8,030 Works
DRAM: A three-dimensional analytical model for the mobilisation of root reinforcement in direct shear conditions – Data repository
Gerrit Meijer, Jonathan Knappett, Glyn Bengough, Daniel Bull, Teng Liang & David Muir Wood
This dataset contains data of experiments underlying the work presented in the linked Ecological Engineering journal publication (DOI: 10.1016/j.ecoleng.2022.106621).
Source code for the DRAM model (written in R) can be found in a separate repository (DOI: 10.5281/zenodo.6375587).
Enhancing integrated denitrifying anaerobic methane oxidation and Anammox processes for nitrogen and methane removal: A review
Yan Chen, Guangming Jiang, Muttucumaru Sivakumar & Jiangping Wu
The integration of denitrifying anaerobic methane oxidation (DAMO) and anaerobic ammonium oxidation (Anammox) simultaneously converts ammonium, methane, and oxidized nitrogen species (nitrite and nitrate) to harmless N2 and CO2. This integrated and complementary process achieves the nitrogen and carbon cycles in wastewater with the potential to be applied widely at full scale to realize energy-positive wastewater treatment plants (WWTPs). In this review, we summarize the collaborative and competitive interactions of DAMO–Anammox microorganisms and systematically evaluate...
Nucleophosmin 1: from its pathogenic role to a tantalizing therapeutic target in acute myeloid leukemia
Yuye Shi, Yuhao Xue, Chunling Wang & Liang Yu
Nucleophosmin 1 (NPM1, also known as B23) is a multifunctional protein involved in a variety of cellular processes, including ribosomal maturation, centrosome replication, maintenance of genomic stability, cell cycle control, and apoptosis. NPM1 is the most commonly mutated gene in adult acute myeloid leukemia (AML) and is present in approximately 40% of all AML cases. The underlying mechanisms of mutant NPM1 (NPM1mut) in leukemogenesis remain unclear. This review summarizes the structure and physiological function of...
Transcriptional Regulation of the Chicken ASMT Gene- A Preliminary Analysis
Jun Teng, Dan Wang, Wenwen Wang, Chao Ning, Qin Zhang & Hui Tang
1. Melatonin is an indole hormone that, among its myriad biological functions, regulates circadian and seasonal rhythms in animals. The ASMT gene plays an essential role in melatonin synthesis. However, in chickens, little is known about the regulatory elements governing its transcription. 2. The following study identified the transcription start site of the chicken ASMT gene by 5’-RACE. Then, the proximal minimal promoter was identified using a series of 5′ truncations of the ASMT promoter...
How Covid-19 affects intercity transportation in China: high-speed rail versus air
Jie Huang, Jiaoe Wang & Yongling Li
This graphic uses cartogram analysis to demonstrate how Covid-19 affects high-speed rail (HSR) and air networks in China. During the first round of the Covid-19 outbreak, intercity transportation networks significantly decreased their service. However, the supply of transport hubs was retained to ensure basic service coverage and efficiency. Conversely, air transportation was affected more than HSR networks. The average number of daily flights declined to 19% of the original traffic, while high-speed trains maintained their...
A short report of novel RARG-HNRNPM fusion gene in resembling acute promyelocytic leukemia
Yang Song, Jiangxue Hou, Li Wan, Kaiqi Liu, Chunlin Zhou, Shuning Wei, Guangji Zhang, Dong Lin, Yan Li, Qiuyun Fang, Yuntao Liu, Benfa Gong, Xiaoyuan Gong, Ying Wang, Hui Wei, Jianxiang Wang & Yingchang Mi
Resembling acute promyelocytic leukemia (APL) is a unique subtype of APL who sharing clinical, morphological, and immunophenotypic features with typical APL, but lacking evidence of PML-RARA fusion gene and usually insensitive to arsenic trioxide (ATO) and all-trans retinoic acid (ATRA). For years, RARA, RARB and RARG rearrangement were found in resembling APL continually. The confirmed partner genes of RARG rearrangement included CPSF6, NUP98, NPM1, PML, and HNRNPC. These patients were a group of resembling APL...
DARS-AS1 recruits METTL3/METTL14 to bind and enhance DARS mRNA m6A modification and translation for cytoprotective autophagy in cervical cancer
Miaohua Zhu, Weiwei Shen, Qiming Wang, Xiaoming Zhou, Jiaying Wang, Tingting Wang & Jing Zhang
Cervical cancer (CC) is one of the most prevalent malignancies among females. Cytoprotective autophagy could confer cancer cell tolerance to hypoxic stress, promoting cell survival and adaptation. Aspartyl-tRNA synthetase 1 antisense 1 (DARS-AS1) is an oncogenic long non-coding RNA (lncRNA) in various cancers, but how DARS-AS1 regulates cytoprotective autophagy in hypoxic environment in CC remains unclear. Chromatin immunoprecipitation (ChIP) and luciferase reporter assays were conducted to explore the interaction between hypoxia-inducible factor 1 subunit alpha...
