Antenatal code list for: \"The effects of antenatal care, ethnicity and social deprivation on the risk of stillbirth in the UK: A cohort study using routinely collected data\"Amanda Clery, Caroline Minnasian, Liam Smeeth & Rohini Mathur
A list of Read codes and entity types used to identify events in the Clinical Practice Research Datalink that identify the antenatal appointments women in the Pregnancy Register had. These were used to quantify the frequency and timing of antenatal care, the exposure variable for the study.
Read codes associated with a paper on clinical risk groups for a Pneumococcal Polysaccharide Vaccine.
Clinical code lists for: \"The effects of antenatal care, ethnicity and social deprivation on the risk of stillbirth in the UK: A cohort study using routinely collected data\"Amanda Clery, Caroline Minassian, Liam Smeeth & Rohini Mathur
Clinical code lists for: "The effects of antenatal care, ethnicity and social deprivation on the risk of stillbirth in the UK: A cohort study using routinely collected data"
Behavioural change towards reduced intensity physical activity is disproportionately prevalent among adults with serious health issues or self-perception of high risk during the UK COVID-19 lockdown.Chrissy Roberts, Nina Rogers, Naomi Waterlow, Hannah Brindle, Luisa Enria & Shelley Lees
Quantitative data on physical activity and health behaviours during the UK COVID-19 lockdown. The anonymous web-based survey was performed between 6th April and 22 April 2020, approximately mapping to weeks 3-5 of the lockdown in the UK. The main survey included 49 questions which covered a broad range of topics including (1) Demographics, (2) Health and Health Behaviours, (3) Adherence to COVID-19 Control measures, (4) Information sources used to learn about COVID-19, (5) Trust in...
Effectiveness of a peer-led adolescent mental health intervention on HIV virological suppression and mental health in Zimbabwe: Baseline and Endline questionnairesVicky Simms & Silindweyinkosi Chinoda
Adolescents living with HIV have poor virological suppression and high levels of common mental disorders. In Zimbabwe the Zvandiri adolescent peer support programme is effective at improving ART adherence and virological suppression. We assessed the effect of training peer supporters in problem-solving therapy (PST) using a cluster-randomised controlled trial. Sixty clinics stratified by district were randomised 1:1 to either normal Zvandiri peer support or a peer supporter trained in PST by Friendship Bench. We enrolled...
Data from: Safety and immunogenicity of H1/IC31®, an adjuvanted TB subunit vaccine, in HIV-infected adults with CD4+ Lymphocyte counts greater than 350 cells/mm3: a phase II, multi-centre, double-blind, randomized, placebo-controlled trialKlaus Reither, Lynn Katsoulis, Trevor Beattie, Nicolene Gardiner, Nicole Lenz, Khadija Said, Elirehema Mfinanga, Christian Pohl, Katherine L. Fielding, Hannah Jeffery, Benjamin M. Kagina, Elisabeth J. Hughes, Thomas J. Scriba, Willem A. Hanekom, Søren T. Hoff, Peter Bang, Ingrid Kromann, Claudia Daubenberger, Peter Andersen & Gavin J. Churchyard
Background: Novel tuberculosis vaccines should be safe, immunogenic, and effective in various population groups, including HIV-infected individuals. In this phase II multi-centre, double-blind, placebo-controlled trial, the safety and immunogenicity of the novel H1/IC31 vaccine, a fusion protein of Ag85B-ESAT-6 (H1) formulated with the adjuvant IC31, was evaluated in HIV-infected adults. Methods: HIV-infected adults with CD4+ T cell counts >350/mm3 and without evidence of active tuberculosis were enrolled and followed until day 182. H1/IC31 vaccine or...
Objective: To clarify whether deaths associated with hot and cold days are among the frail who would have died anyway in the next few weeks or months. Design: Time series regression analysis of annual deaths in relation to annual summaries of cold and heat. Setting: London, UK. Participants: 3 530 280 deaths from all natural causes among London residents between October 1949 and September 2006. Main outcome measures: Change in annual risk of death (all...
Data from: A randomized feasibility trial comparing four antimalarial drug regimens to induce Plasmodium falciparum gametocytemia in the controlled human malaria infection modelIsaie J. Reuling, Lisanne A Van De Schans, Luc E Coffeng, Kjerstin Lanke, Lisette Meerstein-Kessel, Wouter Graumans, Geert-Jan Van Gemert, Karina Teelen, Rianne Siebelink-Stoter, Marga Van De Vegte-Bolmer, Quirijn De Mast, André J Van Der Ven, Karen Ivinson, Cornelus C Hermsen, Sake De Vlas, John Bradley, Katharine A Collins, Christian F Ockenhouse, James McCarthy, Robert W. Sauerwein & Teun Bousema
Background: Malaria elimination strategies require a thorough understanding of parasite transmission from human to mosquito. A clinical model to induce gametocytes to understand their dynamics and evaluate transmission-blocking interventions (TBI) is currently unavailable. Here, we explore the use of the well-established Controlled Human Malaria Infection model (CHMI) to induce gametocyte carriage with different antimalarial drug regimens. Methods: In a single centre, open-label randomised trial, healthy malaria-naive participants (aged 18–35 years) were infected with Plasmodium falciparum...
