Supplemental material, sj-docx-1-dhj-10.1177_20552076221131145 for Study protocol of EMPOWER: A cluster randomized trial of a multimodal eHealth intervention for promoting mental health in the workplace following a stepped wedge trial design by Beatriz Olaya, Christina M. Van der Feltz-Cornelis and Leona Hakkaart-van Roijen, Dorota Merecz-Kot, Marjo Sinokki, Päivi Naumanen, Jessie Shepherd, Frédérique van Krugten, Marleen de Mul, Kaja Staszewska, Ellen Vorstenbosch, Carlota de Miquel, Rodrigo Antunes Lima, José Luis Ayuso-Mateos, Luis Salvador-Carulla, Oriol Borrega, Carla Sabariego,...

Background:Multiracial individuals appear to be at higher risk for mental health problems; however, more research is needed to confirm these racial disparities among young adult college populations.Methods:We analyzed data from the Health Minds Study (N = 99728 young adult college students aged 18–34), collected online across 140 college campuses from September 2020 to June 2021. We used multivariable logistic regression to examine associations between multiracial identity and several mental health outcomes, including mental and behavioral...

Abstract Background Small extracellular vesicles (sEVs) are emerging natural nanoplatforms in cancer diagnosis and therapy, through the incorporation of signal components or drugs in their structure. However, for their translation into the clinical field, there is still a lack of tools that enable a deeper understanding of their in vivo pharmacokinetics or their interactions with the cells of the tumor microenvironment. In this study, we have designed a dual-sEV probe based on radioactive and fluorescent...

Supplemental material, sj-docx-1-isp-10.1177_00207640221135849 for Religiousness and psychotic experiences among young adult college students in the United States by Hans Y Oh, Edward B Davis, Mallory Klaunig, Zui Narita, Ai Koyanagi and Nicole R Karcher in International Journal of Social Psychiatry

Background:Religiousness and psychotic experiences have been related, though findings have been mixed, with little attention paid to specific religious affiliations and religious importance.Methods:We analyzed data from the Healthy Minds Study (2020–2021), which was an online survey administered at 140 college campuses across the United States. We used multivariable logistic regression to examine the associations between religiousness (affiliation and importance) and 12-month psychotic experiences, adjusting for age, gender, and race/ethnicity.Results:Only Christian religious affiliation was associated with...

Supplemental material, sj-docx-1-isp-10.1177_00207640221137993 for The association of physical multimorbidity with suicidal ideation and suicide attempts in England: A mediation analysis of influential factors by Lee Smith, Jae Il Shin, San Lee, Jae Won Oh, Guillermo F López Sánchez, Karel Kostev, Louis Jacob, Mark A. Tully, Felipe Schuch, Daragh T. McDermott, Damiano Pizzol, Nicola Veronese, Junmin Song, Pinar Soysal and Ai Koyanagi in International Journal of Social Psychiatry

Background:Suicide is one of the most important causes of deaths in the United Kingdom, and the numbers are currently increasing.Aim:There are numerous identified determinants of suicidality, and physical multimorbidity is potentially important but is currently understudied. Thus, this study aims to investigate the association of physical multimorbidity with suicidality.Methods:Cross-sectional data from the Adult Psychiatric Morbidity Survey 2007, which was conducted in England between October 2006 and December 2007 by the National Center for Social Research...

Abstract Background Pain-sensitized osteoarthritis and fibromyalgia patients characteristically show nociceptive system augmented responsiveness as a common feature. However, sensitization can be originally related to the peripheral injury in osteoarthritis patients, whereas pain and bodily discomfort spontaneously occur in fibromyalgia with no apparent origin. We investigated the distinct functional repercussion of pain sensitization in the cerebral cortex in both conditions. Methods Thirty-one pain-sensitized knee osteoarthritis patients and 38 fibromyalgia patients were compared with matched control groups....

Background:Multiracial individuals appear to be at higher risk for mental health problems; however, more research is needed to confirm these racial disparities among young adult college populations.Methods:We analyzed data from the Health Minds Study (N = 99728 young adult college students aged 18–34), collected online across 140 college campuses from September 2020 to June 2021. We used multivariable logistic regression to examine associations between multiracial identity and several mental health outcomes, including mental and behavioral...

Dataset from a randomized controlled trial testing the efficacy of 20 x 1 hour weekly sessions of Eye Movement Desensitization and Reprocessing (EMDR) therapy, with Supportive Therapy, in Bipolar Disorder patients with psychological trauma symptoms.

Objective: This article describes the EMPOWER study, a controlled trial aiming to determine the effectiveness and cost-effectiveness of an eHealth intervention to prevent common health problems and reduce presenteeism and absenteeism in the workplace. Intervention: The EMPOWER intervention spans universal, secondary and tertiary prevention and consists of an eHealth platform delivered via a website and a smartphone app designed to guide employees throughout different modules according to their specific profiles. Design: A stepped-wedge cluster randomized...

