVID-19 vaccine hesitancy is necessary. The present study...

Data from: Strong premating reproductive isolation drives incipient speciation in Mimulus aurantiacus

James M. Sobel & Matthew A. Streisfeld
Determining which forms of reproductive isolation have the biggest impact on the process of divergence is a major goal of speciation research. These barriers are often divided into those that affect the potential for hybridization (premating isolation), and those that occur after mating (postmating isolation), and much debate has surrounded the relative importance of these categories. Within the species Mimulus aurantiacus, red- and yellow-flowered ecotypes occur in the southwest corner of California, and a hybrid...

Data from: Tropical forest restoration: fast resilience of plant biomass contrasts with slow recovery of stable soil C stocks

Faming Wang, Yongzhen Ding, Emma Sayer, Qinlu Li, Bi Zou, Qifeng Mo, Yingwen Li, Xiaoliang Lu, Jianwu Tang, Weixing Zhu, Zhian Li & Emma J. Sayer
1. Due to intensifying human disturbance, over half of the world’s tropical forests are reforested or afforested secondary forests or plantations. Understanding the resilience of carbon (C) stocks in these forests, and estimating the extent to which they can provide equivalent carbon (C) sequestration and stabilization to the old growth forest they replace, is critical for the global C balance. 2. In this study, we combined estimates of biomass C stocks with a detailed assessment...

Data from: Divergent subgenome evolution after allopolyploidization in African clawed frogs (Xenopus)

Benjamin L.S. Furman, Utkarsh J. Dang, Ben J. Evans, G. Brian Golding & Benjamin L. S. Furman
Whole genome duplication (WGD), the doubling of the nuclear DNA of a species, contributes to biological innovation by creating genetic redundancy. One mode of WGD is allopolyploidization, wherein each genome from two ancestral species becomes a 'subgenom' of a polyploid descendant species. The evolutionary trajectory of a duplicated gene that arises from WGD is influenced both by natural selection, creating new or partitioning functions, and by gene silencing (pseudogenization). Here, we explored how these two...

Data from: Rapid and Repeatable Host Plant Shifts Drive Reproductive Isolation Following a Recent Human-Mediated Introduction of the Apple Maggot Fly, Rhagoletis pomonella

Glen R. Hood, Thomas H.Q. Powell, Doellman, Sheina B. Sim, Mary Glover, Wee L. Yee, Robert B. Goughnour, Monte Mattsson, Dietmar Schwarz & Jeffrey L. Feder
Ecological speciation via host-shifting is often invoked as a mechanism for insect diversification, but the relative importance of this process is poorly understood. The shift of Rhagoletis pomonella in the 1850s from the native downy hawthorn, Crataegus mollis, to introduced apple, Malus pumila, is a classic example of sympatric host race formation, a hypothesized early stage of ecological speciation. The accidental human-mediated introduction of R. pomonella into the Pacific Northwest (PNW) in the late-1970’s allows...

Data from: The ecological stage changes benefits of mate choice and drives preference divergence

Robin Tinghitella, Alycia Lackey, Catherine Durso, Jennifer Koop & Janette Boughman
Preference divergence is thought to contribute to reproductive isolation. Ecology can alter the way selection acts on female preferences, making them most likely to diverge when ecological conditions vary among populations. We present a novel mechanism for ecologically dependent sexual selection, termed ‘the ecological stage’ to highlight its ecological dependence. Our hypothesized mechanism emphasizes that males and females interact over mating in a specific ecological context, and different ecological conditions change the costs and benefits...

Data from: Estimating dispersal and evolutionary dynamics in diploporan blastozoans (Echinodermata) across the Great Ordovician Biodiversification Event

Adriane Lam, Sarah Sheffield & Nicholas Matzke
Echinoderms make up a substantial component of Ordovician marine invertebrates, yet their speciation and dispersal history as inferred within a rigorous phylogenetic and statistical framework is lacking. We use Biogeographic Stochastic Mapping (BSM; implemented in the R package BioGeoBEARS) to infer ancestral area relationships and the number and type of dispersal events through the Ordovician for diploporan blastozoans and related species. The BSM analysis was divided into three time slices to analyze how dispersal paths...