Data from: Understanding willingness to use oral pre-exposure prophylaxis for HIV prevention among men who have sex with men in ChinaXia Wang, Adam Bourne, Pulin Liu, Jiangli Sun, Thomas Cai, Gitau Mburu, Matteo Cassolato, Bangyuan Wang & Wang Zhou
Background: Oral pre-exposure prophylaxis (PrEP) is recommended as an additional prevention choice for men who have sex with men (MSM) at substantial risk of HIV. The aim of this study was to evaluate the extent, and reasons, for MSM’s willingness to use oral PrEP in Wuhan and Shanghai, China. Methods: Between May and December 2015, a cross-sectional survey was conducted among 487 MSM recruited through snowball sampling in physical locations frequented by MSM and through...
The MAISHA study (component A) is a mixed-methods evaluation, including a cluster randomised trial (CRT), of a small group based social empowerment intervention to prevent intimate partner violence (IPV) against women in Mwanza city, Tanzania. The trial was conducted among women already participating in a group-based microfinance scheme, with the microfinance group being the unit of randomisation and (in the intervention arm) the unit of intervention delivery. The CRT involved two surveys of trial participants...
Data repository for AZ-SMC - a trial of seasonal malaria chemoprevention combined with azithromycin in African childrenDaniel Chandramohan, Alassane Dicko, Issaka Zongo, Issaka Sagara, Matthew Cairns, Irene Kuepfer, Modibo Diarra, Barry Amadou, Amadou Tapily, Frederic Nikiema, Serge Yerbanga, Samba Coumare, Ismaila Thera, Abdourhamane Traore, Paul Milligan, Halidou Tinto, Ogobara Doumbo, Jean-Bosco Ouedraogo & Brian Greenwood
Data collected during the AZ-SMC trial (clinicaltrials.gov NCT02211729) in Houndé District, Burkina Faso and Bougouni District, Mali between 2014 and 2016.
Effectiveness of a peer-led adolescent mental health intervention on HIV virological suppression and mental health in Zimbabwe: data collection documentsVictoria Simms
In Zimbabwe, the Zvandiri adolescent peer-support programme is effective at improving virological suppression. We assessed the effect of training Zvandiri peer-counsellors known as Community Adolescent Treatment Supporters (CATS) in problem-solving therapy (PST) on virological suppression and mental health outcomes. Sixty clinics were randomised 1:1 to either normal Zvandiri peer-counselling or a peer-counsellor trained in problem solving therapy. We enrolled on average 14 adolescents per clinic (N=842) aged 10-19 years, living with HIV who screened positive...
Data from: Temperature and population density determine reservoir regions of spatial persistence in highland malariaAmir S. Siraj, Menno J. Bouma, Mauricio Santos-Vega, Asnakew K. Yeshiwondim, Dale S. Rothman, Damtew Yadeta, Paul C. Sutton & Mercedes Pascual
A better understanding of malaria persistence in highly seasonal environments such as highlands and desert fringes requires identifying the factors behind the spatial reservoir of the pathogen in the low season. In these ‘unstable’ malaria regions, such reservoirs play a critical role by allowing persistence during the low transmission season and therefore, between seasonal outbreaks. In the highlands of East Africa, the most populated epidemic regions in Africa, temperature is expected to be intimately connected...
Data from: Substantial contribution of submicroscopical Plasmodium falciparum gametocyte carriage to the infectious reservoir in an area of seasonal transmission.André Lin Ouédraogo, Teun Bousema, Petra Schneider, Sake J. De Vlas, Edith Ilboudo-Sanogo, Nadine Cuzin-Ouattara, Issa Nébié, Will Roeffen, Jan Peter Verhave, Adrian J.F. Luty & Robert Sauerwein
Background: Man to mosquito transmission of malaria depends on the presence of the sexual stage parasites, gametocytes, that often circulate at low densities. Gametocyte densities below the microscopical threshold of detection may be sufficient to infect mosquitoes but the importance of submicroscopical gametocyte carriage in different transmission settings is unknown. Methodology/Principal Findings: Membrane feeding experiments were carried out on 80 children below 14 years of age at the end of the wet season in an...
Background: Universal access to Primary Eye Care (PEC) is a key global initiative to reduce and prevent avoidable causes of visual impairment (VI). PEC can address minor eye conditions, simple forms of uncorrected refractive error (URE) and create a referral pathway for specialist eye care, thus offering a potential solution to a lack of eye health specialists in low-income countries. However, there is little information on the population need for PEC, including prevalence of URE...
Data from: Weekend admission as an independent predictor of mortality: an analysis of Scottish hospital admissionsAdam E. Handel, Sunil V. Patel, Andrew Skingsley, Katrina Bramley, Roma Sobieski & Sreeram V. Ramagopalan
OBJECTIVES: Weekend admissions have been shown to be associated with an increased risk of mortality compared with weekday admissions for many diagnoses. We analysed emergency department admissions within the Scottish National Health Service to investigate whether mortality is increased in case of weekend emergency department admissions. DESIGN: A cohort study. SETTING: Scotland National Health Service (NHS) emergency departments. PARTICIPANTS: 5 271 327 emergency department admissions between 1999 and 2009. We included all patients admitted via...
London School of Hygiene & Tropical Medicine91
Radboud University Nijmegen6
Medical Research Council6
Centre National de Recherche et de Formation sur le Paludisme5
Imperial College London4
University College London3
Radboud University Nijmegen Medical Centre3
Erasmus University Medical Center2
University of Edinburgh2