Numerical investigation of asymmetric weld fusion geometry in laser welding of aluminium alloy with beam oscillation
Xi Chen, Nan Jiang, Meng Jiang, Yang Du, Shengchong Ma, Yuan Chen, Caiwang Tan, Zhenglong Lei, Sicong Zhao & Yanbin Chen
In this work, the asymmetric weld fusion geometry in oscillating laser beam welding (OLBW) of aluminium alloy was reported and investigated using a numerical approach. A multi-physics heat transfer and fluid flow model of OLBW was developed and validated with the corresponding experimental results. The weld fusion geometry, temperature fields, and fluid flow behaviours for four commonly used oscillation modes, line, circle, eight, and infinity, were calculated to analyse the origin of the asymmetric weld...
Epg5 deficiency leads to primary ovarian insufficiency due to WT1 accumulation in mouse granulosa cells
Wenwen Liu, Min Chen, Chao Liu, Liying Wang, Huafang Wei, Ruidan Zhang, Zhengxing Ren, Yinghong Chen, Mengcheng Luo, Jianguo Zhao, Hongwei Jiang, Fei Gao & Wei Li
Primary ovarian insufficiency (POI), also known as premature ovarian failure, is an ovarian defect in humans characterized by the premature depletion of ovarian follicles before the age of 40. However, the mechanisms underlying POI remain largely unknown. Here, we show that knockout of Epg5 (ectopic P-granules autophagy protein 5 homolog (C. elegans)) results in subfertility in female mice, which exhibit a POI-like phenotype. Single-cell RNA sequencing analysis revealed that the knockout of Epg5 affected the...
A SERS-based immunochromatographic assay for ultrasensitive and quantitative detection of florfenicol using long wavelength absorption of Au nanocubes
Ying Liu, Ting Zhou, Penghui Zhou, Hanwen Liu, Jianguo Li & Anping Deng
An immunochromatographic assay (ICA) based on surface-enhanced Raman scattering (SERS) for ultrasensitive and quantitative detection of florfenicol (FF) in food samples was developed. Au nanocubers (AuNCs) with long wavelength absorption were synthesised, characterised and used as the substrate in SERS-ICA. Immunoprobe was prepared by linking Raman reporter and the antibody against FF on AuNCs. The SERS-ICA was completed in 15 min. By measuring the Raman intensities on T lines, quantitative detection of FF was achieved....
sj-pdf-1-imr-10.1177_03000605221126874 - Supplemental material for Fibrinogen like protein-1 knockdown suppresses the proliferation and metastasis of TU-686 cells and sensitizes laryngeal cancer to LAG-3 blockade
Jiameng Huang, Qiang Huang, Jiyao Xue, Huiqin Liu, Yang Guo, Hui Chen & Liang Zhou
Supplemental material, sj-pdf-1-imr-10.1177_03000605221126874 for Fibrinogen like protein-1 knockdown suppresses the proliferation and metastasis of TU-686 cells and sensitizes laryngeal cancer to LAG-3 blockade by Jiameng Huang, Qiang Huang, Jiyao Xue, Huiqin Liu, Yang Guo, Hui Chen and Liang Zhou in Journal of International Medical Research
sj-pdf-1-imr-10.1177_03000605221126874 - Supplemental material for Fibrinogen like protein-1 knockdown suppresses the proliferation and metastasis of TU-686 cells and sensitizes laryngeal cancer to LAG-3 blockade
Jiameng Huang, Qiang Huang, Jiyao Xue, Huiqin Liu, Yang Guo, Hui Chen & Liang Zhou
Supplemental material, sj-pdf-1-imr-10.1177_03000605221126874 for Fibrinogen like protein-1 knockdown suppresses the proliferation and metastasis of TU-686 cells and sensitizes laryngeal cancer to LAG-3 blockade by Jiameng Huang, Qiang Huang, Jiyao Xue, Huiqin Liu, Yang Guo, Hui Chen and Liang Zhou in Journal of International Medical Research
Fibrinogen like protein-1 knockdown suppresses the proliferation and metastasis of TU-686 cells and sensitizes laryngeal cancer to LAG-3 blockade
Jiameng Huang, Qiang Huang, Jiyao Xue, Huiqin Liu, Yang Guo, Hui Chen & Liang Zhou
ObjectiveTo detect the expression of fibrinogen like protein-1 (FGL-1) in laryngeal cancer and evaluate its effect on tumor proliferation, metastasis, and antitumor immunity.MethodsELISA and immunohistochemistry were performed to detect FGL-1 expression in laryngeal cancer. The effects of FGL-1 knockdown on the proliferation, cell cycle progression, apoptosis, migration, and invasion of laryngeal cancer cells were evaluated by the CCK-8, colony formation, flow cytometry, Transwell migration, and western blot assays. We detected changes in tumorigenesis and drug...
