Additional file 4: Table S3. Top 10 gene interaction pairs identified by JDINAC after adjusting for BMI and menopause status.

Additional file 5: Table S4. The association of IFI30 polymorphisms with BC adjusted for BMI and menopause status.

Additional file 1: Supplementary Fig. 1. (A) RT-qPCR analyses of FOXD1 mRNA in the indicated breast tumor cell lines and MCF-10A. Error bars, SEM. n = 3. (B) Western blotting analyses of FOXD1 expression in the indicated breast tumor cell lines and MCF-10A. (C)RT-qPCR analysis of FOXD1 expression in control and sh-FOXD1 cells (MDA231 and MDA468), or control and FOXD1 overexpression cells (MCF-7). Error bars, SEM. n = 3. **p < 0.01, ***p<0.001 by Student’s...

Abstract Background Early metastasis is a key factor contributing to poor breast cancer (BC) prognosis. Circulating tumor cells (CTCs) are regarded as the precursor cells of metastasis, which are ultimately responsible for the main cause of death in BC. However, to date molecular mechanisms underlying CTC formation in BC have been insufficiently defined. Methods RNA-seq was carried out in primary tissues from early-stage BC patients (with CTCs≥5 and CTCs = 0, respectively) and the validation...

Additional file 1: Supplemental Table 1. Cognitive performance of participants having different reading years.

Additional file 2: Supplemental Table 2. Cognitive performance of participants reading different content.

Additional file 3: Supplemental Table 3. Cognitive performance of participants using different reading materials.

Additional file 1. Supplementary Figure 1. CAV-1 regulated the expression of occludin under hypoxic conditions. (A) bEnd.3 cells were exposed to 1% O2 for 24 h. HIF-1α protein levels were detected by Western blot. (B and C) After transfection with siCAV1 for 48 h, bEnd.3 cells were exposed to 1% O2 for 24 h; Occludin protein levels were detected by Western blot (B) and quantified (C) (*p<0.05 and **p<0.01).

Supplemental material, sj-docx-1-msj-10.1177_13524585221125382 for Recurrent disability progression endpoints in multiple sclerosis clinical trials by Alexandra Bühler, Marcel Wolbers, Fabian Model, Qing Wang, Shibeshih Belachew, Marianna Manfrini, Johannes Lorscheider, Ludwig Kappos and Jan Beyersmann in Multiple Sclerosis Journal

Abstract Background This study aimed to investigate whether the combination of Macleaya cordata extract (MCE) and Bacillus could improve the laying performance and health of laying hens better. Methods A total of 360 29-week-old Jingbai laying hens were randomly divided into 4 treatments: control group (basal diet), MCE group (basal diet + MCE), Probiotics Bacillus Compound (PBC) group (basal diet + compound Bacillus), MCE + PBC group (basal diet + MCE + compound Bacillus). The...

Additional file 2: Fig S1. (A) Echocardiography shows transposition of great arteries and ventricular septal defect in the patient JM0087 (F-2: II-1). (B) Chest X-ray shows dextrocardia in the patient JM0529 (F-4:II-1) at the age of 2 years

Additional file 4: Table S2. Probes sequences targeting NUP188 and PDXDC1 in MLPA. GAPDH served as a internal control

Additional file 4: Table S2. Probes sequences targeting NUP188 and PDXDC1 in MLPA. GAPDH served as a internal control

Additional file 7: Table S3. Primers used for Sanger sequencing for TTC21B and TTC12 variants that identified from WES analyzes

Additional file 7: Table S3. Primers used for Sanger sequencing for TTC21B and TTC12 variants that identified from WES analyzes

Performance evaluation of localization algorithms in stochastic optical localization nanoscopy is necessary and important to applications. By simulation, a localization algorithm estimates a set of emitter locations from a simulated data movie, whose error in comparison with the set of true locations indicates the performance of the algorithm. Since the partition of estimated locations is unknown, the sample root mean square error (RMSE) cannot be computed and the universal root mean square minimum distance (RMSMD)...

