588 Works

Role of lncRNA LINC01194 in hepatocellular carcinoma via the miR-655-3p/SMAD family member 5 axis

Yang Liu, Jie Liu, Junkai Cui, Ruolei Zhong & Guoyang Sun
Long non-coding RNAs (lncRNAs) are involved in developing hepatocellular carcinoma (HCC). The present study explored the role of lncRNA LINC01194, which is upregulated in HCC tissues and might be a vital regulator in HCC progression. Levels of LINC01194, microRNA (miR)-655-3p, and SMAD family member 5 (SMAD5) were assessed using reverse transcription quantitative real-time polymerase chain reaction (RT-qPCR). The bioactivity of Huh-7 cells was assessed using cell counting kit-8 and transwell assays and flow cytometry. Western...

Ultrasound targeted microbubble destruction-mediated SOCS3 attenuates biological characteristics and epithelial-mesenchymal transition (EMT) of breast cancer stem cells

Xiaojiang Tang, Na Hao, Yuhui Zhou & Yang Liu
SOCS3 is low-expressed in breast cancer and may be a potential target. Ultrasound targeted microbubble destruction (UTMD) improved the efficiency of gene transfection. We explored the effects of UTMD-mediated transfection of SOCS3 on the biological characteristics and epithelial-mesenchymal transition (EMT) of breast cancer stem cells (BCSCs). The expression of SOCS3 in breast cancer (BC) and its association with prognosis were evaluated by GEPIA and The Cancer Genome Atlas (TCGA) websites. BCSCs were sorted by flow...

Plasmodium falciparum drug resistant genotypes - SUMUT study, North Sumatera, 2015

Colin Sutherland & Inke Nadia Lubis
A dataset produced as part of the SUMUT study, investigating plasmodium falciparum drug resistant genotypes. It consists of two tables: (1) a "full data" table that contains individual-level information on 404 individuals who were found to be positive, either by pfmdr1 nested PCR or 18S rDNA nested PCR; and (2) a "cohort data" table that contains information on 195 individuals positive by microscopy and randomised to receive either dihydroartemisinin-piperaquine (DP) or artemether-lumefantrine (AL). Data was...

Abietane diterpenoids with neuroprotective activities from Phlegmariurus carinatus

Yang Liu, Qiang Wang, Dong-Kun Zheng, De Zhang, Zhen Xie, Jia-Wei Hu, Xin-Hua Xie, Jing Li & Shu-Ping Jiang
Two new abietane diterpenoids, phlecarinatone A (1) and phlecarinatone B (2), along with two known analogues (3 and 4), were isolated from Phlegmariurus carinatus. The structures of 1 − 4 were unambiguously elucidated by comprehensive spectroscopic analyses. Abietane diterpenoids were isolated from the plant for the first time. All isolates were tested for their neuroprotective activities against H2O2-induced SH-SY5Y cells injury, and compound 2 showed moderate effect at the concentrations ranging from 5 ∼ 20...

Catastrophic ice-debris flow in the Rishiganga River, Chamoli, Uttarakhand (India)

Vijendra Kumar Pandey, Rajesh Kumar, Rupendra Singh, Suresh Chand, Ramesh P. Singh, Arun Kumar Tripathi, Vijay Kumar Soni, S. Nawaz Ali, Dakshina Tamang & Syed Umer Latief
A catastrophic flood occurred on 7 February 2021 around 10:30 AM (local time) in the Rishiganga River, which has been attributed to a rockslide in the upper reach of the Raunthi River. The Resourcesat 2 LISS IV (8 February 2021) and CNES Airbus satellite imagery (9 February 2021) clearly show the location of displaced materials. The solar radiation observed was higher than normal by 10% and 25% on 6 and 7 February 2021, respectively, however,...

How do foundation year and internship experience shape doctors’ career intentions and decisions? A meta-ethnography

Yingxi Zhao, Daniel Mbuthia, Claire Blacklock, David Gathara, Catia Nicodemo, Sassy Molyneux & Mike English
Foundation years or internships are an important period for junior doctors to apply their knowledge and gain clinical competency. Experiences gained during the foundation years or internships are likely to inform newly qualified doctors’ opinions about how they want to continue their career. We aimed to understand how medical doctors’ internship experiences influence their career intention/decision. We conducted qualitative evidence synthesis using meta-ethnography. We searched six electronic bibliographic databases for papers published between 2000–2020 and...

Additional file 1 of The role of proteoglycan form of DMP1 in cranial repair

Yang Liu, Pingping Niu, Mengqi Zhou & Hui Xue
Additional file 1: SupplementaryTable 1.