δ15N of nitric oxide produced under aerobic or anaerobic conditions from seven soils and their associated N isotope fractionations

Chenxia Su, Ronghua Kang, Weixing Zhu, Wentao Huang, Linlin Song, Ang Wang, Dongwei Liu, Zhi Quan, Feifei Zhu, Pingqing Fu & Yunting Fang
Measuring the nitrogen isotope compositions (δ15N) of nitric oxide (NO) from different sources helps to quantify the relative contributions of atmospheric NOx. Soil is one of the most important sources of atmospheric NOx, but only limited measurements on the δ15N of soil emitted NO exist, hampering our ability to partition sources to air pollution. Here we conducted soil incubations to measure the δ15N-NO under defined aerobic or anaerobic conditions, favoring either nitrification or denitrification. Soils...

Data from: A rapidly evolved shift in life history timing during ecological speciation is driven by the transition between developmental phases

Thomas Powell, Andrew Nguyen, Qinwen Xia, Jeffrey Feder, Gregory Ragland & Daniel Hahn
For insect species in temperate environments, seasonal timing is often governed by the regulation of diapause, a complex developmental program that allows insects to weather unfavorable conditions and synchronize their lifecycles with available resources. Diapause development consists of a series of distinct phases including initiation, maintenance, termination, and post-diapause development. The evolution of insect seasonal timing depends in part on how these phases of diapause development and post-diapause development interact to affect variation in phenology....

Data from: Experimental shelter-switching shows shelter type alters predation on caterpillars (Hesperiidae)

Christina Baer
Caterpillars build various shelters that protect them from natural enemies, but whether specific shelters provide different protection is unknown. To disentangle a caterpillar species’ shelter from the rest of its phenotype, we performed a field experiment in which two caterpillar species (Urbanus dorantes and U. proteus) were removed from their original shelters, placed into shelters made by conspecifics or heterospecifics, and monitored for predation and parasitism. Predation was intense, with 0-48% of caterpillars surviving depending...

Database PCA: A middle Pleistocene Homo from Nesher Ramla, Israel

Hila May, Israel Hershkovitz, Rachel Sarig, Ariel Pokhojaev, Dominique Grimaud-Hervé, Emiliano Bruner, Cinzia Fornai, Rolf Quam, Juan-Luis Arsuaga, Viktoria A. Krenn, Maria Martinón-Torres, José María Bermúdez De Castro, Laura Martín-Francés, Viviane Slon, Lou Albessard-Ball, Amélie Vialet, Tim Schüler, Giorgio Manzi, Antonio Profico, Fabio Di Vincenzo, Gerhard W. Weber & Yossi Zaidner
It has long been believed that Neanderthals originated and flourished on the European continent. However, recent morphological and genetic studies have suggested that they may have received a genetic contribution from a yet unknown non-European group. Here we report on the recent discovery of archaic Homo fossils from the site of Nesher Ramla, Israel, which we dated to 140,000 to 120,000 years ago. Comprehensive qualitative and quantitative analyses of the parietal bones, mandible, and lower...

Association between frequency of dairy product consumption and hypertension: a cross-sectional study in Zhejiang Province, China

Hao Wang, Lingli Chen, Yuan Cao, Kaixu Xie, Chunmei Wang, Pei Pei, Yu Guo, Fiona Bragg, Min Yu, Zhengming Chen & Liming Li
Abstract Background Hypertension, a well-known risk factor, contributes to millions of deaths from cardiovascular and renal diseases worldwide. However, evidence on the association between frequency of dairy product consumption and hypertension is inconsistent. Methods The data for the present study are from the Tongxiang baseline dataset of the China Kadoorie Biobank prospective study. A total of 53,916 participants aged 30–79 years were included in the final analysis. Multivariable logistic regression was utilized to evaluate the...