Additional file 1: Table S1. Top three reasons for willing to be vaccinated against herpes zoster for the elderly in China (n=9482). Table S2. Top three reasons for not willing to be vaccinated against herpes zoster for the elderly in China (n=9805). Table S3. Sensitivity analysis of intent to be vaccinated based on participant characteristics.

Supplementary Material 1 Fig. S1. Full length blots of Fig. 3G. Fig. S2. Full length blots of Fig. 6 F. Fig. S3. Full length blots of Fig. 7 H. Fig. S4. Additional bands used for statistics in Fig. 3 H. Fig. S5. Additional bands used for statistics in Fig. 6G. Fig. S6. Additional bands used for statistics in Fig. 7I.

We introduce a unified framework, formulated as general latent space models, to study complex higher-order network interactions among multiple entities. Our framework covers several popular models in recent network analysis literature, including mixture multi-layer latent space model and hypergraph latent space model. We formulate the relationship between the latent positions and the observed data via a generalized multilinear kernel as the link function. While our model enjoys decent generality, its maximum likelihood parameter estimation is...

Sichuan Province is located at the transitional junction regions of the Qinghai-Tibet Plateau and the low-altitude plains. It also serves as the corridor of Sino-Tibetan-speaking population migration and expansion since neolithic expansion of Proto-Tibeto-Burman populations from Middle/Upper Yellow River during Majiayao period (3300–2000 BC). However, the population structure and the corresponding genetic diversity of forensic-related markers in this region remain unclear. Thus, we genotyped 30 insertion-deletion (InDel) markers in 444 samples from four ethnic groups...

The awnless trait is the favorite trait for wheat breeding in Qinghai, China, but the major gene underlying the trait is unknown. This study aimed to analyze a recombinant inbred line (RIL) population containing 112 lines by crossing common wheat varieties GY448 (awnless) and GY115 (awned) using genotyping-by-sequencing analysis. A total of 56.62 Gb of clean sequence data were generated. A major gene was identified for the awnless trait based on 101,275 single-nucleotide polymorphisms by...

In this paper we develop a likelihood ratio test for independence between multivariate discrete random vectors whose components may be dependent or may have different marginal distributions. A special case that tests independence between two discrete random variables is also discussed. The model under the null hypothesis is constructed based on the marginal distributions of the random variables, while the model under the alternative is built by adding a common random effect which is not...

We have designed and prepared four new cellulose cross-linking agents using NaClO/NaBr/TEMPO and sodium periodate selective catalytic oxidation systems. First, the primary hydroxyl group of sucrose, trehalose, maltose, or lactose was carboxylated through NaClO/NaBr/TEMPO system, and then sodium periodate was used to selectively oxidize the carboxyl compound to obtain carboxyl polyaldehyde sugars. They contained multiple aldehyde groups and carboxyl groups in the molecule, had high reactivity, and can be covalently cross-linked with cellulose. To evaluate...

Electrocatalytic CO2 reduction to fuel is one of the important ways to solve energy and environmental problems. In this work, the preparation of hollow Aux-Cu2O electrocatalyst and the performance of electrocatalytic CO2 reduction to ethanol were studied. Hollow Cu2O nanospheres were prepared by a soft template method, and Aux-Cu2O composites were prepared by galvanic replacement. The characterization results of XRD and XPS reveal that Cu+ is the main chemical state of Cu in the catalysts....

Two 2D Zn(II) coordination polymers, formulated as [Zn(μ2-tdc)(μ-pmid)] (1), {[Zn(μ2-tdc)(μ-pmmid)2·4H2O]}n (2) (H2tdc = 2,5-thiophenedicarboxylic acid, pmid = 1-(4-pyridylmethyl)imidazole; pmmid = 1-(4-pyridylmethyl)-2-methylimidazole) have been synthesized by reactions of Zn(OAc)2·2H2O and H2tdc with flexibleN-(4-pyridylmethyl)imidazole derivatives under the mild reaction conditions and characterized by single-crystal X-ray diffraction and other physicochemical methods. Structure determination demonstrates compound 1 displays a 2-fold 2D → 2D parallel interpenetrating structure, while compound 2 shows a 2D non-interpenetrating network. These results reveal that the...