Objective: To determine black-white differences in 1-year recurrent stroke and 30-day case fatality following a recurrent stroke in older US adults. Methods: We conducted a retrospective cohort study using a 5% random sample of Medicare beneficiaries with fee-for-service health insurance coverage who were hospitalized for ischemic stroke between 1999 and 2013. Hazard ratios (HR) for recurrent ischemic stroke and risk ratios (RR) for 30-day case fatality comparing blacks to whites were calculated with adjustment for...
Data from: Real or fake? natural and artificial social stimuli elicit divergent behavioral and neural responses in mangrove rivulus, Kryptolebias marmoratusCheng-Yu Li, Hans A. Hofmann, Melissa L. Harris & Ryan L. Earley
Understanding how the brain processes social information and generates adaptive behavioural responses is a major goal in neuroscience. We examined behaviour and neural activity patterns in socially relevant brain nuclei of hermaphroditic mangrove rivulus fish (Kryptolebias marmoratus) provided with different types of social stimuli: stationary model opponent, regular mirror, non-reversing mirror and live opponent. We found that: i) individuals faced with a regular mirror were less willing to interact with, delivered fewer attacks towards, and...
Data from: Revisiting protein aggregation as pathogenic in sporadic Parkinson’s and Alzheimer’s diseasesAlberto J. Espay, Joaquin A. Vizcarra, Luca Marsili, Anthony E. Lang, David K. Simon, Aristide Merola, Keith A. Josephs, Alfonso Fasano, Francesca Morgante, Rodolfo Savica, J. Timothy Greenamyre, Franca Cambi, Tritia R. Yamasaki, Caroline M. Tanner, Ziv Gan-Or, Irene Litvan, Ignacio F. Mata, Cyrus P. Zabetian, Patrik Brundin, Hubert H. Fernandez, David G. Standaert, Marcelo A. Kauffman, Michael A. Schwarzschild, S. Pablo Sardi, Todd Sherer … & James B. Leverenz
The gold standard for a definitive diagnosis of Parkinson’s disease (PD) is the pathologic finding of aggregated alpha-synuclein into Lewy bodies and for Alzheimer’s disease (AD) aggregated amyloid into plaques and hyperphosphorylated tau into tangles. Implicit in this clinico-pathologic-based nosology is the assumption that pathological protein aggregation at autopsy reflect pathogenesis at disease onset. While these aggregates may in exceptional cases be on a causal pathway in humans (e.g., aggregated alpha-synuclein in SNCA gene multiplication...
We examine the implications of a recent report providing evidence that two transducins must bind to the rod phosphodiesterase to elicit significant hydrolytic activity. To predict the rod photoreceptor's electrical response, we use numerical simulation of the two-dimensional diffusional contact of interacting molecules at the surface of the disc membrane, and then we use the simulated PDE activity as the driving function for the downstream reaction cascade. The results account for a number of aspects...
Data from: Female investment in offspring size and number shifts seasonally in a lizard with single-egg clutchesTimothy S. Mitchell, Joshua M. Hall & Daniel A. Warner
The timing of reproduction strongly influences reproductive success in many organisms. For species with extended reproductive seasons, the quality of the environment may change throughout the season in ways that impact offspring survival, and, accordingly, aspects of reproductive strategies may shift to maximize fitness. Life-history theory predicts that if offspring environments deteriorate through the season, females should shift from producing more, smaller offspring early in the season to fewer, higher quality offspring later in the...
Objective: To investigate whether dietary patterns (Mediterranean diet (MedDiet), Dietary Approaches to Stop Hypertension (DASH) and A Priori Diet Quality Score (APDQS)) during adulthood are associated with better midlife cognitive performance. Methods: We studied 2,621 CARDIA participants: 45% black, 57% female, and age 25±3.5 years at baseline (1985-6). Diet scores were calculated from repeated diet history up to year 20. Linear models were used to examine association between tertiles of diet score and year 25...
University of Alabama at Birmingham6
University of Minnesota2
Massachusetts General Hospital1
University of Pennsylvania1
The University of Texas at Austin1
VA Puget Sound Health Care System1
University of California, San Diego1
Australian National University1
University of Pittsburgh1