Additional file 1 of Prevalence, determinants and outcomes of traditional, complementary and alternative medicine use for hypertension among low-income households in Malaysia and the Philippines

Lia M. Palileo-Villanueva, Benjamin Palafox, Arianna Maever L. Amit, Veincent Christian F. Pepito, Fadhlina Ab-Majid, Farnaza Ariffin, Dina Balabanova, Mohamad-Rodi Isa, Nafiza Mat-Nasir, Mazapuspavina My, Alicia Renedo, Maureen L. Seguin, Khalid Yusoff, Antonio L. Dans & Martin Mckee
Additional file 1: Appendix 1. Variable definitions. Appendix 2. Derivation of sampling probability weights. Appendix 3. Characteristics of participants included and excluded from the RESPOND study TCAM analysis. Appendix 4. STROBE checklist of items that should be included in reports of cross-sectional studies and sample derivation flow diagram. Appendix 5. Full model results for association of TCAM use with hypertension management outcomes and wellbeing.

Additional file 1 of Prevalence, determinants and outcomes of traditional, complementary and alternative medicine use for hypertension among low-income households in Malaysia and the Philippines

Lia M. Palileo-Villanueva, Benjamin Palafox, Arianna Maever L. Amit, Veincent Christian F. Pepito, Fadhlina Ab-Majid, Farnaza Ariffin, Dina Balabanova, Mohamad-Rodi Isa, Nafiza Mat-Nasir, Mazapuspavina My, Alicia Renedo, Maureen L. Seguin, Khalid Yusoff, Antonio L. Dans & Martin Mckee
Additional file 1: Appendix 1. Variable definitions. Appendix 2. Derivation of sampling probability weights. Appendix 3. Characteristics of participants included and excluded from the RESPOND study TCAM analysis. Appendix 4. STROBE checklist of items that should be included in reports of cross-sectional studies and sample derivation flow diagram. Appendix 5. Full model results for association of TCAM use with hypertension management outcomes and wellbeing.

Additional file 1 of The duration of protection against clinical malaria provided by the combination of seasonal RTS,S/AS01E vaccination and seasonal malaria chemoprevention versus either intervention given alone

Matthew Cairns, Amadou Barry, Issaka Zongo, Issaka Sagara, Serge R. Yerbanga, Modibo Diarra, Charles Zoungrana, Djibrilla Issiaka, Abdoul Aziz Sienou, Amadou Tapily, Koualy Sanogo, Mahamadou Kaya, Seydou Traore, Kalifa Diarra, Hama Yalcouye, Youssoufa Sidibe, Alassane Haro, Ismaila Thera, Paul Snell, Jane Grant, Halidou Tinto, Paul Milligan, Daniel Chandramohan, Brian Greenwood, Alassane Dicko … & Jean Bosco Ouedraogo
Additional file 1: Table S1. Number of clinical malaria episodes by time since vaccination in each year of the study, using 90-day periods (as used in the Piecewise Cox regression models). Table S2. Number of clinical malaria episodes by time since vaccination in each year of the study, using 60-day periods (not used in the Piecewise Cox regression models, but provided to show the declining incidence of malaria further into the dry season). Table S3....

The duration of protection against clinical malaria provided by the combination of seasonal RTS,S/AS01E vaccination and seasonal malaria chemoprevention versus either intervention given alone

Matthew Cairns, Amadou Barry, Issaka Zongo, Issaka Sagara, Serge R. Yerbanga, Modibo Diarra, Charles Zoungrana, Djibrilla Issiaka, Abdoul Aziz Sienou, Amadou Tapily, Koualy Sanogo, Mahamadou Kaya, Seydou Traore, Kalifa Diarra, Hama Yalcouye, Youssoufa Sidibe, Alassane Haro, Ismaila Thera, Paul Snell, Jane Grant, Halidou Tinto, Paul Milligan, Daniel Chandramohan, Brian Greenwood, Alassane Dicko … & Jean Bosco Ouedraogo
Abstract Background A recent trial of 5920 children in Burkina Faso and Mali showed that the combination of seasonal vaccination with the RTS,S/AS01E malaria vaccine (primary series and two seasonal boosters) and seasonal malaria chemoprevention (four monthly cycles per year) was markedly more effective than either intervention given alone in preventing clinical malaria, severe malaria, and deaths from malaria. Methods In order to help optimise the timing of these two interventions, trial data were reanalysed...

Additional file 2 of β-Arrestin2-biased Drd2 agonist UNC9995 alleviates astrocyte inflammatory injury via interaction between β-arrestin2 and STAT3 in mouse model of depression

Yang Liu, Nanshan Song, Hang Yao, Siyuan Jiang, Yueping Wang, Ying Zheng, Yuanzhang Zhou, Jianhua Ding, Gang Hu & Ming Lu
Additional file 2: The original data of Western blot in the study.