Inconsistency analysis between metagenomic next-generation sequencing results of cerebrospinal fluid and clinical diagnosis with suspected central nervous system infection
Jin Wang, Jun Ye, Liqi Yang, Xiangfeng Chen, Haoshu Fang, Zhou Liu, Guomei Xia, Yafei Zhang & Zhenhua Zhang
Abstract Background Recently, with the rapid progress of metagenomic next-generation sequencing (mNGS), inconsistency between mNGS results and clinical diagnoses has become more common. There is currently no reasonable explanation for this, and the interpretation of mNGS reports still needs to be standardised. Methods A retrospective analysis was conducted on 47 inpatients with suspected central nervous system (CNS) infections, and clinical data were recorded. The final diagnosis was determined by an expert group based on the...
Mucosal-associated invariant T cells predict increased acute graft-versus-host-disease incidence in patients receiving allogeneic hematopoietic stem cell transplantation
Zhao Wang, Sudong Zhang, Xiaoyu Zhang, Li Liu, Lukun Zhou, Yuyan Shen, Rongli Zhang, Yi He, Donglin Yang, Erlie Jiang, Xiaoming Feng, Jiaxi Zhou, Tao Cheng, Mingzhe Han & Sizhou Feng
Abstract Background Mucosal-associated invariant T (MAIT) cells are innate-like T cells, some studies have reported that the number of circulating MAIT cells reduced in patients with acute graft-versus-host-disease (aGVHD) development. However, the role of donor MAIT cells on aGVHD development and subsequent functional change still remain unclear. Methods The study recruited 86 patients with hematological malignancies who underwent allogeneic hematopoietic cell transplantation (HCT) from May 1, 2018 to June 30, 2019. MAIT cells, their subset,...
Additional file 1 of LPAR5 confers radioresistance to cancer cells associated with EMT activation via the ERK/Snail pathway
Xiao-Ya Sun, Hao-Zheng Li, Da-Fei Xie, Shan-Shan Gao, Xin Huang, Hua Guan, Chen-Jun Bai & Ping-Kun Zhou
Additional file 1: Figure S1. Heatmap plot showing RNA expression changes of genes in HeLa cells 0.5 h A and 2 h B after irradiation compared to unirradiated cells
Additional file 1 of Metabolic differences in women with premature ovarian insufficiency: a systematic review and meta-analysis
Wang-Yu Cai, Xi Luo, Wei Wu, Jianyuan Song, Ning-Ning Xie, Cuicui Duan, Xiao-Ke Wu & Jian Xu
Additional file 1: Supplementary Figure 1. Funnel plot in themeta-analysis on the association of waist circumference between prematureovarian insufficiency and control group. Supplementary Figure 2. Funnel plot in the meta-analysis on the association of systolic blood pressure betweenpremature ovarian insufficiency and control group. Supplementary Figure 3. Funnel plot in the meta-analysis on the association of diastolic blood pressurebetween premature ovarian insufficiency and control group. Supplementary Figure 4. Funnel plot in the meta-analysis on the association...
Additional file 2 of Metabolic differences in women with premature ovarian insufficiency: a systematic review and meta-analysis
Wang-Yu Cai, Xi Luo, Wei Wu, Jianyuan Song, Ning-Ning Xie, Cuicui Duan, Xiao-Ke Wu & Jian Xu
Additional file 2: Supplementary table 1. PRISMA 2022 checklist.
AADAC protects colorectal cancer liver colonization from ferroptosis through SLC7A11-dependent inhibition of lipid peroxidation
Rongquan Sun, Zhifei Lin, Xiangyu Wang, Lu Liu, Meisi Huo, Rui Zhang, Jing Lin, Chao Xiao, Yitong Li, Wenwei Zhu, Lu Lu, Jubo Zhang & Jinhong Chen
Abstract Background Oxidative stress is a highly active metabolic process in the liver, that poses great threats to disseminated tumor cells during their colonization. Here, we aimed to investigate how colorectal cancer (CRC) cells overcome lipid peroxidation to sustain their metastatic colonization in the liver. Methods Orthotopic colorectal liver metastasis (CRLM) and CRC liver colonization mouse models were constructed to determine the roles of lipid peroxidation and AADAC in CRC liver colonization. The levels of...
A novel subtype to predict prognosis and treatment response with DNA driver methylation–transcription in ovarian cancer.
Yan Hou, Kang Li, Liuying Wang, Shuang Li, Min Zhang,, Yue Huang, Meng Wang, Liuchao Zhang & Zhenyi Xu
TableS1. Clinical data of ovarian cancer patients from TCGA and ICGC.
