7 Works

Data from: Myelin basic protein induces neuron-specific toxicity by directly damaging the neuronal plasma membrane

Jie Zhang, Xin Sun, Sixin Zheng, Xiao Liu, Jinghua Jin, Yi Ren & Jianhong Luo
The central nervous system (CNS) insults may cause massive demyelination and lead to the release of myelin-associated proteins including its major component myelin basic protein (MBP). MBP is reported to induce glial activation but its effect on neurons is still little known. Here we found that MBP specifically bound to the extracellular surface of the neuronal plasma membrane and induced neurotoxicity in vitro. This effect of MBP on neurons was basicity-dependent because the binding was...

Data from: Dissecting the phenotypic components of crop plant growth and drought responses based on high-throughput image analysis

Dijun Chen, Kerstin Neumann, Swetlana Friedel, Benjamin Kilian, Ming Chen, Thomas Altmann & Christian Klukas
Significantly improved crop varieties are urgently needed to feed the rapidly growing human population under changing climates. While genome sequence information and excellent genomic tools are in place for major crop species, the systematic quantification of phenotypic traits or components thereof in a high-throughput fashion remains an enormous challenge. In order to help bridge the genotype to phenotype gap, we developed a comprehensive framework for high-throughput phenotype data analysis in plants, which enables the extraction...

Data from: Potential role of Cyr61 induced degeneration of human Müller cells in diabetic retinopathy

Fen Zhou, Yikui Zhang, Ding Chen, Zhitao Su, Ling Jin, Lei Wang, Zhixiang Hu, Zhisheng Ke & Zongming Song
The degeneration of Müller cells has been recognized to involve in the pathogenesis of diabetic retinopathy. However, the mechanism is not yet clear. This study is to explore the potential role of Cyr61, a secreted signaling protein in extracellular matrix, in inducing human Müller cell degeneration in diabetic retinopathy (DR). Twenty patients with proliferative diabetic retinopathy (PDR) and twelve non-diabetic patients were recruited for this study. Vitreous fluid was collected during vitrectomy surgery for Cyr61...

Data from: A comparative study on genetic effects of artificial and natural habitat fragmentation on Loropetalum chinense (Hamamelidaceae) in Southeast China

Na Yuan, Hans-Peter Comes, Ya-Nan Cao, Rui Guo, Yong-Hua Zhang & Ying-Xiong Qiu
Elucidating the demographic and landscape features that determine the genetic effects of habitat fragmentation has become fundamental to research in conservation and evolutionary biology. Land-bridge islands provide ideal study areas for investigating the genetic effects of habitat fragmentation at different temporal and spatial scales. In this context, we compared patterns of nuclear microsatellite variation between insular populations of a shrub of evergreen broad-leaved forest, Loropetalum chinense, from the artificially created Thousand-Island Lake (TIL) and the...

Data from: Do microorganism stoichiometric alterations affect carbon sequestration in paddy soil subjected to phosphorus input?

Zhi Jian Zhang, Qiang He, ZhiJian Zhang, HongYi Li, Jiao Hu, Xia Li, GuangMing Tian, Hang Wang, ShunYao Wang & Bei Wang
Ecological stoichiometry provides a powerful tool for integrating microbial biomass stoichiometry with ecosystem processes, opening far-reaching possibilities for linking microbial dynamics to soil carbon (C) metabolism in response to agricultural nutrient management. Despite its importance to crop yield, the role of phosphorus (P) with respect to ecological stoichiometry and soil C sequestration in paddy fields remains poorly understood, which limits our ability to predict nutrient-related soil C cycling. Here, we collected soil samples from a...

Data from: Mixed linear model approach for mapping quantitative trait loci underlying crop seed traits

Ting Qi & Haiming Xu
The crop seed is a complex organ that may be composed of the diploid embryo, the triploid endosperm and the diploid maternal tissues. According to the genetic features of seed characters, two genetic models for mapping quantitative trait loci (QTLs) of crop seed traits are proposed, with inclusion of maternal effects, embryo or endosperm effects of QTL, environmental effects and QTL-by-environment (QE) interactions. The mapping population can be generated either from double back-cross of immortalized...

Data from: The efficacy of activated protein C for the treatment of sepsis: incorporating observational evidence with a Bayesian approach

Zhongheng Zhang
Objective: The present study aimed to combine observational evidence with randomised controlled trials (RCTs) by using the Bayesian approach. Data sources: Electronic databases, including PubMed, Cochrane Central Register of Controlled Trials (CENTRAL), ISI Web of Science, EMBASE and EBSCO were searched from inception to January 2014. Study eligibility: RCTs and observational studies (OS) investigating the effectiveness of activated protein C (aPC) on mortality reduction were included for analysis. Participants: Patients with sepsis. Intervention: aPC. Synthesis...

Registration Year

  • 2014

Resource Types

  • Dataset


  • Zhejiang University
  • Wenzhou Medical University
  • University of Tennessee at Knoxville
  • Johns Hopkins University School of Medicine
  • Institute of Plant Genetics and Crop Plant Research
  • Florida State University