Additional file 2 of β-Arrestin2-biased Drd2 agonist UNC9995 alleviates astrocyte inflammatory injury via interaction between β-arrestin2 and STAT3 in mouse model of depression

Yang Liu, Nanshan Song, Hang Yao, Siyuan Jiang, Yueping Wang, Ying Zheng, Yuanzhang Zhou, Jianhua Ding, Gang Hu & Ming Lu
Additional file 2: The original data of Western blot in the study.

β-Arrestin2-biased Drd2 agonist UNC9995 alleviates astrocyte inflammatory injury via interaction between β-arrestin2 and STAT3 in mouse model of depression

Yang Liu, Nanshan Song, Hang Yao, Siyuan Jiang, Yueping Wang, Ying Zheng, Yuanzhang Zhou, Jianhua Ding, Gang Hu & Ming Lu
Abstract Background Major depressive disorder (MDD) is a prevalent and devastating psychiatric illness. Unfortunately, the current therapeutic practice, generally depending on the serotonergic system for drug treatment is unsatisfactory and shows intractable side effects. Multiple evidence suggests that dopamine (DA) and dopaminergic signals associated with neuroinflammation are highly involved in the pathophysiology of depression as well as in the mechanism of antidepressant drugs, which is still in the early stage of study and well worthy...

β-Arrestin2-biased Drd2 agonist UNC9995 alleviates astrocyte inflammatory injury via interaction between β-arrestin2 and STAT3 in mouse model of depression

Yang Liu, Nanshan Song, Hang Yao, Siyuan Jiang, Yueping Wang, Ying Zheng, Yuanzhang Zhou, Jianhua Ding, Gang Hu & Ming Lu
Abstract Background Major depressive disorder (MDD) is a prevalent and devastating psychiatric illness. Unfortunately, the current therapeutic practice, generally depending on the serotonergic system for drug treatment is unsatisfactory and shows intractable side effects. Multiple evidence suggests that dopamine (DA) and dopaminergic signals associated with neuroinflammation are highly involved in the pathophysiology of depression as well as in the mechanism of antidepressant drugs, which is still in the early stage of study and well worthy...

Resilience of people with chronic medical conditions during the COVID-19 pandemic: a 1-year longitudinal prospective survey

Lorenzo Tarsitani, Irene Pinucci, Federico Tedeschi, Martina Patanè, Davide Papola, Christina Palantza, Ceren Acarturk, Emma Björkenstam, Richard Bryant, Sebastian Burchert, Camille Davisse-Paturet, Amanda Díaz-García, Rachel Farrel, Daniela C. Fuhr, Brian J. Hall, Anja C. Huizink, Agnes Iok Fong Lam, Gülşah Kurt, Ingmar Leijen, Ellenor Mittendorfer-Rutz, Naser Morina, Catherine Panter-Brick, Fredrick Dermawan Purba, Soledad Quero, Soraya Seedat … & Corrado Barbui
Abstract Backgrounds Individuals with chronic medical conditions are considered highly exposed to COVID-19 pandemic stress, but emerging evidence is demonstrating that resilience is common even among them. We aimed at identifying sustained resilient outcomes and their predictors in chronically ill people during the first year of the pandemic. Methods This international 4-wave 1-year longitudinal online survey included items on socio-demographic characteristics, economic and living situation, lifestyle and habits, pandemic-related issues, and history of mental disorders....

Novel hybrid molecules based on disulfides and 1,2,4-triazole as antiproliferative agents

Junjie Li, Yang Liu, Yanle Men, Zijian Li, Yanping Shi, Xuguang Liu & Baoquan Chen
A series of novel hybrid molecules based on disulfides and 1,2,4-triazole were synthesized, and the structures of the resulting compounds (7a–7g, 8a–8g and 9a–9g) were confirmed by their IR, 1H NMR, 13C NMR and HR-ESI-MS spectroscopic data. The in vitro antiproliferative activity of the tested compounds on human cancer cells A549, Hela, SMMC-7721, and normal cells L929 was determined by CCK-8 assay. The obtained data revealed that most of the tested compounds showed some degrees...