TableS2.Identified DNA driver methylation (DNAme) in TCGA, ICGC and GSE146556.
TableS3. The correlation between DNAme and corresponding mRNA expression in TCGA, ICGC and GSE146556. TableS4.Analysis of pathway enrichment (KEGG) and Gene Ontology (GO) of DNAme-associated mRNA in TCGA.
TableS5. Univariate Cox regression analysis of DNAme-associated mRNA. (P < 0.05)
TableS6. Analysis of pathway enrichment (KEGG) and Gene Ontology (GO) of...
TableS2.Identified DNA driver methylation (DNAme) in TCGA, ICGC and GSE146556.
TableS3. The correlation between DNAme and corresponding mRNA expression in TCGA, ICGC and GSE146556. TableS4.Analysis of pathway enrichment (KEGG) and Gene Ontology (GO) of DNAme-associated mRNA in TCGA.
TableS5. Univariate Cox regression analysis of DNAme-associated mRNA. (P < 0.05)
TableS6. Analysis of pathway enrichment (KEGG) and Gene Ontology (GO) of...
Additional file 1 of Prognostic value of lymph node density on cancer staging system for gastric cancer without distal metastasis: a population-based analysis of SEER database
Yuhua Liu, Hao Cui, Xinxin Xu & Wenquan Liang
Additional file 1: Supplemental Figure 1. Determining the optimal cutoff value of LND for predicting cancer-specific survival using x tile software. (A) Bar graph representing population distribution; (B) Kaplan–Meier survival curves divided by LND cutoff; (C) relative risk analysis among subgroups divided by cutoff value of LND.
sj-docx-1-tct-10.1177_15330338221124658 - Supplemental material for In Vitro and in Vivo Study of the Effect of Osteogenic Pulsed Electromagnetic Fields on Breast and Lung Cancer Cells
Mike Y. Chen, Jing Li, Nianli Zhang, Erik I. Waldorff, James T. Ryaby, Philip Fedor, Yongsheng Jia & Yujun Wang
Supplemental material, sj-docx-1-tct-10.1177_15330338221124658 for In Vitro and in Vivo Study of the Effect of Osteogenic Pulsed Electromagnetic Fields on Breast and Lung Cancer Cells by Mike Y. Chen, Jing Li, Nianli Zhang and Erik I. Waldorff, James T. Ryaby, Philip Fedor, Yongsheng Jia, Yujun Wang in Technology in Cancer Research & Treatment
sj-xlsx-5-tct-10.1177_15330338221124658 - Supplemental material for In Vitro and in Vivo Study of the Effect of Osteogenic Pulsed Electromagnetic Fields on Breast and Lung Cancer Cells
Mike Y. Chen, Jing Li, Nianli Zhang, Erik I. Waldorff, James T. Ryaby, Philip Fedor, Yongsheng Jia & Yujun Wang
Supplemental material, sj-xlsx-5-tct-10.1177_15330338221124658 for In Vitro and in Vivo Study of the Effect of Osteogenic Pulsed Electromagnetic Fields on Breast and Lung Cancer Cells by Mike Y. Chen, Jing Li, Nianli Zhang and Erik I. Waldorff, James T. Ryaby, Philip Fedor, Yongsheng Jia, Yujun Wang in Technology in Cancer Research & Treatment
Transcriptome analysis reveals the roles of phytohormone signaling in tea plant (Camellia sinensis L.) flower development
Xiaohan Xu, Jing Tao, Anqi Xing, Zichen Wu, Yuqin Xu, Yi Sun, Jiangyuan Zhu, Xiang Dai & Yuhua Wang
Abstract Background Tea plant (Camellia sinensis (L.) O. Kuntze) is an important economic tea crop, but flowering will consume a lot of nutrients of C. sinensis, which will seriously affect the nutritional growth of C. sinensis. However, there are few studies on the development mechanism of C. sinensis flower, and most studies focus on a single C. sinensis cultivar. Results Here, we identified a 92-genes’ C. sinensis flower development core transcriptome from the transcriptome of...
Additional file 1 of SPARC plays an important role in the oviposition and nymphal development in Nilaparvata lugens Stål
Weixia Wang, Tingheng Zhu, Pinjun Wan, Qi Wei, Jiachun He, Fengxiang Lai & Qiang Fu
Additional file 1: Table S1. Information of protein sequences used in alignment.
Resource Types
Affiliations
-
Zhejiang University8,030
-
Chinese Academy of Medical Sciences & Peking Union Medical College5,213
-
Shanghai Jiao Tong University4,744
-
Fudan University4,307
-
Sichuan University4,091
-
Capital Medical University3,901
-
Huazhong University of Science and Technology3,834
-
Sun Yat-sen University3,722
-
Chinese Academy of Sciences3,602
-
Nanjing Medical University3,382