Additional file 4 of Aberrant methylation of Serpine1 mediates lung injury in neonatal mice prenatally exposed to intrauterine inflammation

Dongting Yao, Jiuru Zhao, Qianqian Zhang, Tao Wang, Meng Ni, Sudong Qi, Qianwen Shen, Wei Li, Baihe Li, Xiya Ding & Zhiwei Liu
Additional file 4: Figure S4. Enrichment of differentially expressed genes in Serpine1-overexpressing MLE-12 cells. A, B GO and KEGG enrichment of the upregulated genes. C, D GO and KEGG enrichment of the downregulated genes. Q-value ≤ 0.05 and fold-change ≥ 2 were used as the thresholds for screening the differentially expressed genes.

Additional file 6 of Aberrant methylation of Serpine1 mediates lung injury in neonatal mice prenatally exposed to intrauterine inflammation

Dongting Yao, Jiuru Zhao, Qianqian Zhang, Tao Wang, Meng Ni, Sudong Qi, Qianwen Shen, Wei Li, Baihe Li, Xiya Ding & Zhiwei Liu
Additional file 6: Figure S6. HDAC2 inhibition promoted the expression of Serpine1. A SDS-PAGE identification of the proteins pulled-down by DNA fragment of Serpine1 promoter. The gel was stained with Coomassie blue. The indicated differential bands were excised with a scalpel and identified by LC-MS. B Total ion chromatogram of proteins. C–E Serpine1 expression analysed using RT-qPCR and western blot in trichostatin A (TSA)-treated MLE-12 cells. Data show mean ± SEM; Data was analysed using...

Additional file 6 of Aberrant methylation of Serpine1 mediates lung injury in neonatal mice prenatally exposed to intrauterine inflammation

Dongting Yao, Jiuru Zhao, Qianqian Zhang, Tao Wang, Meng Ni, Sudong Qi, Qianwen Shen, Wei Li, Baihe Li, Xiya Ding & Zhiwei Liu
Additional file 6: Figure S6. HDAC2 inhibition promoted the expression of Serpine1. A SDS-PAGE identification of the proteins pulled-down by DNA fragment of Serpine1 promoter. The gel was stained with Coomassie blue. The indicated differential bands were excised with a scalpel and identified by LC-MS. B Total ion chromatogram of proteins. C–E Serpine1 expression analysed using RT-qPCR and western blot in trichostatin A (TSA)-treated MLE-12 cells. Data show mean ± SEM; Data was analysed using...

Diverse early diagenetic processes of ferromanganese nodules from the eastern Pacific Ocean: evidence from mineralogy and in-situ geochemistry

Rong Su, Fengyue Sun, Xiaohu Li, Fengyou Chu, Guosheng Sun, Jie Li, Hao Wang, Zhenggang Li, Cong Zhang, Weiyan Zhang, Xiaohan Gong & Yanhui Dong
Ferromanganese nodules are a potential energy resource because of their high contents of economically interesting elements (i.e. Mn, Ni, Cu, and Zn). These are higher in diagenetic layers than in hydrogenetic layers. The study of the causes of elemental accumulation in the diagenetic layer is useful for the exploration metal-rich nodules. A diagenetic-dominant ferromanganese nodule, from the central Clarion–Clipperton Fracture Zone of the eastern Pacific Ocean was studied from core to rim. It was divided...

Additional file 1 of Risk factors and outcomes of postoperative stroke in surgical treatment for giant intracranial aneurysms

Hao Wang, Junlin Lu, Xin Chen & Qiang Hao
Additional file 1: Table Supplementary. Logistic regression analysis for postoperative strokes in clipping sub-group.

Risk factors and outcomes of postoperative stroke in surgical treatment for giant intracranial aneurysms

Hao Wang, Junlin Lu, Xin Chen & Qiang Hao
Abstract Background Giant intracranial aneurysms (GIAs) are challenges for surgical treatment. Risk factors of postoperative stroke remain unclear. This study aims to investigate the predictors of postoperative stroke in GIAs and the impact of stroke on outcomes. Methods We performed a retrospective medical record review of patients with GIAs who received microsurgery at our institution between 2011 and 2018. Multivariate logistic regression analyses were carried out to identify risk factors for postoperative stroke. The clinical...

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