Additional file 1 of A cross-sectional national investigation of COVID-19 outbreaks in nurseries during rapid spread of the Alpha (B.1.1.7) variant of SARS-CoV-2 in England

Felicity Aiano, Kelsey McOwat, Chinelo Obi, Annabel A. Powell, Jessica Flood, Shivraj Bhardwaj, Kelly Stoker, Donna Haskins, Brian Wong, Marta Bertran, Maria Zavala, Johanna Bosowski, Samuel E. I. Jones, Zahin Amin-Chowdhury, Laura Coughlan, Mary Sinnathamby, Asad Zaidi, Rachel Merrick, Hongxin Zhao, Sharif Ismail, Mary E. Ramsay, Shamez N. Ladhani & Vanessa Saliba
Additional file 1: Table S1. Size and number of bubbles in nurseries reporting a COVID-19 outbreak to Public Health England (PHE). Table S2. Reported social distancing between and within bubbles in nurseries reporting a COVID-19 outbreak to Public Health England (PHE). Table S3. Shared facilities in nurseries reporting a COVID-19 outbreak to Public Health England (PHE). Table S4. reason for testing in the first four cases, where known, among staff and children in nurseries reporting...

Evaluating the effects of supplementing ward nurses on quality of newborn care in Kenyan neonatal units: protocol for a prospective workforce intervention study

Abdulazeez Imam, David Gathara, Jalemba Aluvaala, Michuki Maina & Mike English
Abstract Background Data from High Income Countries have now linked low nurse staff to patient ratios to poor quality patient care. Adequately staffing hospitals is however still a challenge in resource-constrained Low-middle income countries (LMICs) and poor staff-to-patient ratios are largely taken as a norm. This in part relates to limited evidence on the relationship between staffing and quality of patient care in these settings and also an absence of research on benefits that might...

Evaluating the effects of supplementing ward nurses on quality of newborn care in Kenyan neonatal units: protocol for a prospective workforce intervention study

Abdulazeez Imam, David Gathara, Jalemba Aluvaala, Michuki Maina & Mike English
Abstract Background Data from High Income Countries have now linked low nurse staff to patient ratios to poor quality patient care. Adequately staffing hospitals is however still a challenge in resource-constrained Low-middle income countries (LMICs) and poor staff-to-patient ratios are largely taken as a norm. This in part relates to limited evidence on the relationship between staffing and quality of patient care in these settings and also an absence of research on benefits that might...

Cooking or heating with solid fuels increased the all-cause mortality risk among mid-aged and elderly People in China

Yuxiang Yang, Yang Liu, Luolan Peng, Shuai Zhang, Changzheng Yuan, Wenyuan Li, Zuyun Liu & Yanan Ma
Abstract Background Our study aimed to explore the associations between solid fuels burning for either heating or cooking and all-cause mortality based on 2859 participants from the China Health and Retirement Longitudinal Study during 2011–2018. Methods Logistic regression models were performed to estimate the risk for all-cause mortality between different types of fuels in the current longitudinal study. Furthermore, the combined impacts of applying solid fuels for both cooking and heating and the effect among...

Supplementary document for Broadband behavior of quadratic metalenses with a wide field of view - 6011078.pdf

Yang Liu, Jianhao Zhang, Xavier Le Roux, Eric Cassan, Delphine Marris-Morini, Laurent Vivien, Carlos Alonso Ramos & Daniele Melati
Supplemental document with additional data, simulation results, and figures.

Additional file 5 of Strengthening vaccination delivery system resilience in the context of protracted humanitarian crisis: a realist-informed systematic review

Sharif A. Ismail, Sze Tung Lam, Sadie Bell, Fouad M. Fouad, Karl Blanchet & Josephine Borghi
Additional file 5: Appendix 5. Overall summary of quality appraisal results.

Additional file 1 of Diagnostic accuracy of multiplex respiratory pathogen panels for influenza or respiratory syncytial virus infections: systematic review and meta-analysis

Sophie Jullien, Felicity Fitzgerald, Suzanne Keddie, Oliver Baerenbold, Quique Bassat, John Bradley, Jane Falconer, Colin Fink, Ruth Keogh, Heidi Hopkins & Marie Voice
Additional file 1: Annex S1. Search methodology. Annex S2. Databases. Annex S3. Statistical model. Annex S4. Literature search results. Additional tables and figures.

Diagnostic accuracy of multiplex respiratory pathogen panels for influenza or respiratory syncytial virus infections: systematic review and meta-analysis

Sophie Jullien, Felicity Fitzgerald, Suzanne Keddie, Oliver Baerenbold, Quique Bassat, John Bradley, Jane Falconer, Colin Fink, Ruth Keogh, Heidi Hopkins & Marie Voice
Abstract Respiratory syncytial virus (RSV) and influenza viruses are important global causes of morbidity and mortality. We evaluated the diagnostic accuracy of the Luminex NxTAG respiratory pathogen panels (RPPs)™ (index) against other RPPs (comparator) for detection of RSV and influenza viruses. Studies comparing human clinical respiratory samples tested with the index and at least one comparator test were included. A random-effect latent class meta-analysis was performed to assess the specificity and sensitivity of the index...

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