Supplemental material, sj-docx-1-isp-10.1177_00207640221137993 for The association of physical multimorbidity with suicidal ideation and suicide attempts in England: A mediation analysis of influential factors by Lee Smith, Jae Il Shin, San Lee, Jae Won Oh, Guillermo F López Sánchez, Karel Kostev, Louis Jacob, Mark A. Tully, Felipe Schuch, Daragh T. McDermott, Damiano Pizzol, Nicola Veronese, Junmin Song, Pinar Soysal and Ai Koyanagi in International Journal of Social Psychiatry

Background:Suicide is one of the most important causes of deaths in the United Kingdom, and the numbers are currently increasing.Aim:There are numerous identified determinants of suicidality, and physical multimorbidity is potentially important but is currently understudied. Thus, this study aims to investigate the association of physical multimorbidity with suicidality.Methods:Cross-sectional data from the Adult Psychiatric Morbidity Survey 2007, which was conducted in England between October 2006 and December 2007 by the National Center for Social Research...

Background and aimsThe coronavirus disease 2019 pandemic has challenged health services worldwide, with a worsening of healthcare workers’ mental health within initial pandemic hotspots. In early 2022, the Omicron variant is spreading rapidly around the world. This study explores the effectiveness and cost-effectiveness of a stepped-care programme of scalable, internet-based psychological interventions for distressed health workers on self-reported anxiety and depression symptoms.MethodsWe present the study protocol for a multicentre (two sites), parallel-group (1:1 allocation ratio),...

Background and aimsThe coronavirus disease 2019 pandemic has challenged health services worldwide, with a worsening of healthcare workers’ mental health within initial pandemic hotspots. In early 2022, the Omicron variant is spreading rapidly around the world. This study explores the effectiveness and cost-effectiveness of a stepped-care programme of scalable, internet-based psychological interventions for distressed health workers on self-reported anxiety and depression symptoms.MethodsWe present the study protocol for a multicentre (two sites), parallel-group (1:1 allocation ratio),...

Additional file 1. Fig. S1. Physicochemical characterization of non-labeled sEVs by transmission electron microscopy. Images showing the morphology and size of unlabeled sEVs. Fig. S2. In vivo and ex vivo studies of dual-sEVs. A In vivo SPECT/CT imaging of a tumor 24 h after i.v injection of the dual-sEVs. B In vivo optical imaging of tumor-bearing mice 3 h after i.v. injection in the lateral (left) and prone (right) positions. C Ex vivo optical imaging...

Additional file 1: Supplementary Material. Description of data: Supplementary Methods. Supplementary Figures. Supplementary Tables.

Supplemental material, sj-docx-1-isp-10.1177_00207640221135817 for Mental health differences between multiracial and monoracial college students in the United States: Emerging racial disparities by Hans Oh, Jinyu Du, Lee Smith and Ai Koyanagi in International Journal of Social Psychiatry

Supplemental material, sj-docx-1-isp-10.1177_00207640221135817 for Mental health differences between multiracial and monoracial college students in the United States: Emerging racial disparities by Hans Oh, Jinyu Du, Lee Smith and Ai Koyanagi in International Journal of Social Psychiatry

Additional file 1. Fig. S1. Physicochemical characterization of non-labeled sEVs by transmission electron microscopy. Images showing the morphology and size of unlabeled sEVs. Fig. S2. In vivo and ex vivo studies of dual-sEVs. A In vivo SPECT/CT imaging of a tumor 24 h after i.v injection of the dual-sEVs. B In vivo optical imaging of tumor-bearing mice 3 h after i.v. injection in the lateral (left) and prone (right) positions. C Ex vivo optical imaging...

Additional file 1: Supplementary Material. Description of data: Supplementary Methods. Supplementary Figures. Supplementary Tables.

Abstract Background Pain-sensitized osteoarthritis and fibromyalgia patients characteristically show nociceptive system augmented responsiveness as a common feature. However, sensitization can be originally related to the peripheral injury in osteoarthritis patients, whereas pain and bodily discomfort spontaneously occur in fibromyalgia with no apparent origin. We investigated the distinct functional repercussion of pain sensitization in the cerebral cortex in both conditions. Methods Thirty-one pain-sensitized knee osteoarthritis patients and 38 fibromyalgia patients were compared with matched control groups....

Abstract Background Small extracellular vesicles (sEVs) are emerging natural nanoplatforms in cancer diagnosis and therapy, through the incorporation of signal components or drugs in their structure. However, for their translation into the clinical field, there is still a lack of tools that enable a deeper understanding of their in vivo pharmacokinetics or their interactions with the cells of the tumor microenvironment. In this study, we have designed a dual-sEV probe based on radioactive and fluorescent...

Supplemental material, sj-docx-1-dhj-10.1177_20552076221131145 for Study protocol of EMPOWER: A cluster randomized trial of a multimodal eHealth intervention for promoting mental health in the workplace following a stepped wedge trial design by Beatriz Olaya, Christina M. Van der Feltz-Cornelis and Leona Hakkaart-van Roijen, Dorota Merecz-Kot, Marjo Sinokki, Päivi Naumanen, Jessie Shepherd, Frédérique van Krugten, Marleen de Mul, Kaja Staszewska, Ellen Vorstenbosch, Carlota de Miquel, Rodrigo Antunes Lima, José Luis Ayuso-Mateos, Luis Salvador-Carulla, Oriol Borrega, Carla Sabariego,...

Objective: This article describes the EMPOWER study, a controlled trial aiming to determine the effectiveness and cost-effectiveness of an eHealth intervention to prevent common health problems and reduce presenteeism and absenteeism in the workplace. Intervention: The EMPOWER intervention spans universal, secondary and tertiary prevention and consists of an eHealth platform delivered via a website and a smartphone app designed to guide employees throughout different modules according to their specific profiles. Design: A stepped-wedge cluster randomized...